Results 161 to 170 of about 78,214 (186)
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Lymphoid neogenesis in chronic inflammatory diseases
Nature Reviews Immunology, 2006The frequent observation of organized lymphoid structures that resemble secondary lymphoid organs in tissues that are targeted by chronic inflammatory processes, such as autoimmunity and infection, has indicated that lymphoid neogenesis might have a role in maintaining immune responses against persistent antigens.
Ricardo Pujol-Borrell +2 more
exaly +3 more sources
Seminars in Immunology, 2008
The plasticity of the immune system is evident in the reorganization of secondary lymphoid organs during immune responses, lymphoid tissue neogenesis occurring during chronic inflammation or graft rejection, and the engineered lymphoid tissue formation induced by ectopic expression of single lymphoid tissue-associated genes.
Darrell J Irvine, Agnieszka N Stachowiak
exaly +3 more sources
The plasticity of the immune system is evident in the reorganization of secondary lymphoid organs during immune responses, lymphoid tissue neogenesis occurring during chronic inflammation or graft rejection, and the engineered lymphoid tissue formation induced by ectopic expression of single lymphoid tissue-associated genes.
Darrell J Irvine, Agnieszka N Stachowiak
exaly +3 more sources
Lymphoid organ development: from ontogeny to neogenesis
Nature Immunology, 2006The development of lymphoid organs can be viewed as a continuum. At one end are the 'canonical' secondary lymphoid organs, including lymph nodes and spleen; at the other end are 'ectopic' or tertiary lymphoid organs, which are cellular accumulations arising during chronic inflammation by the process of lymphoid neogenesis. Secondary lymphoid organs are
Nancy Ruddle +2 more
exaly +3 more sources
Synovial lymphoid neogenesis does not define a specific clinical rheumatoid arthritis phenotype.
Arthritis and Rheumatism, 2008 OBJECTIVE: To investigate the relationship between lymphoid neogenesis in the synovium of patients with rheumatoid arthritis (RA) and characteristics of inflammation and disease severity.
Paul P Tak, Tineke Cantaert
exaly +2 more sources
Lymphoid neogenesis in chronic rejection
Current Opinion in Organ Transplantation, 2008Although chronic rejection is currently one of the main causes of long-term allograft failure, its pathogenesis remains elusive, thereby preventing the development of effective therapy.Recent advances in the comprehension of the pathophysiology of chronic inflammatory diseases could shed new light on the pathogenesis of chronic rejection.
Olivier, Thaunat, Antonino, Nicoletti
openaire +2 more sources
Lymphoid neogenesis in chronic rejection: the murderer is in the house
Current Opinion in Immunology, 2006Although chronic rejection is currently the main cause of long-term allograft failure, its pathogenesis remains elusive, hereby preventing the development of effective therapy. Recent advances in the comprehension of the pathophysiology of chronic inflammatory diseases could shed new light on the pathogenesis of chronic rejection.
Olivier, Thaunat +4 more
openaire +2 more sources
Is defective lymphatic drainage a trigger for lymphoid neogenesis?
Trends in Immunology, 2006The progressive organization of cellular infiltrates into functional ectopic germinal centers (i.e. lymphoid neogenesis) has been recently evidenced in various chronic inflammatory diseases. Failure of the immune system to eradicate the targeted antigen(s) is a shared feature of all of the pathological situations associated with lymphoid neogenesis ...
Olivier, Thaunat +2 more
openaire +2 more sources
Ectopic lymphoid follicles: inducible centres for generating antigen-specific immune responses within tissues [PDF]
Immunology, 2016 Lymphoid neogenesis is traditionally viewed as a pre-programmed process that promotes the formation of lymphoid organs during development. Here, the spatial organization of T and B cells in lymph nodes and spleen into discrete structures regulates ...
Simon Jones, Gareth W Jones
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Lymphocyte Trafic in Lymphoid Organ Neogenesis
2002The three members of the immediate lymphotoxin (LT) tumor necrosis factor (TNF) family play important roles in inflammation and lymphoid organ development. Here their differential roles and mechanisms in lymphoid organ genesis and neogenesis are considered with particular emphasis on LTa and the LTas complex.
Danielle L. Drayton +5 more
openaire +1 more source
Current Pharmaceutical Biotechnology, 2012
It has long been demonstrated that a subset of patients with Sjogren's syndrome (SS) develop ectopic lymphoid structures (ELS) in the salivary glands (SG). These structures are characterised by periductal clusters of T and B lymphocytes, development of high endothelial venules and differentiation of follicular dendritic cells (FDC) networks.
Michele, Bombardieri +1 more
openaire +2 more sources
It has long been demonstrated that a subset of patients with Sjogren's syndrome (SS) develop ectopic lymphoid structures (ELS) in the salivary glands (SG). These structures are characterised by periductal clusters of T and B lymphocytes, development of high endothelial venules and differentiation of follicular dendritic cells (FDC) networks.
Michele, Bombardieri +1 more
openaire +2 more sources