Results 1 to 10 of about 3,969,489 (270)
Initiation of Tertiary Lymphoid Structures for Cancer Immunotherapy [PDF]
ResearchTertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates formed by lymphocytes and antigen-presenting cells within chronic inflammatory microenvironments or tumor microenvironments (TMEs), and their initiation phase is a critical step for ...
Ji-Yuan Zou +4 more
doaj +5 more sources
Tertiary lymphoid structures in thyroid cancer [PDF]
Archives of Endocrinology and MetabolismObjective: This study aimed to investigate the presence of tertiary lymphoid structures (TLSs) and tumor-infiltrating B cells within the germinal centers of TLSs in the tumor microenvironment of thyroid cancer, utilizing a morphological approach ...
Katia Sakimi Nakadaira +7 more
doaj +5 more sources
The formation and function of tertiary lymphoid structures [PDF]
Biomarker ResearchTertiary lymphoid structures (TLSs) are immune cell aggregates that emerge in nonlymphoid tissues during various disease states, including chronic inflammation, autoimmunity, and cancer.
Chengzhang Zhang +7 more
doaj +3 more sources
Tertiary Lymphoid Structures and Cancer Prognosis (Brief Review) [PDF]
Креативная хирургия и онкология, 2020 This brief review is devoted to the role of tertiary lymphoid structures in oncological processes. A number of research studies carried out over the past ten years have shed light on the functions of such structures in various diseases, as well as their ...
R. A. Rustamkhanov +2 more
doaj +2 more sources
Newly formated (tertiary) lymphoid structures in tumor growth [PDF]
Наука и инновации в медицине, 2022 Aim to reproduce tertiary lymphoid structures and study their features in a malignant neoplasm in the experiment. Material and methods. Male white rats of the Wistar stress-resistant line were inoculated with the tumor strain sarcoma M1.
Rasul A. Rustamkhanov +5 more
doaj +3 more sources
Non-immune regulation of tertiary lymphoid structures in cancer [PDF]
Frontiers in ImmunologyTertiary lymphoid structures (TLS) are ectopic immune aggregates that form in response to chronic inflammation, and their presence across many solid tumors has been associated with improved survival and enhanced responses to immunotherapy.
Owen K. Challen +20 more
doaj +2 more sources
Mature tertiary lymphoid structures in pilonidal sinus disease [PDF]
JID InnovationsPilonidal sinus disease (PSD) is characterized by recurrent purulent abscesses or sinus tracts in the sacrococcygeal region. Although its pathophysiology remains unclear, mixed inflammatory infiltrates are seen on histopathology.
Radhika Gupta +5 more
doaj +2 more sources
The Emerging Role of Tertiary Lymphoid Structures as Predictive and Prognostic Biomarkers of Immunotherapy in Cancer [PDF]
Cancer MedicineBackground Immune checkpoint inhibitors (ICIs) have improved outcomes across several cancers, yet many patients do not respond, highlighting the need for robust predictive biomarkers.
Lidia B. Medhin +5 more
doaj +2 more sources
Does TLS Exist in Canine Mammary Gland Tumours? Preliminary Results in Simple Carcinomas
Veterinary Sciences, 2022 Neoplastic progression is influenced by the expression of tumour antigens that activate an anti-tumour immune response. Human medical studies show that this body defence is carried out in secondary lymphoid organs (SLOs) but also directly in the tumour ...
Giada Giambrone +7 more
doaj +1 more source
Frontiers in Immunology, 2021 The complex tumor microenvironment (TME) plays a vital role in cancer development and dramatically determines the efficacy of immunotherapy. Tertiary lymphoid structures (TLSs) within the TME are well recognized and consist of T cell-rich areas ...
Wendi Kang +8 more
doaj +1 more source