Results 1 to 10 of about 13,821 (239)
Tertiary lymphoid structures in thyroid cancer [PDF]
Archives of Endocrinology and MetabolismObjective: This study aimed to investigate the presence of tertiary lymphoid structures (TLSs) and tumor-infiltrating B cells within the germinal centers of TLSs in the tumor microenvironment of thyroid cancer, utilizing a morphological approach ...
Katia Sakimi Nakadaira +7 more
doaj +5 more sources
Heterogeneity of tertiary lymphoid structures in cancer
Frontiers in Immunology, 2023 The success of immunotherapy approaches, such as immune checkpoint blockade and cellular immunotherapy with genetically modified lymphocytes, has firmly embedded the immune system in the roadmap for combating cancer. Unfortunately, the majority of cancer
Xin You +5 more
doaj +5 more sources
Tertiary Lymphoid Structures: Autoimmunity Goes Local [PDF]
Frontiers in Immunology, 2018 Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune diseases. TLS present features of secondary lymphoid organs such as segregated T and B cell zones, presence of follicular dendritic cell networks, high endothelial ...
Elena Pipi +6 more
doaj +6 more sources
Tertiary lymphoid structures in autoimmune diseases
Frontiers in ImmunologyTertiary lymphoid structures (TLSs) are organized lymphoid-like aggregations in non-lymphoid tissues. Tissues with chronic and persistent inflammation infiltration may drive and form ectopic germinal center-like structures, which are very common in ...
Yuanji Dong, Ting Wang, Huaxiang Wu
doaj +5 more sources
Initiation of Tertiary Lymphoid Structures for Cancer Immunotherapy [PDF]
ResearchTertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates formed by lymphocytes and antigen-presenting cells within chronic inflammatory microenvironments or tumor microenvironments (TMEs), and their initiation phase is a critical step for ...
Ji-Yuan Zou +4 more
doaj +4 more sources
Tertiary lymphoid structures: new immunotherapy biomarker
Frontiers in ImmunologyImmunotherapy shows substantial advancement in cancer and is becoming widely used in clinical practice. A variety of biomarkers have been proposed to predict the efficacy of immunotherapy, but most of them have low predictive ability.
Fangyuan Yang +5 more
doaj +5 more sources
Tertiary lymphoid structures in cancer: maturation and induction
Frontiers in ImmunologyTertiary lymphoid structure (TLS) is an ectopic lymphocyte aggregate formed in peripheral non-lymphoid tissues, including inflamed or cancerous tissue.
Yulu Chen +11 more
doaj +5 more sources
The Emerging Role of Tertiary Lymphoid Structures as Predictive and Prognostic Biomarkers of Immunotherapy in Cancer [PDF]
Cancer MedicineBackground Immune checkpoint inhibitors (ICIs) have improved outcomes across several cancers, yet many patients do not respond, highlighting the need for robust predictive biomarkers.
Lidia B. Medhin +5 more
doaj +2 more sources
Tertiary lymphoid structures in genitourinary cancers: a comprehensive review [PDF]
Frontiers in OncologyTertiary lymphoid structures (TLSs) are lymphoid cell clusters that form in non-lymphoid tissues in response to chronic inflammation and function as sites for localized, antigen-specific immune responses, potentially enhancing anti-tumor immunity.
Alvaro Abreu +7 more
doaj +2 more sources
Frontiers in ImmunologyTertiary Lymphoid Structures (TLS) are organized aggregates of immune cells such as T cells, B cells, and Dendritic Cells (DCs), as well as fibroblasts, formed postnatally in response to signals from cytokines and chemokines.
Mariana Reste +11 more
doaj +3 more sources