Tertiary lymphoid structures in thyroid cancer [PDF]
Archives of Endocrinology and MetabolismObjective: This study aimed to investigate the presence of tertiary lymphoid structures (TLSs) and tumor-infiltrating B cells within the germinal centers of TLSs in the tumor microenvironment of thyroid cancer, utilizing a morphological approach ...
Katia Sakimi Nakadaira +7 more
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The Emerging Role of Tertiary Lymphoid Structures as Predictive and Prognostic Biomarkers of Immunotherapy in Cancer [PDF]
Cancer MedicineBackground Immune checkpoint inhibitors (ICIs) have improved outcomes across several cancers, yet many patients do not respond, highlighting the need for robust predictive biomarkers.
Lidia B. Medhin +5 more
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Initiation of Tertiary Lymphoid Structures for Cancer Immunotherapy [PDF]
ResearchTertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates formed by lymphocytes and antigen-presenting cells within chronic inflammatory microenvironments or tumor microenvironments (TMEs), and their initiation phase is a critical step for ...
Ji-Yuan Zou +4 more
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Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease? [PDF]
Frontiers in Immunology, 2017 Secondary lymphoid organs are integral to initiation and execution of adaptive immune responses. These organs provide a setting for interactions between antigen-specific lymphocytes and antigen-presenting cells recruited from local infected or inflamed ...
Emily Jayne Colbeck +3 more
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Orchestration of tertiary lymphoid structures: decoding developmental mechanisms for next-generation cancer immunotherapies [PDF]
Medical ReviewTertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates that form in non-lymphoid organs, frequently observed in conditions such as cancer, autoimmune diseases, transplant rejection, and chronic inflammation.
Hao Wenqin, Zhao Ying
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Tertiary lymphoid structures in genitourinary cancers: a comprehensive review [PDF]
Frontiers in OncologyTertiary lymphoid structures (TLSs) are lymphoid cell clusters that form in non-lymphoid tissues in response to chronic inflammation and function as sites for localized, antigen-specific immune responses, potentially enhancing anti-tumor immunity.
Alvaro Abreu +7 more
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Tertiary lymphoid structures in the era of cancer therapy [PDF]
Journal of Experimental & Clinical Cancer ResearchOn September 9th, 2025, the 3rd Workshop on Tertiary lymphoid structures (TLS) took place in Utrecht as pre-meeting to CICON2025. Advances in TLS biology, diversity, and clinical significance are rapidly reshaping the field.
Isaias Hernández-Verdin +9 more
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Tertiary lymphoid structures: The touchstone for tumor immunotherapy [PDF]
Acta Pharmaceutica Sinica BLisha Zhou, Shunji Liu, Yang Sun
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Newly formated (tertiary) lymphoid structures in tumor growth [PDF]
Наука и инновации в медицине, 2022 Aim to reproduce tertiary lymphoid structures and study their features in a malignant neoplasm in the experiment. Material and methods. Male white rats of the Wistar stress-resistant line were inoculated with the tumor strain sarcoma M1.
Rasul A. Rustamkhanov +5 more
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Tertiary Lymphoid Structures and Cancer Prognosis (Brief Review)
Креативная хирургия и онкология, 2020 This brief review is devoted to the role of tertiary lymphoid structures in oncological processes. A number of research studies carried out over the past ten years have shed light on the functions of such structures in various diseases, as well as their ...
R. A. Rustamkhanov +2 more
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