Results 11 to 20 of about 3,969,489 (270)

Tertiary Lymphoid Structures: Autoimmunity Goes Local [PDF]

Frontiers in Immunology, 2018
Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune diseases. TLS present features of secondary lymphoid organs such as segregated T and B cell zones, presence of follicular dendritic cell networks, high endothelial ...
Elena Pipi, Elena Pipi, Saba Nayar, David H. Gardner, Serena Colafrancesco, Charlotte Smith, Francesca Barone   +6 more
doaj   +6 more sources

Tertiary lymphoid structures in colorectal cancer

Annals of Medicine
Background Tertiary lymphoid structures (TLS) are ectopic clusters of immune cells found in non-lymphoid tissues, particularly within the tumor microenvironment (TME).
Jianyu Lv, Xiuyu Zhang, Mi Zhou, Junbin Yan, Guanqun Chao, Shuo Zhang   +5 more
doaj   +4 more sources

Molecular and spatial analysis of tertiary lymphoid structures in Sjogren’s syndrome [PDF]

Nature Communications
Tertiary lymphoid structures play important roles in autoimmune and non-autoimmune conditions. While many of the molecular mechanisms involved in tertiary lymphoid structure formation have been identified, the cellular sources and temporal and spatial ...
Saba Nayar, Jason D. Turner, Saba Asam, Eanna Fennell, Matthew Pugh, Serena Colafrancesco, Onorina Berardicurti, Charlotte G. Smith, Joe Flint, Ana Teodosio, Valentina Iannizzotto, David H. Gardner, Joel van Roon, Ilya Korsunsky, Dawn Howdle, Roche Fibroblast Network Consortium, Andreas P. Frei, Kara G. Lassen, Simon J. Bowman, Wan-Fai Ng, Adam P. Croft, Andrew Filer, Benjamin A. Fisher, Christopher D. Buckley, Francesca Barone   +24 more
doaj   +9 more sources

Heterogeneity of tertiary lymphoid structures in cancer

Frontiers in Immunology, 2023
The success of immunotherapy approaches, such as immune checkpoint blockade and cellular immunotherapy with genetically modified lymphocytes, has firmly embedded the immune system in the roadmap for combating cancer. Unfortunately, the majority of cancer
Xin You, Kristina Koop, Andreas Weigert, Andreas Weigert, Andreas Weigert, Andreas Weigert   +5 more
doaj   +3 more sources

Induction of Secondary and Tertiary Lymphoid Structures in the Skin [PDF]

Immunity, 2004
During embryogenesis a developmental program leading to the formation of lymph nodes and Peyer's patches is initiated. We now show that lymph node-like structures as well as tertiary lymphoid structures can ectopically be induced by intradermal injection of newborn lymph node-derived cells.
Cupedo, Tom, Jansen, Wendy, Kraal, Georg, Mebius, Reina E   +3 more
openaire   +4 more sources

Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer

Frontiers in Immunology, 2023
Tertiary lymphoid structures (TLS) are lymph node-like aggregates that can form in association with chronic inflammation or cancer. Mature TLS are organized into B and T cell zones, and are not encapsulated but include all cell types necessary for ...
Alessandra Vaccaro, Tiarne van de Walle, Mohanraj Ramachandran, Magnus Essand, Anna Dimberg   +4 more
doaj   +4 more sources

Tertiary lymphoid structures, a historical reappraisal

Tissue and Cell
Tertiary lymphoid structures (TLSs) are accumulations of lymphoid cells within non-lymphoid organs that share the cellular compartments, spatial organization, vasculature, chemokines, and function with secondary lymphoid organs, especially lymph nodes. TLSs are organized into a separate T cell and B cell compartments which contain germinal centers with
Ribatti, Domenico
openaire   +4 more sources

Tertiary lymphoid structures in autoimmune diseases

Frontiers in Immunology
Tertiary lymphoid structures (TLSs) are organized lymphoid-like aggregations in non-lymphoid tissues. Tissues with chronic and persistent inflammation infiltration may drive and form ectopic germinal center-like structures, which are very common in ...
Yuanji Dong, Ting Wang, Huaxiang Wu
doaj   +3 more sources

Tertiary lymphoid structures in pulmonary granulomas of cattle experimentally infected with aerosolized Mycobacterium bovis

BMC Veterinary Research
Mycobacterium bovis is the primary cause of tuberculosis in animals, most notably cattle. In cattle and other susceptible hosts, the hallmark lesion of tuberculosis is the granuloma.
Mitchell V. Palmer, Douglas E. Jones, Nicholas J. Bockenstedt, Paola M. Boggiatto   +3 more
doaj   +2 more sources

Tertiary lymphoid structures in ovarian cancer

Frontiers in Immunology
Ovarian cancer (OC) is a significant cause of cancer-related mortality in women worldwide. Despite advances in treatment modalities, including surgery and chemotherapy, the overall prognosis for OC patients remains poor, particularly for patients with ...
Guojuan Sun, Yi Liu
doaj   +3 more sources