Results 31 to 40 of about 3,969,489 (270)

The gene signature of tertiary lymphoid structures within ovarian cancer predicts the prognosis and immunotherapy benefit

Frontiers in Genetics, 2023
Ovarian cancer (OC) has the lowest survival rate among gynecologic malignancies. Ectopic lymphocyte aggregates, namely tertiary lymphoid structures (TLSs), have been reported as positive biomarkers for tumor prognosis. However, the related gene signature
Yue Hou, Yue Hou, Yue Hou, Yue Hou, Sijing Qiao, Sijing Qiao, Sijing Qiao, Sijing Qiao, Miao Li, Miao Li, Miao Li, Miao Li, Xue Han, Xue Han, Xue Han, Xue Han, Xuan Wei, Xuan Wei, Xuan Wei, Xuan Wei, Yingxin Pang, Yingxin Pang, Yingxin Pang, Yingxin Pang, Hongluan Mao, Hongluan Mao, Hongluan Mao, Hongluan Mao   +27 more
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Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium [PDF]

, 2009
BackgroundFollicular structures resembling germinal centres (GCs) that are characterized by follicular dendritic cell (FDC) networks have long been recognized in chronically inflamed tissues in autoimmune diseases, including the synovium of rheumatoid ...
Kelly, Stephen, Kelly, S, Blades, Mark C., Kirkham, Bruce, Spencer, Jo, Frances Humby, Bruce Kirkham, Pitzalis, Costantino, Michele Bombardieri, Kelly Stephen, Mark C Blades, Humby, F, Bombardieri M., Blades, MC, Manzo Antonio, Humby, Frances, Stephen Kelly, Bombardieri, M, Pitzalis C., Bombardieri, Michele, Spencer, J, Humby F., Blades M.C., Bombardieri Michele, Humby Frances, Blades Mark C, Kirkham, B, Kirkham Bruce, Manzo, A, Spencer Jo, Spencer J., MANZO, ANTONIO, Pitzalis Costantino, Antonio Manzo, Pitzalis, C, Kirkham B., Jo Spencer, Costantino Pitzalis, Kelly S.   +38 more
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Correlations between clinicopathological factors and Tertiary Lymphoid Structures (TLS).

, 2022
Correlations between clinicopathological factors and Tertiary Lymphoid Structures (TLS).
Shigeru Lee (11919604), Hiroaki Tanaka (372008), Tatsuro Tamura (7841207), Sota Deguchi (11919598), Yoshihito Yamakoshi (11919601), Takuya Mori (445318), Kazuya Muguruma (656230), Mami Yoshii (8307636), Masaichi Ohira (656231), Yuichiro Miki (5754011), Takahiro Toyokawa (765421)   +10 more
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Mesenchymal stem cells and T cells in the formation of Tertiary Lymphoid Structures in Lupus Nephritis [PDF]

, 2018
Tertiary lymphoid structures (TLS) develop in the kidneys of lupus-prone mice and systemic lupus erythematosus (SLE) patients with lupus nephritis (LN).
Fenton, Kristin Andreassen, Aud-Malin K. Hovd, Kristin A. Fenton, Dorraji, Seyed Esmaeil, Kanapathippillai, Premasany, Gunnstein Bakland, Eilertsen, Gro Østli, Stine L. Figenschau, S. Esmaeil Dorraji, Figenschau, Stine, Premasany Kanapathippillai, Gro Østli Eilertsen, Bakland, Gunnstein, Hovd, Aud-Malin Karlsson   +13 more
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Tertiary lymphoid structures and gastric cancer prognosis

APMIS, 2022
Tertiary lymphoid structures (TLSs) are part of immune response against cancer. Their high density and high diameter have been shown to be associated with prognosis in different cancer types. The aim of this study was to examine the prognostic significance of TLS density and diameter in gastric cancer and reproducibility of their assessments.
Kemi, N. (Niko), Ylitalo, O. (Olli), Väyrynen, J. P. (Juha P.), Helminen, O. (Olli), Junttila, A. (Anna), Mrena, J. (Johanna), Böhm, J. (Jan), Kauppila, J. H. (Joonas H.)   +7 more
openaire   +4 more sources

Tertiary lymphoid structures in the era of cancer immunotherapy [PDF]

Nature Reviews Cancer, 2019
Tertiary lymphoid structures (TLSs) are ectopic lymphoid organs that develop in non-lymphoid tissues at sites of chronic inflammation including tumours. Key common characteristics between secondary lymphoid organogenesis and TLS neogenesis have been identified.
Catherine Sautès-Fridman, Florent Petitprez, Julien Calderaro, Wolf Herman Fridman   +3 more
openaire   +2 more sources

The roles of tertiary lymphoid structures in chronic diseases

Nature Reviews Nephrology, 2023
Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such as lymph nodes, TLSs lack capsules and have their own unique characteristics and functions.
Sato, Yuki, Silina, Karina, van den Broek, Maries, Hirahara, Kiyoshi, Yanagita, Motoko   +4 more
openaire   +3 more sources

Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma [PDF]

, 2014
Background -Oral squamous cell carcinomas are often heavily infiltrated by immune cells. The organization of B-cells, follicular dendritic cells, T-cells and high-endothelial venules into structures termed tertiary lymphoid structures have been detected ...
Wirsing, Anna Maria, Oddveig G Rikardsen, Anna M Wirsing, Sonja E Steigen, Hadler-Olsen, Elin Synnøve, Elin Hadler-Olsen, Steigen, Sonja Eriksson, Uhlin-Hansen, Lars, Rikardsen, Oddveig G, Lars Uhlin-Hansen   +9 more
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Characteristics of tertiary lymphoid structures in primary cancers [PDF]

OncoImmunology, 2013
Tumors are sustained by complex networks of interactions between malignant cells, stromal cells and tumor-infiltrating immune cells. These networks differ from patient to patient in terms of nature, composition and organization as well as with regard to the precise localization of tumor-infiltrating cells.
Goc, Jérémy, Fridman, Wolf-Herman, Sautès-Fridman, Catherine, Dieu-Nosjean, Marie-Caroline   +3 more
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Tertiary Lymphoid Structures as Mediators of Immunotherapy Response

Cancers, 2022
Since its first application in the treatment of cancer during the 1800s, immunotherapy has more recently become the leading edge of novel treatment strategies. Even though the efficacy of these agents can at times be predicted by more traditional metrics and biomarkers, often patient responses are variable.
Raj G. Vaghjiani, Joseph J. Skitzki
openaire   +2 more sources