IJU Case Reports, 2023 Introduction Although undifferentiated pleomorphic sarcomas are aggressive, a subset of these tumors are immunogenic and may respond to immunotherapy.
Hidetoshi Kokubun +9 more
doaj +2 more sources
Tertiary lymphoid structures: The touchstone for tumor immunotherapy [PDF]
Acta Pharmaceutica Sinica BLisha Zhou, Shunji Liu, Yang Sun
doaj +5 more sources
Tertiary Lymphoid Structures in Microorganism-Related Cancer
CancersTertiary lymphoid structures (TLSs) are ectopic lymphoid tissues formed by the accumulation of lymphocytes and other components outside lymphoid organs. They have been shown to be widespread in cancers and have predictive effects on prognosis and immunotherapy efficacy; however, there is no standardized measurement guide.
Shuzhe Deng +4 more
openaire +3 more sources
Tertiary lymphoid structures: new immunotherapy biomarker
Frontiers in ImmunologyImmunotherapy shows substantial advancement in cancer and is becoming widely used in clinical practice. A variety of biomarkers have been proposed to predict the efficacy of immunotherapy, but most of them have low predictive ability.
Fangyuan Yang +5 more
doaj +3 more sources
Tertiary Lymphoid Structures in the Central Nervous System: Implications for Glioblastoma [PDF]
Frontiers in Immunology, 2021 Glioblastoma is the most common and aggressive brain tumor, which is uniformly lethal due to its extreme invasiveness and the absence of curative therapies.
Tiarne van de Walle +5 more
doaj +2 more sources
Tertiary lymphoid structures in cancer: maturation and induction
Frontiers in ImmunologyTertiary lymphoid structure (TLS) is an ectopic lymphocyte aggregate formed in peripheral non-lymphoid tissues, including inflamed or cancerous tissue.
Yulu Chen +11 more
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Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease? [PDF]
Frontiers in Immunology, 2017 Secondary lymphoid organs are integral to initiation and execution of adaptive immune responses. These organs provide a setting for interactions between antigen-specific lymphocytes and antigen-presenting cells recruited from local infected or inflamed ...
Emily Jayne Colbeck +3 more
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Cellular and Vascular Components of Tertiary Lymphoid Structures
, 2018 Inflammatory immune cells recruited at the site of chronic inflammation form structures that resemble secondary lymphoid organs (SLO). These are characterized by segregated areas of prevalent T- or B-cell aggregation, differentiation of high endothelial venules, and local activation of resident stromal cells, including lymphatic endothelial cells.
Christopher George, Mueller +3 more
openaire +3 more sources
Kidney tertiary lymphoid structures in Lupus Nephritis develop into large interconnected networks and resemble lymph nodes in gene signature [PDF]
, 2020 Immune aggregates organized as tertiary lymphoid structures (TLS) are observed within the kidneys of patients with systemic lupus erythematosus and lupus nephritis (LN).
Figenschau, Stine +10 more
core +1 more source
Characterization of lymphoid tissue inducer cells and lymphoid tissue development in adult interleukin 7 transgenic mice [PDF]
, 2008 During embryogenesis, the development of secondary lymphoid organs (SLOs) such as lymph nodes (LNs) and Peyer’s patches (PPs) requires the cellular crosstalk between vascular cell adhesion molecule (VCAM)-1+ mesenchymal organizer cells and CD45+CD4 ...
Schmutz, Sandrine
core +1 more source