Results 21 to 30 of about 13,821 (239)

Tertiary Lymphoid Structures in Cancer: The Double-Edged Sword Role in Antitumor Immunity and Potential Therapeutic Induction Strategies

Frontiers in Immunology, 2021
The complex tumor microenvironment (TME) plays a vital role in cancer development and dramatically determines the efficacy of immunotherapy. Tertiary lymphoid structures (TLSs) within the TME are well recognized and consist of T cell-rich areas ...
Wendi Kang, Zhichao Feng, Zhichao Feng, Jianwei Luo, Zhenhu He, Jun Liu, Jianzhen Wu, Pengfei Rong, Pengfei Rong   +8 more
doaj   +1 more source

A case of adrenal undifferentiated pleomorphic sarcoma with tertiary lymphoid structures responded to pembrolizumab

IJU Case Reports, 2023
Introduction Although undifferentiated pleomorphic sarcomas are aggressive, a subset of these tumors are immunogenic and may respond to immunotherapy.
Hidetoshi Kokubun, Toshiki Kijima, Atsuko Takada‐Owada, Daisuke Mamiya, Ryo Kurashina, Naoya Okubo, Toshitaka Uematsu, Kohei Takei, Kazuyuki Ishida, Takao Kamai   +9 more
doaj   +1 more source

The gene signature of tertiary lymphoid structures within ovarian cancer predicts the prognosis and immunotherapy benefit

Frontiers in Genetics, 2023
Ovarian cancer (OC) has the lowest survival rate among gynecologic malignancies. Ectopic lymphocyte aggregates, namely tertiary lymphoid structures (TLSs), have been reported as positive biomarkers for tumor prognosis. However, the related gene signature
Yue Hou, Yue Hou, Yue Hou, Yue Hou, Sijing Qiao, Sijing Qiao, Sijing Qiao, Sijing Qiao, Miao Li, Miao Li, Miao Li, Miao Li, Xue Han, Xue Han, Xue Han, Xue Han, Xuan Wei, Xuan Wei, Xuan Wei, Xuan Wei, Yingxin Pang, Yingxin Pang, Yingxin Pang, Yingxin Pang, Hongluan Mao, Hongluan Mao, Hongluan Mao, Hongluan Mao   +27 more
doaj   +1 more source

Tertiary lymphoid structures in the era of cancer therapy. [PDF]

J Exp Clin Cancer Res
Abstract On September 9th, 2025, the 3rd Workshop on Tertiary lymphoid structures (TLS) took place in Utrecht as pre-meeting to CICON2025. Advances in TLS biology, diversity, and clinical significance are rapidly reshaping the field.
Hernández-Verdin I, Dimberg A, Thommen DS, Engblom C, Vanhersecke L, Silina K, Bruno TC, Fridman WH, Nisticò P, Sautès-Fridman C.   +9 more
europepmc   +4 more sources

Tertiary lymphoid structures and gastric cancer prognosis

APMIS, 2022
Tertiary lymphoid structures (TLSs) are part of immune response against cancer. Their high density and high diameter have been shown to be associated with prognosis in different cancer types. The aim of this study was to examine the prognostic significance of TLS density and diameter in gastric cancer and reproducibility of their assessments.
Kemi, N. (Niko), Ylitalo, O. (Olli), Väyrynen, J. P. (Juha P.), Helminen, O. (Olli), Junttila, A. (Anna), Mrena, J. (Johanna), Böhm, J. (Jan), Kauppila, J. H. (Joonas H.)   +7 more
openaire   +4 more sources

The roles of tertiary lymphoid structures in chronic diseases

Nature Reviews Nephrology, 2023
Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such as lymph nodes, TLSs lack capsules and have their own unique characteristics and functions.
Sato, Yuki, Silina, Karina, van den Broek, Maries, Hirahara, Kiyoshi, Yanagita, Motoko   +4 more
openaire   +3 more sources

From Lymphotoxin to Tertiary Lymphoid Structures and Beyond. [PDF]

Immunol Rev
ABSTRACT Lymphoid organ development occurs in ontogeny in the absence of antigenic stimulation; inflammation occurs after some immunological insult. These subjects had originally been considered as separate fields of research. Inflammation is due to inflammatory mediators such as lymphotoxin (LT) and its close relative, tumor necrosis
Ruddle NH.
europepmc   +3 more sources

Induction of Secondary and Tertiary Lymphoid Structures in the Skin [PDF]

Immunity, 2004
During embryogenesis a developmental program leading to the formation of lymph nodes and Peyer's patches is initiated. We now show that lymph node-like structures as well as tertiary lymphoid structures can ectopically be induced by intradermal injection of newborn lymph node-derived cells.
Cupedo, Tom, Jansen, Wendy, Kraal, Georg, Mebius, Reina E   +3 more
openaire   +2 more sources

Characteristics of tertiary lymphoid structures in primary cancers [PDF]

OncoImmunology, 2013
Tumors are sustained by complex networks of interactions between malignant cells, stromal cells and tumor-infiltrating immune cells. These networks differ from patient to patient in terms of nature, composition and organization as well as with regard to the precise localization of tumor-infiltrating cells.
Goc, Jérémy, Fridman, Wolf-Herman, Sautès-Fridman, Catherine, Dieu-Nosjean, Marie-Caroline   +3 more
openaire   +2 more sources

Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy [PDF]

Cellular & Molecular Immunology, 2017
Tertiary lymphoid structures (TLS) often develop at sites of persistent inflammation, including cancers and autoimmune diseases. In most cases, the presence of TLS correlates with active immune responses. Because of their proximity to pathological loci, TLS are an intriguing target for the manipulation of immune responses.
Haidong, Tang, Mingzhao, Zhu, Jian, Qiao, Yang-Xin, Fu   +3 more
openaire   +2 more sources