Editorial: Tertiary lymphoid structures (TLS) in the tumor immune microenvironment [PDF]
Frontiers in ImmunologyXinbo Gao +5 more
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Turning Tertiary Lymphoid Structures (TLS) into Hot Spots: Values of TLS in Gastrointestinal Tumors [PDF]
Cancers, 2023 Tertiary lymphoid structures (TLSs) are ectopic lymphocyte aggregation structures found in the tumor microenvironment (TME). Emerging evidence shows that TLSs are significantly correlated with the progression of gastrointestinal tumors, patients’ prognosis, and the efficacy of adjuvant therapy. Besides, there are still some immunosuppressive factors in
Daming Cai +7 more
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Tertiary lymphoid structures (TLS) identification and density assessment on H&E-stained digital slides of lung cancer [PDF]
PLOS ONE, 2021 Tertiary lymphoid structures (TLS) are ectopic aggregates of lymphoid cells in inflamed, infected, or tumoral tissues that are easily recognized on an H&E histology slide as discrete entities, distinct from lymphocytes. TLS are associated with improved cancer prognosis but there is no standardised method available to quantify their presence ...
Panagiotis Barmpoutis +6 more
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Prognostic value of tertiary lymphoid structures (TLS) in digestive system cancers: a systematic review and meta-analysis [PDF]
BMC Cancer, 2023 Abstract Background Existing literature suggests that tertiary lymphatic structure (TLS) is associated with the progression of cancer. However, the prognostic role of TLS in digestive system cancers remains controversial.
Hao Sun +9 more
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Tertiary lymphoid structures critical for prognosis in endometrial cancer patients [PDF]
Nature Communications, 2022 Tertiary lymphoid structures (TLS) are associated with a reduced risk of cancer recurrence and improved response to immune checkpoint blockade in several tumor types.
Nanda Horeweg +21 more
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Stromal fibroblasts in tertiary lymphoid structures: a novel target in chronic inflammation. [PDF]
Frontiers in Immunology, 2016 Tertiary lymphoid structures (TLS) are organized aggregates of lymphocytes, myeloid and stromal cells that provide ectopic hubs for acquired immune responses.
Francesca Barone +5 more
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The pivotal role of tertiary lymphoid structures in the tumor immune microenvironment [PDF]
Frontiers in OncologyTertiary lymphoid structures (TLS) are ectopic lymphoid structures that form in non-lymphoid tissues in response to chronic inflammatory stimulation. Structurally and functionally resembling lymph nodes, TLS are primarily composed of B cells, T cells ...
Chengsen Liu, Jiandong Cao
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Initiation of Tertiary Lymphoid Structures for Cancer Immunotherapy [PDF]
ResearchTertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates formed by lymphocytes and antigen-presenting cells within chronic inflammatory microenvironments or tumor microenvironments (TMEs), and their initiation phase is a critical step for ...
Ji-Yuan Zou +4 more
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Multi-omics profiling and experimental verification of tertiary lymphoid structure-related genes: molecular subgroups, immune infiltration, and prognostic implications in lung adenocarcinoma [PDF]
Frontiers in ImmunologyLung adenocarcinoma (LUAD), characterized by a low 5-year survival rate, is the most common and aggressive type of lung cancer. Recent studies have shown that tertiary lymphoid structures (TLS), which resemble lymphoid structures, are closely linked to ...
Sixuan Wu +6 more
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Translational and oncologic significance of tertiary lymphoid structures in pancreatic adenocarcinoma [PDF]
Frontiers in ImmunologyPancreatic adenocarcinoma (PDAC) is an aggressive tumor with poor survival and limited treatment options. PDAC resistance to immunotherapeutic strategies is multifactorial, but partially owed to an immunosuppressive tumor immune microenvironment (TiME ...
Zachary Gao +15 more
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