Editorial: Tertiary lymphoid structures (TLS) in the tumor immune microenvironment [PDF]
Frontiers in ImmunologyXinbo Gao +5 more
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Tertiary lymphoid structures and B lymphocytes: a promising therapeutic strategy to fight cancer
Frontiers in Immunology, 2023 Tertiary lymphoid structures (TLSs) are clusters of lymphoid cells with an organization that resembles that of secondary lymphoid organs. Both structures share common developmental characteristics, although TLSs usually appear in chronically inflamed non-
Laura Esparcia-Pinedo +7 more
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Tertiary lymphoid structures in urothelial carcinoma: bridging spatial architecture with therapeutic vulnerability in the post-BCG era [PDF]
Frontiers in ImmunologyUrothelial carcinoma (UC) remains a persistent clinical challenge in the post-Bacillus Calmette-Guérin (BCG) era, particularly because a substantial proportion of patients with high-risk non-muscle-invasive bladder cancer (NMIBC) experience recurrence or
Xin Wei, Xin Pei, Shanshan Yu
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The pivotal role of tertiary lymphoid structures in the tumor immune microenvironment
Frontiers in OncologyTertiary lymphoid structures (TLS) are ectopic lymphoid structures that form in non-lymphoid tissues in response to chronic inflammatory stimulation. Structurally and functionally resembling lymph nodes, TLS are primarily composed of B cells, T cells ...
Chengsen Liu, Jiandong Cao
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Clinical impact and therapeutic potential of tertiary lymphoid structures in melanoma [PDF]
Frontiers in ImmunologyTertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that arise in non-lymphoid tissues under conditions of chronic inflammation, including cancer. Structurally and functionally resembling secondary lymphoid organs, TLS consist of organized
Daniele Carenza +3 more
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Tertiary lymphoid structures as biomarkers and therapeutic targets in neoadjuvant cancer immunotherapy [PDF]
Frontiers in ImmunologyNeoadjuvant immunotherapy is reshaping the treatment of resectable solid tumors, but biomarkers that reflect spatially organized antitumor immunity remain limited.
Tong Wang, Wenlong Xu, Xiaofeng Wu
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Tertiary lymphoid structures in breast cancer: formation, immune functions and clinical implications [PDF]
Frontiers in ImmunologyTertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that arise in non-lymphoid tissues under chronic inflammatory conditions and during tumor development.
Wenting Dong +4 more
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Tertiary lymphoid structures and B lymphocytes in cancer prognosis and response to immunotherapies
OncoImmunology, 2021 Tertiary lymphoid structures (TLS) are ectopic cellular aggregates that resemble secondary lymphoid organs in their composition and structural organization.
Jacquelot N, Tellier J, Nutt Sl, Belz Gt
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STINGing the Tumor Microenvironment to Promote Therapeutic Tertiary Lymphoid Structure Development
Frontiers in Immunology, 2021 Tertiary lymphoid structures (TLS), also known as ectopic lymphoid structures (ELS) or tertiary lymphoid organs (TLO), represent a unique subset of lymphoid tissues noted for their architectural similarity to lymph nodes, but which conditionally form in ...
Jessica N. Filderman +7 more
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Tertiary lymphoid structures are critical for cancer prognosis and therapeutic response
Frontiers in Immunology, 2023 Tertiary lymphoid structures (TLSs) are ectopic lymphocyte aggregates that form at sites of chronic inflammation, including cancers, in non-lymphoid tissues.
Qianqian Zhang, Suhui Wu
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