Results 31 to 40 of about 4,240 (183)

Advances on tumor-associated tertiary lymphoid structures in immunotherapy

生物医学转化
Tertiary lymphoid structures (TLS) are ectopic lymphoid structures found in non-lymphoid tissues under chronic inflammatory conditions in recent years.
Hu Chupeng, Chen Yun
doaj   +1 more source

Prognostic and therapeutic potential of gene profiles related to tertiary lymphoid structures in colorectal cancer [PDF]

PeerJ
The role of tertiary lymphoid structures (TLS) in oncology is gaining interest, particularly in colorectal carcinoma, yet a thorough analysis remains elusive.
Jinglu Yu, Yabin Gong, Xiaowei Huang, Yufang Bao   +3 more
doaj   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Stromal fibroblasts in tertiary lymphoid structures: a novel target in chronic inflammation.

Frontiers in Immunology, 2016
Tertiary lymphoid structures (TLS) are organized aggregates of lymphocytes, myeloid and stromal cells that provide ectopic hubs for acquired immune responses.
Francesca Barone, David Harry Gardner, Saba Nayar, Nathalie Steinthal, Christopher Buckley, Sanjiv A Luther   +5 more
doaj   +1 more source

Deciphering the maturation of tertiary lymphoid structures in cancer and inflammatory diseases of the digestive tract using imaging mass cytometry

Frontiers in Immunology, 2023
Persistent inflammation can promote the development of tertiary lymphoid structures (TLS) within tissues resembling secondary lymphoid organs (SLO) such as lymph nodes (LN).
Marion Le Rochais, Patrice Hémon, Danivanh Ben-guigui, Soizic Garaud, Christelle Le Dantec, Jacques-Olivier Pers, Jacques-Olivier Pers, Divi Cornec, Divi Cornec, Arnaud Uguen, Arnaud Uguen   +10 more
doaj   +1 more source

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

A novel tertiary lymphoid structure-associated signature accurately predicts patient prognosis and facilitates the selection of personalized treatment strategies for HNSCC

Frontiers in Immunology
BackgroundHead and neck squamous cell carcinoma (HNSCC) is the most common type of head and neck cancer and is characterized by its aggressive nature and variable prognosis and response to immunotherapy.
Jinhao Zhang, Lu Zeng, Lu Zeng, Guobin Song, Gaoge Peng, Gaoge Peng, Zhezheng Chen, Zhezheng Chen, Yamin Yuan, Taowu Chen, Tao Zhong, Shixi Chen, Zhengzhou Luo, Zhengzhou Luo, Jingang Xiao, Jingang Xiao, Jingang Xiao, Lin Liu, Lin Liu, Lin Liu   +19 more
doaj   +1 more source

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, EarlyView.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source

Infiltrating characteristics and prognostic value of tertiary lymphoid structures in resected gastric neuroendocrine neoplasm patients

Clinical & Translational Immunology
Objectives Tertiary lymphoid structures (TLSs) are lymphocyte aggregates that play an anti‐tumor role in most solid tumors. However, the functions of TLS in gastric neuroendocrine neoplasms (GNENs) remain unknown.
Daming Cai, Xingzhou Wang, Heng Yu, Chunhua Bai, Yonghuan Mao, Mengjie Liang, Xuefeng Xia, Song Liu, Meng Wang, Xiaofeng Lu, Junfeng Du, Xiaofei Shen, Wenxian Guan   +12 more
doaj   +1 more source

Prognostic Significance of Gene Signature of Tertiary Lymphoid Structures in Patients With Lung Adenocarcinoma

Frontiers in Oncology, 2021
BackgroundLung adenocarcinoma (LUAD) is a highly mortal cancer. Tertiary lymphoid structures (TLS) are ectopic lymphoid organs with similar morphological and molecular characters to secondary lymphoid organ.
Hong Feng, Hong Feng, Fujun Yang, Lihong Qiao, Kai Zhou, Kai Zhou, Junfei Wang, Jiao Zhang, Tian Tian, Ying Du, Hong Shangguan   +10 more
doaj   +1 more source