Results 11 to 20 of about 4,769 (183)

Turning Tertiary Lymphoid Structures (TLS) into Hot Spots: Values of TLS in Gastrointestinal Tumors. [PDF]

Cancers (Basel), 2023
Tertiary lymphoid structures (TLSs) are ectopic lymphocyte aggregation structures found in the tumor microenvironment (TME). Emerging evidence shows that TLSs are significantly correlated with the progression of gastrointestinal tumors, patients’ prognosis, and the efficacy of adjuvant therapy. Besides, there are still some immunosuppressive factors in
Cai D, Yu H, Wang X, Mao Y, Liang M, Lu X, Shen X, Guan W.   +7 more
europepmc   +3 more sources

Prognostic value of tertiary lymphoid structures (TLS) in digestive system cancers: a systematic review and meta-analysis. [PDF]

BMC Cancer, 2023
Abstract Background Existing literature suggests that tertiary lymphatic structure (TLS) is associated with the progression of cancer. However, the prognostic role of TLS in digestive system cancers remains controversial.
Sun H, Shi Y, Ran H, Peng J, Li Q, Zheng G, He Y, Liu S, Chang W, Xiao Y.   +9 more
europepmc   +4 more sources

Tertiary lymphoid structures (TLS) identification and density assessment on H&E-stained digital slides of lung cancer. [PDF]

PLoS One, 2021
Tertiary lymphoid structures (TLS) are ectopic aggregates of lymphoid cells in inflamed, infected, or tumoral tissues that are easily recognized on an H&E histology slide as discrete entities, distinct from lymphocytes. TLS are associated with improved cancer prognosis but there is no standardised method available to quantify their presence ...
Barmpoutis P, Di Capite M, Kayhanian H, Waddingham W, Alexander DC, Jansen M, Kwong FNK.   +6 more
europepmc   +6 more sources

CD86-Positive Mature Tertiary Lymphoid Structures Are Associated With CD8⁺ T-Cell Infiltration and Favorable Clinical Outcomes in Pancreatic Ductal Adenocarcinoma. [PDF]

Ann Gastroenterol Surg
CD86‐positive mature tertiary lymphoid structures were associated with increased intratumoral CD8+ T‐cell infiltration, a higher proportion of Granzyme B‐expressing CD8+ T cells in an exploratory analysis, and favorable clinical outcomes in pancreatic ductal adenocarcinoma.
Seki T, Araki K, Yokobori T, Ikota H, Kubo N, Igarashi T, Tsukagoshi M, Ishii N, Hosouchi Y, Saeki H, Shirabe K.   +10 more
europepmc   +2 more sources

Intratumoral tertiary lymphoid structure (TLS) maturation is influenced by draining lymph nodes of lung cancer

Journal for ImmunoTherapy of Cancer, 2023
Background Tertiary lymphoid structure (TLS) is an organized infiltration of immune cells, showing features of germinal center (GC) commonly seen in secondary lymphoid organs. However, its relationship with tumor-draining lymph nodes (TDLNs) has not been studied and we hypothesized that TDLN may influence maturation
Miao He, Qihua He, Xiuyu Cai, Jun Liu, Hongshen Deng, Feng Li, Ran Zhong, Yi Lu, Haoxin Peng, Xiangrong Wu, Zisheng Chen, Shen Lao, Caichen Li, Jianfu Li, Jianxing He, Wenhua Liang   +15 more
openaire   +3 more sources

Tertiary lymphoid structures critical for prognosis in endometrial cancer patients

Nature Communications, 2022
Tertiary lymphoid structures (TLS) are associated with a reduced risk of cancer recurrence and improved response to immune checkpoint blockade in several tumor types.
Nanda Horeweg, Hagma H. Workel, Dominik Loiero, David N. Church, Lisa Vermij, Alicia Léon-Castillo, Ricki T. Krog, Stephanie M. de Boer, Remi A. Nout, Melanie E. Powell, Linda R. Mileshkin, Helen MacKay, Alexandra Leary, Naveena Singh, Ina M. Jürgenliemk-Schulz, Vincent T. H. B. M. Smit, Carien L. Creutzberg, Viktor H. Koelzer, Hans W. Nijman, Tjalling Bosse, Marco de Bruyn, TransPORTEC consortium   +21 more
doaj   +1 more source

Tertiary Lymphoid Structures in cancers: prognostic value, regulation and manipulation for therapeutic intervention

Frontiers in Immunology, 2016
Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that reflect lymphoid neogenesis occurring in tissues at sites of inflammation. They are detected in tumors where they orchestrate local and systemic anti-tumor responses.
Catherine Sautes-Fridman, Catherine Sautes-Fridman, Catherine Sautes-Fridman, Myriam Lawand, Myriam Lawand, Myriam Lawand, Nicolas A. Giraldo, Nicolas A. Giraldo, Nicolas A. Giraldo, Helene Kaplon, Helene Kaplon, Helene Kaplon, Claire Germain, Claire Germain, Claire Germain, Wolf Hervé Fridman, Wolf Hervé Fridman, Wolf Hervé Fridman, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean   +20 more
doaj   +1 more source

Role of Tertiary Lymphoid Structures (TLS) in Anti-Tumor Immunity: Potential Tumor-Induced Cytokines/Chemokines that Regulate TLS Formation in Epithelial-Derived Cancers [PDF]

Cancers, 2014
Following the successes of monoclonal antibody immunotherapies (trastuzumab (Herceptin®) and rituximab (Rituxan®)) and the first approved cancer vaccine, Provenge® (sipuleucel-T), investigations into the immune system and how it can be modified by a tumor has become an exciting and promising new field of cancer research.
Pimenta, Erica M., Barnes, Betsy J.
openaire   +2 more sources

B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma

Nature Communications, 2021
Recent studies have highlighted the importance of B cells and tertiary lymphoid structures (TLS) in the modulation of anti-tumor immune responses. Here, the authors characterize how HPV status influences the phenotype of tumor infiltrating B cells in ...
Ayana T. Ruffin, Anthony R. Cillo, Tracy Tabib, Angen Liu, Sayali Onkar, Sheryl R. Kunning, Caleb Lampenfeld, Huda I. Atiya, Irina Abecassis, Cornelius H. L. Kürten, Zengbiao Qi, Ryan Soose, Umamaheswar Duvvuri, Seungwon Kim, Steffi Oesterrich, Robert Lafyatis, Lan G. Coffman, Robert L. Ferris, Dario A. A. Vignali, Tullia C. Bruno   +19 more
doaj   +1 more source

Recent Progress of Tertiary Lymphoid Structure in Prognosis and Immunotherapy of Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2023
Lung cancer is the leading cause of cancer death, and non-small cell lung cancer (NSCLC) accounts for 85%. Immunotherapy has significantly improved the clinical prognosis of patients with NSCLC. However, because of the complexity and heterogeneousness of
Ying LIU, Lei XIONG, Ruoxue CAI, Yue CHEN, Jinjun YE, Bo SHEN, Guoren ZHOU   +6 more
doaj   +1 more source