Results 11 to 20 of about 4,240 (183)

Initiation of Tertiary Lymphoid Structures for Cancer Immunotherapy [PDF]

Research
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates formed by lymphocytes and antigen-presenting cells within chronic inflammatory microenvironments or tumor microenvironments (TMEs), and their initiation phase is a critical step for ...
Ji-Yuan Zou, Ze-Tong Li, Ze-Cheng Wang, Hao Li, Zhi-Jun Sun   +4 more
doaj   +2 more sources

Tumor-Infiltrating Lymphocytes (TIL), Tertiary Lymphoid Structures (TLS), and Expression of PD-1, TIM-3, LAG-3 on TIL in Invasive and In Situ Ductal Breast Carcinomas and Their Relationship with Prognostic Factors

Clinical Breast Cancer, 2022
Immunotherapy has been determined as an important choice in breast carcinomas, especially in tumors with markedly inflammatory response. About this promising subject, tumor-infiltrating lymphocytes (TIL) and the expression of immune control point receptors on TIL have gained importance.In this study, stromal TIL and tertiary lymphoid structures (TLS ...
Elif Acar, Ayse Dursun
exaly   +5 more sources

Automated classification of tertiary lymphoid structures in colorectal cancer using TLS-PAT artificial intelligence tool

Scientific Reports
Abstract Colorectal cancer (CRC) ranks as the third most common and second deadliest cancer worldwide. The immune system, particularly tertiary lymphoid structures (TLS), significantly influences CRC progression and prognosis. TLS maturation, especially in the presence of germinal centers, correlates with improved patient outcomes; however ...
Arnaud Uguen, R Zeghlache, Amélie Bourhis   +2 more
exaly   +5 more sources

Tertiary lymphoid structures in renal cell carcinoma: from heterogeneity dissection to translational precision immunotherapy [PDF]

Frontiers in Immunology
Renal cell carcinoma (RCC), characterized by its distinctive hypoxic and immunosuppressive tumor microenvironment (TME), demonstrates suboptimal responses to current immunotherapeutic interventions.
Zhexian Li, Zhexian Li, Sensen Ruan, Yang Yu, Hao Xiang, Wenjie Mi, Wenjie Mi   +6 more
doaj   +2 more sources

Intratumoral tertiary lymphoid structure (TLS) maturation is influenced by draining lymph nodes of lung cancer

Journal for ImmunoTherapy of Cancer, 2023
Background Tertiary lymphoid structure (TLS) is an organized infiltration of immune cells, showing features of germinal center (GC) commonly seen in secondary lymphoid organs. However, its relationship with tumor-draining lymph nodes (TDLNs) has not been studied and we hypothesized that TDLN may influence maturation
Miao He, Qihua He, Xiuyu Cai, Jun Liu, Hongshen Deng, Feng Li, Ran Zhong, Yi Lu, Haoxin Peng, Xiangrong Wu, Zisheng Chen, Shen Lao, Caichen Li, Jianfu Li, Jianxing He, Wenhua Liang   +15 more
openaire   +3 more sources

Tertiary lymphoid structures and B lymphocytes in cancer prognosis and response to immunotherapies

OncoImmunology, 2021
Tertiary lymphoid structures (TLS) are ectopic cellular aggregates that resemble secondary lymphoid organs in their composition and structural organization.
Jacquelot N, Tellier J, Nutt Sl, Belz Gt
doaj   +1 more source

STINGing the Tumor Microenvironment to Promote Therapeutic Tertiary Lymphoid Structure Development

Frontiers in Immunology, 2021
Tertiary lymphoid structures (TLS), also known as ectopic lymphoid structures (ELS) or tertiary lymphoid organs (TLO), represent a unique subset of lymphoid tissues noted for their architectural similarity to lymph nodes, but which conditionally form in ...
Jessica N. Filderman, Mark Appleman, Manoj Chelvanambi, Jennifer L. Taylor, Walter J. Storkus, Walter J. Storkus, Walter J. Storkus, Walter J. Storkus   +7 more
doaj   +1 more source

Tertiary lymphoid structures are critical for cancer prognosis and therapeutic response

Frontiers in Immunology, 2023
Tertiary lymphoid structures (TLSs) are ectopic lymphocyte aggregates that form at sites of chronic inflammation, including cancers, in non-lymphoid tissues.
Qianqian Zhang, Suhui Wu
doaj   +1 more source

Tertiary lymphoid structures critical for prognosis in endometrial cancer patients

Nature Communications, 2022
Tertiary lymphoid structures (TLS) are associated with a reduced risk of cancer recurrence and improved response to immune checkpoint blockade in several tumor types.
Nanda Horeweg, Hagma H. Workel, Dominik Loiero, David N. Church, Lisa Vermij, Alicia Léon-Castillo, Ricki T. Krog, Stephanie M. de Boer, Remi A. Nout, Melanie E. Powell, Linda R. Mileshkin, Helen MacKay, Alexandra Leary, Naveena Singh, Ina M. Jürgenliemk-Schulz, Vincent T. H. B. M. Smit, Carien L. Creutzberg, Viktor H. Koelzer, Hans W. Nijman, Tjalling Bosse, Marco de Bruyn, TransPORTEC consortium   +21 more
doaj   +1 more source

Tertiary Lymphoid Structures in cancers: prognostic value, regulation and manipulation for therapeutic intervention

Frontiers in Immunology, 2016
Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that reflect lymphoid neogenesis occurring in tissues at sites of inflammation. They are detected in tumors where they orchestrate local and systemic anti-tumor responses.
Catherine Sautes-Fridman, Catherine Sautes-Fridman, Catherine Sautes-Fridman, Myriam Lawand, Myriam Lawand, Myriam Lawand, Nicolas A. Giraldo, Nicolas A. Giraldo, Nicolas A. Giraldo, Helene Kaplon, Helene Kaplon, Helene Kaplon, Claire Germain, Claire Germain, Claire Germain, Wolf Hervé Fridman, Wolf Hervé Fridman, Wolf Hervé Fridman, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean   +20 more
doaj   +1 more source