Results 11 to 20 of about 5,610 (204)

Tertiary Lymphoid Structures in cancers: prognostic value, regulation and manipulation for therapeutic intervention

Frontiers in Immunology, 2016
Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that reflect lymphoid neogenesis occurring in tissues at sites of inflammation. They are detected in tumors where they orchestrate local and systemic anti-tumor responses.
Catherine Sautes-Fridman, Catherine Sautes-Fridman, Catherine Sautes-Fridman, Myriam Lawand, Myriam Lawand, Myriam Lawand, Nicolas A. Giraldo, Nicolas A. Giraldo, Nicolas A. Giraldo, Helene Kaplon, Helene Kaplon, Helene Kaplon, Claire Germain, Claire Germain, Claire Germain, Wolf Hervé Fridman, Wolf Hervé Fridman, Wolf Hervé Fridman, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean   +20 more
doaj   +3 more sources

Tertiary Lymphoid Structures: Autoimmunity Goes Local

Frontiers in Immunology, 2018
Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune diseases. TLS present features of secondary lymphoid organs such as segregated T and B cell zones, presence of follicular dendritic cell networks, high endothelial ...
Elena Pipi, Elena Pipi, Saba Nayar, David H. Gardner, Serena Colafrancesco, Charlotte Smith, Francesca Barone   +6 more
doaj   +3 more sources

Tertiary lymphoid structures in renal cell carcinoma: from heterogeneity dissection to translational precision immunotherapy [PDF]

Frontiers in Immunology
Renal cell carcinoma (RCC), characterized by its distinctive hypoxic and immunosuppressive tumor microenvironment (TME), demonstrates suboptimal responses to current immunotherapeutic interventions.
Zhexian Li, Zhexian Li, Sensen Ruan, Yang Yu, Hao Xiang, Wenjie Mi, Wenjie Mi   +6 more
doaj   +2 more sources

Exploring the impact of tertiary lymphoid structures maturity in NSCLC: insights from TLS scoring

Frontiers in Immunology
Tertiary Lymphoid Structures (TLS) are lymphoid structures commonly associated with improved survival of cancer patients and response to immunotherapies. However, conflicting reports underscore the need to consider TLS heterogeneity and multiple features such as TLS size, composition, and maturation status, when assessing their functional impact.
Julie Berthe, Pawan Poudel, Felix J. Segerer, Emily C. Jennings, Felicia Ng, Michael Surace, Alma Andoni, Marco Testori, Megha Saraiya, Miljenka Vuko, Harald Hessel, Mari Heininen-Brown, Jorge Blando, Emma V. Jones, Sophie E. Willis, Jérôme Galon, Jérôme Galon, Jérôme Galon, Rieneke van de Ven, Rieneke van de Ven, Rieneke van de Ven, Tanja D. de Gruijl, Tanja D. de Gruijl, Tanja D. de Gruijl, Helen K. Angell   +24 more
openaire   +6 more sources

From mechanisms to therapy: the role of tertiary lymphoid structures in bladder cancer [PDF]

World Journal of Surgical Oncology
Tertiary lymphoid structures (TLS) are ectopic lymphoid tissues that form within the tumor microenvironment (TME) and play a crucial role in anti-tumor immunity.
Jinshan Yang, Xinxin Li, Hao Xie, Jiahao Guo, Jiahui Wang, Chunhua Lin   +5 more
doaj   +2 more sources

The Emerging Role of Tertiary Lymphoid Structures as Predictive and Prognostic Biomarkers of Immunotherapy in Cancer [PDF]

Cancer Medicine
Background Immune checkpoint inhibitors (ICIs) have improved outcomes across several cancers, yet many patients do not respond, highlighting the need for robust predictive biomarkers.
Lidia B. Medhin, Rodas Amanuel, Lydia Warburton, Leslie Calapre, Benhur Amanuel, Elin S. Gray   +5 more
doaj   +2 more sources

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research
Tertiary lymphoid structures (TLSs) are inducible, ectopic aggregates that mirror the architecture and immunological functions of secondary lymphoid organs, arising in nonlymphoid tissues during chronic inflammation, infection, autoimmunity, and cancer ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
doaj   +2 more sources

Role of tertiary lymphoid structures in the tumour microenvironment and immunotherapy response of renal cell carcinoma [PDF]

Clinical and Translational Medicine
In the tumour microenvironment (TME) of renal cell carcinoma (RCC), tertiary lymphoid structures (TLS) play a crucial role in anti‐tumour immune responses.
Lin Yang, Wentai Shangguan, Weijia Li, Wenxue Huang, Zhuohang Li, Boyuan Sun, Cunzhen Ma, Xunguo Yang, Bisheng Cheng, Peng Wu   +9 more
doaj   +2 more sources

Intratumoral tertiary lymphoid structure (TLS) maturation is influenced by draining lymph nodes of lung cancer

Journal for ImmunoTherapy of Cancer, 2023
Background Tertiary lymphoid structure (TLS) is an organized infiltration of immune cells, showing features of germinal center (GC) commonly seen in secondary lymphoid organs. However, its relationship with tumor-draining lymph nodes (TDLNs) has not been studied and we hypothesized that TDLN may influence maturation
Miao He, Qihua He, Xiuyu Cai, Jun Liu, Hongshen Deng, Feng Li, Ran Zhong, Yi Lu, Haoxin Peng, Xiangrong Wu, Zisheng Chen, Shen Lao, Caichen Li, Jianfu Li, Jianxing He, Wenhua Liang   +15 more
openaire   +3 more sources

Tertiary lymphoid structures and B lymphocytes in cancer prognosis and response to immunotherapies

OncoImmunology, 2021
Tertiary lymphoid structures (TLS) are ectopic cellular aggregates that resemble secondary lymphoid organs in their composition and structural organization.
Jacquelot N, Tellier J, Nutt Sl, Belz Gt
doaj   +1 more source