Results 21 to 30 of about 4,240 (183)

B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma

Nature Communications, 2021
Recent studies have highlighted the importance of B cells and tertiary lymphoid structures (TLS) in the modulation of anti-tumor immune responses. Here, the authors characterize how HPV status influences the phenotype of tumor infiltrating B cells in ...
Ayana T. Ruffin, Anthony R. Cillo, Tracy Tabib, Angen Liu, Sayali Onkar, Sheryl R. Kunning, Caleb Lampenfeld, Huda I. Atiya, Irina Abecassis, Cornelius H. L. Kürten, Zengbiao Qi, Ryan Soose, Umamaheswar Duvvuri, Seungwon Kim, Steffi Oesterrich, Robert Lafyatis, Lan G. Coffman, Robert L. Ferris, Dario A. A. Vignali, Tullia C. Bruno   +19 more
doaj   +1 more source

The Impact of Programmed Cell Death on the Formation of Tertiary Lymphoid Structures

Frontiers in Immunology, 2021
Tertiary lymphoid structures are clusters of lymphoid tissue that develop post-natally at sites of chronic inflammation. They have been described in association with infection, autoimmune disorders, cancer, and allograft rejection. In their mature stage,
Mélanie Dieudé, Mélanie Dieudé, Mélanie Dieudé, Imane Kaci, Imane Kaci, Imane Kaci, Marie-Josée Hébert, Marie-Josée Hébert, Marie-Josée Hébert   +8 more
doaj   +1 more source

Recent Progress of Tertiary Lymphoid Structure in Prognosis and Immunotherapy of Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2023
Lung cancer is the leading cause of cancer death, and non-small cell lung cancer (NSCLC) accounts for 85%. Immunotherapy has significantly improved the clinical prognosis of patients with NSCLC. However, because of the complexity and heterogeneousness of
Ying LIU, Lei XIONG, Ruoxue CAI, Yue CHEN, Jinjun YE, Bo SHEN, Guoren ZHOU   +6 more
doaj   +1 more source

Tertiary lymphoid structures in desmoplastic melanoma have increased lymphocyte density, lymphocyte proliferation, and immune cross talk with tumor when compared to non-desmoplastic melanomas

OncoImmunology, 2023
Tertiary lymphoid structures (TLS) are ectopic lymphoid structures that can arise in human cancers and are associated with improved overall survival (OS) and response to immune checkpoint blockade (ICB) in several cancers, including non-desmoplastic ...
Nicole L. Edmonds, Sarah E Gradecki, Priya Katyal, Kevin T Lynch, Anne M Stowman, Alejandro A Gru, Victor H Engelhard, Craig L Slingluff, Ileana S. Mauldin   +8 more
doaj   +1 more source

Regulatory T cells infiltrate the tumor-induced tertiary lymphoïd structures and are associated with poor clinical outcome in NSCLC

Communications Biology, 2022
Regulatory T cells (Tregs) have similar immune profiles in tertiary lymphoid structures of lung cancer and non-TLS areas, with tumor-infiltrating Tregs found to inhibit the proliferation and cytokine secretion of CD4 + conventional T cells.
Priyanka Devi-Marulkar, Solène Fastenackels, Pierre Karapentiantz, Jérémy Goc, Claire Germain, Hélène Kaplon, Samantha Knockaert, Daniel Olive, Marylou Panouillot, Pierre Validire, Diane Damotte, Marco Alifano, Juliette Murris, Sandrine Katsahian, Myriam Lawand, Marie-Caroline Dieu-Nosjean   +15 more
doaj   +1 more source

Cutaneous Melanoma: Mutational Status and Potential Links to Tertiary Lymphoid Structure Formation

Frontiers in Immunology, 2021
Recent advances in immunotherapy have enabled rapid evolution of novel interventional approaches designed to reinvigorate and expand patient immune responses against cancer.
Deepak Salem, Manoj Chelvanambi, Walter J. Storkus, Walter J. Storkus, Walter J. Storkus, Walter J. Storkus, Ronald J. Fecek   +6 more
doaj   +1 more source

Tertiary Lymphoid Structures as a Predictive Biomarker of Response to Cancer Immunotherapies

Frontiers in Immunology, 2021
Tertiary lymphoid structures (TLS) are ectopic lymphoid formations which are formed under long-lasting inflammatory conditions, including tumours. TLS are composed predominantly of B cells, T cells and dendritic cells, and display various levels of ...
Marta Trüb, Alfred Zippelius, Alfred Zippelius   +2 more
doaj   +1 more source

Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies

Life Science Alliance, 2021
We found that acute insult to the central nervous system induces the formation of lymphocyte aggregates reminiscent of tertiary lymphoid structures within the spinal cord meninges.
Merav Cohen, Amir Giladi, Catarina Raposo, Mor Zada, Baoguo Li, Julia Ruckh, Aleksandra Deczkowska, Boaz Mohar, Ravid Shechter, Rachel G Lichtenstein, Ido Amit, Michal Schwartz   +11 more
doaj   +1 more source

Additional file 1 of Prognostic value of tertiary lymphoid structures (TLS) in digestive system cancers: a systematic review and meta-analysis

, 2023
Additional file 1: Supplementary Materials. Table S1. Quality assessment details for included studies. Table S2. Summary of controlled covariates in multivariate analyses. Figure S1. Sensitivity analysis for TLS with OS in digestive system cancers patients. Figure S2.
Sun, Hao, Shi, Yuanyu, Ran, Hailiang, Peng, Junwei, Li, Qiongxian, Zheng, Guiqing, He, Yandie, Liu, Shuqing, Chang, Wei, Xiao, Yuanyuan   +9 more
openaire   +1 more source

Abstract 1021: Clinical significance of tertiary lymphoid structures (TLS) and tumor-infiltrating plasma cells in ovarian cancer

Cancer Research, 2018
Abstract Objective: Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates that reflect lymphoid neogenesis mainly through CXCL13 and develop under chronic inflammation. Recently TLS have been detected in several types of cancers; however, there are few reports about TLS in ovarian cancer.
Masayo Ukita, Junzo Hamanishi, Tsukasa Baba, Ryusuke Murakami, Kaoru Abiko, Masaki Mandai   +5 more
openaire   +1 more source