Results 21 to 30 of about 4,769 (183)

The Impact of Programmed Cell Death on the Formation of Tertiary Lymphoid Structures

Frontiers in Immunology, 2021
Tertiary lymphoid structures are clusters of lymphoid tissue that develop post-natally at sites of chronic inflammation. They have been described in association with infection, autoimmune disorders, cancer, and allograft rejection. In their mature stage,
Mélanie Dieudé, Mélanie Dieudé, Mélanie Dieudé, Imane Kaci, Imane Kaci, Imane Kaci, Marie-Josée Hébert, Marie-Josée Hébert, Marie-Josée Hébert   +8 more
doaj   +1 more source

Tertiary Lymphoid Structures: Autoimmunity Goes Local

Frontiers in Immunology, 2018
Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune diseases. TLS present features of secondary lymphoid organs such as segregated T and B cell zones, presence of follicular dendritic cell networks, high endothelial ...
Elena Pipi, Elena Pipi, Saba Nayar, David H. Gardner, Serena Colafrancesco, Charlotte Smith, Francesca Barone   +6 more
doaj   +1 more source

Tertiary lymphoid structures in desmoplastic melanoma have increased lymphocyte density, lymphocyte proliferation, and immune cross talk with tumor when compared to non-desmoplastic melanomas

OncoImmunology, 2023
Tertiary lymphoid structures (TLS) are ectopic lymphoid structures that can arise in human cancers and are associated with improved overall survival (OS) and response to immune checkpoint blockade (ICB) in several cancers, including non-desmoplastic ...
Nicole L. Edmonds, Sarah E Gradecki, Priya Katyal, Kevin T Lynch, Anne M Stowman, Alejandro A Gru, Victor H Engelhard, Craig L Slingluff, Ileana S. Mauldin   +8 more
doaj   +1 more source

Regulatory T cells infiltrate the tumor-induced tertiary lymphoïd structures and are associated with poor clinical outcome in NSCLC

Communications Biology, 2022
Regulatory T cells (Tregs) have similar immune profiles in tertiary lymphoid structures of lung cancer and non-TLS areas, with tumor-infiltrating Tregs found to inhibit the proliferation and cytokine secretion of CD4 + conventional T cells.
Priyanka Devi-Marulkar, Solène Fastenackels, Pierre Karapentiantz, Jérémy Goc, Claire Germain, Hélène Kaplon, Samantha Knockaert, Daniel Olive, Marylou Panouillot, Pierre Validire, Diane Damotte, Marco Alifano, Juliette Murris, Sandrine Katsahian, Myriam Lawand, Marie-Caroline Dieu-Nosjean   +15 more
doaj   +1 more source

Cutaneous Melanoma: Mutational Status and Potential Links to Tertiary Lymphoid Structure Formation

Frontiers in Immunology, 2021
Recent advances in immunotherapy have enabled rapid evolution of novel interventional approaches designed to reinvigorate and expand patient immune responses against cancer.
Deepak Salem, Manoj Chelvanambi, Walter J. Storkus, Walter J. Storkus, Walter J. Storkus, Walter J. Storkus, Ronald J. Fecek   +6 more
doaj   +1 more source

Tertiary Lymphoid Structures as a Predictive Biomarker of Response to Cancer Immunotherapies

Frontiers in Immunology, 2021
Tertiary lymphoid structures (TLS) are ectopic lymphoid formations which are formed under long-lasting inflammatory conditions, including tumours. TLS are composed predominantly of B cells, T cells and dendritic cells, and display various levels of ...
Marta Trüb, Alfred Zippelius, Alfred Zippelius   +2 more
doaj   +1 more source

Additional file 1 of Prognostic value of tertiary lymphoid structures (TLS) in digestive system cancers: a systematic review and meta-analysis

, 2023
Additional file 1: Supplementary Materials. Table S1. Quality assessment details for included studies. Table S2. Summary of controlled covariates in multivariate analyses. Figure S1. Sensitivity analysis for TLS with OS in digestive system cancers patients. Figure S2.
Sun, Hao, Shi, Yuanyu, Ran, Hailiang, Peng, Junwei, Li, Qiongxian, Zheng, Guiqing, He, Yandie, Liu, Shuqing, Chang, Wei, Xiao, Yuanyuan   +9 more
openaire   +1 more source

Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies

Life Science Alliance, 2021
We found that acute insult to the central nervous system induces the formation of lymphocyte aggregates reminiscent of tertiary lymphoid structures within the spinal cord meninges.
Merav Cohen, Amir Giladi, Catarina Raposo, Mor Zada, Baoguo Li, Julia Ruckh, Aleksandra Deczkowska, Boaz Mohar, Ravid Shechter, Rachel G Lichtenstein, Ido Amit, Michal Schwartz   +11 more
doaj   +1 more source

Abstract 1021: Clinical significance of tertiary lymphoid structures (TLS) and tumor-infiltrating plasma cells in ovarian cancer

Cancer Research, 2018
Abstract Objective: Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates that reflect lymphoid neogenesis mainly through CXCL13 and develop under chronic inflammation. Recently TLS have been detected in several types of cancers; however, there are few reports about TLS in ovarian cancer.
Masayo Ukita, Junzo Hamanishi, Tsukasa Baba, Ryusuke Murakami, Kaoru Abiko, Masaki Mandai   +5 more
openaire   +1 more source

Exploring the impact of tertiary lymphoid structures maturity in NSCLC: insights from TLS scoring

Frontiers in Immunology
Tertiary Lymphoid Structures (TLS) are lymphoid structures commonly associated with improved survival of cancer patients and response to immunotherapies. However, conflicting reports underscore the need to consider TLS heterogeneity and multiple features such as TLS size, composition, and maturation status, when assessing their functional impact.
Julie Berthe, Pawan Poudel, Felix J. Segerer, Emily C. Jennings, Felicia Ng, Michael Surace, Alma Andoni, Marco Testori, Megha Saraiya, Miljenka Vuko, Harald Hessel, Mari Heininen-Brown, Jorge Blando, Emma V. Jones, Sophie E. Willis, Jérôme Galon, Jérôme Galon, Jérôme Galon, Rieneke van de Ven, Rieneke van de Ven, Rieneke van de Ven, Tanja D. de Gruijl, Tanja D. de Gruijl, Tanja D. de Gruijl, Helen K. Angell   +24 more
openaire   +4 more sources