Tertiary lymphoid structures and B lymphocytes: a promising therapeutic strategy to fight cancer
Frontiers in Immunology, 2023 Tertiary lymphoid structures (TLSs) are clusters of lymphoid cells with an organization that resembles that of secondary lymphoid organs. Both structures share common developmental characteristics, although TLSs usually appear in chronically inflamed non-
Laura Esparcia-Pinedo +7 more
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STINGing the Tumor Microenvironment to Promote Therapeutic Tertiary Lymphoid Structure Development
Frontiers in Immunology, 2021 Tertiary lymphoid structures (TLS), also known as ectopic lymphoid structures (ELS) or tertiary lymphoid organs (TLO), represent a unique subset of lymphoid tissues noted for their architectural similarity to lymph nodes, but which conditionally form in ...
Jessica N. Filderman +7 more
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Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis [PDF]
, 2021 Tertiary lymphoid structures (TLSs) develop in non-lymphatic tissue in chronic inflammation and cancer. TLS can mature to lymph node (LN) like structures with germinal centers and associated vasculature.
Monypenny, J, Mustapha, R, Ng, K, Ng, T
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Tertiary lymphoid structures are critical for cancer prognosis and therapeutic response
Frontiers in Immunology, 2023 Tertiary lymphoid structures (TLSs) are ectopic lymphocyte aggregates that form at sites of chronic inflammation, including cancers, in non-lymphoid tissues.
Qianqian Zhang, Suhui Wu
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Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures. [PDF]
, 2016 Lymphangiogenesis associated with tertiary lymphoid structure (TLS) has been reported in numerous studies. However, the kinetics and dynamic changes occurring to the lymphatic vascular network during TLS development have not been studied.
Barone, F. +14 more
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Role of Tertiary Lymphoid Structures (TLS) in Anti-Tumor Immunity: Potential Tumor-Induced Cytokines/Chemokines that Regulate TLS Formation in Epithelial-Derived Cancers [PDF]
Cancers, 2014 Following the successes of monoclonal antibody immunotherapies (trastuzumab (Herceptin®) and rituximab (Rituxan®)) and the first approved cancer vaccine, Provenge® (sipuleucel-T), investigations into the immune system and how it can be modified by a tumor has become an exciting and promising new field of cancer research.
Pimenta, Erica M., Barnes, Betsy J.
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Nature Communications, 2021 Recent studies have highlighted the importance of B cells and tertiary lymphoid structures (TLS) in the modulation of anti-tumor immune responses. Here, the authors characterize how HPV status influences the phenotype of tumor infiltrating B cells in ...
Ayana T. Ruffin +19 more
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The Impact of Programmed Cell Death on the Formation of Tertiary Lymphoid Structures
Frontiers in Immunology, 2021 Tertiary lymphoid structures are clusters of lymphoid tissue that develop post-natally at sites of chronic inflammation. They have been described in association with infection, autoimmune disorders, cancer, and allograft rejection. In their mature stage,
Mélanie Dieudé +8 more
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Stromal cells in tertiary lymphoid structures:Architects of autoimmunity [PDF]
, 2021 The molecular mediators present within the inflammatory microenvironment are able, in certain conditions, to favor the initiation of tertiary lymphoid structure (TLS) development.
Acton SE +107 more
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Chinese Journal of Lung Cancer, 2023 Lung cancer is the leading cause of cancer death, and non-small cell lung cancer (NSCLC) accounts for 85%. Immunotherapy has significantly improved the clinical prognosis of patients with NSCLC. However, because of the complexity and heterogeneousness of
Ying LIU +6 more
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