B cells in the formation of Tertiary Lymphoid Organs in autoimmunity, transplantation and tumorigenesis. [PDF]
, 2019 TLS develop in target organs of autoimmune diseases, transplantation and cancer. • TLS can function as germinal centres supporting B-cell selection/differentiation.
BOMBARDIERI, M +3 more
core +1 more source
Tertiary lymphoid structures and gastric cancer prognosis [PDF]
, 2022 Tertiary lymphoid structures (TLSs) are part of immune response against cancer. Their high density and high diameter have been shown to be associated with prognosis in different cancer types.
Böhm, Jan +7 more
core +1 more source
Fibroblasts in Sjögren’s Syndrome [PDF]
, 2021 The Sjögren’s syndrome is an autoimmune disease characterized by chronic inflammation of the exocrine glands, leading to dryness of mucosal surfaces, and often to severe systemic manifestations.
Klein, Kerstin
core +2 more sources
Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies
Life Science Alliance, 2021 We found that acute insult to the central nervous system induces the formation of lymphocyte aggregates reminiscent of tertiary lymphoid structures within the spinal cord meninges.
Merav Cohen +11 more
doaj +1 more source
The Tumor Immune Landscape and Architecture of Tertiary Lymphoid Structures in Urothelial Cancer [PDF]
, 2021 Candidate immune biomarkers have been proposed for predicting response to immunotherapy in urothelial cancer (UC). Yet, these biomarkers are imperfect and lack predictive power.
Broeks, Annegien +16 more
core +1 more source
Cancer Research, 2018 Abstract Objective: Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates that reflect lymphoid neogenesis mainly through CXCL13 and develop under chronic inflammation. Recently TLS have been detected in several types of cancers; however, there are few reports about TLS in ovarian cancer.
Masayo Ukita +5 more
openaire +1 more source
Tertiary lymphoid structures are associated with higher tumor grade in primary operable breast cancer patients [PDF]
, 2015 Published version, also available at http://dx.doi.org/10.1186/s12885-015-1116-1Background: Tertiary lymphoid structures (TLS) are highly organized immune cell aggregates that develop at sites of inflammation or infection in non-lymphoid organs ...
Fenton, Christopher Graham +4 more
core +1 more source
Regular and young investigator award abstracts, 2020 Background An intriguing phenomenon in many solid tumors is the de novo lymphoid neogenesis of tertiary lymphoid structure (TLS). However, it remains unclear whether spontaneous TLS restricts or promotes tumor progression. MDSCs are major contributors to tumor evasion of adaptive immune responses.
Xin Lu +3 more
openaire +2 more sources
Kidney tertiary lymphoid structures in Lupus Nephritis develop into large interconnected networks and resemble lymph nodes in gene signature [PDF]
, 2020 Immune aggregates organized as tertiary lymphoid structures (TLS) are observed within the kidneys of patients with systemic lupus erythematosus and lupus nephritis (LN).
Dorraji, Seyed Esmaeil +10 more
core +1 more source
Prognostic and therapeutic potential of gene profiles related to tertiary lymphoid structures in colorectal cancer [PDF]
PeerJThe role of tertiary lymphoid structures (TLS) in oncology is gaining interest, particularly in colorectal carcinoma, yet a thorough analysis remains elusive.
Jinglu Yu +3 more
doaj +2 more sources