Results 61 to 70 of about 5,610 (204)

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Fluorine‐18‐Labeled Nucleotide Analogs Targeting Ecto‐5'‐Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
Fluorine‐18‐labeled CD73 inhibitor [18F]PSB‐19427 enables noninvasive PET mapping of CD73 overexpression in triple‐negative breast (TNBC) and pancreatic cancer. For [18F]PSB‐19427, specific binding in human tumor tissues, favorable biodistribution with prolonged blood retention, robust tumor uptake, and superiority to [18F]FDG in a TNBC model ...
Clemens Dobelmann, Constanze C. Schmies, Georg Wilhelm Rolshoven, Mirko Scortichini, Stefan Wagner, Andreas Isaak, Riham M. Idris, Jennifer Dabel, Lucie Grey, Karolina Losenkova, Susanne Moschütz, Haneen Al Hroub, Antje Keim, Sandra Höppner, Jouko Sandholm, Pia Boström, Maija Hollmén, Norbert Sträter, Sven Hermann, Gennady G. Yegutkin, Kenneth A. Jacobson, Sonja Schelhaas, Christa E. Müller, Anna Junker   +23 more
wiley   +2 more sources

Infiltrating characteristics and prognostic value of tertiary lymphoid structures in resected gastric neuroendocrine neoplasm patients

Clinical & Translational Immunology
Objectives Tertiary lymphoid structures (TLSs) are lymphocyte aggregates that play an anti‐tumor role in most solid tumors. However, the functions of TLS in gastric neuroendocrine neoplasms (GNENs) remain unknown.
Daming Cai, Xingzhou Wang, Heng Yu, Chunhua Bai, Yonghuan Mao, Mengjie Liang, Xuefeng Xia, Song Liu, Meng Wang, Xiaofeng Lu, Junfeng Du, Xiaofei Shen, Wenxian Guan   +12 more
doaj   +1 more source

A novel tertiary lymphoid structure-associated signature accurately predicts patient prognosis and facilitates the selection of personalized treatment strategies for HNSCC

Frontiers in Immunology
BackgroundHead and neck squamous cell carcinoma (HNSCC) is the most common type of head and neck cancer and is characterized by its aggressive nature and variable prognosis and response to immunotherapy.
Jinhao Zhang, Lu Zeng, Lu Zeng, Guobin Song, Gaoge Peng, Gaoge Peng, Zhezheng Chen, Zhezheng Chen, Yamin Yuan, Taowu Chen, Tao Zhong, Shixi Chen, Zhengzhou Luo, Zhengzhou Luo, Jingang Xiao, Jingang Xiao, Jingang Xiao, Lin Liu, Lin Liu, Lin Liu   +19 more
doaj   +1 more source

Tertiary lymphoid structures (TLS) identification and density assessment on H&E-stained digital slides of lung cancer [PDF]

, 2021
Tertiary lymphoid structures (TLS) are ectopic aggregates of lymphoid cells in inflamed, infected, or tumoral tissues that are easily recognized on an H&E histology slide as discrete entities, distinct from lymphocytes.
Alexander, DC, Barmpoutis, P, Di Capite, M, Jansen, M, Kayhanian, H, Kwong, FNK, Waddingham, W   +6 more
core  

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Does TLS Exist in Canine Mammary Gland Tumours? Preliminary Results in Simple Carcinomas [PDF]

, 2022
: Neoplastic progression is influenced by the expression of tumour antigens that activate an anti-tumour immune response. Human medical studies show that this body defence is carried out in secondary lymphoid organs (SLOs) but also directly in the ...
Alessandra, Sfacteria, Cecilia, Vullo, Francesca, Mariotti, Gabriele, Marino, Giada, Giambrone, Giuseppe, Mazzullo, Roberto, Puleio, Stefania, Di Giorgio   +7 more
core   +1 more source

Mature Tertiary Lymphoid Structures Indicate Good Chemotherapy Response and Prognosis in Advanced Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
In advanced colorectal cancer, tumors with mature tertiary lymphoid structures (TLS) exhibited abundant infiltration of CD3‐ and CD8‐positive lymphocytes in both primary and metastatic sites, indicating an activated immune response. The presence of mature TLS was also associated with favorable chemotherapy sensitivity and improved prognosis.
Nobuhiro Hosoi, Chika Komine, Gendensuren Dorjkhorloo, Takuya Shiraishi, Takuhisa Okada, Akihiko Sano, Makoto Sakai, Takehiko Yokobori, Ken Shirabe, Hiroshi Saeki   +9 more
wiley   +1 more source

Intratumoral bacterial load and tertiary lymphoid structure density in hepatocellular carcinoma: association and prognostic significance

Frontiers in Immunology
BackgroundThe tertiary lymphoid structures (TLS) within the immune microenvironment of hepatocellular carcinoma (HCC) have been shown to significantly influence patient prognosis.
Shen Qu, Shen Qu, Weili Jia, Weili Jia, Xiaoyan Liu, Xiaoyan Liu, Qianyun Yao, Chao Chen, Chao Chen, Zihao Zhao, Ye Nie, Feng Chang, Feng Chang, Zexu Yang, Chaosheng Peng, Yangang Wang, Wenjie Song   +16 more
doaj   +1 more source

Patterns of tumor infiltrating lymphocytes in adenoid cystic carcinoma of the head and neck [PDF]

, 2022
Adenoid cystic carcinoma (ACC) is a rare malignancy in the head and neck. The prognosis remains poor and late recurrences often occur after 5 years and later. To date, there are no reliable prognostic markers for ACC.
Arolt, Christoph, Bankfalvi, Agnes, Bastian, Tobias, Brunner, Cornelia, Doescher, Johannes, Hoffmann, Thomas K., Klußmann, Jens Peter, Laban, Simon, Lang, Stephan, Meyer, Moritz, Quaas, Alexander, Schildhaus, Hans-Ulrich, Schuler, Patrick J., Weissinger, Stephanie E., Wolber, Philipp   +14 more
core   +1 more source