Results 61 to 70 of about 4,769 (183)

Absence of sympathetic innervation hampers the generation of tertiary lymphoid structures upon acute lung inflammation

Scientific Reports
Tertiary lymphoid structures (TLS) are lymphoid organs present in inflammatory non-lymphoid tissues. Studies have linked TLS to favorable outcomes for patients with cancers or infectious diseases, but the mechanisms underlying their formation are not ...
Clémence Riffard, Laïla Letaïef, Safa Azar, Armanda Casrouge, Isabelle Brunet, Jean-Luc Teillaud, Marie-Caroline Dieu-Nosjean   +6 more
doaj   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, Volume 13, Issue 57, 14 October 2026.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Efficacy and Safety of PD‐1/PD‐L1 Inhibitors Combined With Anti‐Angiogenic Tyrosine Kinase Inhibitors for Recurrent or Metastatic Nasopharyngeal Carcinoma: A Systematic Review and Single‐Arm Meta‐Analysis

Cancer Medicine, Volume 15, Issue 10, October 2026.
This single‐arm meta‐analysis (9 studies, 357 patients) shows that PD‐1/PD‐L1 inhibitors plus anti‐angiogenic TKIs yield an ORR of 48% and DCR of 83% in recurrent/metastatic nasopharyngeal carcinoma. Median PFS is 9.95 months. ICI‐naive patients benefit more (ORR 60.9% vs. 36.1%, p = 0.0028).
Rongyi Hu, Tiebin Li, Ziman Luo, Huining Chen, Song Qu   +4 more
wiley   +1 more source

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

Translational and oncologic significance of tertiary lymphoid structures in pancreatic adenocarcinoma

Frontiers in Immunology
Pancreatic adenocarcinoma (PDAC) is an aggressive tumor with poor survival and limited treatment options. PDAC resistance to immunotherapeutic strategies is multifactorial, but partially owed to an immunosuppressive tumor immune microenvironment (TiME ...
Zachary Gao, Joseph Azar, Huili Zhu, Sophia Williams-Perez, Sung Wook Kang, Sung Wook Kang, Sung Wook Kang, Celia Marginean, Mark P. Rubinstein, Shalini Makawita, Hyun-Sung Lee, Hyun-Sung Lee, Hyun-Sung Lee, E. Ramsay Camp, E. Ramsay Camp, E. Ramsay Camp   +15 more
doaj   +1 more source

Spatiotemporal transcriptomics for tumour microenvironment remodelling in cancer progression and therapy

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review summarises how spatial transcriptomics technologies reveal tumour microenvironment heterogeneity and support the inference of dynamic remodelling during cancer progression. Abstract Background Spatiotemporal transcriptomics (STT) integrates spatially resolved gene expression with temporal information derived from staged samples, paired ...
Ying Kang, Qinjing Wang, Siqi Xu, Jiming Guo, Yue Ming, Weixing Chen, Min Wang, Zhijie Huang, Yisheng Huang, Bo Jia   +9 more
wiley   +1 more source

47 Tertiary lymphoid structures (TLS) in desmoplastic melanomas (DM) differ from non-DM-associated TLS by their intratumoral location and enhanced immune activity [PDF]

Regular and Young Investigator Award Abstracts, 2021
Nolan Wages, Ileana Mauldin, Max Meneveau, Kevin Lynch, Craig Slingluff, Alejandro Gru, Anne Stowman, Alexandra Hickman, Adela Mahmutovic, Samuel Young, Victor Engelhard   +10 more
openaire   +2 more sources

Parasite‐Derived IL‐33 Inhibitors Prevent Bleomycin‐Induced Lung Fibrosis

European Journal of Immunology, Volume 56, Issue 10, October 2026.
Infection with the intestinal helminth Heligmosomoides polygyrus bakeri, or administration of the parasite products (HES), or administration of recombinant HpARI2+HpBARI_Hom2 can all suppress the development of lung fibrosis in the mouse bleomycin model, via suppression of the IL‐33 pathway. Graphic abstract created in BioRender. McSorley, HJ.
Samuele Di Carmine, Tania Frangova, Suzanne H. Hodge, Danielle J. Smyth, Tera Birchall, Josh Richards, Ian Newton, Sarah Kelly, Alice R. Savage, E. Suzanne Cohen, J. Simon C. Arthur, Henry J. McSorley   +11 more
wiley   +1 more source

Harnessing Natural Killer Cells: From Neuroimmunology to Novel Therapies for Central Nervous System Diseases

MedComm, Volume 7, Issue 10, October 2026.
This review delineates the multifaceted roles of natural killer (NK) cells in the central nervous system, spanning direct cytolysis, immunoregulation, and crosstalk with the brain microenvironment. We evaluate the translational potential and challenges of NK cell immunotherapies for a spectrum of neurological conditions.
Kaihang Deng, Wai Po Chong
wiley   +1 more source

Integrative Multiomics Profiling Reveals Immune Determinants of Response to Disitamab Vedotin Plus Penpulimab in HER2‐Low Breast Cancer

MedComm, Volume 7, Issue 10, October 2026.
This prospective single‐arm study evaluated neoadjuvant disitamab vedotin plus penpulimab in 20 patients with Stage II–III HER2‐low breast cancer. The regimen showed preliminary activity (pCR 20.0% intention‐to‐treat, 25.0% evaluable; ORR 56.3%) with manageable toxicity.
Xiaoxiao Liu, Yuting Song, Lei Liu, Aaron Qi Zhang, Xin Xie, Bing Wei, Ping He, Chunying Zhuang, Juanjuan Li, Xi Yan, Tinglun Tian, Xiaorong Zhong, Jie Chen, Yan Cheng, Dan Zheng, Shibao Li, Hao Wang, Ting Luo   +17 more
wiley   +1 more source