Results 81 to 90 of about 4,769 (183)

Genomic Evolution and Immune Contexture With Therapeutic Relevance in Pancreatic Neuroendocrine Neoplasms

Cancer Science, Volume 117, Issue 10, Page 2619-2635, October 2026.
Lineage‐dependent immunogenomic landscapes and biologically informed therapy in pancreatic neuroendocrine neoplasms. Pancreatic neuroendocrine neoplasms display lineage‐dependent immunogenomic landscapes, in which genomic alterations, epigenetic states, antigen‐presentation status, immune‐cell infiltration, and suppressive microenvironments co‐evolve ...
Yohei Tabe, Eito Nakagawa, Daisuke Asano, Eriko Katsuta, Daisuke Ban, Shogo Kumagai   +5 more
wiley   +1 more source

Tertiary Lymphoid Structures as Independent Predictors of Favorable Prognosis in Muscle‐Invasive Bladder Cancer

Cancer Medicine
Background Tertiary lymphoid structure (TLS) has been reported to be associated with prognosis and immunotherapy in certain cancers. The objective of our study was to investigate the prognostic significance of Tertiary Lymphoid Structures (TLS) within ...
Xiaodong Teng, Zhen Chen, Yanfeng Bai, Hui Cao, Jing Zhang, Liming Xu, Kaihua Liu, Yuqian Shi, Yang Shao   +8 more
doaj   +1 more source

Tertiary lymphoid structures in renal cell carcinoma: from heterogeneity dissection to translational precision immunotherapy

Frontiers in Immunology
Renal cell carcinoma (RCC), characterized by its distinctive hypoxic and immunosuppressive tumor microenvironment (TME), demonstrates suboptimal responses to current immunotherapeutic interventions.
Zhexian Li, Zhexian Li, Sensen Ruan, Yang Yu, Hao Xiang, Wenjie Mi, Wenjie Mi   +6 more
doaj   +1 more source

Tertiary Lymphoid Structures Associate with Tumour Stage in Urothelial Bladder Cancer

Bladder Cancer, 2017
Background: Urothelial bladder cancer (UBC) is a highly prevalent disease in North America, however its optimal management remains elusive. The contribution of B cell associated responses is poorly understood in bladder cancer.
Madhuri Koti, Amanda Shuo Xu, Kevin Yi Mi Ren, Kash Visram, Runhan Ren, David M. Berman, D. Robert Siemens   +6 more
doaj   +1 more source

Spatial and Single‐Cell Multi‐Omics Analyses of T‐Cell Subsets and Interactions in Melanoma Lymph Node Metastasis

Experimental Dermatology, Volume 35, Issue 10, October 2026.
This figure illustrates how single‐cell and spatial multi‐omics can be applied to map T‐cell states and immune organisation in melanoma tumour‐draining lymph nodes (TDLNs). During regional immune remodelling and nodal metastasis, immune‐active and immune‐suppressed regions may coexist within the same tissue.
Ras Azira Ramli, Samuel Tan, Yibi Chen, Glen Boyle, Quan Nguyen   +4 more
wiley   +1 more source

Impact of PD‐1 Inhibitor Timing Relative to Locoregional Therapy on Outcomes in uHCC Treated With Lenvatinib‐Based Triple Therapy

Liver International, Volume 46, Issue 10, October 2026.
ABSTRACT Background and Aims The optimal sequencing of programmed cell death protein 1 (PD‐1) inhibitors relative to locoregional therapy (LRT) in unresectable hepatocellular carcinoma (uHCC) remains undefined. This study evaluated the impact of PD‐1 inhibitor timing on outcomes in patients receiving hepatic arterial infusion chemotherapy (HAIC) or ...
Jian He, Jian Chen, Bohua Yu, Fuqun Wei, Weifu Liu, Peishu Huang, Songhui Wu, Xiang You, Zhisheng Chen, Ziqi Lin, Wuhua Guo, Shaowu Zhuang, Yiping Chen, Zhongwu Chen   +13 more
wiley   +1 more source

Mature tertiary lymphoid structure associated CD103+ CD8+ Trm cells determined improved anti-tumor immune in breast cancer

Frontiers in Oncology
BackgroundAlthough tertiary lymphoid structures (TLS) play crucial roles in the anti-tumor immune response and are associated with favorable prognoses in many solid tumors, the precise mechanisms by which TLSs enhance anti-tumor immunity remain poorly ...
Qin Fang, Shuru Chen, Xiaoyue Chen, Wei Zou, Di Chen, Yukang Huang, Chucheng Wu   +6 more
doaj   +1 more source

Differences in the pathological, transcriptomic, and prognostic implications of lymphoid structures between primary and metastatic cutaneous melanomas

Journal for ImmunoTherapy of Cancer
Background While the prognostic role of tertiary lymphoid structures (TLS) has been well studied in solid cancers, the prevalence and impact of immature precursor lymphoid structures known as lymphoid aggregates (LA) remain unresolved in relation to the ...
Jin Xu, Andrew Knight, Jonathan Nguyen, Hong Wang, Walter J Storkus, Cindy Sander, John M Kirkwood, Jiqiang Yao, Xiaofei Song, Jane Messina, James J Mulé, Lilit Karapetyan, Carlos Moran-Segura, Aofei Li, Marion Joy, Sabrina Bruno, Hassan M Abushukair, Danielle Vargas De Stefano, Ayah N Al-Bzour, Caroline Layding   +19 more
doaj   +1 more source

Integrated spatial transcriptomic profiling to dissect the cellular characteristics of tumor-associated tertiary lymphoid structures

Cell Reports
Summary: The presence and maturation of tumor-associated tertiary lymphoid structures (TA-TLSs) significantly influence immune activation and clinical outcome.
Xiangjie Li, Xiaojing Chu, Wenbin Xu, Yi Yang, Ting Wei, Yufei Bo, Yuhui Miao, Yu Zhang, Jinyu Wang, Teng Wang, Guohui Dang, Lu Qi, Dan Tong, Linnan Zhu, Hong Zhao, Zemin Zhang, Sijin Cheng   +16 more
doaj   +1 more source

Role of tertiary lymphoid structures in the tumour microenvironment and immunotherapy response of renal cell carcinoma

Clinical and Translational Medicine
In the tumour microenvironment (TME) of renal cell carcinoma (RCC), tertiary lymphoid structures (TLS) play a crucial role in anti‐tumour immune responses.
Lin Yang, Wentai Shangguan, Weijia Li, Wenxue Huang, Zhuohang Li, Boyuan Sun, Cunzhen Ma, Xunguo Yang, Bisheng Cheng, Peng Wu   +9 more
doaj   +1 more source