Results 101 to 110 of about 5,610 (204)

Mature tertiary lymphoid structure associated CD103+ CD8+ Trm cells determined improved anti-tumor immune in breast cancer

Frontiers in Oncology
BackgroundAlthough tertiary lymphoid structures (TLS) play crucial roles in the anti-tumor immune response and are associated with favorable prognoses in many solid tumors, the precise mechanisms by which TLSs enhance anti-tumor immunity remain poorly ...
Qin Fang, Shuru Chen, Xiaoyue Chen, Wei Zou, Di Chen, Yukang Huang, Chucheng Wu   +6 more
doaj   +1 more source

Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical Levers [PDF]

: Tertiary lymphoid structures (TLSs) arise in non-lymphoid tissues in response to persistent antigen stimulation and chronic inflammation. Spanning organs from lung and liver to meninges, skin, and beyond, TLSs range from loose aggregates of immune ...
Beccaria C. G., Guillaume S. M., Iannacone M., Linterman M. A.   +3 more
core   +1 more source

HLA class II neoantigen presentation for CD4+ T cell surveillance in HLA class II-negative colorectal cancer [PDF]

札幌医科大学博士（医学）doctoral ...
松本, 哲
core   +2 more sources

Integrated spatial transcriptomic profiling to dissect the cellular characteristics of tumor-associated tertiary lymphoid structures

Cell Reports
Summary: The presence and maturation of tumor-associated tertiary lymphoid structures (TA-TLSs) significantly influence immune activation and clinical outcome.
Xiangjie Li, Xiaojing Chu, Wenbin Xu, Yi Yang, Ting Wei, Yufei Bo, Yuhui Miao, Yu Zhang, Jinyu Wang, Teng Wang, Guohui Dang, Lu Qi, Dan Tong, Linnan Zhu, Hong Zhao, Zemin Zhang, Sijin Cheng   +16 more
doaj   +1 more source

Assessment of tertiary lymphoid structures in salivary glands, pancreas, and lungs of NZB/W lupus prone mice. [PDF]

, 2020
Autoimmune diseases are complex genetic traits. Factors that trigger autoimmune diseases have yet to be deciphered. It is however suspected that a combination of copious risk factors is implicated in the development of autoimmunity.
Miancho, Diana Roza Kibancha
core  

Differences in the pathological, transcriptomic, and prognostic implications of lymphoid structures between primary and metastatic cutaneous melanomas

Journal for ImmunoTherapy of Cancer
Background While the prognostic role of tertiary lymphoid structures (TLS) has been well studied in solid cancers, the prevalence and impact of immature precursor lymphoid structures known as lymphoid aggregates (LA) remain unresolved in relation to the ...
Jin Xu, Andrew Knight, Jonathan Nguyen, Hong Wang, Walter J Storkus, Cindy Sander, John M Kirkwood, Jiqiang Yao, Xiaofei Song, Jane Messina, James J Mulé, Lilit Karapetyan, Carlos Moran-Segura, Aofei Li, Marion Joy, Sabrina Bruno, Hassan M Abushukair, Danielle Vargas De Stefano, Ayah N Al-Bzour, Caroline Layding   +19 more
doaj   +1 more source

Podoplanin expressing macrophages and their involvement in tertiary lymphoid structures in mouse models of Sjögren’s disease [PDF]

Tertiary lymphoid structures (TLSs) are formed in tissues targeted by chronic inflammation processes, such as infection and autoimmunity. In Sjögren’s disease, the organization of immune cells into TLS is an important part of disease progression.
Barone, Francesca, Fenton, Kristin Andreassen, Hovd, Aud-Malin Karlsson, Iannizzotto, Valentina, Kanapathippillai, Premasany, Nayar, Saba, Pedersen, Hege Lynum, Smith, Charlotte G.   +7 more
core   +2 more sources

Tertiary Lymphoid Structures Generation through Graph-based Diffusion

, 2023
Graph-based representation approaches have been proven to be successful in the analysis of biomedical data, due to their capability of capturing intricate dependencies between biological entities, such as the spatial organization of different cell types ...
Frossard, Pascal, Madeira, Manuel, Thanou, Dorina   +2 more
core  

Tertiary lymphoid structures associated with improved survival and enhanced antitumor immunity in acral melanoma

npj Precision Oncology
Understanding the impact of tertiary lymphoid structures (TLSs) on acral melanoma (AM) and the tumor microenvironment (TME) is critical. We analyzed TLS features in primary AM lesions from 46 patients and identified intratumoral TLSs (intra-TLSs) in 25 ...
Xinyu Su, Donglin Kang, Jiayu Wang, Lin Li, Rong Huang, Zhengyun Zou   +5 more
doaj   +1 more source

Past failures and new horizons: the nuances of tertiary lymphoid structures in high-grade serous ovarian cancer may contribute to immunotherapy effectiveness

Journal for ImmunoTherapy of Cancer
Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that allow for optimal B-T cell crosstalk in solid tumors. Further, TLS are found in many solid tumors and are associated with improved patient survival and superior immunotherapeutic ...
Tullia C Bruno, Ian MacFawn, Lan Coffman, Rufiaat Rashid   +3 more
doaj   +1 more source