Results 91 to 100 of about 3,823 (146)

Immunogenic cell death as a cornerstone for combination therapies with immune checkpoint blockade. [PDF]

Mol Cancer
Niu Y, Zhu S, Fu K, Lai Y, Pan C, Yang Y, Li S, Wang X, To KKW, Wang F, Fu L.   +10 more
europepmc   +1 more source

Integrating tertiary lymphoid structures and microvascular invasion to refine postoperative prognostic stratification in hepatocellular carcinoma. [PDF]

Int J Surg
Gan K, Gao F.
europepmc   +1 more source

Advances in deciphering intratumoral versus peritumoral heterogeneity of infiltrating lymphocytes in pancreatic cancer: a spatial perspective. [PDF]

Transl Oncol
Zhao K, Yang Q, Yan Y, Zhu J, Zheng S.
europepmc   +1 more source

Integrative Molecular Analyses of Inflammatory and Autoimmune Signals in Cardiac Sarcoidosis. [PDF]

Circulation
Neyazi M, Venturini G, Brown KJ, Choi Y, Gorham JM, Layton OG, Verma A, Wang AJ, Gross RT, McDonough BA, Mendiola Pla M, Viveiros A, DeLaughter DM, DePalma SR, Kim Y, Reichart D, Wakimoto H, Elledge SJ, Divakaran S, Mitchell RN, Koh J, Park JB, Bowles DE, Glass C, Oudit GY, Seidman JG, Seidman CE.   +26 more
europepmc   +1 more source

Tertiary lymphoid structures in renal cell carcinoma: from heterogeneity dissection to translational precision immunotherapy. [PDF]

Front Immunol
Li Z, Ruan S, Yu Y, Xiang H, Mi W.
europepmc   +1 more source

Exploring the impact of tertiary lymphoid structures maturity in NSCLC: insights from TLS scoring

Frontiers in Immunology
Tertiary Lymphoid Structures (TLS) are lymphoid structures commonly associated with improved survival of cancer patients and response to immunotherapies. However, conflicting reports underscore the need to consider TLS heterogeneity and multiple features such as TLS size, composition, and maturation status, when assessing their functional impact.
Harald Hessel, Jorge Blando, Jérôme Galon   +2 more
exaly   +5 more sources

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A digital imaging analysis (DIA) platform for identifying tertiary lymphoid structures (TLS) in lung adenocarcinoma (LUAD).

Journal of Clinical Oncology, 2022
3142 Background: Previous studies of non-small cell lung cancer (NSCLC) have shown that TLS can be predictive of therapy response and a positive prognostic factor for survival. Currently, TLS identification is manually performed by pathologists with limited morphological criteria. Standardizing TLS detection with an automated DIA workflow could guide
Vladimir Kushnarev, Anna Belozerova, Daniil Dymov, Yuriy Popov, Nadezhda Lukashevich, Ivan Valiev, Diana Shamsutdinova, Aida Akaeva, Ilia Galkin, Lev Popyvanov, Viktor Svekolkin, Krystle Nomie, Anna Love, Alexander Bagaev, Ekaterina Postovalova, Nathan Fowler   +15 more
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Tumor-Infiltrating Lymphocytes (TIL), Tertiary Lymphoid Structures (TLS), and Expression of PD-1, TIM-3, LAG-3 on TIL in Invasive and In Situ Ductal Breast Carcinomas and Their Relationship with Prognostic Factors

Clinical Breast Cancer, 2022
Immunotherapy has been determined as an important choice in breast carcinomas, especially in tumors with markedly inflammatory response. About this promising subject, tumor-infiltrating lymphocytes (TIL) and the expression of immune control point receptors on TIL have gained importance.In this study, stromal TIL and tertiary lymphoid structures (TLS ...
Elif Acar
exaly   +5 more sources

Abstract 4655: The prognostic significance of a 12-chemokine tertiary lymphoid structure (TLS) gene signature in uveal melanoma (UM)

Cancer Research, 2023
Abstract Introduction Lymphoid aggregates are commonly associated with better prognosis and enhanced response to immune modulators in several cancers. Considering the immune-privileged status of the eye we sought to investigate the immune, genomic and prognostic significance of 12-chemokine TLS gene signature in UM patients.
Hassan Mohammed Abushukair, Ayah Al-Bzour, Andrew Knight, Walter J. Storkus, John M. Kirkwood, Lilit Karapetyan   +5 more
openaire   +1 more source