Results 91 to 100 of about 5,610 (204)

Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Local complement production by pulmonary artery adventitial fibroblasts, activated intracellularly by CFD and CFB and extracellularly by GZMK+ CD8 T cells, and its secretion in soluble form and within EVs promotes macrophage and T cell chemotaxis and activation.
Hui Zhang, Ram Raj Prasad, Sushil Kumar, Min Li, Dallas Jones, Cheng‐Jun Hu, Claudia Mickael, Yen‐Rei Yu, Rubin M. Tuder, Kurt R. Stenmark   +9 more
wiley   +1 more source

Tertiary lymphoid structure-associated B cells are key players in anti-tumor immunity

Frontiers in Immunology, 2015
It is now admitted that the immune system plays a major role in tumor control. Besides the existence of tumor-specific T cells and B cells, many studies have demonstrated that high numbers of tumor-infiltrating lymphocytes are associated with good ...
Claire eGermain, Sacha eGnjatic, Marie-Caroline eDieu-Nosjean   +2 more
doaj   +1 more source

Epigenetic targets to enhance antitumor immune response through the induction of tertiary lymphoid structures [PDF]

Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates found in sites of chronic inflammation such as tumors and autoimmune diseases. The discovery that TLS formation at tumor sites correlated with good patient prognosis has triggered ...
Barragán, Isabel, Escamilla-Sánchez, Alejandro, Frecha, Cecilia, Omotesho, Quadri Ajibola, Pérez-Ruiz, Elisabeth, Rueda-Domínguez, Antonio   +5 more
core   +1 more source

Multi-resolution deep learning characterizes tertiary lymphoid structures and their prognostic relevance in solid tumors [PDF]

BACKGROUND Tertiary lymphoid structures (TLSs) are dense accumulations of lymphocytes in inflamed peripheral tissues, including cancer, and are associated with improved survival and response to immunotherapy in various solid tumors.
Ciompi, Francesco, Moch, Holger, Obahor, Simon, Pagliarulo, Fabio, Schraml, Peter, Silina, Karina, van den Broek, Maries, van der Laak, Jeroen, van Rijthoven, Mart   +8 more
core   +1 more source

Multiple mechanisms and applications of tertiary lymphoid structures and immune checkpoint blockade

Journal of Experimental & Clinical Cancer Research
Background Immune checkpoint blockade (ICB) inhibits tumor immune escape and has significantly advanced tumor therapy. However, ICB benefits only a minority of patients treated and may lead to many immune-related adverse events.
Zelin Li, Shuhan Liu, Deyu Liu, Kangping Yang, Jing Xiong, Ziling Fang   +5 more
doaj   +1 more source

Tertiary lymphoid structures: exploring opportunities to improve immunotherapy in ovarian cancer

Frontiers in Immunology
Tertiary lymphoid structures (TLS) are organized ectopic lymphoid clusters of immune cells that develop in non-lymphoid tissue to promote antigen presentation, drive cytotoxic immune responses, and enhance humoral immunity via B cell clonal expansion ...
Aaron Varghese, Aaron Varghese, Suzanne M. Hess, Shanmuga Chilakapati, Shanmuga Chilakapati, Jose R. Conejo-Garcia, A.J. Robert McGray, A.J. Robert McGray, Emese Zsiros   +8 more
doaj   +1 more source

Tertiary Lymphoid Structures as Independent Predictors of Favorable Prognosis in Muscle‐Invasive Bladder Cancer

Cancer Medicine
Background Tertiary lymphoid structure (TLS) has been reported to be associated with prognosis and immunotherapy in certain cancers. The objective of our study was to investigate the prognostic significance of Tertiary Lymphoid Structures (TLS) within ...
Xiaodong Teng, Zhen Chen, Yanfeng Bai, Hui Cao, Jing Zhang, Liming Xu, Kaihua Liu, Yuqian Shi, Yang Shao   +8 more
doaj   +1 more source

Tertiary Lymphoid Structures Associate with Tumour Stage in Urothelial Bladder Cancer

Bladder Cancer, 2017
Background: Urothelial bladder cancer (UBC) is a highly prevalent disease in North America, however its optimal management remains elusive. The contribution of B cell associated responses is poorly understood in bladder cancer.
Madhuri Koti, Amanda Shuo Xu, Kevin Yi Mi Ren, Kash Visram, Runhan Ren, David M. Berman, D. Robert Siemens   +6 more
doaj   +1 more source

Cellular Composition and Contribution of Tertiary Lymphoid Structures to Tumor Immune Infiltration and Modulation by Radiation Therapy

Frontiers in Oncology, 2018
Immune-based anti-cancer strategies combined with radiation therapy (RT) are actively being investigated but many questions remain, such as the ideal treatment scheme and whether a potent immune response can be generated both locally and systemically. In
Gaël Boivin, Pradeep Kalambaden, Julien Faget, Sylvie Rusakiewicz, Pierre Montay-Gruel, Etienne Meylan, Jean Bourhis, Jean Bourhis, Guy Lesec, Marie-Catherine Vozenin, Marie-Catherine Vozenin   +10 more
doaj   +1 more source

Spatial Positioning of Immune Hotspots Reflects the Interplay between B and T Cells in Lung Squamous Cell Carcinoma [PDF]

, 2023
Beyond tertiary lymphoid structures, a significant number of immune-rich areas without germinal center-like structures are observed in non–small cell lung cancer.
AbdulJabbar, Khalid, Akarca, Ayse, Enfield, Katey SS, Jamal-Hanjani, Mariam, Le Quesne, John, Marafioti, Teresa, McGranahan, Nicholas, Moore, David A, Raza, Shan E Ahmed, Salgado, Roberto, Swanton, Charles, Veeriah, Selvaraju, Yuan, Yinyin, Zhang, Hanyun   +13 more
core