Results 1 to 10 of about 11,902 (192)

Tertiary lymphoid structures in cancer: maturation and induction [PDF]

Frontiers in Immunology
Tertiary lymphoid structure (TLS) is an ectopic lymphocyte aggregate formed in peripheral non-lymphoid tissues, including inflamed or cancerous tissue.
Yulu Chen, Yulu Chen, Yulu Chen, Yuhao Wu, Yuhao Wu, Yuhao Wu, Guorong Yan, Guorong Yan, Guorong Yan, Guolong Zhang, Guolong Zhang, Guolong Zhang   +11 more
doaj   +6 more sources

Tertiary Lymphoid Structures and Cancer Prognosis (Brief Review)

Креативная хирургия и онкология, 2020
This brief review is devoted to the role of tertiary lymphoid structures in oncological processes. A number of research studies carried out over the past ten years have shed light on the functions of such structures in various diseases, as well as their ...
R. A. Rustamkhanov, K. Sh. Gantsev, D. S. Tursumetov   +2 more
doaj   +3 more sources

Molecular and spatial analysis of tertiary lymphoid structures in Sjogren’s syndrome [PDF]

Nature Communications
Tertiary lymphoid structures play important roles in autoimmune and non-autoimmune conditions. While many of the molecular mechanisms involved in tertiary lymphoid structure formation have been identified, the cellular sources and temporal and spatial ...
Saba Nayar, Jason D. Turner, Saba Asam, Eanna Fennell, Matthew Pugh, Serena Colafrancesco, Onorina Berardicurti, Charlotte G. Smith, Joe Flint, Ana Teodosio, Valentina Iannizzotto, David H. Gardner, Joel van Roon, Ilya Korsunsky, Dawn Howdle, Roche Fibroblast Network Consortium, Andreas P. Frei, Kara G. Lassen, Simon J. Bowman, Wan-Fai Ng, Adam P. Croft, Andrew Filer, Benjamin A. Fisher, Christopher D. Buckley, Francesca Barone   +24 more
doaj   +5 more sources

Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation

OncoImmunology, 2022
Inducing a full antitumor immune response in the tumor microenvironment (TME) is essential for successful cancer immunotherapy. Here, we report that an oncolytic adenovirus carrying mIL-15 (Ad-IL15) can effectively induce antitumor immune response and ...
Teng He, Zhixing Hao, Mingjie Lin, Zhongwei Xin, Yongyuan Chen, Wei Ouyang, Qi Yang, Xiaoke Chen, Hui Zhou, Wanying Zhang, Pin Wu, Feng Xu   +11 more
doaj   +3 more sources

Exploring effects of gut microbiota on tertiary lymphoid structure formation for tumor immunotherapy [PDF]

Frontiers in Immunology
Anti-tumor immunity, including innate and adaptive immunity is critical in inhibiting tumorigenesis and development of tumor. The adaptive immunity needs specific lymph organs such as tertiary lymphoid structures (TLSs), which are highly correlated with ...
Yuqing Liu, Fan Li, Juanjuan Wang, Rongcun Yang, Rongcun Yang, Rongcun Yang   +5 more
doaj   +2 more sources

Stromal cells in tertiary lymphoid structures: Architects of autoimmunity [PDF]

Immunological Reviews, 2021
AbstractThe molecular mediators present within the inflammatory microenvironment are able, in certain conditions, to favor the initiation of tertiary lymphoid structure (TLS) development. TLS is organized lymphocyte clusters able to support antigen‐specific immune response in non‐immune organs.
Saba Asam, Saba Nayar, David Gardner, Francesca Barone   +3 more
openaire   +3 more sources

Tertiary lymphoid structures in pulmonary granulomas of cattle experimentally infected with aerosolized Mycobacterium bovis

BMC Veterinary Research
Mycobacterium bovis is the primary cause of tuberculosis in animals, most notably cattle. In cattle and other susceptible hosts, the hallmark lesion of tuberculosis is the granuloma.
Mitchell V. Palmer, Douglas E. Jones, Nicholas J. Bockenstedt, Paola M. Boggiatto   +3 more
doaj   +2 more sources

The prognostic value of the tertiary lymphoid structure in gastrointestinal cancers

Frontiers in Immunology, 2023
BackgroundNumerous studies and research papers have provided evidence suggesting that tertiary lymphoid structures (TLS) play a crucial role in combating and suppressing tumor growth and progression.
Aoyang Yu, Menghan Cao, Kaile Zhang, Yule Yang, Luyao Ma, Xinran Zhang, Yang Zhao, Xiao Ma, Zhixiang Fan, Zhengxiang Han, Hongmei Wang   +10 more
doaj   +3 more sources

Tertiary lymphoid structures in colorectal cancer

Annals of Medicine
Background Tertiary lymphoid structures (TLS) are ectopic clusters of immune cells found in non-lymphoid tissues, particularly within the tumor microenvironment (TME).
Jianyu Lv, Xiuyu Zhang, Mi Zhou, Junbin Yan, Guanqun Chao, Shuo Zhang   +5 more
doaj   +3 more sources

Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections. [PDF]

Adv Sci (Weinh)
Tertiary lymphoid structure (TLS) is associated with various pathologies, including those of cancers and chronic infections. Depending on the organ, multiple factors regulate the formation of TLS.
Li R, Gu F, Peng L, Huan T, Zhou Z, Song Y, He J, Ye K, Sun Y, Li T, He M, Bian Z, Yin W.   +12 more
europepmc   +3 more sources