Results 1 to 10 of about 11,725 (256)

Tertiary lymphoid structures in cancer: maturation and induction

Frontiers in Immunology
Tertiary lymphoid structure (TLS) is an ectopic lymphocyte aggregate formed in peripheral non-lymphoid tissues, including inflamed or cancerous tissue.
Yulu Chen, Yulu Chen, Yulu Chen, Yuhao Wu, Yuhao Wu, Yuhao Wu, Guorong Yan, Guorong Yan, Guorong Yan, Guolong Zhang, Guolong Zhang, Guolong Zhang   +11 more
doaj   +5 more sources

Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation

OncoImmunology, 2022
Inducing a full antitumor immune response in the tumor microenvironment (TME) is essential for successful cancer immunotherapy. Here, we report that an oncolytic adenovirus carrying mIL-15 (Ad-IL15) can effectively induce antitumor immune response and ...
Teng He, Zhixing Hao, Mingjie Lin, Zhongwei Xin, Yongyuan Chen, Wei Ouyang, Qi Yang, Xiaoke Chen, Hui Zhou, Wanying Zhang, Pin Wu, Feng Xu   +11 more
doaj   +3 more sources

Exploring effects of gut microbiota on tertiary lymphoid structure formation for tumor immunotherapy [PDF]

Frontiers in Immunology
Anti-tumor immunity, including innate and adaptive immunity is critical in inhibiting tumorigenesis and development of tumor. The adaptive immunity needs specific lymph organs such as tertiary lymphoid structures (TLSs), which are highly correlated with ...
Yuqing Liu, Fan Li, Juanjuan Wang, Rongcun Yang, Rongcun Yang, Rongcun Yang   +5 more
doaj   +2 more sources

The prognostic value of the tertiary lymphoid structure in gastrointestinal cancers

Frontiers in Immunology, 2023
BackgroundNumerous studies and research papers have provided evidence suggesting that tertiary lymphoid structures (TLS) play a crucial role in combating and suppressing tumor growth and progression.
Aoyang Yu, Menghan Cao, Kaile Zhang, Yule Yang, Luyao Ma, Xinran Zhang, Yang Zhao, Xiao Ma, Zhixiang Fan, Zhengxiang Han, Hongmei Wang   +10 more
doaj   +3 more sources

STINGing the Tumor Microenvironment to Promote Therapeutic Tertiary Lymphoid Structure Development

Frontiers in Immunology, 2021
Tertiary lymphoid structures (TLS), also known as ectopic lymphoid structures (ELS) or tertiary lymphoid organs (TLO), represent a unique subset of lymphoid tissues noted for their architectural similarity to lymph nodes, but which conditionally form in ...
Jessica N. Filderman, Mark Appleman, Manoj Chelvanambi, Jennifer L. Taylor, Walter J. Storkus, Walter J. Storkus, Walter J. Storkus, Walter J. Storkus   +7 more
doaj   +3 more sources

Mechanisms of tertiary lymphoid structure formation: cooperation between inflammation and antigenicity

Frontiers in Immunology, 2023
To mount an effective anti-tumor immune response capable of controlling or eliminating disease, sufficient numbers of lymphocytes must be recruited to malignant tissue and allowed to sustain their effector functions.
Shrijan Khanal, Andreas Wieland, Andrew J. Gunderson   +2 more
doaj   +3 more sources

The gene signature of tertiary lymphoid structures within ovarian cancer predicts the prognosis and immunotherapy benefit

Frontiers in Genetics, 2023
Ovarian cancer (OC) has the lowest survival rate among gynecologic malignancies. Ectopic lymphocyte aggregates, namely tertiary lymphoid structures (TLSs), have been reported as positive biomarkers for tumor prognosis. However, the related gene signature
Yue Hou, Yue Hou, Yue Hou, Yue Hou, Sijing Qiao, Sijing Qiao, Sijing Qiao, Sijing Qiao, Miao Li, Miao Li, Miao Li, Miao Li, Xue Han, Xue Han, Xue Han, Xue Han, Xuan Wei, Xuan Wei, Xuan Wei, Xuan Wei, Yingxin Pang, Yingxin Pang, Yingxin Pang, Yingxin Pang, Hongluan Mao, Hongluan Mao, Hongluan Mao, Hongluan Mao   +27 more
doaj   +1 more source

Expression of lymphoid structure-associated cytokine/chemokine gene transcripts in tumor and protein in serum are prognostic of melanoma patient outcomes

Frontiers in Immunology, 2023
BackgroundProinflammatory chemokines/cytokines support development and maturation of tertiary lymphoid structures (TLS) within the tumor microenvironment (TME).
Lilit Karapetyan, Hassan M. AbuShukair, Aofei Li, Andrew Knight, Ayah Nedal Al Bzour, Ian P. MacFawn, Zachary J. Thompson, Ann Chen, Xi Yang, Rebekah Dadey, Arivarasan Karunamurthy, Danielle Vargas De Stefano, Cindy Sander, Sheryl R. Kunning, Yana G. Najjar, Diwakar Davar, Jason J. Luke, William Gooding, Tullia C. Bruno, Tullia C. Bruno, John M. Kirkwood, John M. Kirkwood, Walter J. Storkus, Walter J. Storkus   +23 more
doaj   +1 more source

Intratumoral bacterial load and tertiary lymphoid structure density in hepatocellular carcinoma: association and prognostic significance. [PDF]

Front Immunol
Qu S, Jia W, Liu X, Yao Q, Chen C, Zhao Z, Nie Y, Chang F, Yang Z, Peng C, Wang Y, Song W.   +11 more
europepmc   +2 more sources

Tumor-Associated Tertiary Lymphoid Structures: From Basic and Clinical Knowledge to Therapeutic Manipulation

Frontiers in Immunology, 2021
The tumor microenvironment is a complex ecosystem almost unique to each patient. Most of available therapies target tumor cells according to their molecular characteristics, angiogenesis or immune cells involved in tumor immune-surveillance ...
Charlotte Domblides, Charlotte Domblides, Charlotte Domblides, Juliette Rochefort, Juliette Rochefort, Juliette Rochefort, Juliette Rochefort, Juliette Rochefort, Clémence Riffard, Clémence Riffard, Clémence Riffard, Marylou Panouillot, Marylou Panouillot, Marylou Panouillot, Géraldine Lescaille, Géraldine Lescaille, Géraldine Lescaille, Géraldine Lescaille, Géraldine Lescaille, Jean-Luc Teillaud, Jean-Luc Teillaud, Jean-Luc Teillaud, Véronique Mateo, Véronique Mateo, Véronique Mateo, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean   +27 more
doaj   +1 more source