Results 1 to 10 of about 6,745 (243)

Intratumoral tertiary lymphoid structure (TLS) maturation is influenced by draining lymph nodes of lung cancer [PDF]

Journal for ImmunoTherapy of Cancer, 2023
Background Tertiary lymphoid structure (TLS) is an organized infiltration of immune cells, showing features of germinal center (GC) commonly seen in secondary lymphoid organs. However, its relationship with tumor-draining lymph nodes (TDLNs) has not been
Jun Liu, Xiuyu Cai, Wenhua Liang, Jianxing He, Yi Lu, Feng Li, Miao He, Qihua He, Hongshen Deng, Ran Zhong, Haoxin Peng, Xiangrong Wu, Zisheng Chen, Shen Lao, Caichen Li, Jianfu Li   +15 more
doaj   +5 more sources

Tertiary lymphoid structures in cancer: maturation and induction [PDF]

Frontiers in Immunology
Tertiary lymphoid structure (TLS) is an ectopic lymphocyte aggregate formed in peripheral non-lymphoid tissues, including inflamed or cancerous tissue.
Yulu Chen, Yulu Chen, Yulu Chen, Yuhao Wu, Yuhao Wu, Yuhao Wu, Guorong Yan, Guorong Yan, Guorong Yan, Guolong Zhang, Guolong Zhang, Guolong Zhang   +11 more
doaj   +5 more sources

Tertiary lymphoid structures as local perpetuators of organ-specific immune injury: implication for lupus nephritis [PDF]

Frontiers in Immunology, 2023
In response to inflammatory stimuli in conditions such as autoimmune disorders, infections and cancers, immune cells organize in nonlymphoid tissues, which resemble secondary lymphoid organs.
Meiying Wang, Meiying Wang, Meiying Wang, Snehin Rajkumar, Yupeng Lai, Xingjiao Liu, Jing He, Jing He, Tatsuya Ishikawa, Dhiraj Nallapothula, Ram Raj Singh, Ram Raj Singh, Ram Raj Singh, Ram Raj Singh   +13 more
doaj   +3 more sources

Role of Tertiary Lymphoid Structures (TLS) in Anti-Tumor Immunity: Potential Tumor-Induced Cytokines/Chemokines that Regulate TLS Formation in Epithelial-Derived Cancers [PDF]

Cancers, 2014
Following the successes of monoclonal antibody immunotherapies (trastuzumab (Herceptin®) and rituximab (Rituxan®)) and the first approved cancer vaccine, Provenge® (sipuleucel-T), investigations into the immune system and how it can be modified by a tumor has become an exciting and promising new field of cancer research.
Betsy J Barnes
exaly   +3 more sources

Multi-omics profiling and experimental verification of tertiary lymphoid structure-related genes: molecular subgroups, immune infiltration, and prognostic implications in lung adenocarcinoma [PDF]

Frontiers in Immunology
Lung adenocarcinoma (LUAD), characterized by a low 5-year survival rate, is the most common and aggressive type of lung cancer. Recent studies have shown that tertiary lymphoid structures (TLS), which resemble lymphoid structures, are closely linked to ...
Sixuan Wu, Sixuan Wu, Junfan Pan, Qihong Pan, Lijun Zeng, Renji Liang, Yuehua Li   +6 more
doaj   +3 more sources

The prognostic value of the tertiary lymphoid structure in gastrointestinal cancers

Frontiers in Immunology, 2023
BackgroundNumerous studies and research papers have provided evidence suggesting that tertiary lymphoid structures (TLS) play a crucial role in combating and suppressing tumor growth and progression.
Aoyang Yu, Menghan Cao, Kaile Zhang, Yule Yang, Luyao Ma, Xinran Zhang, Yang Zhao, Xiao Ma, Zhixiang Fan, Zhengxiang Han, Hongmei Wang   +10 more
doaj   +3 more sources

Exploring the impact of tertiary lymphoid structures maturity in NSCLC: insights from TLS scoring

Frontiers in Immunology
Tertiary Lymphoid Structures (TLS) are lymphoid structures commonly associated with improved survival of cancer patients and response to immunotherapies. However, conflicting reports underscore the need to consider TLS heterogeneity and multiple features such as TLS size, composition, and maturation status, when assessing their functional impact.
Emily C Jennings, Jorge Blando, Jérôme Galon   +2 more
exaly   +5 more sources

The enrichment of the gut microbiota Lachnoclostridium is associated with the presence of intratumoral tertiary lymphoid structures in hepatocellular carcinoma

Frontiers in Immunology, 2023
Backgrounds and aimsImmunotherapies have formed an entirely new treatment paradigm for hepatocellular carcinoma (HCC). Tertiary lymphoid structure (TLS) has been associated with good response to immunotherapy in most solid tumors.
Rui Zhao, Jiacheng Li, Bo Chen, Jungang Zhao, Leyin Hu, Kate Huang, Qiwen Chen, Jiangqiao Yao, Ganglian Lin, Lishimeng Bao, Mengmeng Lu, Yi Wang, Yi Wang, Gang Chen, Gang Chen, Gang Chen, Fang Wu   +16 more
doaj   +3 more sources

The High Level of Tertiary Lymphoid Structure Is Correlated With Superior Survival in Patients With Advanced Gastric Cancer

Frontiers in Oncology, 2020
Background: A tertiary lymphoid structure (TLS) is a crucial component of the tumor microenvironment, which reflects the anti-tumor immune response in the host.
Wenting He, Dachuan Zhang, Dachuan Zhang, Hong Liu, Tongbing Chen, Jun Xie, Lei Peng, Xiao Zheng, Xiao Zheng, Xiao Zheng, Bin Xu, Bin Xu, Bin Xu, Qing Li, Jingting Jiang, Jingting Jiang, Jingting Jiang   +16 more
doaj   +3 more sources

Tertiary lymphoid structures in renal cell carcinoma: from heterogeneity dissection to translational precision immunotherapy [PDF]

Frontiers in Immunology
Renal cell carcinoma (RCC), characterized by its distinctive hypoxic and immunosuppressive tumor microenvironment (TME), demonstrates suboptimal responses to current immunotherapeutic interventions.
Zhexian Li, Zhexian Li, Sensen Ruan, Yang Yu, Hao Xiang, Wenjie Mi, Wenjie Mi   +6 more
doaj   +2 more sources