Results 1 to 10 of about 3,165 (152)

Intratumoral tertiary lymphoid structure (TLS) maturation is influenced by draining lymph nodes of lung cancer [PDF]

Journal for ImmunoTherapy of Cancer, 2023
Background Tertiary lymphoid structure (TLS) is an organized infiltration of immune cells, showing features of germinal center (GC) commonly seen in secondary lymphoid organs. However, its relationship with tumor-draining lymph nodes (TDLNs) has not been
Jun Liu, Xiuyu Cai, Wenhua Liang, Jianxing He, Yi Lu, Feng Li, Miao He, Qihua He, Hongshen Deng, Ran Zhong, Haoxin Peng, Xiangrong Wu, Zisheng Chen, Shen Lao, Caichen Li, Jianfu Li   +15 more
doaj   +4 more sources

Non-immune regulation of tertiary lymphoid structures in cancer [PDF]

Frontiers in Immunology
Tertiary lymphoid structures (TLS) are ectopic immune aggregates that form in response to chronic inflammation, and their presence across many solid tumors has been associated with improved survival and enhanced responses to immunotherapy.
Owen K. Challen, Owen K. Challen, Evelyn Fitzsimons, Wyatt W. Anderson, Wyatt W. Anderson, Daniella Liao, Daniella Liao, Willie Wu, Willie Wu, Vanessa G. P. Souza, Katya H. Bénard, Katya H. Bénard, Julia R. Naso, Julia R. Naso, Spencer D. Martin, Wan L. Lam, Wan L. Lam, Wan L. Lam, Katey S. S. Enfield, Katey S. S. Enfield, Katey S. S. Enfield   +20 more
doaj   +2 more sources

Tertiary lymphoid structures in chronic rhinosinusitis with nasal polyps: spatial organization, pathological functions, and implications for surgical strategy and biologic therapy [PDF]

Frontiers in Immunology
Chronic rhinosinusitis with nasal polyps (CRSwNP) presents three persistent clinical enigmas that conventional immunological frameworks have failed to resolve.
Yu-Shan Lin, Yu-Shan Lin, Guan-Jiang Huang, Guan-Jiang Huang, Biao-Qing Lu, Biao-Qing Lu, Qi-Ping Luo, Qi-Ping Luo, Zhi-Jun Fan, Zhi-Jun Fan, Xue-Sen Yang, Xue-Sen Yang, Chao-Qing Long, Chao-Qing Long   +13 more
doaj   +2 more sources

GCUNet: a graph neural network-based contextual learning network for tertiary lymphoid structure semantic segmentation in whole slide image [PDF]

Visual Computing for Industry, Biomedicine, and Art
This study focuses on tertiary lymphoid structure (TLS) semantic segmentation in whole slide images (WSIs). Unlike TLS binary segmentation, TLS semantic segmentation identifies boundaries and maturity and requires the integration of contextual ...
Lei Su, Ruiyu Li, Guangyao Zhang, Zonghao Liu, Xuqing Geng, Hetong Wang, Weihao Gai, Huanwen Wu, Jie Tian, Yang Du   +9 more
doaj   +2 more sources

Research progress of tertiary lymphoid structure in hepatocellular carcinoma: from prognostic biomarkers to new strategies for immunotherapy [PDF]

Frontiers in Immunology
Tertiary lymphoid structures (TLS) are important ectopic immune aggregates that develop within the tumor microenvironment (TME) of hepatocellular carcinoma (HCC) and have attracted increasing attention due to their potential clinical value.
Shimin Yuan, Shimin Yuan, Xianting Luo, Shu Li, Long Cao, Long Cao, Xiang Chen, Ling Wang, Yan Liu, Zipeng Li, Tongnuo Wu, Hongcai Fang, Hongcai Fang, Mingfu Tong   +13 more
doaj   +2 more sources

The pivotal role of tertiary lymphoid structures in the tumor immune microenvironment

Frontiers in Oncology
Tertiary lymphoid structures (TLS) are ectopic lymphoid structures that form in non-lymphoid tissues in response to chronic inflammatory stimulation. Structurally and functionally resembling lymph nodes, TLS are primarily composed of B cells, T cells ...
Chengsen Liu, Jiandong Cao
doaj   +3 more sources

Identification of a tertiary lymphoid structure (TLS)-related signature for ovarian cancer prognosis suggests a potential role of STAT5A in TLS maturation. [PDF]

Genes Dis
Yang J, Zhang Y, Cheng S, Xu Y, Wu M, Gu S, Ma M, Zhao Y, Wang C, Wang Y.   +9 more
europepmc   +4 more sources

Automated classification of tertiary lymphoid structures in colorectal cancer using TLS-PAT artificial intelligence tool

Scientific Reports
Abstract Colorectal cancer (CRC) ranks as the third most common and second deadliest cancer worldwide. The immune system, particularly tertiary lymphoid structures (TLS), significantly influences CRC progression and prognosis. TLS maturation, especially in the presence of germinal centers, correlates with improved patient outcomes; however ...
Arnaud Uguen, Rachid Zeghlache
exaly   +5 more sources

Tumor-Infiltrating Lymphocytes (TIL), Tertiary Lymphoid Structures (TLS), and Expression of PD-1, TIM-3, LAG-3 on TIL in Invasive and In Situ Ductal Breast Carcinomas and Their Relationship with Prognostic Factors

Clinical Breast Cancer, 2022
Immunotherapy has been determined as an important choice in breast carcinomas, especially in tumors with markedly inflammatory response. About this promising subject, tumor-infiltrating lymphocytes (TIL) and the expression of immune control point receptors on TIL have gained importance.In this study, stromal TIL and tertiary lymphoid structures (TLS ...
Ozan Yazıcı, Elif Acar, Güldal Esendagli   +2 more
exaly   +5 more sources

Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections

Advanced Science
Tertiary lymphoid structure (TLS) is associated with various pathologies, including those of cancers and chronic infections. Depending on the organ, multiple factors regulate the formation of TLS.
Ruiqi Li, Fan Gu, Linlin Peng, Tingting Huan, Zhuo Zhou, Yaling Song, Jinmei He, Kaili Ye, Yao Sun, Tiejun Li, Miao He, Zhuan Bian, Wei Yin   +12 more
doaj   +2 more sources