Results 41 to 50 of about 2,945 (208)

Tumor-Resident T Cells, Associated With Tertiary Lymphoid Structure Maturity, Improve Survival in Patients With Stage III Lung Adenocarcinoma

Frontiers in Immunology, 2022
Tertiary lymphoid structure (TLS) and tumor-resident memory T cells (TRM) play crucial roles in the anti-tumor immune response, facilitating a good prognosis in patients with cancer. However, there have been no reports on the relationship between TRM and
Hua Zhao, Hua Zhao, Hua Zhao, Hua Zhao, Hua Zhao, Hao Wang, Hao Wang, Hao Wang, Hao Wang, Hao Wang, Yu Zhao, Yu Zhao, Yu Zhao, Yu Zhao, Yu Zhao, Qian Sun, Qian Sun, Qian Sun, Qian Sun, Qian Sun, Xiubao Ren, Xiubao Ren, Xiubao Ren, Xiubao Ren, Xiubao Ren, Xiubao Ren   +25 more
doaj   +1 more source

Tertiary lymphoid structures in head and neck squamous cell carcinoma

Translational Oncology
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Smoking, drinking, and human papillomavirus (HPV) infection are the main risk factors.
Jing Zhu, Hui Lu, Kongcheng Wang, Baorui Liu, Jing Yan   +4 more
doaj   +1 more source

DataSheet_1_Combination of Tertiary Lymphoid Structure and Neutrophil-to-Lymphocyte Ratio Predicts Survival in Patients With Hepatocellular Carcinoma.docx

, 2022
BackgroundHepatocellular carcinoma (HCC) is the most common pathological type of primary liver cancer. The lack of prognosis indicators is one of the challenges in HCC.
Yuzhong Chen (1556500), Xiaoyue Du (1624822), Yun Chen (279569), Bo Shen (419737), Qingbo Wang (8561751), Chupeng Hu (6710015), Jingwei Xia (10801584), Xin Wang (91924), Wei Zhu (23646), Miaolin Zhu (11940524), Shaodi Wen (10801581)   +10 more
core   +1 more source

Abstract 1021: Clinical significance of tertiary lymphoid structures (TLS) and tumor-infiltrating plasma cells in ovarian cancer

Cancer Research, 2018
Abstract Objective: Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates that reflect lymphoid neogenesis mainly through CXCL13 and develop under chronic inflammation. Recently TLS have been detected in several types of cancers; however, there are few reports about TLS in ovarian cancer.
Masayo Ukita, Junzo Hamanishi, Tsukasa Baba, Ryusuke Murakami, Kaoru Abiko, Masaki Mandai   +5 more
openaire   +1 more source

DataSheet_1_Deciphering the maturation of tertiary lymphoid structures in cancer and inflammatory diseases of the digestive tract using imaging mass cytometry.pdf

, 2023
Persistent inflammation can promote the development of tertiary lymphoid structures (TLS) within tissues resembling secondary lymphoid organs (SLO) such as lymph nodes (LN).
Jacques-Olivier Pers (356421), Soizic Garaud (5989271), Danivanh Ben-guigui (15308827), Christelle Le Dantec (15308830), Divi Cornec (795436), Arnaud Uguen (587564), Patrice Hémon (12446181), Marion Le Rochais (14710666)   +7 more
core   +1 more source

Tertiary lymphoid structure signatures are associated with survival and immunotherapy response in muscle-invasive bladder cancer

OncoImmunology, 2021
Immunotherapy that block PD-1–PD-L1 pathway can induce durable tumor control and result in the long-term survival of patients with advanced bladder cancers. However, these responses only occur in a subset of patients. We study gene expression profiles in
Lin Zhou, Bin Xu, Yushan Liu, Zhong Wang
doaj   +1 more source

Additional file 1 of Prognostic value of tertiary lymphoid structures (TLS) in digestive system cancers: a systematic review and meta-analysis

, 2023
Additional file 1: Supplementary Materials. Table S1. Quality assessment details for included studies. Table S2. Summary of controlled covariates in multivariate analyses. Figure S1. Sensitivity analysis for TLS with OS in digestive system cancers patients. Figure S2.
Sun, Hao, Shi, Yuanyu, Ran, Hailiang, Peng, Junwei, Li, Qiongxian, Zheng, Guiqing, He, Yandie, Liu, Shuqing, Chang, Wei, Xiao, Yuanyuan   +9 more
openaire   +1 more source

Distinct Tertiary Lymphoid Structure Associations and Their Prognostic Relevance in HER2 Positive and Negative Breast Cancers

, 2017
Background The presence of tumor infiltrating lymphocytes (TIL) is associated with favorable prognosis. Recent evidence suggested that not only their density, but also the spatial organization as tertiary lymphoid structures (TLS), play
Thazin Hlaing, Yun-Bi Ni, Sai Yin Cheung, Jintao Hu, Siu Ki Chan, Julia Y.S. Tsang, Gary M. Tse, Xia Liu   +7 more
core   +1 more source

Complete pathological remission and tertiary lymphoid structures are associated with the efficacy of resectable NSCLC receiving neoadjuvant chemoimmunotherapy: A double-center retrospective study

Human Vaccines & Immunotherapeutics, 2023
This study aimed to investigate the relationship between complete pathological remission (PCR), tertiary lymphoid structure (TLS) maturation and expression and clinical outcomes of patients with resectable non-small cell lung cancer (NSCLC) receiving ...
Ying Liu, Lei Xiong, Yue Chen, Ruoxue Cai, Xinyu Xu, Tian Wang, Yiyu Guo, Luxi Ruan, Ying Fang, Quanan Zhang, Bo Shen, Jinjun Ye, Guoren Zhou   +12 more
doaj   +1 more source

504 Using multiplexed immunofluorescence to quantitatively analyze myeloid derived suppressor cells (MDSCs) in relation to tertiary lymphoid structures (TLS) in bladder cancer

Regular and young investigator award abstracts, 2020
Background An intriguing phenomenon in many solid tumors is the de novo lymphoid neogenesis of tertiary lymphoid structure (TLS). However, it remains unclear whether spontaneous TLS restricts or promotes tumor progression. MDSCs are major contributors to tumor evasion of adaptive immune responses.
Xin Lu, Anna Juncker-Jensen, Gang Huang, Mate Nagy   +3 more
openaire   +2 more sources