Results 41 to 50 of about 6,745 (243)
Tertiary lymphoid structures and gastric cancer prognosis [PDF]
, 2022 Tertiary lymphoid structures (TLSs) are part of immune response against cancer. Their high density and high diameter have been shown to be associated with prognosis in different cancer types.
Böhm, Jan +7 more
core +1 more source
Molecular and spatial analysis of tertiary lymphoid structures in Sjogren's syndrome [PDF]
Tertiary lymphoid structures play important roles in autoimmune and non-autoimmune conditions. While many of the molecular mechanisms involved in tertiary lymphoid structure formation have been identified, the cellular sources and temporal and spatial ...
core +8 more sources
Prognostic and therapeutic potential of gene profiles related to tertiary lymphoid structures in colorectal cancer [PDF]
PeerJThe role of tertiary lymphoid structures (TLS) in oncology is gaining interest, particularly in colorectal carcinoma, yet a thorough analysis remains elusive.
Jinglu Yu +3 more
doaj +2 more sources
Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]
, 2008 Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad +4 more
core +1 more source
Frontiers in Immunology, 2021 Acquired immunity is orchestrated in various lymphoid organs, including bone marrow, thymus, spleen, and lymph nodes in humans. However, mucosa-associated lymphoid tissue (MALT) is evolutionally known to be emerged in the oldest vertebrates as an ...
Toshiaki Kogame +2 more
doaj +1 more source
Turning an old GADDget into a troublemaker [PDF]
, 2018 Life must continually defend against infection. One of the most ancient types of immunity is the process of active cell death, which first arose in evolution plausibly with protists, as a primordial defence against intracellular ...
C McCormick +21 more
core +1 more source
Frontiers in Immunology, 2022 Tertiary lymphoid structure (TLS) and tumor-resident memory T cells (TRM) play crucial roles in the anti-tumor immune response, facilitating a good prognosis in patients with cancer. However, there have been no reports on the relationship between TRM and
Hua Zhao +25 more
doaj +1 more source
Myc Cooperates with Ras by Programming Inflammation and Immune Suppression. [PDF]
, 2017 The two oncogenes KRas and Myc cooperate to drive tumorigenesis, but the mechanism underlying this remains unclear. In a mouse lung model of KRasG12D-driven adenomas, we find that co-activation of Myc drives the immediate transition to highly ...
Brown Swigart, Lamorna +7 more
core +1 more source
Tertiary lymphoid structure can be a potential therapeutic target for head and neck squamous cell carcinoma (Review). [PDF]
Mol Clin OncolTertiary lymphoid structure (TLS) is a kind of ectopic lymphoid tissues that form in chronic inflammation or tumor microenvironment (TME) and is structurally similar to secondary lymphoid organs such as lymph nodes, containing B cell follicles, T cell ...
Shen J, Yang X.
europepmc +2 more sources
The Tumor Immune Landscape and Architecture of Tertiary Lymphoid Structures in Urothelial Cancer [PDF]
, 2021 Candidate immune biomarkers have been proposed for predicting response to immunotherapy in urothelial cancer (UC). Yet, these biomarkers are imperfect and lack predictive power.
Broeks, Annegien +16 more
core +1 more source