Results 41 to 50 of about 3,198 (184)

Complete pathological remission and tertiary lymphoid structures are associated with the efficacy of resectable NSCLC receiving neoadjuvant chemoimmunotherapy: A double-center retrospective study

Human Vaccines & Immunotherapeutics, 2023
This study aimed to investigate the relationship between complete pathological remission (PCR), tertiary lymphoid structure (TLS) maturation and expression and clinical outcomes of patients with resectable non-small cell lung cancer (NSCLC) receiving ...
Ying Liu, Lei Xiong, Yue Chen, Ruoxue Cai, Xinyu Xu, Tian Wang, Yiyu Guo, Luxi Ruan, Ying Fang, Quanan Zhang, Bo Shen, Jinjun Ye, Guoren Zhou   +12 more
doaj   +1 more source

504 Using multiplexed immunofluorescence to quantitatively analyze myeloid derived suppressor cells (MDSCs) in relation to tertiary lymphoid structures (TLS) in bladder cancer

Regular and young investigator award abstracts, 2020
Background An intriguing phenomenon in many solid tumors is the de novo lymphoid neogenesis of tertiary lymphoid structure (TLS). However, it remains unclear whether spontaneous TLS restricts or promotes tumor progression. MDSCs are major contributors to tumor evasion of adaptive immune responses.
Xin Lu, Anna Juncker-Jensen, Gang Huang, Mate Nagy   +3 more
openaire   +2 more sources

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, EarlyView.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source

Microbiome and Tumor Microenvironment Interactions: Advances From Ecological Niches to Precision Oncology

Cancer Nexus, EarlyView.
Tumor‐associated microbiota occupies spatially organized ecological niches and influence cancer progression by reshaping tumor‐cell signaling, metabolism, immunity, stromal remodeling, and therapeutic response. Integrating microbiome‐derived biomarkers, targeted microbial interventions, spatial multi‐omics, longitudinal monitoring, and AI may enable ...
Yiwen Zhang, Ji'an Liu, Jing Li, Xue Liu, Yang Su, Peng Luo, Yuhan Zhang, Zhengrui Li   +7 more
wiley   +1 more source

Tertiary Lymphoid Structures as Independent Predictors of Favorable Prognosis in Muscle‐Invasive Bladder Cancer

Cancer Medicine
Background Tertiary lymphoid structure (TLS) has been reported to be associated with prognosis and immunotherapy in certain cancers. The objective of our study was to investigate the prognostic significance of Tertiary Lymphoid Structures (TLS) within ...
Xiaodong Teng, Zhen Chen, Yanfeng Bai, Hui Cao, Jing Zhang, Liming Xu, Kaihua Liu, Yuqian Shi, Yang Shao   +8 more
doaj   +1 more source

The tertiary lymphoid structure-related signature identified PTGDS in regulating PD-L1 and promoting the proliferation and migration of glioblastoma

Heliyon
Background: Tertiary lymphoid structure (TLS) is a unique organ that carries out tumor cell elimination at tumor sites. It is continuously stimulated by inflammatory tumor signals and has been found to augment immunotherapy response.
Wantao Wu, He Li, Zeyu Wang, Ziyu Dai, Xisong Liang, Peng Luo, Kun Liu, Hao Zhang, Nan Zhang, Shuyu Li, Chi Zhang   +10 more
doaj   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Review: radiotherapy-mediated B cells within the TLS influence the tumor microenvironment

Journal for ImmunoTherapy of Cancer
The tumor microenvironment (TME) is a diverse and intricate structure consisting of tumor cells, stromal cells, endothelial cells, and immune cells. It is characterized by the communication between tumor cells and both innate and adaptive immune cells ...
Haihua Yang, Dandan Zhou, Kuifei Chen, Yinan Meng, Ziran Chen, Yixiu Xu, Suna Zhou, Xiaozhi Zhang   +7 more
doaj   +1 more source

The enrichment of the gut microbiota Lachnoclostridium is associated with the presence of intratumoral tertiary lymphoid structures in hepatocellular carcinoma

Frontiers in Immunology, 2023
Backgrounds and aimsImmunotherapies have formed an entirely new treatment paradigm for hepatocellular carcinoma (HCC). Tertiary lymphoid structure (TLS) has been associated with good response to immunotherapy in most solid tumors.
Rui Zhao, Jiacheng Li, Bo Chen, Jungang Zhao, Leyin Hu, Kate Huang, Qiwen Chen, Jiangqiao Yao, Ganglian Lin, Lishimeng Bao, Mengmeng Lu, Yi Wang, Yi Wang, Gang Chen, Gang Chen, Gang Chen, Fang Wu   +16 more
doaj   +1 more source

Prognostic Value of FST and Relevance to Immune Infiltration in Head and Neck Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Immunotherapy response rates in head and neck squamous cell carcinoma (HNSCC) are limited by multiple factors. Tumor cell‐derived follistatin (FST) has been linked to immunotherapy resistance, but the underlying mechanisms remain poorly understood. This study aimed to investigate the prognostic value of FST and its associations with
Pan Song, Tao‐Wei Wu, Jing‐Yi Wang, Yu‐Chu Ye, Fa‐ya Liang, Xiao‐Ming Huang, Ping Han   +6 more
wiley   +1 more source