Results 21 to 30 of about 2,807 (182)

Impact of mature tertiary lymphoid structures on prognosis and therapeutic response of Epstein-Barr virus-associated gastric cancer patients

Frontiers in Immunology, 2022
BackgroundEpstein-Barr virus-associated gastric cancer (EBVaGC) exhibits unique histological characteristics within the immune-cell-rich microenvironment, but the role of tertiary lymphoid structure (TLS) in EBVaGC is not yet fully understood.MethodsWe ...
Yi-Xin Yin, Yi-Hong Ling, Yi-Hong Ling, Xiao-Li Wei, Xiao-Li Wei, Cai-Yun He, Cai-Yun He, Bing-Zhi Wang, Chun-Fang Hu, Wen-Ping Lin, Wen-Ping Lin, Run-Cong Nie, Run-Cong Nie, Jie-Wei Chen, Jie-Wei Chen, Jin-Long Lin, Jie Zhou, Juan-Juan Xie, Jing-Ping Yun, Jing-Ping Yun, Dan Xie, Dan Xie, Li-Yan Xue, Mu-Yan Cai, Mu-Yan Cai   +24 more
doaj   +1 more source

Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in MiceSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background and aims: The presence of tertiary lymphoid structures (TLSs) may confer survival benefit to patients with pancreatic ductal adenocarcinoma (PDAC), in an otherwise immunologically inert malignancy.
Francesca R. Delvecchio, Rachel E.A. Fincham, Sarah Spear, Andrew Clear, Marina Roy-Luzarraga, Frances R. Balkwill, John G. Gribben, Michele Bombardieri, Kairbaan Hodivala-Dilke, Melania Capasso, Hemant M. Kocher   +10 more
doaj   +1 more source

Prognostic and therapeutic potential of gene profiles related to tertiary lymphoid structures in colorectal cancer [PDF]

PeerJ
The role of tertiary lymphoid structures (TLS) in oncology is gaining interest, particularly in colorectal carcinoma, yet a thorough analysis remains elusive.
Jinglu Yu, Yabin Gong, Xiaowei Huang, Yufang Bao   +3 more
doaj   +2 more sources

Putative Immunological Functions of Inducible Skin-Associated Lymphoid Tissue in the Context of Mucosa-Associated Lymphoid Tissue

Frontiers in Immunology, 2021
Acquired immunity is orchestrated in various lymphoid organs, including bone marrow, thymus, spleen, and lymph nodes in humans. However, mucosa-associated lymphoid tissue (MALT) is evolutionally known to be emerged in the oldest vertebrates as an ...
Toshiaki Kogame, Kenji Kabashima, Gyohei Egawa   +2 more
doaj   +1 more source

Tumor-Resident T Cells, Associated With Tertiary Lymphoid Structure Maturity, Improve Survival in Patients With Stage III Lung Adenocarcinoma

Frontiers in Immunology, 2022
Tertiary lymphoid structure (TLS) and tumor-resident memory T cells (TRM) play crucial roles in the anti-tumor immune response, facilitating a good prognosis in patients with cancer. However, there have been no reports on the relationship between TRM and
Hua Zhao, Hua Zhao, Hua Zhao, Hua Zhao, Hua Zhao, Hao Wang, Hao Wang, Hao Wang, Hao Wang, Hao Wang, Yu Zhao, Yu Zhao, Yu Zhao, Yu Zhao, Yu Zhao, Qian Sun, Qian Sun, Qian Sun, Qian Sun, Qian Sun, Xiubao Ren, Xiubao Ren, Xiubao Ren, Xiubao Ren, Xiubao Ren, Xiubao Ren   +25 more
doaj   +1 more source

Tertiary lymphoid structures in head and neck squamous cell carcinoma

Translational Oncology
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Smoking, drinking, and human papillomavirus (HPV) infection are the main risk factors.
Jing Zhu, Hui Lu, Kongcheng Wang, Baorui Liu, Jing Yan   +4 more
doaj   +1 more source

Additional file 1 of Prognostic value of tertiary lymphoid structures (TLS) in digestive system cancers: a systematic review and meta-analysis

, 2023
Additional file 1: Supplementary Materials. Table S1. Quality assessment details for included studies. Table S2. Summary of controlled covariates in multivariate analyses. Figure S1. Sensitivity analysis for TLS with OS in digestive system cancers patients. Figure S2.
Sun, Hao, Shi, Yuanyu, Ran, Hailiang, Peng, Junwei, Li, Qiongxian, Zheng, Guiqing, He, Yandie, Liu, Shuqing, Chang, Wei, Xiao, Yuanyuan   +9 more
openaire   +1 more source

Tertiary lymphoid structures in cancer: maturation and induction

Frontiers in Immunology
Tertiary lymphoid structure (TLS) is an ectopic lymphocyte aggregate formed in peripheral non-lymphoid tissues, including inflamed or cancerous tissue.
Yulu Chen, Yulu Chen, Yulu Chen, Yuhao Wu, Yuhao Wu, Yuhao Wu, Guorong Yan, Guorong Yan, Guorong Yan, Guolong Zhang, Guolong Zhang, Guolong Zhang   +11 more
doaj   +1 more source

Tertiary lymphoid structure signatures are associated with survival and immunotherapy response in muscle-invasive bladder cancer

OncoImmunology, 2021
Immunotherapy that block PD-1–PD-L1 pathway can induce durable tumor control and result in the long-term survival of patients with advanced bladder cancers. However, these responses only occur in a subset of patients. We study gene expression profiles in
Lin Zhou, Bin Xu, Yushan Liu, Zhong Wang
doaj   +1 more source

Multi-omics profiling and experimental verification of tertiary lymphoid structure-related genes: molecular subgroups, immune infiltration, and prognostic implications in lung adenocarcinoma

Frontiers in Immunology
Lung adenocarcinoma (LUAD), characterized by a low 5-year survival rate, is the most common and aggressive type of lung cancer. Recent studies have shown that tertiary lymphoid structures (TLS), which resemble lymphoid structures, are closely linked to ...
Sixuan Wu, Sixuan Wu, Junfan Pan, Qihong Pan, Lijun Zeng, Renji Liang, Yuehua Li   +6 more
doaj   +1 more source