Results 21 to 30 of about 6,745 (243)

Deciphering the maturation of tertiary lymphoid structures in cancer and inflammatory diseases of the digestive tract using imaging mass cytometry

Frontiers in Immunology, 2023
Persistent inflammation can promote the development of tertiary lymphoid structures (TLS) within tissues resembling secondary lymphoid organs (SLO) such as lymph nodes (LN).
Marion Le Rochais, Patrice Hémon, Danivanh Ben-guigui, Soizic Garaud, Christelle Le Dantec, Jacques-Olivier Pers, Jacques-Olivier Pers, Divi Cornec, Divi Cornec, Arnaud Uguen, Arnaud Uguen   +10 more
doaj   +1 more source

Prognostic value of tertiary lymphoid structures (TLS) in digestive system cancers: a systematic review and meta-analysis

BMC Cancer, 2023
Abstract Background Existing literature suggests that tertiary lymphatic structure (TLS) is associated with the progression of cancer. However, the prognostic role of TLS in digestive system cancers remains controversial.
Hao Sun, Yuanyu Shi, Hailiang Ran, Junwei Peng, Qiongxian Li, Guiqing Zheng, Yandie He, Shuqing Liu, Wei Chang, Yuanyuan Xiao   +9 more
openaire   +3 more sources

Stromal cells in tertiary lymphoid structures:Architects of autoimmunity [PDF]

, 2021
The molecular mediators present within the inflammatory microenvironment are able, in certain conditions, to favor the initiation of tertiary lymphoid structure (TLS) development.
Acton SE, Aguzzi A, Alcântara C, Aloisi F, Asam S, Avagliano A, Barnhoorn MC, Barone F, Barone F, Barone F, Barone F, Bartoschek M, Bombardieri M, Bombardieri M, Brendolan A, Bronte V, Brown FD, Buechler MB, Buettner M, Bénézech C, Bénézech C, Cabrita R, Carragher DM, Chen Z, Cheng HW, Choi SY, Colbeck EJ, Croft AP, Cupedo T, Cupedo T, Cupedo T, Cyster JG, Davidson S, Denton AE, Dubrot J, Efremova M, Elmusrati AA, Fletcher AL, Fox RI, Friščić J, Gago da Graça C, Gardner JM, Germain C, Gregory JL, Groom JR, Haan JM, Helmink BA, Hosokawa Y, Jarjour M, Karagiannis GS, Kinchen J, Koenig A, Koning JJ, Koning JJ, Koning JJ, Korsunsky I, Kratz A, Krausgruber T, Krautler NJ, Krishnamurty AT, Kumar V, Kündig TM, Lewis SM, Marinkovic T, Martin JC, Mebius RE, Mionnet C, Mu L, Mueller CG, Mueller SN, Muhl L, Nayar S, Neyt K, Ng CT, Ngo VN, Nocturne G, Noort AR, Parikh K, Patel SA, Pavert SA, Peduto L, Perez‐Shibayama C, Peters A, Petitprez F, Picker LJ, Pikor NB, Pikor NB, Pipi E, Pitzalis C, Prados A, Quistrebert J, Rangel‐Moreno J, Rodda LB, Roozendaal R, Ruddle NH, Salomonsson S, Sautès‐Fridman C, Sitnik KM, Smillie CS, Solé‐Boldo L, Tang H, Vondenhoff MF, Wei K, Weinstein AM, White A, Wiede F, Yang C‐Y, Zeissig S   +107 more
core   +1 more source

Recent Progress of Tertiary Lymphoid Structure in Prognosis and Immunotherapy of Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2023
Lung cancer is the leading cause of cancer death, and non-small cell lung cancer (NSCLC) accounts for 85%. Immunotherapy has significantly improved the clinical prognosis of patients with NSCLC. However, because of the complexity and heterogeneousness of
Ying LIU, Lei XIONG, Ruoxue CAI, Yue CHEN, Jinjun YE, Bo SHEN, Guoren ZHOU   +6 more
doaj   +1 more source

Inducible Tertiary Lymphoid Structures: Promise and Challenges for Translating a New Class of Immunotherapy

Frontiers in Immunology, 2021
Tertiary lymphoid structures (TLS) are ectopically formed aggregates of organized lymphocytes and antigen-presenting cells that occur in solid tissues as part of a chronic inflammation response.
Shota Aoyama, Ryosuke Nakagawa, James J. Mulé, James J. Mulé, Adam W. Mailloux   +4 more
doaj   +1 more source

Cutaneous Melanoma: Mutational Status and Potential Links to Tertiary Lymphoid Structure Formation

Frontiers in Immunology, 2021
Recent advances in immunotherapy have enabled rapid evolution of novel interventional approaches designed to reinvigorate and expand patient immune responses against cancer.
Deepak Salem, Manoj Chelvanambi, Walter J. Storkus, Walter J. Storkus, Walter J. Storkus, Walter J. Storkus, Ronald J. Fecek   +6 more
doaj   +1 more source

Tertiary lymphoid structures (TLS) identification and density assessment on H&E-stained digital slides of lung cancer

PLOS ONE, 2021
Tertiary lymphoid structures (TLS) are ectopic aggregates of lymphoid cells in inflamed, infected, or tumoral tissues that are easily recognized on an H&E histology slide as discrete entities, distinct from lymphocytes. TLS are associated with improved cancer prognosis but there is no standardised method available to quantify their presence ...
Panagiotis Barmpoutis, Matthew Di Capite, Hamzeh Kayhanian, William Waddingham, Daniel C. Alexander, Marnix Jansen, Francois Ng Kee Kwong   +6 more
openaire   +5 more sources

Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures. [PDF]

, 2016
Lymphangiogenesis associated with tertiary lymphoid structure (TLS) has been reported in numerous studies. However, the kinetics and dynamic changes occurring to the lymphatic vascular network during TLS development have not been studied.
Barone, F., Buckley, C.D., Caamaño, J.H., Campos, J., Chachlani, M., Chung, M.M., Cloake, T., Gardner, D.H., Luther, S., McGettrick, H.M., Navarro-Núñez, L., Nayar, S., Rankin, P., Steinthal, N., Watson, S.P.   +14 more
core   +5 more sources

Impact of mature tertiary lymphoid structures on prognosis and therapeutic response of Epstein-Barr virus-associated gastric cancer patients

Frontiers in Immunology, 2022
BackgroundEpstein-Barr virus-associated gastric cancer (EBVaGC) exhibits unique histological characteristics within the immune-cell-rich microenvironment, but the role of tertiary lymphoid structure (TLS) in EBVaGC is not yet fully understood.MethodsWe ...
Yi-Xin Yin, Yi-Hong Ling, Yi-Hong Ling, Xiao-Li Wei, Xiao-Li Wei, Cai-Yun He, Cai-Yun He, Bing-Zhi Wang, Chun-Fang Hu, Wen-Ping Lin, Wen-Ping Lin, Run-Cong Nie, Run-Cong Nie, Jie-Wei Chen, Jie-Wei Chen, Jin-Long Lin, Jie Zhou, Juan-Juan Xie, Jing-Ping Yun, Jing-Ping Yun, Dan Xie, Dan Xie, Li-Yan Xue, Mu-Yan Cai, Mu-Yan Cai   +24 more
doaj   +1 more source

Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis [PDF]

, 2021
Tertiary lymphoid structures (TLSs) develop in non-lymphatic tissue in chronic inflammation and cancer. TLS can mature to lymph node (LN) like structures with germinal centers and associated vasculature.
Monypenny, J, Mustapha, R, Ng, K, Ng, T
core   +2 more sources