Results 11 to 20 of about 2,807 (182)

The pivotal role of tertiary lymphoid structures in the tumor immune microenvironment

Frontiers in Oncology
Tertiary lymphoid structures (TLS) are ectopic lymphoid structures that form in non-lymphoid tissues in response to chronic inflammatory stimulation. Structurally and functionally resembling lymph nodes, TLS are primarily composed of B cells, T cells ...
Chengsen Liu, Jiandong Cao
doaj   +3 more sources

The High Level of Tertiary Lymphoid Structure Is Correlated With Superior Survival in Patients With Advanced Gastric Cancer

Frontiers in Oncology, 2020
Background: A tertiary lymphoid structure (TLS) is a crucial component of the tumor microenvironment, which reflects the anti-tumor immune response in the host.
Wenting He, Dachuan Zhang, Dachuan Zhang, Hong Liu, Tongbing Chen, Jun Xie, Lei Peng, Xiao Zheng, Xiao Zheng, Xiao Zheng, Bin Xu, Bin Xu, Bin Xu, Qing Li, Jingting Jiang, Jingting Jiang, Jingting Jiang   +16 more
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Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections

Advanced Science
Tertiary lymphoid structure (TLS) is associated with various pathologies, including those of cancers and chronic infections. Depending on the organ, multiple factors regulate the formation of TLS.
Ruiqi Li, Fan Gu, Linlin Peng, Tingting Huan, Zhuo Zhou, Yaling Song, Jinmei He, Kaili Ye, Yao Sun, Tiejun Li, Miao He, Zhuan Bian, Wei Yin   +12 more
doaj   +2 more sources

Editorial: Tertiary lymphoid structures (TLS) in the tumor immune microenvironment

Frontiers in Immunology
Xinbo Gao, Xiangqin Zhao, Xuesong Li, Jin Zhang, Hui Zhao, Ying Ma   +5 more
exaly   +4 more sources

Deciphering the maturation of tertiary lymphoid structures in cancer and inflammatory diseases of the digestive tract using imaging mass cytometry

Frontiers in Immunology, 2023
Persistent inflammation can promote the development of tertiary lymphoid structures (TLS) within tissues resembling secondary lymphoid organs (SLO) such as lymph nodes (LN).
Marion Le Rochais, Patrice Hémon, Danivanh Ben-guigui, Soizic Garaud, Christelle Le Dantec, Jacques-Olivier Pers, Jacques-Olivier Pers, Divi Cornec, Divi Cornec, Arnaud Uguen, Arnaud Uguen   +10 more
doaj   +1 more source

Recent Progress of Tertiary Lymphoid Structure in Prognosis and Immunotherapy of Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2023
Lung cancer is the leading cause of cancer death, and non-small cell lung cancer (NSCLC) accounts for 85%. Immunotherapy has significantly improved the clinical prognosis of patients with NSCLC. However, because of the complexity and heterogeneousness of
Ying LIU, Lei XIONG, Ruoxue CAI, Yue CHEN, Jinjun YE, Bo SHEN, Guoren ZHOU   +6 more
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Prognostic value of tertiary lymphoid structures (TLS) in digestive system cancers: a systematic review and meta-analysis

BMC Cancer, 2023
Abstract Background Existing literature suggests that tertiary lymphatic structure (TLS) is associated with the progression of cancer. However, the prognostic role of TLS in digestive system cancers remains controversial.
Hao Sun, Yuanyu Shi, Hailiang Ran, Junwei Peng, Qiongxian Li, Guiqing Zheng, Yandie He, Shuqing Liu, Wei Chang, Yuanyuan Xiao   +9 more
openaire   +3 more sources

Tertiary lymphoid structures (TLS) identification and density assessment on H&E-stained digital slides of lung cancer

PLOS ONE, 2021
Tertiary lymphoid structures (TLS) are ectopic aggregates of lymphoid cells in inflamed, infected, or tumoral tissues that are easily recognized on an H&E histology slide as discrete entities, distinct from lymphocytes. TLS are associated with improved cancer prognosis but there is no standardised method available to quantify their presence ...
Panagiotis Barmpoutis, Matthew Di Capite, Hamzeh Kayhanian, William Waddingham, Daniel C. Alexander, Marnix Jansen, Francois Ng Kee Kwong   +6 more
openaire   +5 more sources

Tertiary lymphoid structures as local perpetuators of organ-specific immune injury: implication for lupus nephritis

Frontiers in Immunology, 2023
In response to inflammatory stimuli in conditions such as autoimmune disorders, infections and cancers, immune cells organize in nonlymphoid tissues, which resemble secondary lymphoid organs.
Meiying Wang, Meiying Wang, Meiying Wang, Snehin Rajkumar, Yupeng Lai, Xingjiao Liu, Jing He, Jing He, Tatsuya Ishikawa, Dhiraj Nallapothula, Ram Raj Singh, Ram Raj Singh, Ram Raj Singh, Ram Raj Singh   +13 more
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LLT1-CD161 Interaction in Cancer: Promises and Challenges

Frontiers in Immunology, 2022
The success of immune checkpoint therapy in cancer has changed our way of thinking, promoting the design of future cancer treatments that places the immune system at the center stage.
Veronique M. Braud, Aïda Meghraoui-Kheddar, Roxane Elaldi, Luciana Petti, Claire Germain, Fabienne Anjuère   +5 more
doaj   +1 more source