Results 11 to 20 of about 6,745 (243)

Identification of a tertiary lymphoid structure (TLS)-related signature for ovarian cancer prognosis suggests a potential role of STAT5A in TLS maturation. [PDF]

Genes Dis
Yang J, Zhang Y, Cheng S, Xu Y, Wu M, Gu S, Ma M, Zhao Y, Wang C, Wang Y.   +9 more
europepmc   +4 more sources

The impact of metabolic reprogramming on tertiary lymphoid structure formation: enhancing cancer immunotherapy

BMC Medicine
Background Cancer immunotherapy has achieved unprecedented success in the field of cancer therapy. However, its potential is constrained by a low therapeutic response rate.
Meng-Jie Zhang, Yan Wen, Zhi-Jun Sun
doaj   +2 more sources

Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections

Advanced Science
Tertiary lymphoid structure (TLS) is associated with various pathologies, including those of cancers and chronic infections. Depending on the organ, multiple factors regulate the formation of TLS.
Ruiqi Li, Fan Gu, Linlin Peng, Tingting Huan, Zhuo Zhou, Yaling Song, Jinmei He, Kaili Ye, Yao Sun, Tiejun Li, Miao He, Zhuan Bian, Wei Yin   +12 more
doaj   +2 more sources

Podoplanin expressing macrophages and their involvement in tertiary lymphoid structures in mouse models of Sjögren’s disease [PDF]

Frontiers in Immunology
Tertiary lymphoid structures (TLSs) are formed in tissues targeted by chronic inflammation processes, such as infection and autoimmunity. In Sjögren’s disease, the organization of immune cells into TLS is an important part of disease progression.
Aud-Malin Karlsson Hovd, Saba Nayar, Charlotte G. Smith, Premasany Kanapathippillai, Valentina Iannizzotto, Francesca Barone, Kristin Andreassen Fenton, Hege Lynum Pedersen   +7 more
doaj   +4 more sources

Artificial Intelligence (AI)-Powered H&E Whole-Slide Image Analysis of Tertiary Lymphoid Structure (TLS) Independently Predicts Survival in Patients with Non-Small Cell Lung Cancer (NSCLC) Receiving Immunotherapy

medRxiv
ABSTRACT Background Tertiary lymphoid structures (TLSs) within the tumor microenvironment have emerged as potential indicators of treatment response to immune checkpoint inhibitors (ICIs). This study aims to explore the association between artificial intelligence (AI)-powered TLS analysis and ...
Leeseul Kim, Sangwon Shin, Behtash G Nezami, Borislav Alexiev, Soo Ick Cho, Sanghoon Song, Wonkyung Jung, Lee AD Cooper, Donghoon Shin, Junho Song, Taekyu Um, Liam Il-Young Chung, Young Kwang Chae   +12 more
openaire   +2 more sources

Neoadjuvant Immunochemotherapy Increases the Abundance of Tertiary Lymphoid Structures and Lymphocyte Subpopulations Is Associated With Prognosis of Esophageal Squamous Cell Carcinoma. [PDF]

Cancer Med
ABSTRACT Neoadjuvant immunochemotherapy (NIC) has emerged as a promising strategy for esophageal squamous cell carcinoma (ESCC). However, its impact on tertiary lymphoid structures (TLSs) and the immune microenvironment remains to be fully elucidated. We retrospectively analyzed 50 ESCC patients treated with NIC (n = 25) or chemotherapy alone (n = 25 ...
Li N, Zhang X, Tang X, Shen J, Qi Q, Wu H, Zhao Y, Wang S.   +7 more
europepmc   +2 more sources

Editorial: Tertiary lymphoid structures (TLS) in the tumor immune microenvironment

Frontiers in Immunology
Xinbo Gao, Xiangqin Zhao, Xuesong Li, Jin Zhang, Hui Zhao, Ying Ma   +5 more
exaly   +4 more sources

Tertiary lymphoid structures critical for prognosis in endometrial cancer patients [PDF]

, 2022
B-cells play a key role in cancer suppression, particularly when aggregated in tertiary lymphoid structures (TLS). Here, we investigate the role of B-cells and TLS in endometrial cancer (EC).
, Bosse, Tjalling, Church, David N, Creutzberg, Carien L, de Boer, Stephanie M, de Bruyn, Marco, Horeweg, Nanda, Jürgenliemk-Schulz, Ina M, Koelzer, Viktor H, Krog, Ricki T, Leary, Alexandra, Loiero, Dominik, Léon-Castillo, Alicia, MacKay, Helen, Mileshkin, Linda R, Nijman, Hans W, Nout, Remi A, Powell, Melanie E, Singh, Naveena, Smit, Vincent T H B M, Vermij, Lisa, Workel, Hagma H   +21 more
core   +6 more sources

Turning Tertiary Lymphoid Structures (TLS) into Hot Spots: Values of TLS in Gastrointestinal Tumors

Cancers, 2023
Tertiary lymphoid structures (TLSs) are ectopic lymphocyte aggregation structures found in the tumor microenvironment (TME). Emerging evidence shows that TLSs are significantly correlated with the progression of gastrointestinal tumors, patients’ prognosis, and the efficacy of adjuvant therapy. Besides, there are still some immunosuppressive factors in
Daming Cai, Heng Yu, Xingzhou Wang, Yonghuan Mao, Mengjie Liang, Xiaofeng Lu, Xiaofei Shen, Wenxian Guan   +7 more
openaire   +2 more sources

Inflammation-Driven Lymphoid Structures: Organization, Function, and Clinical Impact Across Autoimmunity, Cancer, and Checkpoint Toxicity. [PDF]

Immunol Rev
ABSTRACT Lymphoid structures (LS) arising in nonlymphoid tissues are increasingly recognized as active immune niches rather than simple consequences of chronic inflammation. In this review, we propose a framework that distinguishes inflammatory lymphoid structures (ILS) from mature tertiary lymphoid structures (mTLS), while acknowledging that these ...
Frutoso M, Delmas E, Corty R, Bettacchioli E, Cornec D, Hillion S, Garaud S.   +6 more
europepmc   +2 more sources