Results 31 to 40 of about 2,945 (208)

Kidney tertiary lymphoid structures in Lupus Nephritis develop into large interconnected networks and resemble lymph nodes in gene signature [PDF]

, 2020
Immune aggregates organized as tertiary lymphoid structures (TLS) are observed within the kidneys of patients with systemic lupus erythematosus and lupus nephritis (LN).
Figenschau, Stine, Thiyagarajan, Dhivya Borra, Fenton, Kristin Andreassen, Horvei, Kjersti Daae, Dorraji, Seyed Esmaeil, Kanapathippillai, Premasany, Fenton, Christopher Graham, Ursvik, anita, Stenersrød, Mikael Ryan, Pedersen, Hege Lynum, Hovd, Aud-Malin Karlsson   +10 more
core   +1 more source

Mechanisms of tertiary lymphoid structure formation: cooperation between inflammation and antigenicity [PDF]

, 2023
To mount an effective anti-tumor immune response capable of controlling or eliminating disease, sufficient numbers of lymphocytes must be recruited to malignant tissue and allowed to sustain their effector functions.
Andreas Wieland, Shrijan Khanal, Andrew J. Gunderson   +2 more
core   +1 more source

Impact of mature tertiary lymphoid structures on prognosis and therapeutic response of Epstein-Barr virus-associated gastric cancer patients

Frontiers in Immunology, 2022
BackgroundEpstein-Barr virus-associated gastric cancer (EBVaGC) exhibits unique histological characteristics within the immune-cell-rich microenvironment, but the role of tertiary lymphoid structure (TLS) in EBVaGC is not yet fully understood.MethodsWe ...
Yi-Xin Yin, Yi-Hong Ling, Yi-Hong Ling, Xiao-Li Wei, Xiao-Li Wei, Cai-Yun He, Cai-Yun He, Bing-Zhi Wang, Chun-Fang Hu, Wen-Ping Lin, Wen-Ping Lin, Run-Cong Nie, Run-Cong Nie, Jie-Wei Chen, Jie-Wei Chen, Jin-Long Lin, Jie Zhou, Juan-Juan Xie, Jing-Ping Yun, Jing-Ping Yun, Dan Xie, Dan Xie, Li-Yan Xue, Mu-Yan Cai, Mu-Yan Cai   +24 more
doaj   +1 more source

LLT1-CD161 Interaction in Cancer: Promises and Challenges

Frontiers in Immunology, 2022
The success of immune checkpoint therapy in cancer has changed our way of thinking, promoting the design of future cancer treatments that places the immune system at the center stage.
Veronique M. Braud, Aïda Meghraoui-Kheddar, Roxane Elaldi, Luciana Petti, Claire Germain, Fabienne Anjuère   +5 more
doaj   +1 more source

A cellular and spatial map of salivary glands at single cell resolution reveals the functional basis of tertiary lymphoid structure formation in Sjogren’s syndrome

, 2022
The key role of tertiary lymphoid structures in autoimmune and non-autoimmune conditions has been recently appreciated. While many of the molecular mechanisms involved in tertiary lymphoid structure (TLS) formation have been identified, their cellular ...
van, Roon J, Fennell, Eanna, Pugh, M, Teodosio, A, Flint, J, Turner, JD; id_orcid, Smith, Charlotte, Iannizzotto, V, Consortium, Roche Fibroblast Network, Nayar, S, Gardner, DH, Berardicurti, O, Asam, S, Colfrancesco, S   +13 more
core   +1 more source

T Follicular Helper Cells in Tertiary Lymphoid Structure Contribute to Renal Fibrosis by IL-21

, 2023
Tertiary lymphoid structure (TLS) represents lymphocyte clusters in non-lymphoid organs. The formation and maintenance of TLS are dependent on follicular helper T (TFH) cells.
Yichun Cheng, Shuwang Ge, Nanhui Zhang, Ran Luo, Gang Xu, Dan Chang   +5 more
core   +1 more source

Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development [PDF]

, 2018
Tertiary lymphoid structures (TLSs) display phenotypic and functional characteristics of secondary lymphoid organs, and often develop in tissues affected by chronic inflammation, as well as in certain inflammation-associated cancers where they are ...
Yu, L, Gallimore, A, Ferrero, RL, Jones, GW, Bhathal, PS, Oshima, M, Hill, DG, Gao, H, Sievert, W, McLeod, L, Jenkins, BJ, Balic, JJ, D'Costa, K, Oshima, H, West, A   +14 more
core   +2 more sources

Prognostic and therapeutic potential of gene profiles related to tertiary lymphoid structures in colorectal cancer [PDF]

PeerJ
The role of tertiary lymphoid structures (TLS) in oncology is gaining interest, particularly in colorectal carcinoma, yet a thorough analysis remains elusive.
Jinglu Yu, Yabin Gong, Xiaowei Huang, Yufang Bao   +3 more
doaj   +2 more sources

Putative Immunological Functions of Inducible Skin-Associated Lymphoid Tissue in the Context of Mucosa-Associated Lymphoid Tissue

Frontiers in Immunology, 2021
Acquired immunity is orchestrated in various lymphoid organs, including bone marrow, thymus, spleen, and lymph nodes in humans. However, mucosa-associated lymphoid tissue (MALT) is evolutionally known to be emerged in the oldest vertebrates as an ...
Toshiaki Kogame, Kenji Kabashima, Gyohei Egawa   +2 more
doaj   +1 more source

Close Association between Altered Urine–Urothelium Barrier and Tertiary Lymphoid Structure Formation in the Renal Pelvis during Nephritis [PDF]

, 2022
BACKGROUND: Kidneys with chronic inflammation develop tertiary lymphoid structures (TLSs). Infectious pyelonephritis is characterized by renal pelvis (RP) inflammation.
Teppei Nakamura, Taro Horino, Nakamura, Teppei, Horino, Taro, Ali, Elewa Yaser Hosny, Masum, Md. Abdul, Namba, Takashi, Marina Hosotani, Elewa Yaser Hosny Ali, Hosotani, Marina, Md. Abdul Masum, Yuki Otani, Osamu Ichii, Takashi Namba, Yasuhiro Kon, Kon, Yasuhiro, Ichii, Osamu, Hosny Ali, Elewa Yaser, Otani, Yuki   +18 more
core   +1 more source