Results 51 to 60 of about 2,945 (208)

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

STAID: A Self‐Refining Deep Learning Framework for Spatial Cell‐Type Deconvolution with Biologically Informed Modeling

Advanced Science, EarlyView.
STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu, Shuli Sun, Zhengliang Lv, Xinyu Liu, Yihua Wang, Bingqiang Liu   +5 more
wiley   +1 more source

Tumor-Infiltrating Lymphocytes (TIL), Tertiary Lymphoid Structures (TLS), and Expression of PD-1, TIM-3, LAG-3 on TIL in Invasive and In Situ Ductal Breast Carcinomas and Their Relationship with Prognostic Factors

Clinical Breast Cancer, 2022
Immunotherapy has been determined as an important choice in breast carcinomas, especially in tumors with markedly inflammatory response. About this promising subject, tumor-infiltrating lymphocytes (TIL) and the expression of immune control point receptors on TIL have gained importance.In this study, stromal TIL and tertiary lymphoid structures (TLS ...
Elif Acar, Güldal Esendağlı, Ozan Yazıcı, Ayşe Dursun   +3 more
openaire   +4 more sources

Automated classification of tertiary lymphoid structures in colorectal cancer using TLS-PAT artificial intelligence tool

Scientific Reports
Abstract Colorectal cancer (CRC) ranks as the third most common and second deadliest cancer worldwide. The immune system, particularly tertiary lymphoid structures (TLS), significantly influences CRC progression and prognosis. TLS maturation, especially in the presence of germinal centers, correlates with improved patient outcomes; however ...
Le Rochais, Marion, Brahim, Ikram, Zeghlache, Rachid, Redoulez, Geoffroy, Guillard, Matthieu, Le Noac’h, Pierre, Castillon, Marine, Bourhis, Amélie, Uguen, Arnaud   +8 more
openaire   +4 more sources

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology [PDF]

, 2019
Resident fibroblasts at sites of infection, chronic inflammation, or cancer undergo phenotypic and functional changes to support leukocyte migration and, in some cases, aggregation into tertiary lymphoid structures (TLS).
Buckley, Christopher, Buckley, Christopher, D, Fearon, Douglas T, Turner, Jason; id_orcid, Fisher, Benjamin A, Bowman, Simon, J, Smith, CG, Fearon, D.T., Barone, Francesca; id_orcid, Tarte, Karin, Glaysher, B., Tarte, K., Smith, Charlotte, Luther, Sanjiv A, Buckley, Christopher,, Filer, Andrew, Campos, Joana, Nayar, S, Gardner, David, Gardner, D.H., Iannizzotto, Valentina, Asam, S, Asam, S., Coles, Mark C, Asam, Saba, Iannizzotto, V., Mourcin, F., Roulois, D, Buckley, CD, Nayar, Saba, Roulois, David, Sylvestre, Marvin, Coles, Mark, C, Buckley, Christopher D, Luther, Sanjiv, A, Filer, A., Bowman, Simon J., Mourcin, F, Gardner, DH, Smith, Charlotte,, Coles, Mark C., Filer, A, Nayar, S., Mourcin, Frédéric, Bowman, Simon,, Smith, Charlotte G, Glaysher, B, Campos, J, Fearon, DT, Roulois, D., Fisher, Benjamin,, Bowman, SJ, Glaysher, Bridget, Campos, J., Luther, Sanjiv A., Turner, J, Smith, Charlotte, G, Fisher, BA, Iannizzotto, V, Buckley, C.D., Turner, Jason, Luther, SA, Gardner, David,, Fearon, Douglas,, Tarte, K, Gardner, David, H, Coles, M.C., Barone, F., Dias De Campos, Joana, Turner, J., Fearon, Douglas, T, Gardner, David H, Smith, C.G., Fisher, B.A., Barone, Francesca, Bowman, Simon J, Fisher, Benjamin, A, Sylvestre, M, Sylvestre, M., Luther, S.A., Fearon, Douglas T., Coles, MC, Bowman, S.J., Luther, Sanjiv,, Barone, F, Fisher, Benjamin, Coles, Mark,   +86 more
core   +1 more source

Radiation drives tertiary lymphoid structures to reshape TME for synergized antitumour immunity

Expert Reviews in Molecular Medicine
Radiotherapy (RT) plays a key role in the tumour microenvironment (TME), impacting the immune response via cellular and humoral immunity. RT can induce local immunity to modify the TME.
Shuling Li, Kuifei Chen, Zhenwei Sun, Meng Chen, Wenhu Pi, Suna Zhou, Haihua Yang   +6 more
doaj   +1 more source

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Stromal Regulation of Tumor Perineural Invasion: A Multicellular and Neuro‐Ecological Perspective

Advanced Science, EarlyView.
This review reframes perineural invasion (PNI) as a dynamic, multicellular process within the tumor–nerve–stromal ecosystem. The authors delineate how cancer‐associated fibroblasts, Schwann cells, and immune cells remodel the neural niche to facilitate tumor spread.
Xiaoyang Lin, Yingqiao Liu, Haitao Lin, Kang Feng, Xiqiang Liu   +4 more
wiley   +1 more source

An Integrated and Robust Deep Learning Framework for Denoising and Analyzing Single‐Cell Spatial Transcriptomics

Advanced Intelligent Systems, EarlyView.
Single‐cell Spatial Transcriptomics Analysis and Denoising Engine is introduced as a unified deep learning framework that jointly performs denoising, clustering, and gene prioritization in spatial transcriptomics. By integrating linear and nonlinear representations within a dual‐channel architecture, it improves robustness and accuracy, uncovers ...
Yaxuan Cui, Yang Cui, Ruheng Wang, Xin Zeng, Zheyong Zhu, Ding Yi, Ruihua Guo, Tetsuya Sakurai, Kenta Nakai, Xiucai Ye, Leyi Wei, Yong Chen   +11 more
wiley   +1 more source