Results 51 to 60 of about 3,198 (184)

Spatial Transcriptomics Identifies Characteristic Immunological Niches in Atopic Dermatitis

Allergy, EarlyView.
Spatially organized immune niches containing mature migratory dendritic cells (mmDCs) and CD4+ T cells in atopic dermatitis lesions support localized T cell activation and may contribute to disease persistence. Spatial transcriptomics identifies conserved immune niches in atopic dermatitis lesions, characterized by close co‐localization of CD4+ T cells
Lina Gross, Lukas Bäriswyl, Erik Kupschke, Alexandra Wallimann, Hanne Hillen, Philipp Kirchner, Jivko Kamarashev, Martin Wartenberg, Claudio Rhyner, Christoph Schlapbach, Stephan Traidl, Mirjam Schenk   +11 more
wiley   +1 more source

Tertiary lymphoid structures in esophageal cancer: a novel target for immunotherapy

Frontiers in Immunology
Esophageal cancer (EC), especially esophageal squamous cell carcinoma (ESCC), which is the most common subtype in China, is one of the most aggressive gastrointestinal malignancies. Traditional treatments like surgery, radiotherapy, and chemotherapy have
Ke Zhai, Yuting Ma, Xue Gao, Kun Ru, Miaoqing Zhao   +4 more
doaj   +1 more source

Peritumor tertiary lymphoid structures are associated with infiltrating neutrophils and inferior prognosis in hepatocellular carcinoma

Cancer Medicine, 2023
Background The positive prediction of prognosis and immunotherapy within tertiary lymphoid structure (TLS) in cancerous tissue has been well demonstrated, including liver cancer.
Tianchen Zhang, Xinjun Lei, Weili Jia, Jianhui Li, Ye Nie, Zhenzhen Mao, Yanfang Wang, Kaishan Tao, Wenjie Song   +8 more
doaj   +1 more source

Single‐Cell and Spatial Analysis Reveal the Differences Between Left‐Sided and Right‐Sided Colorectal Cancer

Cell Proliferation, EarlyView.
Single‐cell and spatial analysis revealed distinct CRC microenvironments by tumour laterality. Right‐sided tumours showed enhanced germinal centre B cells, CXCL13+ T cells, and organized TLS‐immune crosstalk via CCL19/21‐CCR7, suggesting better immunotherapy response.
Zongnai Zhang, Jiaqi Xu, Yingchao Wu, Tao Liu, Junling Zhang, Mai Zhou, Jie Qiao, Heng Pan, Xin Wang   +8 more
wiley   +1 more source

Pharmacological Targets for Periodontitis: A Systematic Review of Drug‐Target Mendelian Randomisation Studies

Journal of Periodontal Research, EarlyView.
This systematic review evaluated drug‐target Mendelian randomisation studies on periodontitis. Twelve studies identified host‐response‐related targets mainly involved in inflammatory, complement, and immune pathways. Although some targets were linked to existing drugs, the evidence remains preliminary and heterogeneous, requiring replication and ...
Luigi Nibali, Jing Kang, Simon Haworth, Alessandro Polizzi, Gaetano Isola   +4 more
wiley   +1 more source

Assessment of Clinical and Immunological Factors of Local Recurrence in Canine Soft Tissue Sarcoma

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Canine soft tissue sarcomas (STSs) are locally invasive tumours, making local recurrence a major clinical challenge. Time to recurrence (TTR) and associated immune factors remain poorly characterized. This study aimed to characterize the immune microenvironment of canine STS and identify factors associated with TTR.
Kazuki Mizuta, Helene Philibert, Arata Matsuyama   +2 more
wiley   +1 more source

Pan-cancer analysis of genomic properties and clinical outcome associated with tumor tertiary lymphoid structure

Scientific Reports, 2020
How the genomic landscape of a tumor shapes the formation of tertiary lymphoid structure (TLS) and how might TLS alter the clinical outcome or response to immunotherapy had not been systematically explored. Utilizing the genomic and transcriptome data of
Ziying Lin, Lixia Huang, ShaoLi Li, Jincui Gu, Xiaoxian Cui, Yanbin Zhou   +5 more
doaj   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, Volume 159, Issue 8, Page 1857-1872, 15 October 2026.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

The value of tertiary lymphoid structure on predicting the survival rate of advanced cervical cancer patients

BMC Cancer
Background Cervical cancer (CC) ranks as the fourth most prevalent cancer among women worldwide. However, for patients with advanced-stage disease, reliable prognostic markers remain scarce.
Siting Huang, Shengming Wu, Yongpeng Li, Youzhi Lin, Xin Chang, Xianlin Yi, Ying Long, Chanzhen Liu   +7 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, Volume 20, Issue 10, Page 2393-2409, October 2026.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source