Results 51 to 60 of about 6,745 (243)

B cells in the formation of Tertiary Lymphoid Organs in autoimmunity, transplantation and tumorigenesis. [PDF]

, 2019
TLS develop in target organs of autoimmune diseases, transplantation and cancer. • TLS can function as germinal centres supporting B-cell selection/differentiation.
BOMBARDIERI, M, CORSIERO, E, DELVECCHIO, F, PITZALIS, CONSTANTINO   +3 more
core   +1 more source

Tertiary lymphoid structures in head and neck squamous cell carcinoma

Translational Oncology
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Smoking, drinking, and human papillomavirus (HPV) infection are the main risk factors.
Jing Zhu, Hui Lu, Kongcheng Wang, Baorui Liu, Jing Yan   +4 more
doaj   +1 more source

Abstract 1021: Clinical significance of tertiary lymphoid structures (TLS) and tumor-infiltrating plasma cells in ovarian cancer

Cancer Research, 2018
Abstract Objective: Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates that reflect lymphoid neogenesis mainly through CXCL13 and develop under chronic inflammation. Recently TLS have been detected in several types of cancers; however, there are few reports about TLS in ovarian cancer.
Masayo Ukita, Junzo Hamanishi, Tsukasa Baba, Ryusuke Murakami, Kaoru Abiko, Masaki Mandai   +5 more
openaire   +1 more source

Additional file 1 of Prognostic value of tertiary lymphoid structures (TLS) in digestive system cancers: a systematic review and meta-analysis

, 2023
Additional file 1: Supplementary Materials. Table S1. Quality assessment details for included studies. Table S2. Summary of controlled covariates in multivariate analyses. Figure S1. Sensitivity analysis for TLS with OS in digestive system cancers patients. Figure S2.
Sun, Hao, Shi, Yuanyu, Ran, Hailiang, Peng, Junwei, Li, Qiongxian, Zheng, Guiqing, He, Yandie, Liu, Shuqing, Chang, Wei, Xiao, Yuanyuan   +9 more
openaire   +1 more source

Tertiary lymphoid structure signatures are associated with survival and immunotherapy response in muscle-invasive bladder cancer

OncoImmunology, 2021
Immunotherapy that block PD-1–PD-L1 pathway can induce durable tumor control and result in the long-term survival of patients with advanced bladder cancers. However, these responses only occur in a subset of patients. We study gene expression profiles in
Lin Zhou, Bin Xu, Yushan Liu, Zhong Wang
doaj   +1 more source

Complete pathological remission and tertiary lymphoid structures are associated with the efficacy of resectable NSCLC receiving neoadjuvant chemoimmunotherapy: A double-center retrospective study

Human Vaccines & Immunotherapeutics, 2023
This study aimed to investigate the relationship between complete pathological remission (PCR), tertiary lymphoid structure (TLS) maturation and expression and clinical outcomes of patients with resectable non-small cell lung cancer (NSCLC) receiving ...
Ying Liu, Lei Xiong, Yue Chen, Ruoxue Cai, Xinyu Xu, Tian Wang, Yiyu Guo, Luxi Ruan, Ying Fang, Quanan Zhang, Bo Shen, Jinjun Ye, Guoren Zhou   +12 more
doaj   +1 more source

504 Using multiplexed immunofluorescence to quantitatively analyze myeloid derived suppressor cells (MDSCs) in relation to tertiary lymphoid structures (TLS) in bladder cancer

Regular and young investigator award abstracts, 2020
Background An intriguing phenomenon in many solid tumors is the de novo lymphoid neogenesis of tertiary lymphoid structure (TLS). However, it remains unclear whether spontaneous TLS restricts or promotes tumor progression. MDSCs are major contributors to tumor evasion of adaptive immune responses.
Xin Lu, Anna Juncker-Jensen, Gang Huang, Mate Nagy   +3 more
openaire   +2 more sources

Tumor-Infiltrating Lymphocytes (TIL), Tertiary Lymphoid Structures (TLS), and Expression of PD-1, TIM-3, LAG-3 on TIL in Invasive and In Situ Ductal Breast Carcinomas and Their Relationship with Prognostic Factors

Clinical Breast Cancer, 2022
Immunotherapy has been determined as an important choice in breast carcinomas, especially in tumors with markedly inflammatory response. About this promising subject, tumor-infiltrating lymphocytes (TIL) and the expression of immune control point receptors on TIL have gained importance.In this study, stromal TIL and tertiary lymphoid structures (TLS ...
Elif Acar, Güldal Esendağlı, Ozan Yazıcı, Ayşe Dursun   +3 more
openaire   +4 more sources

Patterns of tumor infiltrating lymphocytes in adenoid cystic carcinoma of the head and neck [PDF]

, 2022
Adenoid cystic carcinoma (ACC) is a rare malignancy in the head and neck. The prognosis remains poor and late recurrences often occur after 5 years and later. To date, there are no reliable prognostic markers for ACC.
Arolt, Christoph, Bankfalvi, Agnes, Bastian, Tobias, Brunner, Cornelia, Doescher, Johannes, Hoffmann, Thomas K., Klußmann, Jens Peter, Laban, Simon, Lang, Stephan, Meyer, Moritz, Quaas, Alexander, Schildhaus, Hans-Ulrich, Schuler, Patrick J., Weissinger, Stephanie E., Wolber, Philipp   +14 more
core   +1 more source

Does TLS Exist in Canine Mammary Gland Tumours? Preliminary Results in Simple Carcinomas [PDF]

, 2022
: Neoplastic progression is influenced by the expression of tumour antigens that activate an anti-tumour immune response. Human medical studies show that this body defence is carried out in secondary lymphoid organs (SLOs) but also directly in the ...
Alessandra, Sfacteria, Cecilia, Vullo, Francesca, Mariotti, Gabriele, Marino, Giada, Giambrone, Giuseppe, Mazzullo, Roberto, Puleio, Stefania, Di Giorgio   +7 more
core   +1 more source