Results 61 to 70 of about 2,945 (208)

Cellular and Vascular Components of Tertiary Lymphoid Structures.

, 2018
Inflammatory immune cells recruited at the site of chronic inflammation form structures that resemble secondary lymphoid organs (SLO). These are characterized by segregated areas of prevalent T- or B-cell aggregation, differentiation of high endothelial ...
Nayar, Saba
core   +1 more source

Effective control of Staphylococcus aureus lung infection despite tertiary lymphoid structure disorganisation

, 2021
International audienceBackground: Tertiary lymphoid structures (TLS) are triggered by persistent bronchopulmonary infection with Staphylococcus aureus, but their roles remain elusive.
Burgel, Pierre-Régis, Teillaud, Jean-Luc, Martin, Clémence, Vicaire, Hugues, Sibéril, Sophie, Regard, Lucile, Ollame-Omvane, Emilie, Lafoeste, Hélène, Ladjemi, Maha Zohra   +8 more
core   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, EarlyView.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

Tertiary lymphoid structure-associated B cells are key players in anti-tumor immunity

, 2015
It is now admitted that the immune system plays a major role in tumor control. Besides the existence of tumor-specific T cells and B cells, many studies have demonstrated that high numbers of tumor-infiltrating lymphocytes are associated with good ...
Germain, Claire, Gnjatic, Sacha, Sacha Gnjatic, Claire eGermain, Claire Germain, Sacha eGnjatic, Dieu-Nosjean, Marie-Caroline, Marie-Caroline eDieu-Nosjean, Marie-Caroline Dieu-Nosjean   +8 more
core   +1 more source

Tertiary Lymphoid Structure-B Cells Narrow Regulatory T Cells Impact in Lung Cancer Patients

, 2021
International audienceThe presence of tertiary lymphoid structures (TLS) in the tumor microenvironment is associated with better clinical outcome in many cancers.
Damotte, Diane, Knockaert, Samantha, Gossot, Dominique, Validire, Pierre, Lemoine, François, M, Girard, Nicolas, Lefèvre, Marine, Seguin-Givelet, Agathe, Biton, Jérôme, Teillaud, Jean-Luc, Hammond, Scott,, Kaplon, Hélène, Dieu-Nosjean, Marie-Caroline, Lemoine, François,, Germain, Claire, Steele, Keith, E, Letaïef, Laïla, Alifano, Marco, Hammond, Scott, A, Devi-Marulkar, Priyanka, Goc, Jérémy, Steele, Keith,   +21 more
core   +1 more source

Review: radiotherapy-mediated B cells within the TLS influence the tumor microenvironment

Journal for ImmunoTherapy of Cancer
The tumor microenvironment (TME) is a diverse and intricate structure consisting of tumor cells, stromal cells, endothelial cells, and immune cells. It is characterized by the communication between tumor cells and both innate and adaptive immune cells ...
Haihua Yang, Dandan Zhou, Kuifei Chen, Yinan Meng, Ziran Chen, Yixiu Xu, Suna Zhou, Xiaozhi Zhang   +7 more
doaj   +1 more source

Spatial Transcriptomics and Bulk RNA‐Seq Analysis Revealed Molecular Classification of Invasive Lobular Carcinoma

Cancer Science, EarlyView.
Spatial transcriptomics and bulk RNA‐seq data analysis revealed the molecular characteristics of invasive lobular carcinoma (ILC). ILC was classified into three clusters: proliferative, immunoreactive, and stromal‐rich, with different prognoses. ABSTRACT Invasive lobular carcinoma (ILC) is a special type of breast cancer.
Momoko Tokura, Jun Nakayama, Hironori Suzuki, Mieko Ochi, Miyaka Umemori, Sho Shiino, Masayuki Yoshida, Shin Takayama, Yasushi Yatabe, Yusuke Yamamoto   +9 more
wiley   +1 more source

Organ‐Specific Cancer‐Associated Fibroblast Subtypes Across the Digestive System Linked to Cancer Hallmarks

Cancer Science, EarlyView.
We integrated 14 single‐cell RNA‐seq datasets and 18 bulk cohorts to define eight CAF subtypes in GI cancers. myCAF1 and myCAF2 promoted immunosuppressive, poor‐prognosis niches, whereas iCAF1 was linked to favorable prognosis and antitumor immunity.
Huaitao Wang, Takashi Semba, Atsuko Yonemura, Hiroshi Naito, Lingfeng Fu, Takuya Tajiri, Masaaki Iwatsuki, Takatsugu Ishimoto   +7 more
wiley   +1 more source

Tertiary lymphoid structures in esophageal cancer: a novel target for immunotherapy

Frontiers in Immunology
Esophageal cancer (EC), especially esophageal squamous cell carcinoma (ESCC), which is the most common subtype in China, is one of the most aggressive gastrointestinal malignancies. Traditional treatments like surgery, radiotherapy, and chemotherapy have
Ke Zhai, Yuting Ma, Xue Gao, Kun Ru, Miaoqing Zhao   +4 more
doaj   +1 more source

Pan-cancer analysis of genomic properties and clinical outcome associated with tumor tertiary lymphoid structure

Scientific Reports, 2020
How the genomic landscape of a tumor shapes the formation of tertiary lymphoid structure (TLS) and how might TLS alter the clinical outcome or response to immunotherapy had not been systematically explored. Utilizing the genomic and transcriptome data of
Ziying Lin, Lixia Huang, ShaoLi Li, Jincui Gu, Xiaoxian Cui, Yanbin Zhou   +5 more
doaj   +1 more source