Results 71 to 80 of about 6,745 (243)

An Integrated and Robust Deep Learning Framework for Denoising and Analyzing Single‐Cell Spatial Transcriptomics

Advanced Intelligent Systems, EarlyView.
Single‐cell Spatial Transcriptomics Analysis and Denoising Engine is introduced as a unified deep learning framework that jointly performs denoising, clustering, and gene prioritization in spatial transcriptomics. By integrating linear and nonlinear representations within a dual‐channel architecture, it improves robustness and accuracy, uncovers ...
Yaxuan Cui, Yang Cui, Ruheng Wang, Xin Zeng, Zheyong Zhu, Ding Yi, Ruihua Guo, Tetsuya Sakurai, Kenta Nakai, Xiucai Ye, Leyi Wei, Yong Chen   +11 more
wiley   +1 more source

Tertiary Lymphoid Structures as Independent Predictors of Favorable Prognosis in Muscle‐Invasive Bladder Cancer

Cancer Medicine
Background Tertiary lymphoid structure (TLS) has been reported to be associated with prognosis and immunotherapy in certain cancers. The objective of our study was to investigate the prognostic significance of Tertiary Lymphoid Structures (TLS) within ...
Xiaodong Teng, Zhen Chen, Yanfeng Bai, Hui Cao, Jing Zhang, Liming Xu, Kaihua Liu, Yuqian Shi, Yang Shao   +8 more
doaj   +1 more source

The tertiary lymphoid structure-related signature identified PTGDS in regulating PD-L1 and promoting the proliferation and migration of glioblastoma

Heliyon
Background: Tertiary lymphoid structure (TLS) is a unique organ that carries out tumor cell elimination at tumor sites. It is continuously stimulated by inflammatory tumor signals and has been found to augment immunotherapy response.
Wantao Wu, He Li, Zeyu Wang, Ziyu Dai, Xisong Liang, Peng Luo, Kun Liu, Hao Zhang, Nan Zhang, Shuyu Li, Chi Zhang   +10 more
doaj   +1 more source

Stem-like CD4+T Cells in Perivascular Tertiary Lymphoid Structures Sustain Autoimmune Vasculitis [PDF]

, 2023
Autoimmune vasculitis of the medium and large elastic arteries can cause blindness, stroke, aortic arch syndrome, and aortic aneurysm. The disease is often refractory to immunosuppressive therapy and progresses over decades as smoldering aortitis.
Berry, Gerald J, Bois, Melanie C, Goronzy, Jörg J, Jain, Abhinav, Le, Kevin-Phu C, Ohtsuki, Shozo, Okuyama, Hirohisa, Sato, Yuki, Sturmlechner, Ines, Takashima, Yoshinori, Warrington, Kenneth J, Weyand, Cornelia M   +11 more
core   +2 more sources

Stratification of chronic rhinosinusitis with nasal polyps by distinct sinonasal microbial communities and their clinical and pathological correlations

iMetaOmics, EarlyView.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory condition. Dysbiosis is commonly observed. This study identified distinct sinonasal microbial communities in CRSwNP patients and explored their clinical and pathological associations. Two distinct microbial communities were identified: community type 1 (CT1), dominated by
Bixing Fang, Yanmin Liu, Qing Bao, Lin Sun, Hexin Chen, Qingxiang Meng, Linyi Jiao, Xiaoyan Ye, Jian Li, Tao Ding, Chunwei Li   +10 more
wiley   +1 more source

Review: radiotherapy-mediated B cells within the TLS influence the tumor microenvironment

Journal for ImmunoTherapy of Cancer
The tumor microenvironment (TME) is a diverse and intricate structure consisting of tumor cells, stromal cells, endothelial cells, and immune cells. It is characterized by the communication between tumor cells and both innate and adaptive immune cells ...
Haihua Yang, Dandan Zhou, Kuifei Chen, Yinan Meng, Ziran Chen, Yixiu Xu, Suna Zhou, Xiaozhi Zhang   +7 more
doaj   +1 more source

Multi-resolution deep learning characterizes tertiary lymphoid structures and their prognostic relevance in solid tumors [PDF]

BACKGROUND Tertiary lymphoid structures (TLSs) are dense accumulations of lymphocytes in inflamed peripheral tissues, including cancer, and are associated with improved survival and response to immunotherapy in various solid tumors.
Ciompi, Francesco, Moch, Holger, Obahor, Simon, Pagliarulo, Fabio, Schraml, Peter, Silina, Karina, van den Broek, Maries, van der Laak, Jeroen, van Rijthoven, Mart   +8 more
core   +1 more source

The Prognostic Significance of Tertiary Lymphoid Structures in Head and Neck Cancers: A Systematic Review and Meta‐Analysis

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Head and neck squamous cell carcinoma (HNSCC), particularly oral squamous cell carcinoma (OSCC), is associated with poor survival despite therapeutic advances. Tertiary lymphoid structures (TLSs) are emerging components of the tumor microenvironment, but their prognostic significance in HNSCC remains unclear.
Everton Freitas de Morais, Bruno Cesar da Costa, Antti Mäkitie, Ricardo D. Coletta, Alhadi Almangush   +4 more
wiley   +1 more source

CXCL9 and CXCL13 shape endometrial cancer immune‐activated microenvironment via tertiary lymphoid structure formation

Cancer Science
Immune checkpoint inhibitor (ICI) therapy has been successfully applied to various cancers; however, not all patients respond to ICI therapy. Tumors with an immune‐activated environment are highly responsive to ICIs.
Yoshihiro Nagase, M. Kodama, E. Aimono, Kohei Nakamura, Reika Takamatsu, Keiko Abe, Takuma Yoshimura, T. Chiyoda, Wataru Yamagami, Hiroshi Nishihara   +9 more
semanticscholar   +1 more source

Tertiary lymphoid structures in esophageal cancer: a novel target for immunotherapy

Frontiers in Immunology
Esophageal cancer (EC), especially esophageal squamous cell carcinoma (ESCC), which is the most common subtype in China, is one of the most aggressive gastrointestinal malignancies. Traditional treatments like surgery, radiotherapy, and chemotherapy have
Ke Zhai, Yuting Ma, Xue Gao, Kun Ru, Miaoqing Zhao   +4 more
doaj   +1 more source