Results 91 to 100 of about 3,198 (184)

Tertiary lymphoid structures in the microenvironment of colorectal cancer: exploring new therapeutic targets

Cancer Immunology, Immunotherapy
Immunotherapy has shown limited efficacy in colorectal cancer (CRC), necessitating the urgent identification of novel immunotherapeutic targets to address this challenge.
Nan-Nan Dai, Man-Yi Hu, Jian-Ping Wang, Zhi-Hui Dai, Li Xu, Tai-Wei Ye   +5 more
doaj   +1 more source

Prognostic Value of N1/N2 Neutrophils Heterogeneity and Tertiary Lymphoid Structure in Hepatocellular Carcinoma Patients

Cancer Medicine
Background The tumor immune microenvironment, including neutrophils and tertiary lymphoid structures (TLSs), is pivotal for HCC prognosis assessment. Tumor‐associated neutrophils exhibit plasticity, adopting either an antitumorigenic N1 (MPO+ CD206−) or ...
Yanfei Lang, Weiwei Fu, Wei Xu, Chao Ma, Xiuyun Tian, Chunyi Hao, Shigang Ding   +6 more
doaj   +1 more source

A distinct tumor microenvironment makes anaplastic thyroid cancer more lethal but immunotherapy sensitive than papillary thyroid cancer

JCI Insight
Both anaplastic thyroid cancer (ATC) and papillary thyroid cancer (PTC) originate from thyroid follicular epithelial cells, but ATC has a significantly worse prognosis and shows resistance to conventional therapies.
Pei-Zhen Han, Wei-Dong Ye, Peng-Cheng Yu, Li-Cheng Tan, Xiao Shi, Xu-Feng Chen, Cong He, Jia-Qian Hu, Wen-Jun Wei, Zhong-Wu Lu, Ning Qu, Yu Wang, Qing-Hai Ji, Dong-Mei Ji, Yu-Long Wang   +14 more
doaj   +1 more source

The impact of tertiary lymphoid structure on the efficacy of postoperative adjuvant transcatheter arterial chemoembolization in patients with hepatocellular carcinoma

Zhongguo Linchuang Yixue
ObjectiveTo explore the impact of tertiary lymphoid structure (TLS) on the efficacy of adjuvant transcatheter arterial chemoembolization (TACE) following curative resection in patients with hepatocellular carcinoma (HCC).
Fansheng MENG, Haokang YANG, Biwei YANG
doaj   +1 more source

SSR4 Sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science
Intratumoral tertiary lymphoid structure (TLS) fosters B‐cell differentiation and antibody production, yet the intrinsic programs sustaining these functions remain unclear.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
doaj   +1 more source

Analyses of germinal center B cells and tertiary lymphoid structures (TLS) in mouse and human HNSCC

Laryngo-Rhino-Otologie, 2019
M Sonntag, C Brunner, TK Hoffmann
openaire   +1 more source

606 IMpower110: Tertiary lymphoid structures (TLS) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) treated with first-line atezolizumab or chemotherapy

Regular and Young Investigator Award Abstracts, 2023
Robert Johnston, Hartmut Koeppen, Roy S Herbst, Kurt Schalper, Filippo De Marinis, Giuseppe Giaccone, Jacek Jassem, Marcus Ballinger, Barani Kumar Rajendran, David R Spigel, Miguel López de Rodas, Minu K Srivastava, Jennifer M Giltnane, Barzin Y Nabet, David S Shames, Velimir Gayevskiy, Vy Ma, Ivette Estay, Tien Hoang, Reena Amin   +19 more
openaire   +2 more sources

Spatial habitat radiomics predicts tertiary lymphoid structure status and identifies an IDO1⁺ migratory dendritic cell axis in breast cancer. [PDF]

J Immunother Cancer
Yu Y, Wang Q, Lin Y, Huang K, Wang R, Wang J, Huang X, Zhang J, Chen W, Chen R, Chen X, Meng F, Zhang H, Yuan J, Lin J, Song C.   +15 more
europepmc   +1 more source

Tertiary lymphoid structures in urothelial carcinoma: bridging spatial architecture with therapeutic vulnerability in the post-BCG era. [PDF]

Front Immunol
Wei X, Pei X, Yu S.
europepmc   +1 more source

IMpower110: tertiary lymphoid structures (TLS) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) treated with first line atezolizumab ro chemotherapy

Journal for ImmunoTherapy of Cancer, 2023
Srivastava, Minu, Gayevskiy, Velimir, Ma, Vy, Estay, Ivette, de Rodas, Miguel, Rajendram, Barani, Hoang, Tien, Ballinger, Marcus, Amin, Reena, Herbst, Roy, de Marinis, Filippo, Giaccone, Giuseppe, Spigel, David, Schalper, Kurt, Koeppen, Hartmut, Shames, David, Johnston, Robert, Giltnane, Jennifer, Nabet, Barzin   +18 more
openaire   +1 more source