Results 91 to 100 of about 2,945 (208)

Tertiary Lymphoid Structures: A Potential Biomarker for Anti-Cancer Therapy

, 2022
A tertiary lymphoid structure (TLS) is a special component in the immune microenvironment that is mainly composed of tumor-infiltrating lymphocytes (TILs), including T cells, B cells, DC cells, and high endothelial venules (HEVs).
Peng, Yurong, Zeng, Yue, Ji’an Zou, Liu, Junqi, Yingzhe Zhang, Yue Zeng, Yurong Peng, Xiao, Chaoyue, Junqi Liu, Zou, Ji’an, Chaoyue Xiao, Fang Wu, Zhang, Yingzhe, Wu, Fang   +13 more
core   +1 more source

The impact of metabolic reprogramming on tertiary lymphoid structure formation: enhancing cancer immunotherapy

BMC Medicine
Background Cancer immunotherapy has achieved unprecedented success in the field of cancer therapy. However, its potential is constrained by a low therapeutic response rate.
Meng-Jie Zhang, Yan Wen, Zhi-Jun Sun
doaj   +1 more source

Table_4_Tumor-Resident T Cells, Associated With Tertiary Lymphoid Structure Maturity, Improve Survival in Patients With Stage III Lung Adenocarcinoma.docx

, 2022
Tertiary lymphoid structure (TLS) and tumor-resident memory T cells (TRM) play crucial roles in the anti-tumor immune response, facilitating a good prognosis in patients with cancer. However, there have been no reports on the relationship between TRM and
Yu Zhao (104852), Xiubao Ren (166422), Qian Sun (53880), Hua Zhao (122671), Hao Wang (39217)   +4 more
core   +1 more source

Heterogeneity in tertiary lymphoid structure B-cells correlates with patient survival in metastatic melanoma

, 2021
Background Tertiary lymphoid structures (TLSs) are immune aggregates in peripheral tissues that may support adaptive immune responses. Their presence has been associated with clinical response to checkpoint blockade therapy (CBT), but it is unknown ...
Nolan A Wages, Victor H Engelhard, Max O Meneveau, Kevin T Lynch, Craig L Slingluff Jr, Samuel J Young, Ileana S Mauldin   +6 more
core   +1 more source

Table_1_Tumor-Resident T Cells, Associated With Tertiary Lymphoid Structure Maturity, Improve Survival in Patients With Stage III Lung Adenocarcinoma.xlsx

, 2022
Tertiary lymphoid structure (TLS) and tumor-resident memory T cells (TRM) play crucial roles in the anti-tumor immune response, facilitating a good prognosis in patients with cancer. However, there have been no reports on the relationship between TRM and
Yu Zhao (104852), Xiubao Ren (166422), Qian Sun (53880), Hua Zhao (122671), Hao Wang (39217)   +4 more
core   +1 more source

Prognostic and clinicopathological significance of tertiary lymphoid structure in non-small cell lung cancer: a systematic review and meta-analysis

BMC Cancer
Background Non-small cell lung cancer (NSCLC) is the primary reason for cancer-related deaths globally. Tertiary lymphoid structure (TLS) is an organized collection of immune cells acquired in non-physiological, non-lymphoid tissues.
Luyuan Ma, Rongyang Li, Xiaomeng Liu, Wenhao Yu, Zhanpeng Tang, Yi Shen, Hui Tian   +6 more
doaj   +1 more source

Mature tertiary lymphoid structure associated CD103+ CD8+ Trm cells determined improved anti-tumor immune in breast cancer [PDF]

BackgroundAlthough tertiary lymphoid structures (TLS) play crucial roles in the anti-tumor immune response and are associated with favorable prognoses in many solid tumors, the precise mechanisms by which TLSs enhance anti-tumor immunity remain poorly ...
Wei Zou, Xiaoyue Chen, Qin Fang, Yukang Huang, Shuru Chen, Di Chen, Chucheng Wu   +6 more
core   +1 more source

Table_2_Tumor-Resident T Cells, Associated With Tertiary Lymphoid Structure Maturity, Improve Survival in Patients With Stage III Lung Adenocarcinoma.xlsx

, 2022
Tertiary lymphoid structure (TLS) and tumor-resident memory T cells (TRM) play crucial roles in the anti-tumor immune response, facilitating a good prognosis in patients with cancer. However, there have been no reports on the relationship between TRM and
Yu Zhao (104852), Xiubao Ren (166422), Qian Sun (53880), Hua Zhao (122671), Hao Wang (39217)   +4 more
core   +1 more source

The Absence of Intra‐Tumoral Tertiary Lymphoid Structures is Associated with a Worse Prognosis and mTOR Signaling Activation in Hepatocellular Carcinoma with Liver Transplantation: A Multicenter Retrospective Study

Advanced Science
Tertiary lymphoid structure (TLS) can predict the prognosis and sensitivity of tumors to immune checkpoint inhibitors (ICIs) therapy, whether it can be noninvasively predicted by radiomics in hepatocellular carcinoma with liver transplantation (HCC‐LT ...
Jianhua Li, Li Zhang, Hao Xing, Yan Geng, Shaocheng Lv, Xiao Luo, Weiqiao He, Zhi Fu, Guangming Li, Bin Hu, Shengran Jiang, Zhe Yang, Ningqi Zhu, Quanbao Zhang, Jing Zhao, Yifeng Tao, Conghuan Shen, Ruidong Li, Feng Tang, Shusen Zheng, Yun Bao, Qiang He, Daoying Geng, Zhengxin Wang   +23 more
doaj   +1 more source

B cells and iBALT in TB immunity & pathogenesis

Frontiers in Immunology
B cells play a crucial role in immunity against various infectious diseases. However, their role in tuberculosis (TB) has been largely understudied. Emerging evidence suggests that B cells actively shape immune responses in TB.
Taru S. Dutt, Robert Krause, David Hertz, Marcela Henao-Tamayo, Alasdair Leslie, Alasdair Leslie, Bianca Schneider   +6 more
doaj   +1 more source