Results 91 to 100 of about 6,745 (243)

Mature Tertiary Lymphoid Structures Indicate Good Chemotherapy Response and Prognosis in Advanced Colorectal Cancer

Annals of Gastroenterological Surgery, Volume 10, Issue 3, Page 710-721, May 2026.
In advanced colorectal cancer, tumors with mature tertiary lymphoid structures (TLS) exhibited abundant infiltration of CD3‐ and CD8‐positive lymphocytes in both primary and metastatic sites, indicating an activated immune response. The presence of mature TLS was also associated with favorable chemotherapy sensitivity and improved prognosis.
Nobuhiro Hosoi, Chika Komine, Gendensuren Dorjkhorloo, Takuya Shiraishi, Takuhisa Okada, Akihiko Sano, Makoto Sakai, Takehiko Yokobori, Ken Shirabe, Hiroshi Saeki   +9 more
wiley   +1 more source

Translational and Oncologic Significance of Tertiary Lymphoid Structures in Pancreatic Adenocarcinoma [PDF]

Pancreatic adenocarcinoma (PDAC) is an aggressive tumor with poor survival and limited treatment options. PDAC resistance to immunotherapeutic strategies is multifactorial, but partially owed to an immunosuppressive tumor immune microenvironment (TiME ...
Azar, Joseph, Camp, E Ramsay, Gao, Zachary, Kang, Sung Wook, Lee, Hyun-Sung, Makawita, Shalini, Marginean, Celia, Rubinstein, Mark P, Williams-Perez, Sophia, Zhu, Huili   +9 more
core   +2 more sources

Impact of Tertiary Lymphoid Structure on Prognosis and Tumor Microenvironment in Undifferentiated Pleomorphic Sarcoma

Cancer Science
Undifferentiated pleomorphic sarcoma (UPS) has a favorable objective response rate to anti‐PD‐1 drugs compared with other sarcomas. Tertiary lymphoid structure (TLS) is a favorable prognostic factor and a biomarker for immune checkpoint inhibitors (ICIs).
Hiroki Sonoda, Takeshi Iwasaki, S. Ishihara, Taro Mori, Y. Nakashima, Y. Oda   +5 more
semanticscholar   +1 more source

Current status and prospects of tertiary lymphoid structure heterogeneity in predicting response to neoadjuvant therapy and characterizing immune microenvironment in triple-negative breast cancer [PDF]

Zhongguo aizheng zazhi
Triple-negative breast cancer (TNBC) is a highly aggressive and prognostically unfavorable subtype. Tertiary lymphoid structure (TLS) within the tumor microenvironment, comprising dendritic cells, B cells, T cells, and other immune cells, modulate the ...
Qing WANG, Yushuai YU, Chenxi WANG, Zirong JIANG, Jialu LI, Shicong TANG, Chuangui SONG   +6 more
doaj   +2 more sources

Chinese Expert Consensus on Assessment and Clinical Application of 
Tertiary Lymphoid Structure for Non-small Cell Lung Cancer (2025 Version)

Chinese Journal of Lung Cancer
The tertiary lymphoid structure (TLS) plays a crucial role in the tumor microenvironment, influencing tumor development and progression. As an emerging biomarker for predicting the prognosis and treatment response in cancer patients, TLS has received ...
Lung Cancer Collaboration Group of Tumor Pathology Committee of Chinese Anti-Cancer Association, Expert Committee on Non-small Cell Lung Cancer of Chinese Society of Clinical Oncology   +1 more
doaj   +1 more source

The pivotal role of tertiary lymphoid structures in the tumor immune microenvironment

Frontiers in Oncology
Tertiary lymphoid structures (TLS) are ectopic lymphoid structures that form in non-lymphoid tissues in response to chronic inflammatory stimulation. Structurally and functionally resembling lymph nodes, TLS are primarily composed of B cells, T cells ...
Chengsen Liu, Jiandong Cao
doaj   +1 more source

Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma [PDF]

, 2014
BACKGROUND: Oral squamous cell carcinomas are often heavily infiltrated by immune cells. The organization of B-cells, follicular dendritic cells, T-cells and high-endothelial venules into structures termed tertiary lymphoid structures have been detected ...
Hadler-Olsen, Elin Synnøve, Rikardsen, Oddveig G, Steigen, Sonja Eriksson, Uhlin-Hansen, Lars, Wirsing, Anna Maria   +4 more
core   +2 more sources

Targeting Tumor Stroma: Current Challenges and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang, Haofan Hu, Weifeng Zeng, Lu Qin, Xiaoping Chen, Zhibin Liao, Furong Liu, Zhanguo Zhang   +7 more
wiley   +1 more source

CD8+ T Cell Infiltration Elicits Molecular Subtype‐Biased Clinical Outcomes in Gastric Cancer Patients

Cancer Science, Volume 117, Issue 5, Page 1434-1445, May 2026.
CD8+ T cell infiltration demonstrates distinct clinical significance across molecular subtypes of gastric cancer. High infiltration correlates with improved survival in EBV‐positive and CIN subtypes, while low infiltration predicts better adjuvant chemotherapy response in MSI patients.
Zhen Ling, Jieti Wang, Yun Gu, Ziqiu Zhang, Fei Shao, Chao Lin, Hongyong He, Ruochen Li, Hao Liu, Jiejie Xu   +9 more
wiley   +1 more source

Beyond the chaos: How architecture structures tumour biology

The FEBS Journal, Volume 293, Issue 9, Page 2519-2540, May 2026.
Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner, Catrin Lutz, Stefan Prekovic, Hendrik A. Messal   +3 more
wiley   +1 more source