Results 101 to 110 of about 2,945 (208)

Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor Immunity

, 2018
Limited representation of intratumoral immune cells is a major barrier to tumor control. However, simply enhancing immune responses in tumor-draining lymph nodes or through adoptive transfer may not overcome the limited ability of tumor vasculature to ...
Anthony B. Rodriguez, Craig L. Slingluff, Ileana S. Mauldin, J. David Peske, Amber N. Woods, Victor H. Engelhard   +5 more
core   +1 more source

Retrospective study on the correlation between CXCL13, immune infiltration, and tertiary lymphoid structures in cutaneous squamous cell carcinoma [PDF]

PeerJ
Background C-X-C motif chemokine ligand 13 (CXCL13) is a crucial chemokine for the recruitment of immune cells and the formation of tertiary lymphoid structure (TLS) in the tumor microenvironment.
Yulu Chen, Yuhao Wu, Zijun Zhao, Long Wen, Mingshun Wu, Dekun Song, Qingyu Zeng, Yeqiang Liu, Guorong Yan, Guolong Zhang   +9 more
doaj   +2 more sources

Trigger inducible tertiary lymphoid structure formation using covalent organic frameworks for cancer immunotherapy

The discovery of tertiary lymphoid structures (TLS) within tumor tissues provides a promising avenue to promote the efficacy of cancer immunotherapy. Yet, the lack of effective strategies to induce TLS formation poses a substantial obstacle.
Wang, Shuo, Zhang, Liang, Zhang, Boxin, Feng, Hai Tao, JIAO, Yantian, LAM, Jacky W.Y., Li, Hao, LI, Wenlang, Sun, Zhi Jun, Liu, Yuan Tong, Kwok, Ryan T.K., Sun, Jianwei, Yang, Qi Chao, Song, An, Zhang, Meng Jie, Tang, Ben Zhong   +15 more
core   +1 more source

The clinical and pathological significance of tertiary lymphoid structure in extramammary Paget's disease [PDF]

BackgroundTumor-associated tertiary lymphoid structures (TLSs) are functional immune-responsive aggregates, which have been reported to be associated with better prognosis in various tumors.
Guolong Zhang, Mingyuan Xu, Jiashe Chen, Ningyuan Xi, Yeqiang Liu, Yuhao Wu, Guorong Yan, Long Jiang, Shuyi Liu, Xiaoxiang Xu, Nanhui Wu   +10 more
core   +1 more source

Tertiary lymphoid structures predict survival and response to neoadjuvant therapy in locally advanced rectal cancer

npj Precision Oncology
Tertiary lymphoid structure (TLS) contributes to the anti-tumor immune response, and predicts the prognosis of colorectal cancer patients. However, the potential impact of TLS in shaping the immune status of rectal adenocarcinoma, and the intrinsic ...
Qianyu Wang, Wentao Zhong, Xiaofei Shen, Zechen Hao, Meng Wan, Xiaopeng Yang, Ran An, Hongyan Zhu, Huiyun Cai, Tao Li, Yuan Lv, Xing Dong, Gang Chen, Aijun Liu, Junfeng Du   +14 more
doaj   +1 more source

Exploring effects of gut microbiota on tertiary lymphoid structure formation for tumor immunotherapy [PDF]

Anti-tumor immunity, including innate and adaptive immunity is critical in inhibiting tumorigenesis and development of tumor. The adaptive immunity needs specific lymph organs such as tertiary lymphoid structures (TLSs), which are highly correlated with ...
Juanjuan Wang, Fan Li, Yuqing Liu, Rongcun Yang   +3 more
core   +1 more source

Tertiary lymphoid structures in the microenvironment of colorectal cancer: exploring new therapeutic targets

Cancer Immunology, Immunotherapy
Immunotherapy has shown limited efficacy in colorectal cancer (CRC), necessitating the urgent identification of novel immunotherapeutic targets to address this challenge.
Nan-Nan Dai, Man-Yi Hu, Jian-Ping Wang, Zhi-Hui Dai, Li Xu, Tai-Wei Ye   +5 more
doaj   +1 more source

Tertiary lymphoid structures in renal cell carcinoma: from heterogeneity dissection to translational precision immunotherapy

Frontiers in Immunology
Renal cell carcinoma (RCC), characterized by its distinctive hypoxic and immunosuppressive tumor microenvironment (TME), demonstrates suboptimal responses to current immunotherapeutic interventions.
Zhexian Li, Zhexian Li, Sensen Ruan, Yang Yu, Hao Xiang, Wenjie Mi, Wenjie Mi   +6 more
doaj   +1 more source

Prognostic Value of N1/N2 Neutrophils Heterogeneity and Tertiary Lymphoid Structure in Hepatocellular Carcinoma Patients

Cancer Medicine
Background The tumor immune microenvironment, including neutrophils and tertiary lymphoid structures (TLSs), is pivotal for HCC prognosis assessment. Tumor‐associated neutrophils exhibit plasticity, adopting either an antitumorigenic N1 (MPO+ CD206−) or ...
Yanfei Lang, Weiwei Fu, Wei Xu, Chao Ma, Xiuyun Tian, Chunyi Hao, Shigang Ding   +6 more
doaj   +1 more source

A distinct tumor microenvironment makes anaplastic thyroid cancer more lethal but immunotherapy sensitive than papillary thyroid cancer

JCI Insight
Both anaplastic thyroid cancer (ATC) and papillary thyroid cancer (PTC) originate from thyroid follicular epithelial cells, but ATC has a significantly worse prognosis and shows resistance to conventional therapies.
Pei-Zhen Han, Wei-Dong Ye, Peng-Cheng Yu, Li-Cheng Tan, Xiao Shi, Xu-Feng Chen, Cong He, Jia-Qian Hu, Wen-Jun Wei, Zhong-Wu Lu, Ning Qu, Yu Wang, Qing-Hai Ji, Dong-Mei Ji, Yu-Long Wang   +14 more
doaj   +1 more source