Results 101 to 110 of about 6,745 (243)

A novel tertiary lymphoid structure-associated signature accurately predicts patient prognosis and facilitates the selection of personalized treatment strategies for HNSCC

Frontiers in Immunology
Background Head and neck squamous cell carcinoma (HNSCC) is the most common type of head and neck cancer and is characterized by its aggressive nature and variable prognosis and response to immunotherapy.
Jinhao Zhang, Lu Zeng, Guobin Song, Gaoge Peng, Zhezheng Chen, Yamin Yuan, Tao Chen, Tao Zhong, Shixi Chen, Zhengzhou Luo, Jingang Xiao, Lin Liu   +11 more
semanticscholar   +1 more source

47 Tertiary lymphoid structures (TLS) in desmoplastic melanomas (DM) differ from non-DM-associated TLS by their intratumoral location and enhanced immune activity [PDF]

Regular and Young Investigator Award Abstracts, 2021
Nolan Wages, Ileana Mauldin, Max Meneveau, Kevin Lynch, Craig Slingluff, Alejandro Gru, Anne Stowman, Alexandra Hickman, Adela Mahmutovic, Samuel Young, Victor Engelhard   +10 more
openaire   +2 more sources

Making sense of TILs: recommendations for morphological assessment of tumour‐infiltrating lymphocytes in gastro‐oesophageal carcinoma

Histopathology, Volume 88, Issue 6, Page 1126-1141, May 2026.
This review examines the role of tumour‐infiltrating lymphocytes (TILs) in gastro‐oesophageal carcinoma (GEC), focusing on their composition, clinical relevance and therapeutic utility. It proposes a framework for standardised evaluation and reporting of TILs, addressing GEC‐specific pathology challenges to support the widespread use and validation of ...
Ylva A Weeda, Roberto Salgado, Filip van Herpe, Daniel Sur, Michael Vieth, Sherene Loi, Ahmad P Tafti, Hardas Alexandros, Akira I Hida, Amarpreet Bhalla, Andrey I Khramtsov, Anna Ehinger, Atsushi Tanaka, Balazs Acs, Caner Ercan, Cornelia M Focke, Daniel Ehinger, Dan Huang, Galina F Khramtsova, Haruto Nishida, Nianyi Li, Nickolas Littlefield, Sanna Steen, Selim Sevim, Shin Ichihara, Shinnosuke Morikawa, Stefan Michiels, Thomas Papathomas, Toshihiro Haga, Qiangqiang Gu, Weiqi Sheng, Hoel Kervadec, Hugo M Horlings, Francisco Sanchez‐Vega, Yelena Y Janjigian, Myriam Chalabi, Hanneke W M van Laarhoven, Liudmila L Kodach, Sybren L Meijer   +38 more
wiley   +1 more source

Mature tertiary lymphoid structure associated CD103+ CD8+ Trm cells determined improved anti-tumor immune in breast cancer

Frontiers in Oncology
Background Although tertiary lymphoid structures (TLS) play crucial roles in the anti-tumor immune response and are associated with favorable prognoses in many solid tumors, the precise mechanisms by which TLSs enhance anti-tumor immunity remain poorly ...
Q. Fang, Shuru Chen, Xiaoyu Chen, Wei Zou, Di Chen, Yukang Huang, Chucheng Wu   +6 more
semanticscholar   +1 more source

Spatial Positioning of Immune Hotspots Reflects the Interplay between B and T Cells in Lung Squamous Cell Carcinoma [PDF]

, 2023
Beyond tertiary lymphoid structures, a significant number of immune-rich areas without germinal center-like structures are observed in non–small cell lung cancer.
AbdulJabbar, Khalid, Akarca, Ayse, Enfield, Katey SS, Jamal-Hanjani, Mariam, Le Quesne, John, Marafioti, Teresa, McGranahan, Nicholas, Moore, David A, Raza, Shan E Ahmed, Salgado, Roberto, Swanton, Charles, Veeriah, Selvaraju, Yuan, Yinyin, Zhang, Hanyun   +13 more
core  

IL‐1β and IL‐6 synergistically drive murine TFH cell differentiation and maintenance in vitro

Immunology &Cell Biology, Volume 104, Issue 5, Page 457-472, May‐June 2026.
We define a physiologically relevant in vitro system that demonstrates the combined function of T‐cell receptor signaling, IL‐6 and IL‐1β individually and jointly to promote TFH cell differentiation. These findings identify the essential requirements for generating functional TFH cells and clarify how cytokines shape their differentiation within the ...
Juliana Restrepo Munera, S Rameeza Allie
wiley   +1 more source

Unraveling Novel Subsets of Lymphocytes Involved in Sac Expansion in the Tertiary Lymphoid Structure Within an Abdominal Aortic Aneurysm

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease
Background Chronic inflammation is involved in the development of abdominal aortic aneurysm (AAA). A tertiary lymphoid structure (TLS) within vascular lesions has recently been focused on for its role in modulation of inflammation in local tissues.
Itaru Hosaka, Ippei Ikegami, Takuma Mikami, Tatsuya Sato, T. Ogawa, Kei Mukawa, Marenao Tanaka, Keisuke Endo, Yukinori Akiyama, Akihito Ohkawa, Junji Nakazawa, T. Shibata, T. Nakajima, Yutaka Iba, Chikara Shiiku, Satoshi Sumino, R. Koshima, K. Takano, S. Ichimiya, Nobuyoshi Kawaharada, M. Furuhashi   +20 more
semanticscholar   +1 more source

Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical Levers [PDF]

: Tertiary lymphoid structures (TLSs) arise in non-lymphoid tissues in response to persistent antigen stimulation and chronic inflammation. Spanning organs from lung and liver to meninges, skin, and beyond, TLSs range from loose aggregates of immune ...
Beccaria C. G., Guillaume S. M., Iannacone M., Linterman M. A.   +3 more
core   +1 more source

Developmental Cues and Function of Tertiary Lymphoid Structures [PDF]

Tertiary lymphoid structures (TLS) resemble follicles of secondary lymphoid organs and develop in non-lymphoid tissues upon inflammation and cancer. However, the cell types and signals driving the development of TLS are unknown.
Calvanese, Anna Laura
core   +1 more source

Prognostic and clinicopathological significance of tertiary lymphoid structure in non-small cell lung cancer: a systematic review and meta-analysis

BMC Cancer
Background Non-small cell lung cancer (NSCLC) is the primary reason for cancer-related deaths globally. Tertiary lymphoid structure (TLS) is an organized collection of immune cells acquired in non-physiological, non-lymphoid tissues.
Luyuan Ma, Rongyang Li, Xiaomeng Liu, Wenhao Yu, Zhanpeng Tang, Yi Shen, Hui Tian   +6 more
doaj   +1 more source