Results 121 to 130 of about 6,745 (243)

Tertiary lymphoid structures in the microenvironment of colorectal cancer: exploring new therapeutic targets

Cancer Immunology, Immunotherapy
Immunotherapy has shown limited efficacy in colorectal cancer (CRC), necessitating the urgent identification of novel immunotherapeutic targets to address this challenge.
Nan-Nan Dai, Man-Yi Hu, Jian-Ping Wang, Zhi-Hui Dai, Li Xu, Tai-Wei Ye   +5 more
doaj   +1 more source

Prognostic Value of N1/N2 Neutrophils Heterogeneity and Tertiary Lymphoid Structure in Hepatocellular Carcinoma Patients

Cancer Medicine
Background The tumor immune microenvironment, including neutrophils and tertiary lymphoid structures (TLSs), is pivotal for HCC prognosis assessment. Tumor‐associated neutrophils exhibit plasticity, adopting either an antitumorigenic N1 (MPO+ CD206−) or ...
Yanfei Lang, Weiwei Fu, Wei Xu, Chao Ma, Xiuyun Tian, Chunyi Hao, Shigang Ding   +6 more
doaj   +1 more source

The impact of tertiary lymphoid structure on the efficacy of postoperative adjuvant transcatheter arterial chemoembolization in patients with hepatocellular carcinoma

Zhongguo Linchuang Yixue
ObjectiveTo explore the impact of tertiary lymphoid structure (TLS) on the efficacy of adjuvant transcatheter arterial chemoembolization (TACE) following curative resection in patients with hepatocellular carcinoma (HCC).
Fansheng MENG, Haokang YANG, Biwei YANG
doaj   +1 more source

Single-Cell Analysis Provides New Insights into the Roles of Tertiary Lymphoid Structures and Immune Cell Infiltration in Kidney Injury and Chronic Kidney Disease [PDF]

Chronic kidney disease (CKD) is a global health concern with high morbidity and mortality. Acute kidney injury (AKI) is a pivotal risk factor for the progression of CKD, and the rate of AKI-to-CKD progression increases with aging. Intrarenal inflammation
Yanagita, Motoko, Yoshikawa, Takahisa
core   +1 more source

cGAS-activated endothelial cell–T cell cross-talk initiates tertiary lymphoid structure formation

Science immunology
Aberrant activation of the cyclic guanosine monophosphate–adenosine monophosphate synthase–stimulator of interferon genes (cGAS-STING) pathway causes autoimmunity in humans and mice; however, the exact mechanism by which the cGAS-STING pathway initiates ...
Ruibo Zhao, Jinghe Zhang, Jialu Ma, Yali Qu, Zhe Yang, Zhinan Yin, Fengyin Li, Zhongjun Dong, Qinmiao Sun, Shu Zhu, Zhijian J. Chen, Daxing Gao   +11 more
semanticscholar   +1 more source

A distinct tumor microenvironment makes anaplastic thyroid cancer more lethal but immunotherapy sensitive than papillary thyroid cancer

JCI Insight
Both anaplastic thyroid cancer (ATC) and papillary thyroid cancer (PTC) originate from thyroid follicular epithelial cells, but ATC has a significantly worse prognosis and shows resistance to conventional therapies.
Pei-Zhen Han, Wei-Dong Ye, Peng-Cheng Yu, Li-Cheng Tan, Xiao Shi, Xu-Feng Chen, Cong He, Jia-Qian Hu, Wen-Jun Wei, Zhong-Wu Lu, Ning Qu, Yu Wang, Qing-Hai Ji, Dong-Mei Ji, Yu-Long Wang   +14 more
doaj   +1 more source

Tertiary lymphoid structure-related score as a predictor for survival prognosis and immunotherapy response in head and neck squamous cell carcinoma

Frontiers in Immunology
BackgroundSubstantial studies reveal that tertiary lymphoid structure (TLS) correlate with prognosis and immunotherapy response in various types of cancers.
Fan Wu, Fan Wu, Haotian Cao, Haotian Cao, Siqi Ren, Siqi Ren, Jiaying Wu, Jiaying Wu, Xin Liu, Xin Liu, Qunxing Li, Qiuping Xu, Qiuping Xu, Jiali Chen, Jiali Chen, Ruixin Wang, Ruixin Wang, Suling Chen, Suling Chen, Shijia Kuang, Shijia Kuang, Binbin Xia, Yanyan Li, Yanyan Li, Liansheng Wang, Jintao Li, Bowen Li, Bowen Li, Jinsong Li, Jinsong Li, Tianjun Lan, Tianjun Lan   +31 more
doaj   +1 more source

Tertiary Lymphoid Structures Generation through Graph-based Diffusion

, 2023
Graph-based representation approaches have been proven to be successful in the analysis of biomedical data, due to their capability of capturing intricate dependencies between biological entities, such as the spatial organization of different cell types ...
Frossard, Pascal, Madeira, Manuel, Thanou, Dorina   +2 more
core  

Deciphering the role of LGALS2: insights into tertiary lymphoid structure-associated dendritic cell activation and immunotherapeutic potential in breast cancer patients

Molecular Cancer
Recent advances in cancer research have highlighted the pivotal role of tertiary lymphoid structures (TLSs) in modulating immune responses, particularly in breast cancer (BRCA).
Shuyu Li, Nan Zhang, Hao Zhang, Zhifang Yang, Q. Cheng, Kang Wei, Meng Zhou, Chen-shen Huang   +7 more
semanticscholar   +1 more source

Tumoral and stromal hMENA isoforms impact tertiary lymphoid structure localization in lung cancer and predict immune checkpoint blockade response in patients with cancer

EBioMedicine
Summary Background Tertiary Lymphoid Structures (TLS) correlate with positive outcomes in patients with NSCLC and the efficacy of immune checkpoint blockade (ICB) in cancer. The actin regulatory protein hMENA undergoes tissue-specific splicing, producing
F. Di Modugno, Anna Di Carlo, Sheila Spada, B. Palermo, L. D’Ambrosio, Daniel D’Andrea, G. Morello, Beatrice Belmonte, Isabella Sperduti, V. Balzano, E. Gallo, Roberta Melchionna, Mariangela Panetta, Giulia Campo, F. De Nicola, F. Goeman, B. Antoniani, S. Carpano, G. Frigè, Sarah E. Warren, F. Gallina, D. Lambrechts, Jieyi Xiong, Benjamin G. Vincent, Nathan E. Wheeler, Dante S. Bortone, F. Cappuzzo, F. Facciolo, Claudio Tripodo, Paolo Visca, Paola Nisticò   +30 more
semanticscholar   +1 more source