Results 111 to 120 of about 6,745 (243)

Assessment of tertiary lymphoid structures in salivary glands, pancreas, and lungs of NZB/W lupus prone mice. [PDF]

, 2020
Autoimmune diseases are complex genetic traits. Factors that trigger autoimmune diseases have yet to be deciphered. It is however suspected that a combination of copious risk factors is implicated in the development of autoimmunity.
Miancho, Diana Roza Kibancha
core  

Development of a tertiary lymphoid structure-based prognostic model for breast cancer: integrating single-cell sequencing and machine learning to enhance patient outcomes

Frontiers in Immunology
Background Breast cancer, a highly prevalent global cancer, poses significant challenges, especially in advanced stages. Prognostic models are crucial to enhance patient outcomes.
Xiaonan Zhang, Li Li, Xiaoyu Shi, Yunxia Zhao, Zhaogen Cai, Ni Ni, Di Yang, Zixin Meng, Xu Gao, Li Huang, Tao Wang   +10 more
semanticscholar   +1 more source

The Absence of Intra‐Tumoral Tertiary Lymphoid Structures is Associated with a Worse Prognosis and mTOR Signaling Activation in Hepatocellular Carcinoma with Liver Transplantation: A Multicenter Retrospective Study

Advanced Science
Tertiary lymphoid structure (TLS) can predict the prognosis and sensitivity of tumors to immune checkpoint inhibitors (ICIs) therapy, whether it can be noninvasively predicted by radiomics in hepatocellular carcinoma with liver transplantation (HCC‐LT ...
Jianhua Li, Li Zhang, Hao Xing, Yan Geng, Shaocheng Lv, Xiao Luo, Weiqiao He, Zhi Fu, Guangming Li, Bin Hu, Shengran Jiang, Zhe Yang, Ningqi Zhu, Quanbao Zhang, Jing Zhao, Yifeng Tao, Conghuan Shen, Ruidong Li, Feng Tang, Shusen Zheng, Yun Bao, Qiang He, Daoying Geng, Zhengxin Wang   +23 more
doaj   +1 more source

B cells and iBALT in TB immunity & pathogenesis

Frontiers in Immunology
B cells play a crucial role in immunity against various infectious diseases. However, their role in tuberculosis (TB) has been largely understudied. Emerging evidence suggests that B cells actively shape immune responses in TB.
Taru S. Dutt, Robert Krause, David Hertz, Marcela Henao-Tamayo, Alasdair Leslie, Alasdair Leslie, Bianca Schneider   +6 more
doaj   +1 more source

Characterizing tertiary lymphoid structures associated single-cell atlas in breast cancer patients

Cancer Cell International
The tertiary lymphoid structure (TLS) is recognized as a potential prognosis factor for breast cancer and is strongly associated with response to immunotherapy.
Xiaokai Fan, Daqin Feng, Donggui Wei, Anqi Li, Fangyi Wei, Shufang Deng, Muling Shen, Congzhi Qin, Yongjia Yu, Lun Liang   +9 more
doaj   +1 more source

Effect of tumor draining lymph nodes in the formation and maturation of tertiary lymphoid structure in patients with lung adenocarcinoma. [PDF]

BMC Cancer
Tertiary lymphoid structures (TLSs), ectopic lymphoid aggregates composed of immune cells, are associated with favorable clinical outcomes and increased efficacy of anti-tumor immunotherapies.
Wen J, Yun W, Yin X, Meng X.
europepmc   +2 more sources

Sustained innate interferon is an essential inducer of tertiary lymphoid structures [PDF]

Tertiary lymphoid structures (TLS) resemble follicles of secondary lymphoid organs and develop in nonlymphoid tissues during inflammation and cancer. Which cell types and signals drive the development of TLS is largely unknown.
Calvanese, Anna Laura, Cecconi, Virginia, Gschwend, Julia, Heikenwälder, Mathias, Ludewig, Burkhard, Nater, Marc, Pereira, Paulo, Schneider, Christoph, Schnepf, Daniel, Silina, Karina, Stäheli, Severin, van den Broek, Maries   +11 more
core   +1 more source

Autocrine/paracrine lysophosphatidylserine signaling suppresses B cell aggregation and tertiary lymphoid structure formation

iScience
Summary Accumulating evidence suggests that Gα13 signaling by G protein-coupled receptors negatively regulate B cell function. We report here that lysophosphatidylserine (LysoPS), an emerging immunoregulatory lysophospholipid, is produced upon B cell ...
Akiharu Uwamizu, Yuji Shinjo, Jumpei Omi, Manae Tatstumi, K. Kano, Kumiko Makide, H. Kitamura, Michiyo Okudaira, K. Satoh, F. Fukami, T. Kawano, T. Miyasaka, Tomoko Takahashi, Osamu Nakajima, Tomohiko Ohwada, A. Inoue, Jun Aoki   +16 more
semanticscholar   +1 more source

Retrospective study on the correlation between CXCL13, immune infiltration, and tertiary lymphoid structures in cutaneous squamous cell carcinoma [PDF]

PeerJ
Background C-X-C motif chemokine ligand 13 (CXCL13) is a crucial chemokine for the recruitment of immune cells and the formation of tertiary lymphoid structure (TLS) in the tumor microenvironment.
Yulu Chen, Yuhao Wu, Zijun Zhao, Long Wen, Mingshun Wu, Dekun Song, Qingyu Zeng, Yeqiang Liu, Guorong Yan, Guolong Zhang   +9 more
doaj   +2 more sources

Tertiary lymphoid structures predict survival and response to neoadjuvant therapy in locally advanced rectal cancer

npj Precision Oncology
Tertiary lymphoid structure (TLS) contributes to the anti-tumor immune response, and predicts the prognosis of colorectal cancer patients. However, the potential impact of TLS in shaping the immune status of rectal adenocarcinoma, and the intrinsic ...
Qianyu Wang, Wentao Zhong, Xiaofei Shen, Zechen Hao, Meng Wan, Xiaopeng Yang, Ran An, Hongyan Zhu, Huiyun Cai, Tao Li, Yuan Lv, Xing Dong, Gang Chen, Aijun Liu, Junfeng Du   +14 more
doaj   +1 more source