Results 81 to 90 of about 2,807 (182)

The Prognostic Significance of Tertiary Lymphoid Structures in Head and Neck Cancers: A Systematic Review and Meta‐Analysis

Journal of Oral Pathology &Medicine, Volume 55, Issue 7, Page 774-783, August 2026.
ABSTRACT Background Head and neck squamous cell carcinoma (HNSCC), particularly oral squamous cell carcinoma (OSCC), is associated with poor survival despite therapeutic advances. Tertiary lymphoid structures (TLSs) are emerging components of the tumor microenvironment, but their prognostic significance in HNSCC remains unclear.
Everton Freitas de Morais, Bruno Cesar da Costa, Antti Mäkitie, Ricardo D. Coletta, Alhadi Almangush   +4 more
wiley   +1 more source

Tertiary lymphoid structures predict survival and response to neoadjuvant therapy in locally advanced rectal cancer

npj Precision Oncology
Tertiary lymphoid structure (TLS) contributes to the anti-tumor immune response, and predicts the prognosis of colorectal cancer patients. However, the potential impact of TLS in shaping the immune status of rectal adenocarcinoma, and the intrinsic ...
Qianyu Wang, Wentao Zhong, Xiaofei Shen, Zechen Hao, Meng Wan, Xiaopeng Yang, Ran An, Hongyan Zhu, Huiyun Cai, Tao Li, Yuan Lv, Xing Dong, Gang Chen, Aijun Liu, Junfeng Du   +14 more
doaj   +1 more source

GCUNet: a graph neural network-based contextual learning network for tertiary lymphoid structure semantic segmentation in whole slide image

Visual Computing for Industry, Biomedicine, and Art
This study focuses on tertiary lymphoid structure (TLS) semantic segmentation in whole slide images (WSIs). Unlike TLS binary segmentation, TLS semantic segmentation identifies boundaries and maturity and requires the integration of contextual ...
Lei Su, Ruiyu Li, Guangyao Zhang, Zonghao Liu, Xuqing Geng, Hetong Wang, Weihao Gai, Huanwen Wu, Jie Tian, Yang Du   +9 more
doaj   +1 more source

Tertiary lymphoid structures in the microenvironment of colorectal cancer: exploring new therapeutic targets

Cancer Immunology, Immunotherapy
Immunotherapy has shown limited efficacy in colorectal cancer (CRC), necessitating the urgent identification of novel immunotherapeutic targets to address this challenge.
Nan-Nan Dai, Man-Yi Hu, Jian-Ping Wang, Zhi-Hui Dai, Li Xu, Tai-Wei Ye   +5 more
doaj   +1 more source

Tertiary lymphoid structures in renal cell carcinoma: from heterogeneity dissection to translational precision immunotherapy

Frontiers in Immunology
Renal cell carcinoma (RCC), characterized by its distinctive hypoxic and immunosuppressive tumor microenvironment (TME), demonstrates suboptimal responses to current immunotherapeutic interventions.
Zhexian Li, Zhexian Li, Sensen Ruan, Yang Yu, Hao Xiang, Wenjie Mi, Wenjie Mi   +6 more
doaj   +1 more source

Prognostic Value of N1/N2 Neutrophils Heterogeneity and Tertiary Lymphoid Structure in Hepatocellular Carcinoma Patients

Cancer Medicine
Background The tumor immune microenvironment, including neutrophils and tertiary lymphoid structures (TLSs), is pivotal for HCC prognosis assessment. Tumor‐associated neutrophils exhibit plasticity, adopting either an antitumorigenic N1 (MPO+ CD206−) or ...
Yanfei Lang, Weiwei Fu, Wei Xu, Chao Ma, Xiuyun Tian, Chunyi Hao, Shigang Ding   +6 more
doaj   +1 more source

The impact of tertiary lymphoid structure on the efficacy of postoperative adjuvant transcatheter arterial chemoembolization in patients with hepatocellular carcinoma

Zhongguo Linchuang Yixue
ObjectiveTo explore the impact of tertiary lymphoid structure (TLS) on the efficacy of adjuvant transcatheter arterial chemoembolization (TACE) following curative resection in patients with hepatocellular carcinoma (HCC).
Fansheng MENG, Haokang YANG, Biwei YANG
doaj   +1 more source

A distinct tumor microenvironment makes anaplastic thyroid cancer more lethal but immunotherapy sensitive than papillary thyroid cancer

JCI Insight
Both anaplastic thyroid cancer (ATC) and papillary thyroid cancer (PTC) originate from thyroid follicular epithelial cells, but ATC has a significantly worse prognosis and shows resistance to conventional therapies.
Pei-Zhen Han, Wei-Dong Ye, Peng-Cheng Yu, Li-Cheng Tan, Xiao Shi, Xu-Feng Chen, Cong He, Jia-Qian Hu, Wen-Jun Wei, Zhong-Wu Lu, Ning Qu, Yu Wang, Qing-Hai Ji, Dong-Mei Ji, Yu-Long Wang   +14 more
doaj   +1 more source

Tertiary lymphoid structure-related score as a predictor for survival prognosis and immunotherapy response in head and neck squamous cell carcinoma

Frontiers in Immunology
BackgroundSubstantial studies reveal that tertiary lymphoid structure (TLS) correlate with prognosis and immunotherapy response in various types of cancers.
Fan Wu, Fan Wu, Haotian Cao, Haotian Cao, Siqi Ren, Siqi Ren, Jiaying Wu, Jiaying Wu, Xin Liu, Xin Liu, Qunxing Li, Qiuping Xu, Qiuping Xu, Jiali Chen, Jiali Chen, Ruixin Wang, Ruixin Wang, Suling Chen, Suling Chen, Shijia Kuang, Shijia Kuang, Binbin Xia, Yanyan Li, Yanyan Li, Liansheng Wang, Jintao Li, Bowen Li, Bowen Li, Jinsong Li, Jinsong Li, Tianjun Lan, Tianjun Lan   +31 more
doaj   +1 more source

Podoplanin expressing macrophages and their involvement in tertiary lymphoid structures in mouse models of Sjögren’s disease

Frontiers in Immunology
Tertiary lymphoid structures (TLSs) are formed in tissues targeted by chronic inflammation processes, such as infection and autoimmunity. In Sjögren’s disease, the organization of immune cells into TLS is an important part of disease progression.
Aud-Malin Karlsson Hovd, Saba Nayar, Charlotte G. Smith, Premasany Kanapathippillai, Valentina Iannizzotto, Francesca Barone, Kristin Andreassen Fenton, Hege Lynum Pedersen   +7 more
doaj   +1 more source