Results 81 to 90 of about 6,745 (243)

Pan-cancer analysis of genomic properties and clinical outcome associated with tumor tertiary lymphoid structure

Scientific Reports, 2020
How the genomic landscape of a tumor shapes the formation of tertiary lymphoid structure (TLS) and how might TLS alter the clinical outcome or response to immunotherapy had not been systematically explored. Utilizing the genomic and transcriptome data of
Ziying Lin, Lixia Huang, ShaoLi Li, Jincui Gu, Xiaoxian Cui, Yanbin Zhou   +5 more
doaj   +1 more source

Prognostic Significance of the Tumour Microenvironment in Surgically Resected Canine Pulmonary Adenocarcinomas

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT The prognostic relevance of the tumour microenvironment in surgically resected canine pulmonary adenocarcinomas (cPACs) remains uncertain. This retrospective single‐centre cohort study evaluated associations between intratumoural immune features and postoperative outcomes.
Masanao Ichimata, Yumiko Kagawa, Atsushi Toshima, Fukiko Matsuyama, Eri Fukazawa, Kei Harada, Ryuzo Katayama, Yuko Nakano, Tetsuya Kobayashi, Masaya Igase, Takuya Mizuno   +10 more
wiley   +1 more source

Tertiary lymphoid structures (TLS) identification and density assessment on H&E-stained digital slides of lung cancer [PDF]

, 2021
Tertiary lymphoid structures (TLS) are ectopic aggregates of lymphoid cells in inflamed, infected, or tumoral tissues that are easily recognized on an H&E histology slide as discrete entities, distinct from lymphocytes.
Alexander, DC, Barmpoutis, P, Di Capite, M, Jansen, M, Kayhanian, H, Kwong, FNK, Waddingham, W   +6 more
core  

Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies

MedComm, Volume 7, Issue 6, June 2026.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by unleashing antitumor immunity. This review comprehensively examines the molecular mechanisms underlying key immune checkpoints—including PD‐1/PD‐L1, CTLA‐4, and TIM‐3—and their clinical applications.
Qintao Ge, Liu Yu, Jiahe Lu, Aihetaimujiang Anwaier, Xiyue Xiao, Yonghao Chen, Dingwei Ye, Hailiang Zhang, Wenhao Xu, Wenbin Dai   +9 more
wiley   +1 more source

Research progress of tertiary lymphoid structure in hepatocellular carcinoma: from prognostic biomarkers to new strategies for immunotherapy

Frontiers in Immunology
Tertiary lymphoid structures (TLS) are important ectopic immune aggregates that develop within the tumor microenvironment (TME) of hepatocellular carcinoma (HCC) and have attracted increasing attention due to their potential clinical value.
Shimin Yuan, Shimin Yuan, Xianting Luo, Shu Li, Long Cao, Long Cao, Xiang Chen, Ling Wang, Yan Liu, Zipeng Li, Tongnuo Wu, Hongcai Fang, Hongcai Fang, Mingfu Tong   +13 more
doaj   +1 more source

Epigenetic targets to enhance antitumor immune response through the induction of tertiary lymphoid structures [PDF]

Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates found in sites of chronic inflammation such as tumors and autoimmune diseases. The discovery that TLS formation at tumor sites correlated with good patient prognosis has triggered ...
Barragán, Isabel, Escamilla-Sánchez, Alejandro, Frecha, Cecilia, Omotesho, Quadri Ajibola, Pérez-Ruiz, Elisabeth, Rueda-Domínguez, Antonio   +5 more
core   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

An immune cell map of human lung adenocarcinoma development reveals an anti-tumoral role of the Tfh-dependent tertiary lymphoid structure

Cell Reports Medicine
Summary The immune responses during the initiation and invasion stages of human lung adenocarcinoma (LUAD) development are largely unknown. Here, we generated a single-cell RNA sequencing map to decipher the immune dynamics during human LUAD development.
Wei Liu, Wenhua You, Zhenwei Lan, Yijiu Ren, Shuangshu Gao, Shuchao Li, Wei-Wei Chen, Chunyu Huang, Yong Zeng, Nengming Xiao, Zeshuai Wang, Huikang Xie, Huan Ma, Yun Chen, Guangsuo Wang, Chang Chen, Hanjie Li   +16 more
semanticscholar   +1 more source

From Theory to Practice: Which Biomarkers Are Ready for Predicting Response in Advanced HCC?

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Systemic therapies for advanced hepatocellular carcinoma (HCC) have expanded considerably with the advent of tyrosine kinase inhibitors, immune checkpoint inhibitors and immunotherapy–anti‐angiogenic combinations. However, despite this therapeutic diversification, first‐line treatment selection remains largely empirical, as few biomarkers are ...
Marie Decraecker, Jean‐Frédéric Blanc, Samuel Amintas, Grégoire Manaud   +3 more
wiley   +1 more source

Intratumoral antigen-presenting cell activation by a nanovesicle for the concurrent tertiary lymphoid structure de novo neogenesis

Science Advances
Tertiary lymphoid structures (TLSs) usually lead to significantly improved clinical benefits in immunotherapy but are rarely observed within native tumors.
Ran Cheng, Sucheng Li, Xianbin Ma, Wanru Zhuang, Yao Lei, Jiaqi He, Chao Liang, Weidong Nie, Haiyan Xie   +8 more
semanticscholar   +1 more source