Tertiary lymphoid organs in central nervous system autoimmunity [PDF]
, 2016 Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS), which results in permanent neuronal damage and substantial disability in patients.
Mitsdoerffer, M., Peters, A.
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Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer [PDF]
, 2016 Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally, in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling pro-tumor chronic inflammation.
BARNABA, Vincenzo +14 more
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Revisited role of B cells in atherosclerosis [PDF]
, 2012 No abstract ...
Blair, Paula, Maffia, Pasquale
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Lymphoid aggregates in desmoplastic melanoma have features of tertiary lymphoid structures [PDF]
Melanoma Research, 2018 Desmoplastic melanomas (DM) have unique and challenging clinical presentations and histomorphology. A characteristic feature is the presence of scattered lymphoid aggregates. However, the nature of these aggregates is not defined. We hypothesized that they may be tertiary lymphoid structures (TLS), and may be associated with programmed death ligand 1 ...
Anne M, Stowman +5 more
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High Endothelial Venules and Other Blood Vessels: Critical Regulators of Lymphoid Organ Development and Function [PDF]
, 2017 The blood vasculature regulates both the development and function of secondary lymphoid organs by providing a portal for entry of hemopoietic cells. During the development of lymphoid organs in the embryo, blood vessels deliver lymphoid tissue inducer ...
Ann Ager
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Current Clinical and Pre-Clinical Imaging Approaches to Study the Cancer-Associated Immune System
Frontiers in Immunology, 2021 In the light of the success and the expected growth of its arsenal, immuno-therapy may become the standard neoadjuvant procedure for many cancers in the near future.
Christopher G. Mueller +3 more
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Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor immunity, immunosuppression, or Bystander Sentinels in Disease? [PDF]
, 2017 Secondary lymphoid organs are integral to initiation and execution of adaptive immune responses. These organs provide a setting for interactions between antigen-specific lymphocytes and antigen-presenting cells recruited from local infected or ...
Adachi +151 more
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LLT1-CD161 Interaction in Cancer: Promises and Challenges
Frontiers in Immunology, 2022 The success of immune checkpoint therapy in cancer has changed our way of thinking, promoting the design of future cancer treatments that places the immune system at the center stage.
Veronique M. Braud +5 more
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Perivascular adipose tissue inflammation in vascular disease [PDF]
, 2017 Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in volume and becomes dysfunctional, with altered cellular composition and molecular ...
Guzik, Tomasz J., Nosalski, Ryszard
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Tertiary Lymphoid Structures as Mediators of Immunotherapy Response
Cancers, 2022 Since its first application in the treatment of cancer during the 1800s, immunotherapy has more recently become the leading edge of novel treatment strategies. Even though the efficacy of these agents can at times be predicted by more traditional metrics and biomarkers, often patient responses are variable.
Raj G. Vaghjiani, Joseph J. Skitzki
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