, 2023 Ovarian cancer (OC) has the lowest survival rate among gynecologic malignancies. Ectopic lymphocyte aggregates, namely tertiary lymphoid structures (TLSs), have been reported as positive biomarkers for tumor prognosis. However, the related gene signature
Yue Hou (2562085) +6 more
core +1 more source
Tertiary lymphoid structures in pancreatic cancer: a new target for immunotherapy
Frontiers in Immunology, 2023 Pancreatic cancer (PC) is extremely malignant and shows limited response to available immunotherapies due to the hypoxic and immunosuppressive nature of its tumor microenvironment (TME). The aggregation of immune cells (B cells, T cells, dendritic cells,
Xinlei Zou +5 more
doaj +1 more source
Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer
Frontiers in Immunology, 2023 Tertiary lymphoid structures (TLS) are lymph node-like aggregates that can form in association with chronic inflammation or cancer. Mature TLS are organized into B and T cell zones, and are not encapsulated but include all cell types necessary for eliciting an adaptive immune response.
Vaccaro, Alessandra +4 more
openaire +4 more sources
Current Clinical and Pre-Clinical Imaging Approaches to Study the Cancer-Associated Immune System
Frontiers in Immunology, 2021 In the light of the success and the expected growth of its arsenal, immuno-therapy may become the standard neoadjuvant procedure for many cancers in the near future.
Christopher G. Mueller +3 more
doaj +1 more source
Unraveling Novel Subsets of Lymphocytes Involved in Sac Expansion in the Tertiary Lymphoid Structure Within an Abdominal Aortic Aneurysm. [PDF]
J Am Heart AssocHosaka I +20 more
europepmc +2 more sources
Tertiary lymphoid structures and gastric cancer prognosis
APMIS, 2022 Tertiary lymphoid structures (TLSs) are part of immune response against cancer. Their high density and high diameter have been shown to be associated with prognosis in different cancer types. The aim of this study was to examine the prognostic significance of TLS density and diameter in gastric cancer and reproducibility of their assessments.
Kemi, N. (Niko) +7 more
openaire +4 more sources
Characterization of lymphoid tissue inducer cells and lymphoid tissue development in adult interleukin 7 transgenic mice [PDF]
, 2008 During embryogenesis, the development of secondary lymphoid organs (SLOs) such as lymph nodes (LNs) and Peyer’s patches (PPs) requires the cellular crosstalk between vascular cell adhesion molecule (VCAM)-1+ mesenchymal organizer cells and CD45+CD4 ...
Schmutz, Sandrine
core +1 more source
LLT1-CD161 Interaction in Cancer: Promises and Challenges
Frontiers in Immunology, 2022 The success of immune checkpoint therapy in cancer has changed our way of thinking, promoting the design of future cancer treatments that places the immune system at the center stage.
Veronique M. Braud +5 more
doaj +1 more source
The roles of tertiary lymphoid structures in chronic diseases
Nature Reviews Nephrology, 2023 Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such as lymph nodes, TLSs lack capsules and have their own unique characteristics and functions.
Sato, Yuki +4 more
openaire +3 more sources
Induction of Secondary and Tertiary Lymphoid Structures in the Skin [PDF]
Immunity, 2004 During embryogenesis a developmental program leading to the formation of lymph nodes and Peyer's patches is initiated. We now show that lymph node-like structures as well as tertiary lymphoid structures can ectopically be induced by intradermal injection of newborn lymph node-derived cells.
Cupedo, Tom +3 more
openaire +2 more sources