Results 21 to 30 of about 7,278,692 (246)

The Impact of Programmed Cell Death on the Formation of Tertiary Lymphoid Structures

Frontiers in Immunology, 2021
Tertiary lymphoid structures are clusters of lymphoid tissue that develop post-natally at sites of chronic inflammation. They have been described in association with infection, autoimmune disorders, cancer, and allograft rejection. In their mature stage,
Mélanie Dieudé, Mélanie Dieudé, Mélanie Dieudé, Imane Kaci, Imane Kaci, Imane Kaci, Marie-Josée Hébert, Marie-Josée Hébert, Marie-Josée Hébert   +8 more
doaj   +1 more source

Inducible Tertiary Lymphoid Structures: Promise and Challenges for Translating a New Class of Immunotherapy

Frontiers in Immunology, 2021
Tertiary lymphoid structures (TLS) are ectopically formed aggregates of organized lymphocytes and antigen-presenting cells that occur in solid tissues as part of a chronic inflammation response.
Shota Aoyama, Ryosuke Nakagawa, James J. Mulé, James J. Mulé, Adam W. Mailloux   +4 more
doaj   +1 more source

Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer. [PDF]

Cancer Cell
Osorio JC, Knorr DA, Weitzenfeld P, Blanchard L, Yao N, Baez M, Sevilla C, DiLillo M, Rahman J, Sharma VP, Bromberg J, Postow MA, Ariyan C, Robson ME, Ravetch JV.   +14 more
europepmc   +2 more sources

Tertiary lymphoid structures in pancreatic cancer: a new target for immunotherapy

Frontiers in Immunology, 2023
Pancreatic cancer (PC) is extremely malignant and shows limited response to available immunotherapies due to the hypoxic and immunosuppressive nature of its tumor microenvironment (TME). The aggregation of immune cells (B cells, T cells, dendritic cells,
Xinlei Zou, Canghai Guan, Jianjun Gao, Wujiang Shi, Yunfu Cui, Xiangyu Zhong   +5 more
doaj   +1 more source

DataSheet1_The gene signature of tertiary lymphoid structures within ovarian cancer predicts the prognosis and immunotherapy benefit.docx

, 2023
Ovarian cancer (OC) has the lowest survival rate among gynecologic malignancies. Ectopic lymphocyte aggregates, namely tertiary lymphoid structures (TLSs), have been reported as positive biomarkers for tumor prognosis. However, the related gene signature
Yue Hou (2562085), Miao Li (337830), Xue Han (25073), Yingxin Pang (4537759), Hongluan Mao (8192757), Sijing Qiao (14367501), Xuan Wei (613185)   +6 more
core   +1 more source

Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation

OncoImmunology, 2022
Inducing a full antitumor immune response in the tumor microenvironment (TME) is essential for successful cancer immunotherapy. Here, we report that an oncolytic adenovirus carrying mIL-15 (Ad-IL15) can effectively induce antitumor immune response and ...
Teng He, Zhixing Hao, Mingjie Lin, Zhongwei Xin, Yongyuan Chen, Wei Ouyang, Qi Yang, Xiaoke Chen, Hui Zhou, Wanying Zhang, Pin Wu, Feng Xu   +11 more
doaj   +1 more source

Simulation and Statistical Techniques to Explore Lymphoid Tissue Organogenesis [PDF]

, 2012
Secondary lymphoid organs have a key role in the initiation of adaptive immune responses to infection. Organogenesis occurs in foetal development, and the use of genetic tools, imaging technologies, and ex vivo culture systems has provided significant ...
Alden, Kieran
core   +6 more sources

Characterization of lymphoid tissue inducer cells and lymphoid tissue development in adult interleukin 7 transgenic mice [PDF]

, 2008
During embryogenesis, the development of secondary lymphoid organs (SLOs) such as lymph nodes (LNs) and Peyer’s patches (PPs) requires the cellular crosstalk between vascular cell adhesion molecule (VCAM)-1+ mesenchymal organizer cells and CD45+CD4 ...
Schmutz, Sandrine
core   +1 more source

Seroprevalence of human T-lymphotropic virus antibodies among patients with lymphoid malignancies at a tertiary center in Lagos, Nigeria [PDF]

, 2014
Background: There is a significant association of human T-lymphotropic viruses (HTLV) with lymphoid malignancies. HTLV causes a lymphoproliferative malignancy of CD4-activated cells called adult T-cell leukemia/lymphoma (ATL) and a chronic myelopathy ...
Ebele Uche, Akinola Dada, Olaitan Okunoye, Adewumi Adediran, Olajumoke Oshinaike, Sarah John-Olabode, Adedoyin Dosunmu, Mojeed Odesanya, Akinsegun Akinbami, Idris Durojaiye   +9 more
core   +1 more source

Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma [PDF]

, 2014
Background -Oral squamous cell carcinomas are often heavily infiltrated by immune cells. The organization of B-cells, follicular dendritic cells, T-cells and high-endothelial venules into structures termed tertiary lymphoid structures have been detected ...
Wirsing, Anna Maria, Oddveig G Rikardsen, Anna M Wirsing, Sonja E Steigen, Hadler-Olsen, Elin Synnøve, Elin Hadler-Olsen, Steigen, Sonja Eriksson, Uhlin-Hansen, Lars, Rikardsen, Oddveig G, Lars Uhlin-Hansen   +9 more
core   +2 more sources