Results 21 to 30 of about 11,725 (256)

LLT1-CD161 Interaction in Cancer: Promises and Challenges

Frontiers in Immunology, 2022
The success of immune checkpoint therapy in cancer has changed our way of thinking, promoting the design of future cancer treatments that places the immune system at the center stage.
Veronique M. Braud, Aïda Meghraoui-Kheddar, Roxane Elaldi, Luciana Petti, Claire Germain, Fabienne Anjuère   +5 more
doaj   +1 more source

The roles of tertiary lymphoid structures in chronic diseases

Nature Reviews Nephrology, 2023
Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such as lymph nodes, TLSs lack capsules and have their own unique characteristics and functions.
Sato, Yuki, Silina, Karina, van den Broek, Maries, Hirahara, Kiyoshi, Yanagita, Motoko   +4 more
openaire   +3 more sources

Induction of Secondary and Tertiary Lymphoid Structures in the Skin [PDF]

Immunity, 2004
During embryogenesis a developmental program leading to the formation of lymph nodes and Peyer's patches is initiated. We now show that lymph node-like structures as well as tertiary lymphoid structures can ectopically be induced by intradermal injection of newborn lymph node-derived cells.
Cupedo, Tom, Jansen, Wendy, Kraal, Georg, Mebius, Reina E   +3 more
openaire   +2 more sources

Tertiary Lymphoid Structures: Autoimmunity Goes Local [PDF]

Frontiers in Immunology, 2018
Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune diseases. TLS present features of secondary lymphoid organs such as segregated T and B cell zones, presence of follicular dendritic cell networks, high endothelial venules and specialized lymphoid fibroblasts and display the mechanisms to support local adaptive ...
Elena Pipi, Elena Pipi, Saba Nayar, David H. Gardner, Serena Colafrancesco, Charlotte Smith, Francesca Barone   +6 more
openaire   +4 more sources

Unraveling Novel Subsets of Lymphocytes Involved in Sac Expansion in the Tertiary Lymphoid Structure Within an Abdominal Aortic Aneurysm. [PDF]

J Am Heart Assoc
Hosaka I, Ikegami I, Mikami T, Sato T, Ogawa T, Mukawa K, Tanaka M, Endo K, Akiyama Y, Ohkawa A, Nakazawa J, Shibata T, Nakajima T, Iba Y, Shiiku C, Sumino S, Koshima R, Takano K, Ichimiya S, Kawaharada N, Furuhashi M.   +20 more
europepmc   +2 more sources

Characteristics of tertiary lymphoid structures in primary cancers [PDF]

OncoImmunology, 2013
Tumors are sustained by complex networks of interactions between malignant cells, stromal cells and tumor-infiltrating immune cells. These networks differ from patient to patient in terms of nature, composition and organization as well as with regard to the precise localization of tumor-infiltrating cells.
Goc, Jérémy, Fridman, Wolf-Herman, Sautès-Fridman, Catherine, Dieu-Nosjean, Marie-Caroline   +3 more
openaire   +2 more sources

Tertiary lymphoid structures as local perpetuators of organ-specific immune injury: implication for lupus nephritis

Frontiers in Immunology, 2023
In response to inflammatory stimuli in conditions such as autoimmune disorders, infections and cancers, immune cells organize in nonlymphoid tissues, which resemble secondary lymphoid organs.
Meiying Wang, Meiying Wang, Meiying Wang, Snehin Rajkumar, Yupeng Lai, Xingjiao Liu, Jing He, Jing He, Tatsuya Ishikawa, Dhiraj Nallapothula, Ram Raj Singh, Ram Raj Singh, Ram Raj Singh, Ram Raj Singh   +13 more
doaj   +1 more source

Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy [PDF]

Cellular & Molecular Immunology, 2017
Tertiary lymphoid structures (TLS) often develop at sites of persistent inflammation, including cancers and autoimmune diseases. In most cases, the presence of TLS correlates with active immune responses. Because of their proximity to pathological loci, TLS are an intriguing target for the manipulation of immune responses.
Haidong, Tang, Mingzhao, Zhu, Jian, Qiao, Yang-Xin, Fu   +3 more
openaire   +2 more sources

Putative Immunological Functions of Inducible Skin-Associated Lymphoid Tissue in the Context of Mucosa-Associated Lymphoid Tissue

Frontiers in Immunology, 2021
Acquired immunity is orchestrated in various lymphoid organs, including bone marrow, thymus, spleen, and lymph nodes in humans. However, mucosa-associated lymphoid tissue (MALT) is evolutionally known to be emerged in the oldest vertebrates as an ...
Toshiaki Kogame, Kenji Kabashima, Gyohei Egawa   +2 more
doaj   +1 more source

Tertiary lymphoid structures are critical for cancer prognosis and therapeutic response

Frontiers in Immunology, 2023
Tertiary lymphoid structures (TLSs) are ectopic lymphocyte aggregates that form at sites of chronic inflammation, including cancers, in non-lymphoid tissues.
Qianqian Zhang, Suhui Wu
doaj   +1 more source