Results 41 to 50 of about 11,902 (192)

Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy [PDF]

Cellular & Molecular Immunology, 2017
Tertiary lymphoid structures (TLS) often develop at sites of persistent inflammation, including cancers and autoimmune diseases. In most cases, the presence of TLS correlates with active immune responses. Because of their proximity to pathological loci, TLS are an intriguing target for the manipulation of immune responses.
Haidong, Tang, Mingzhao, Zhu, Jian, Qiao, Yang-Xin, Fu   +3 more
openaire   +2 more sources

Long‐term B cell depletion associates with regeneration of kidney function

Immunity, Inflammation and Disease, 2021
Background Chronic kidney disease (CKD) is a common condition that increases mortality and the risk of cardiovascular and other morbidities regardless of underlying renal condition. Chronic inflammation promotes renal fibrosis.
Susanne V. Fleig, Franz F. Konen, Christoph Schröder, Jessica Schmitz, Stefan Gingele, Jan H. Bräsen, Svjetlana Lovric, Bernhard M. W. Schmidt, Hermann Haller, Thomas Skripuletz, Sibylle vonVietinghoff   +10 more
doaj   +1 more source

Putative Immunological Functions of Inducible Skin-Associated Lymphoid Tissue in the Context of Mucosa-Associated Lymphoid Tissue

Frontiers in Immunology, 2021
Acquired immunity is orchestrated in various lymphoid organs, including bone marrow, thymus, spleen, and lymph nodes in humans. However, mucosa-associated lymphoid tissue (MALT) is evolutionally known to be emerged in the oldest vertebrates as an ...
Toshiaki Kogame, Kenji Kabashima, Gyohei Egawa   +2 more
doaj   +1 more source

Tertiary lymphoid structures in endometriosis

F&S Science
To determine whether tertiary lymphoid structures (TLSs), which reflect organized immune cell aggregates present in non-lymphoid tissues, are consistent features of endometriosis lesions.Detailed histopathological analysis of endometrial and lesion tissue from patients with endometriosis and controls was performed.
Katherine B. Zutautas, Priyanka Yolmo, Minqi Xu, Timothy Childs, Madhuri Koti, Chandrakant Tayade   +5 more
openaire   +2 more sources

Tertiary lymphoid structures in the era of cancer immunotherapy [PDF]

Nature Reviews Cancer, 2019
Tertiary lymphoid structures (TLSs) are ectopic lymphoid organs that develop in non-lymphoid tissues at sites of chronic inflammation including tumours. Key common characteristics between secondary lymphoid organogenesis and TLS neogenesis have been identified.
Catherine Sautès-Fridman, Florent Petitprez, Julien Calderaro, Wolf Herman Fridman   +3 more
openaire   +2 more sources

A cellular and spatial map of salivary glands at single cell resolution reveals the functional basis of tertiary lymphoid structure formation in Sjogren’s syndrome

, 2022
The key role of tertiary lymphoid structures in autoimmune and non-autoimmune conditions has been recently appreciated. While many of the molecular mechanisms involved in tertiary lymphoid structure (TLS) formation have been identified, their cellular ...
van, Roon J, Fennell, Eanna, Pugh, M, Teodosio, A, Flint, J, Turner, JD; id_orcid, Smith, Charlotte, Iannizzotto, V, Consortium, Roche Fibroblast Network, Nayar, S, Gardner, DH, Berardicurti, O, Asam, S, Colfrancesco, S   +13 more
core   +1 more source

Tertiary Lymphoid Structures as Mediators of Immunotherapy Response

Cancers, 2022
Since its first application in the treatment of cancer during the 1800s, immunotherapy has more recently become the leading edge of novel treatment strategies. Even though the efficacy of these agents can at times be predicted by more traditional metrics and biomarkers, often patient responses are variable.
Raj G. Vaghjiani, Joseph J. Skitzki
openaire   +2 more sources

T Follicular Helper Cells in Tertiary Lymphoid Structure Contribute to Renal Fibrosis by IL-21

, 2023
Tertiary lymphoid structure (TLS) represents lymphocyte clusters in non-lymphoid organs. The formation and maintenance of TLS are dependent on follicular helper T (TFH) cells.
Yichun Cheng, Shuwang Ge, Nanhui Zhang, Ran Luo, Gang Xu, Dan Chang   +5 more
core   +1 more source

Tertiary lymphoid structures in thyroid cancer

Archives of Endocrinology and Metabolism
This study aimed to investigate the presence of tertiary lymphoid structures (TLSs) and tumor-infiltrating B cells within the germinal centers of TLSs in the tumor microenvironment of thyroid cancer, utilizing a morphological approach.Histological samples from patients with papillary thyroid carcinoma (PTC) (n = 112) stained with hematoxylin and eosin ...
Nakadaira, Katia Sakimi, Saito, Kelly Cristina, Fuziwara, Cesar Seigi, Magalhães, Patricia Künzle Ribeiro, Ramalho, Leandra Naira Zambelli, Ricarte-Filho, Julio C., Maciel, Lea Maria Zanini, Kimura, Edna Teruko   +7 more
openaire   +4 more sources

Tertiary lymphoid structures in gliomas: impact on tumour immunity and progression

Journal of Translational Medicine
Tertiary lymphoid structures (TLSs) are ectopic lymphoid formations that develop in chronically inflamed tissues, including various solid tumours. In the context of gliomas, the presence of TLSs has recently attracted considerable attention because of ...
Jiatong Chen, Yuechao Yang, Shuang Luan, Wenhao Xu, Yang Gao   +4 more
doaj   +1 more source