Results 41 to 50 of about 7,278,692 (246)

Identifying Patterns of Hospitalizations Among Childhood Cancer Survivors: A Population‐Based Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Childhood cancer survivors (CCSs) experience more hospitalizations than the general population. We aimed to identify distinct hospitalization patterns among Queensland CCSs and the associated characteristics. Methods Cases (aged ≤14 years) diagnosed between 1995 and 2019 while residents of Queensland were identified through the ...
Hai Pham, Teyl Engstrom, Peter Baade, Natalie Bradford, Sarah Pont, Louise Marquart‐Wilson, Natasha Nassar, Jason D. Pole   +7 more
wiley   +1 more source

Tertiary lymphoid structures in gliomas: impact on tumour immunity and progression

Journal of Translational Medicine
Tertiary lymphoid structures (TLSs) are ectopic lymphoid formations that develop in chronically inflamed tissues, including various solid tumours. In the context of gliomas, the presence of TLSs has recently attracted considerable attention because of ...
Jiatong Chen, Yuechao Yang, Shuang Luan, Wenhao Xu, Yang Gao   +4 more
doaj   +1 more source

The prognostic value of the tertiary lymphoid structure in gastrointestinal cancers

Frontiers in Immunology, 2023
BackgroundNumerous studies and research papers have provided evidence suggesting that tertiary lymphoid structures (TLS) play a crucial role in combating and suppressing tumor growth and progression.
Aoyang Yu, Menghan Cao, Kaile Zhang, Yule Yang, Luyao Ma, Xinran Zhang, Yang Zhao, Xiao Ma, Zhixiang Fan, Zhengxiang Han, Hongmei Wang   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Long‐term B cell depletion associates with regeneration of kidney function

Immunity, Inflammation and Disease, 2021
Background Chronic kidney disease (CKD) is a common condition that increases mortality and the risk of cardiovascular and other morbidities regardless of underlying renal condition. Chronic inflammation promotes renal fibrosis.
Susanne V. Fleig, Franz F. Konen, Christoph Schröder, Jessica Schmitz, Stefan Gingele, Jan H. Bräsen, Svjetlana Lovric, Bernhard M. W. Schmidt, Hermann Haller, Thomas Skripuletz, Sibylle vonVietinghoff   +10 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Distribution of T-lymphocyte subsets in porcine lymphoid tissues [PDF]

, 1987
The distribution of the functional subsets of porcine T cells, the cytolytic/suppressor (Tc/s) and the helper/inducer (Th/i) cells was studied in cryostat sections of thymus, lymph nodes, tonsils, Peyer's patches, spleen and liver using the indirect ...
Saalmüller, Armin, Reddehase, Matthias J., Koszinowski, Ulrich H., Jonjic, Stipan, Bühring, Hans-Jörg   +4 more
core   +1 more source

STINGing the Tumor Microenvironment to Promote Therapeutic Tertiary Lymphoid Structure Development

Frontiers in Immunology, 2021
Tertiary lymphoid structures (TLS), also known as ectopic lymphoid structures (ELS) or tertiary lymphoid organs (TLO), represent a unique subset of lymphoid tissues noted for their architectural similarity to lymph nodes, but which conditionally form in ...
Jessica N. Filderman, Mark Appleman, Manoj Chelvanambi, Jennifer L. Taylor, Walter J. Storkus, Walter J. Storkus, Walter J. Storkus, Walter J. Storkus   +7 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Mechanisms of tertiary lymphoid structure formation: cooperation between inflammation and antigenicity

Frontiers in Immunology, 2023
To mount an effective anti-tumor immune response capable of controlling or eliminating disease, sufficient numbers of lymphocytes must be recruited to malignant tissue and allowed to sustain their effector functions.
Shrijan Khanal, Andreas Wieland, Andrew J. Gunderson   +2 more
doaj   +1 more source