Results 51 to 60 of about 11,902 (192)

Characterizing the B-Cell and Humoral Response in Tertiary Lymphoid Organs in Kidney Allografts

, 2019
OBJECTIVES: Tertiary lymphoid organs are formed at sites of chronic inflammation and are thought to contribute to the immune response. Here, we aimed to characterize the structure and function of tertiary lymphoid organs in a model of murine kidney ...
Brown, Kathryn, Wong, Wilson, Nowocin, Anna K., Meader, Lucy, Elgueta, Raul   +4 more
core   +1 more source

Helper T cell-dominant tertiary lymphoid structures are associated with disease relapse of advanced colorectal cancer

OncoImmunology, 2020
Tertiary lymphoid structures (TLSs), clusters of immune cells found around tumor tissue, have been shown to be associated with anti-tumor immunity, but the cellular composition within each TLS and whether the cellular composition of a TLS affects a ...
Kyoko Yamaguchi, Mamoru Ito, Hirofumi Ohmura, Fumiyasu Hanamura, Michitaka Nakano, Kenji Tsuchihashi, Shuntaro Nagai, Hiroshi Ariyama, Hitoshi Kusaba, Hidetaka Yamamoto, Yoshinao Oda, Masafumi Nakamura, Koichi Akashi, Eishi Baba   +13 more
doaj   +1 more source

Tertiary lymphoid structures in autoimmune diseases

Frontiers in Immunology
Tertiary lymphoid structures (TLSs) are organized lymphoid-like aggregations in non-lymphoid tissues. Tissues with chronic and persistent inflammation infiltration may drive and form ectopic germinal center-like structures, which are very common in autoimmune diseases, chronic infections, and tumor microenvironments.
Yuanji Dong, Ting Wang, Huaxiang Wu
openaire   +3 more sources

The Sunrise of Tertiary Lymphoid Structures in Cancer

Immunological Reviews
ABSTRACTFirst considered as a negative epiphenomenon in autoimmune and inflammatory diseases, with possible deleterious consequences through the production of pathological autoantibodies and antiself T cells, tertiary lymphoid structures (TLS) have gained major scientific and clinical interest in cancer due to their association with better clinical ...
Juliette Rochefort, Gilles Marodon, Jean‐Luc Teillaud, Marie‐Caroline Dieu‐Nosjean   +3 more
openaire   +2 more sources

Regulation Of Tertiary Lymphoid Structure Formation In Periodontitis

International Dental Journal
Aim or purpose: This study investigates the role of gingival fibroblasts in the formation of tertiary lymphoid structures (TLSs) in periodontitis and their impact on inflammation.
Jiawei Lu, Zehui Xiong, Jinyi Zhang, Lijun Luo, Xiao Wu   +4 more
doaj   +1 more source

Tertiary Lymphoid Structures in the Central Nervous System: Implications for Glioblastoma

Frontiers in Immunology, 2021
Glioblastoma is the most common and aggressive brain tumor, which is uniformly lethal due to its extreme invasiveness and the absence of curative therapies.
Tiarne van de Walle, Alessandra Vaccaro, Mohanraj Ramachandran, Ilkka Pietilä, Magnus Essand, Anna Dimberg   +5 more
doaj   +1 more source

Podoplanin expressing macrophages and their involvement in tertiary lymphoid structures in mouse models of Sjögren’s disease [PDF]

Tertiary lymphoid structures (TLSs) are formed in tissues targeted by chronic inflammation processes, such as infection and autoimmunity. In Sjögren’s disease, the organization of immune cells into TLS is an important part of disease progression.
Smith, Charlotte G, Fenton, Kristin Andreassen, Kanapathippilai, Premasany, Kanapathippillai, Premasany, Barone, Francesca; id_orcid, Nayar, Saba, Iannizzotto, Valentina, Smith, Charlotte G., Pedersen, Hege Lynum, Hovd, Aud-Malin Karlsson, Barone, Francesca   +10 more
core   +1 more source

Tertiary lymphoid organs in infection and autoimmunity

, 2012
The lymph nodes (LNs) and spleen have an optimal structure that allows the interaction between T cells, B cells and antigen-presenting dendritic cells (DCs) on a matrix made up by stromal cells.
Perros, F, Geurts van Kessel, Corine; id_orcid, Lambrecht, Bart, Perros, Frédéric, Hammad, H (Hamida), GeurtsvanKessel, Corine H, Hammad, Hamida, Neyt, K, Geurts van Kessel, Corine, Neyt, Katrijn   +9 more
core   +1 more source

Nanovaccines Fostering Tertiary Lymphoid Structure to Attack Mimicry Nasopharyngeal Carcinoma

, 2023
Tertiary lymphoid structures (TLSs) are formed in inflamed tissues, and recent studies demonstrated that the appearance of TLSs in tumor sites is associated with a good prognosis for tumor patients.
Yongming Chen (324923), Lixin Liu (676169), Zhenfu Wen (15294284), Dongdong Qiao (5154467), Hong Liu (50694), Chenxu Zhu (793644), Haolin Chen (747079), Zeyu Yang (8690226), Liyan Li (9420617), Zhipeng Zeng (475308)   +9 more
core   +1 more source

Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma

Nature Communications
Tertiary lymphoid structures are immune cell aggregates linked with cancer outcomes, but their interactions with tumour cell aggregates are unclear. Using nasopharyngeal carcinoma as a model, here we analyse single-cell transcriptomes of 343,829 cells ...
Yang Liu, Shuang-Yan Ye, Shuai He, Dong-Mei Chi, Xiu-Zhi Wang, Yue-Feng Wen, Dong Ma, Run-Cong Nie, Pu Xiang, You Zhou, Zhao-Hui Ruan, Rou-Jun Peng, Chun-Ling Luo, Pan-Pan Wei, Guo-Wang Lin, Jian Zheng, Qian Cui, Mu-Yan Cai, Jing-Ping Yun, Junchao Dong, Hai-Qiang Mai, Xiaojun Xia, Jin-Xin Bei   +22 more
doaj   +1 more source