Results 71 to 80 of about 7,278,692 (246)

Caribbean Tertiary Education Development (1996-2006)

, 2007
The publication reflects the results of a collaboration between the Tertiary Level Institutions Unit (TLIU) of the University of the West Indies (UWI) and over 40 tertiary level institutions in the Caribbean region, focusing on the theme, “A Decade of ...
The University of the West Indies, Tertiary Levels Institutions Unit
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Dynamics of tertiary lymphoid structures and immune cross talk in early versus advanced colorectal cancer: potential implications for immunotherapy

Cancer Immunology, Immunotherapy
Background Irrespective of microsatellite status, immune checkpoint inhibitor therapy shows superior efficacy in early-stage colorectal cancer (CRC) compared to advanced cases.
Zixu Chen, Bang Hu, Keyu Cai, Han Gao, Zhenyu Xian, Shuang Zhang, Zhen Fang, Qian Zhou, Donglin Ren, Qi Zou   +9 more
doaj   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Tertiary lymphoid structures in head and neck squamous cell carcinoma

Translational Oncology
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Smoking, drinking, and human papillomavirus (HPV) infection are the main risk factors.
Jing Zhu, Hui Lu, Kongcheng Wang, Baorui Liu, Jing Yan   +4 more
doaj   +1 more source

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium [PDF]

, 2009
BackgroundFollicular structures resembling germinal centres (GCs) that are characterized by follicular dendritic cell (FDC) networks have long been recognized in chronically inflamed tissues in autoimmune diseases, including the synovium of rheumatoid ...
Kelly, Stephen, Kelly, S, Blades, Mark C., Kirkham, Bruce, Spencer, Jo, Frances Humby, Bruce Kirkham, Pitzalis, Costantino, Michele Bombardieri, Kelly Stephen, Mark C Blades, Humby, F, Bombardieri M., Blades, MC, Manzo Antonio, Humby, Frances, Stephen Kelly, Bombardieri, M, Pitzalis C., Bombardieri, Michele, Spencer, J, Humby F., Blades M.C., Bombardieri Michele, Humby Frances, Blades Mark C, Kirkham, B, Kirkham Bruce, Manzo, A, Spencer Jo, Spencer J., MANZO, ANTONIO, Pitzalis Costantino, Antonio Manzo, Pitzalis, C, Kirkham B., Jo Spencer, Costantino Pitzalis, Kelly S.   +38 more
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Kidney tertiary lymphoid structures in Lupus Nephritis develop into large interconnected networks and resemble lymph nodes in gene signature [PDF]

, 2020
Immune aggregates organized as tertiary lymphoid structures (TLS) are observed within the kidneys of patients with systemic lupus erythematosus and lupus nephritis (LN).
Figenschau, Stine, Thiyagarajan, Dhivya Borra, Fenton, Kristin Andreassen, Horvei, Kjersti Daae, Dorraji, Seyed Esmaeil, Kanapathippillai, Premasany, Fenton, Christopher Graham, Ursvik, anita, Stenersrød, Mikael Ryan, Pedersen, Hege Lynum, Hovd, Aud-Malin Karlsson   +10 more
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Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source

Tertiary lymphoid organs in inflammatory reaction [PDF]

, 2017
Tertiary lymphoid organs (TLOs) are associated with inflammatory reactions in autoimmune diseases or chronic inflammation. These organized T and B cell aggregates are structurally and functionally similar to secondary lymphoid organs (SLOs). TLOs, due to
Miltrová, Veronika
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