Results 71 to 80 of about 11,902 (192)

Tertiary lymphoid structures in head and neck squamous cell carcinoma

Translational Oncology
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Smoking, drinking, and human papillomavirus (HPV) infection are the main risk factors.
Jing Zhu, Hui Lu, Kongcheng Wang, Baorui Liu, Jing Yan   +4 more
doaj   +1 more source

Effective control of Staphylococcus aureus lung infection despite tertiary lymphoid structure disorganisation

, 2021
International audienceBackground: Tertiary lymphoid structures (TLS) are triggered by persistent bronchopulmonary infection with Staphylococcus aureus, but their roles remain elusive.
Burgel, Pierre-Régis, Teillaud, Jean-Luc, Martin, Clémence, Vicaire, Hugues, Sibéril, Sophie, Regard, Lucile, Ollame-Omvane, Emilie, Lafoeste, Hélène, Ladjemi, Maha Zohra   +8 more
core   +1 more source

Tertiary lymphoid structures, a historical reappraisal

Tissue and Cell
Tertiary lymphoid structures (TLSs) are accumulations of lymphoid cells within non-lymphoid organs that share the cellular compartments, spatial organization, vasculature, chemokines, and function with secondary lymphoid organs, especially lymph nodes. TLSs are organized into a separate T cell and B cell compartments which contain germinal centers with
openaire   +3 more sources

Perivascular Tertiary Lymphoid Structures in Autoimmune Disease

Immunological Reviews
ABSTRACTImmunotherapy of autoimmune diseases has expanded substantially, yet autoimmunity remains incurable, and patients suffer from chronic destructive tissue inflammation that fails to resolve. Mechanisms underlying the endurance of autoimmune memory and the lack of exhaustion are beginning to be understood.
Goronzy, Jörg J., Weyand, Cornelia M.
openaire   +2 more sources

Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology [PDF]

, 2019
Resident fibroblasts at sites of infection, chronic inflammation, or cancer undergo phenotypic and functional changes to support leukocyte migration and, in some cases, aggregation into tertiary lymphoid structures (TLS).
Buckley, Christopher, Buckley, Christopher, D, Fearon, Douglas T, Turner, Jason; id_orcid, Fisher, Benjamin A, Bowman, Simon, J, Smith, CG, Fearon, D.T., Barone, Francesca; id_orcid, Tarte, Karin, Glaysher, B., Tarte, K., Smith, Charlotte, Luther, Sanjiv A, Buckley, Christopher,, Filer, Andrew, Campos, Joana, Nayar, S, Gardner, David, Gardner, D.H., Iannizzotto, Valentina, Asam, S, Asam, S., Coles, Mark C, Asam, Saba, Iannizzotto, V., Mourcin, F., Roulois, D, Buckley, CD, Nayar, Saba, Roulois, David, Sylvestre, Marvin, Coles, Mark, C, Buckley, Christopher D, Luther, Sanjiv, A, Filer, A., Bowman, Simon J., Mourcin, F, Gardner, DH, Smith, Charlotte,, Coles, Mark C., Filer, A, Nayar, S., Mourcin, Frédéric, Bowman, Simon,, Smith, Charlotte G, Glaysher, B, Campos, J, Fearon, DT, Roulois, D., Fisher, Benjamin,, Bowman, SJ, Glaysher, Bridget, Campos, J., Luther, Sanjiv A., Turner, J, Smith, Charlotte, G, Fisher, BA, Iannizzotto, V, Buckley, C.D., Turner, Jason, Luther, SA, Gardner, David,, Fearon, Douglas,, Tarte, K, Gardner, David, H, Coles, M.C., Barone, F., Dias De Campos, Joana, Turner, J., Fearon, Douglas, T, Gardner, David H, Smith, C.G., Fisher, B.A., Barone, Francesca, Bowman, Simon J, Fisher, Benjamin, A, Sylvestre, M, Sylvestre, M., Luther, S.A., Fearon, Douglas T., Coles, MC, Bowman, S.J., Luther, Sanjiv,, Barone, F, Fisher, Benjamin, Coles, Mark,   +86 more
core   +1 more source

Mature tertiary lymphoid structures linked to HPV status and anti-PD-1 based chemoimmunotherapy response in head and neck squamous cell carcinoma

OncoImmunology
Mature tertiary lymphoid structures (TLSs) are immune aggregates associated with immune checkpoint blockade (ICB) responses in various cancers, yet their role in chemoimmunotherapy response in head and neck squamous cell carcinoma (HNSCC) remains unclear.
Lizao Zhang, Siqi Ren, Tianjun Lan, Ventin Marco, Niu Liu, Bin Wei, Yunsheng Chen, Jiaying Wu, Qunxing Li, Fan Wu, Peichia Lu, Jiahao Miao, Hsinyu Lin, Xinhui Wang, Jianglong Zhong, Jinsong Li, Song Fan   +16 more
doaj   +1 more source

Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors

Journal for ImmunoTherapy of Cancer, 2019
Background Programmed cell death 1 inhibitors have revolutionized therapy for cancer by their outstanding effectiveness. However, they may cause adverse effects, among which inflammatory myopathy is one of the most disabling.
Shiro Matsubara, Morinobu Seki, Shigeaki Suzuki, Takashi Komori, Mikio Takamori   +4 more
doaj   +1 more source

Tertiary lymphoid structures in the central nervous system

Trends in Molecular Medicine
Tertiary lymphoid structures (TLSs) frequently occur at sites of chronic inflammation. A more advanced stage of multiple sclerosis (MS) has been associated with certain TLSs. However, tumor-associated TLSs have been shown to correlate with a greater treatment response rate and a better prognosis in glioma mouse models.
Chao Yang, Yu-Xiang Cai, Ze-Fen Wang, Su-Fang Tian, Zhi-Qiang Li   +4 more
openaire   +2 more sources

T Follicular Helper-Like Cells in Inflamed Non-Lymphoid Tissues

Frontiers in Immunology, 2018
T and B cell cooperation normally takes place in secondary lymphoid organs (SLO). However, both cell types are also frequently found in inflamed non-lymphoid tissues.
Andreas Hutloff
doaj   +1 more source

Mature tertiary lymphoid structure associated CD103+ CD8+ Trm cells determined improved anti-tumor immune in breast cancer. [PDF]

Front Oncol
BackgroundAlthough tertiary lymphoid structures (TLS) play crucial roles in the anti-tumor immune response and are associated with favorable prognoses in many solid tumors, the precise mechanisms by which TLSs enhance anti-tumor immunity remain poorly ...
Fang Q, Chen S, Chen X, Zou W, Chen D, Huang Y, Wu C.   +6 more
europepmc   +2 more sources