Estimating selection pressures on HIV-1 using phylogenetic likelihood models [PDF]
Human immunodeficiency virus (HIV-1) can rapidly evolve due to selection pressures exerted by HIV-specific immune responses, antiviral agents, and to allow the virus to establish infection in different compartments in the body. Statistical models applied
Anisimova +47 more
core +1 more source
Background Irrespective of microsatellite status, immune checkpoint inhibitor therapy shows superior efficacy in early-stage colorectal cancer (CRC) compared to advanced cases.
Zixu Chen +9 more
doaj +1 more source
Tertiary lymphoid structures in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Smoking, drinking, and human papillomavirus (HPV) infection are the main risk factors.
Jing Zhu +4 more
doaj +1 more source
Expression of endothelia and lymphocyte adhesion molecules in bronchus-associated lymphoid tissue (BALT) in adult human lung [PDF]
Background Bronchus-associated lymphoid tissue (BALT) is the secondary lymphoid tissue in bronchial mucosa and is involved in the development of bronchopulmonary immune responses.
EC Butcher +51 more
core +1 more source
Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures. [PDF]
Lymphangiogenesis associated with tertiary lymphoid structure (TLS) has been reported in numerous studies. However, the kinetics and dynamic changes occurring to the lymphatic vascular network during TLS development have not been studied.
Barone, F. +14 more
core +2 more sources
Tertiary lymphoid structures, a historical reappraisal
Tertiary lymphoid structures (TLSs) are accumulations of lymphoid cells within non-lymphoid organs that share the cellular compartments, spatial organization, vasculature, chemokines, and function with secondary lymphoid organs, especially lymph nodes. TLSs are organized into a separate T cell and B cell compartments which contain germinal centers with
openaire +3 more sources
Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors
Background Programmed cell death 1 inhibitors have revolutionized therapy for cancer by their outstanding effectiveness. However, they may cause adverse effects, among which inflammatory myopathy is one of the most disabling.
Shiro Matsubara +4 more
doaj +1 more source
An improved ontological representation of dendritic cells as a paradigm for all cell types [PDF]
The Cell Ontology (CL) is designed to provide a standardized representation of cell types for data annotation. Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the ...
Arighi Cecilia, N. +7 more
core
The avian lung-associated immune system [PDF]
The lung is a major target organ for numerous viral and bacterial diseases of poultry. To control this constant threat birds have developed a highly organized lung-associated immune system.
Dalamani, Grammatia +2 more
core +3 more sources
Radiation drives tertiary lymphoid structures to reshape TME for synergized antitumour immunity
Radiotherapy (RT) plays a key role in the tumour microenvironment (TME), impacting the immune response via cellular and humoral immunity. RT can induce local immunity to modify the TME.
Shuling Li +6 more
doaj +1 more source

