Results 81 to 90 of about 11,902 (192)

Tertiary lymphoid structures: new immunotherapy biomarker

Frontiers in Immunology
Immunotherapy shows substantial advancement in cancer and is becoming widely used in clinical practice. A variety of biomarkers have been proposed to predict the efficacy of immunotherapy, but most of them have low predictive ability. Tertiary lymphoid structures (TLSs), the aggregation of multiple lymphocytes, have been found to exist in various tumor
Fangyuan Yang, Jiahe Yang, Meijuan Wu, Cheng Chen, Xiaoyuan Chu, Xiaoyuan Chu   +5 more
openaire   +3 more sources

Radiation drives tertiary lymphoid structures to reshape TME for synergized antitumour immunity

Expert Reviews in Molecular Medicine
Radiotherapy (RT) plays a key role in the tumour microenvironment (TME), impacting the immune response via cellular and humoral immunity. RT can induce local immunity to modify the TME.
Shuling Li, Kuifei Chen, Zhenwei Sun, Meng Chen, Wenhu Pi, Suna Zhou, Haihua Yang   +6 more
doaj   +1 more source

Tertiary lymphoid structures and their therapeutic implications in cancer

Cellular Oncology
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates formed by the structured accumulation of immune cells such as B cells and T cells in non-lymphoid tissues induced by infection, inflammation, and tumors. They play a crucial role in the immune response, particularly in association with tumor development, where they primarily exert anti-
Chen, Xun, Wu, Pan, Liu, Ziqi, Li, Tiansheng, Wu, Jie, Zeng, Zhaoyang, Guo, Wenjia, Xiong, Wei   +7 more
openaire   +2 more sources

Involvement of lymphoid inducer cells in the development of secondary and tertiary lymphoid structure

BMB Reports, 2009
During development lymphoid tissue inducer (LTi) cells are the first hematopoietic cells to enter the secondary lymphoid anlagen and induce lymphoid tissue neogenesis. LTi cells induce lymphoid tissue neogensis by expressing a wide range of proteins that are associated with lymphoid organogenesis.
Isabel, Evans, Mi-Yeon, Kim
openaire   +3 more sources

Tertiary lymphoid structure-associated B cells are key players in anti-tumor immunity

, 2015
It is now admitted that the immune system plays a major role in tumor control. Besides the existence of tumor-specific T cells and B cells, many studies have demonstrated that high numbers of tumor-infiltrating lymphocytes are associated with good ...
Germain, Claire, Gnjatic, Sacha, Sacha Gnjatic, Claire eGermain, Claire Germain, Sacha eGnjatic, Dieu-Nosjean, Marie-Caroline, Marie-Caroline eDieu-Nosjean, Marie-Caroline Dieu-Nosjean   +8 more
core   +1 more source

Trigger inducible tertiary lymphoid structure formation using covalent organic frameworks for cancer immunotherapy. [PDF]

Nat Commun
The discovery of tertiary lymphoid structures (TLS) within tumor tissues provides a promising avenue to promote the efficacy of cancer immunotherapy. Yet, the lack of effective strategies to induce TLS formation poses a substantial obstacle.
Zhang L, Zhang B, Zhang MJ, Li W, Li H, Jiao Y, Yang QC, Wang S, Liu YT, Song A, Feng HT, Sun J, Kwok RTK, Lam JWY, Tang BZ, Sun ZJ.   +15 more
europepmc   +2 more sources

Constructing a prognostic model for colon cancer: insights from immunity-related genes

BMC Cancer
Background Colon cancer (CC) is a malignancy associated with significant morbidity and mortality within the gastrointestinal tract. Recurrence and metastasis are the main factors affecting the prognosis of CC patients undergoing radical surgery ...
Ansu Li, Qi Li, Chaoshan Wang, Xue Bao, Feng Sun, Xiaoping Qian, Wu Sun   +6 more
doaj   +1 more source

Biological mechanisms of ectopic lymphoid structure formation and their pathophysiological significance

, 2021
Ectopic lymphoid structures (ELS) or tertiary lymphoid organs are structures with the organization similar to the one of secondary lymphoid organs, formed in non-lymphoid tissues.
Marinković, Tatjana, Marinković, Dragan   +1 more
core   +1 more source

An MRI-based model for preoperative prediction of tertiary lymphoid structures in patients with gallbladder cancer

Insights into Imaging
Objectives To predict tertiary lymphoid structures (TLSs) in gallbladder cancer (GBC) using preoperative magnetic resonance imaging (MRI)-based radiomics. Methods Patients with GBC from two centres served as training (n = 129) and external validation (n =
Ying Xu, Zhuo Li, Weihua Zhi, Yi Yang, Jingzhong Ouyang, Yanzhao Zhou, Zeliang Ma, Sicong Wang, Lizhi Xie, Jianming Ying, Jinxue Zhou, Xinming Zhao, Feng Ye   +12 more
doaj   +1 more source

Adventitial inflammation and its interaction with intimal atherosclerotic lesions

Frontiers in Physiology, 2014
The presence of adventitial inflammation in correlation with atherosclerotic lesions has been recognized for decades. In the last years, several studies have investigated the relevance and impact of adventitial inflammation on atherogenesis.
Mohammadreza eAkhavanpoor, Susanne eWangler, Christian Albert Gleissner, Grigorios eKorosoglou, Hugo Albert Katus, Christian eErbel   +5 more
doaj   +1 more source