Results 81 to 90 of about 7,278,692 (246)

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Tertiary lymphoid organs in systemic autoimmune diseases:  pathogenic or protective?

, 2017
Tertiary lymphoid organs are found at sites of chronic inflammation in autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.
Dragos C. Dasoveanu, Theresa T. Lu, William D. Shipman   +2 more
core   +1 more source

Radiation drives tertiary lymphoid structures to reshape TME for synergized antitumour immunity

Expert Reviews in Molecular Medicine
Radiotherapy (RT) plays a key role in the tumour microenvironment (TME), impacting the immune response via cellular and humoral immunity. RT can induce local immunity to modify the TME.
Shuling Li, Kuifei Chen, Zhenwei Sun, Meng Chen, Wenhu Pi, Suna Zhou, Haihua Yang   +6 more
doaj   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Gender and the tertiary music curriculum in Australia

, 2007
The paper argues that women's music continues to be excluded in tertiary music curricula, translating into the virtual absence of their music on concert platforms.
Macarthur, Sally
core  

Tertiary intratumor lymphoid tissue in colo-rectal cancer [PDF]

, 2012
Ectopic (or tertiary) lymphoid tissue develops at sites of inflammation or infection in non lymphoid organs and is associated with chronic inflammation. In colon mucosa, small lymphoid aggregates are already present in homeostatic conditions, as part of ...
Bergomas F., Marchesi F., Grizzi F., Doni A., Pesce S., Laghi L., Allavena P., Mantovani A.   +7 more
core   +2 more sources

Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors

Journal for ImmunoTherapy of Cancer, 2019
Background Programmed cell death 1 inhibitors have revolutionized therapy for cancer by their outstanding effectiveness. However, they may cause adverse effects, among which inflammatory myopathy is one of the most disabling.
Shiro Matsubara, Morinobu Seki, Shigeaki Suzuki, Takashi Komori, Mikio Takamori   +4 more
doaj   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Tertiary lymphoid organs in infection and autoimmunity

, 2012
The lymph nodes (LNs) and spleen have an optimal structure that allows the interaction between T cells, B cells and antigen-presenting dendritic cells (DCs) on a matrix made up by stromal cells.
Perros, F, Geurts van Kessel, Corine; id_orcid, Lambrecht, Bart, Perros, Frédéric, Hammad, H (Hamida), GeurtsvanKessel, Corine H, Hammad, Hamida, Neyt, K, Geurts van Kessel, Corine, Neyt, Katrijn   +9 more
core   +1 more source

Constructing a prognostic model for colon cancer: insights from immunity-related genes

BMC Cancer
Background Colon cancer (CC) is a malignancy associated with significant morbidity and mortality within the gastrointestinal tract. Recurrence and metastasis are the main factors affecting the prognosis of CC patients undergoing radical surgery ...
Ansu Li, Qi Li, Chaoshan Wang, Xue Bao, Feng Sun, Xiaoping Qian, Wu Sun   +6 more
doaj   +1 more source