Results 81 to 90 of about 11,725 (256)

T Follicular Helper-Like Cells in Inflamed Non-Lymphoid Tissues

Frontiers in Immunology, 2018
T and B cell cooperation normally takes place in secondary lymphoid organs (SLO). However, both cell types are also frequently found in inflamed non-lymphoid tissues.
Andreas Hutloff
doaj   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Constructing a prognostic model for colon cancer: insights from immunity-related genes

BMC Cancer
Background Colon cancer (CC) is a malignancy associated with significant morbidity and mortality within the gastrointestinal tract. Recurrence and metastasis are the main factors affecting the prognosis of CC patients undergoing radical surgery ...
Ansu Li, Qi Li, Chaoshan Wang, Xue Bao, Feng Sun, Xiaoping Qian, Wu Sun   +6 more
doaj   +1 more source

Single-cell and spatial landscape reveals impaired tertiary lymphoid structure maturation in Helicobacter pylori–associated gastric cancer

Frontiers in Immunology
BackgroundTertiary lymphoid structures (TLSs) are key immune niches involved in antitumor immunity. However, their functional impact depends on spatial localization, maturation status, and cellular composition within the tumor immune microenvironment ...
Nenglin Zhang, Qiuyu Jiang, Qian Ma, Haisheng Huang, Lijie Ma, Shuping Zhou   +5 more
doaj   +1 more source

Tertiary lymphoid structures: new immunotherapy biomarker

Frontiers in Immunology
Immunotherapy shows substantial advancement in cancer and is becoming widely used in clinical practice. A variety of biomarkers have been proposed to predict the efficacy of immunotherapy, but most of them have low predictive ability. Tertiary lymphoid structures (TLSs), the aggregation of multiple lymphocytes, have been found to exist in various tumor
Fangyuan Yang, Jiahe Yang, Meijuan Wu, Cheng Chen, Xiaoyuan Chu, Xiaoyuan Chu   +5 more
openaire   +3 more sources

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

An MRI-based model for preoperative prediction of tertiary lymphoid structures in patients with gallbladder cancer

Insights into Imaging
Objectives To predict tertiary lymphoid structures (TLSs) in gallbladder cancer (GBC) using preoperative magnetic resonance imaging (MRI)-based radiomics. Methods Patients with GBC from two centres served as training (n = 129) and external validation (n =
Ying Xu, Zhuo Li, Weihua Zhi, Yi Yang, Jingzhong Ouyang, Yanzhao Zhou, Zeliang Ma, Sicong Wang, Lizhi Xie, Jianming Ying, Jinxue Zhou, Xinming Zhao, Feng Ye   +12 more
doaj   +1 more source

Tertiary lymphoid structures and their therapeutic implications in cancer

Cellular Oncology
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates formed by the structured accumulation of immune cells such as B cells and T cells in non-lymphoid tissues induced by infection, inflammation, and tumors. They play a crucial role in the immune response, particularly in association with tumor development, where they primarily exert anti-
Chen, Xun, Wu, Pan, Liu, Ziqi, Li, Tiansheng, Wu, Jie, Zeng, Zhaoyang, Guo, Wenjia, Xiong, Wei   +7 more
openaire   +2 more sources

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source