Results 81 to 90 of about 25,496 (206)

Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]

, 2008
Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad, Daley, George, Gray, Nathanael, KURIYAN, John, Seeliger, Markus   +4 more
core   +1 more source

Tertiary Lymphoid Structures in Microorganism-Related Cancer

Cancers
Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues formed by the accumulation of lymphocytes and other components outside lymphoid organs. They have been shown to be widespread in cancers and have predictive effects on prognosis and immunotherapy efficacy; however, there is no standardized measurement guide.
Shuzhe Deng, Xinxin Yang, Lin He, Yunjing Hou, Hongxue Meng   +4 more
openaire   +2 more sources

Constructing a prognostic model for colon cancer: insights from immunity-related genes

BMC Cancer
Background Colon cancer (CC) is a malignancy associated with significant morbidity and mortality within the gastrointestinal tract. Recurrence and metastasis are the main factors affecting the prognosis of CC patients undergoing radical surgery ...
Ansu Li, Qi Li, Chaoshan Wang, Xue Bao, Feng Sun, Xiaoping Qian, Wu Sun   +6 more
doaj   +1 more source

T Follicular Helper-Like Cells in Inflamed Non-Lymphoid Tissues

Frontiers in Immunology, 2018
T and B cell cooperation normally takes place in secondary lymphoid organs (SLO). However, both cell types are also frequently found in inflamed non-lymphoid tissues.
Andreas Hutloff
doaj   +1 more source

Nutrigenomics and immune function in fish : new insights from omics technologies [PDF]

, 2017
This study was funded by BBSRC grant BB/M026604/1.Peer reviewedPublisher ...
Krol, Elzbieta, Martin, Samuel A. M.
core   +1 more source

An MRI-based model for preoperative prediction of tertiary lymphoid structures in patients with gallbladder cancer

Insights into Imaging
Objectives To predict tertiary lymphoid structures (TLSs) in gallbladder cancer (GBC) using preoperative magnetic resonance imaging (MRI)-based radiomics. Methods Patients with GBC from two centres served as training (n = 129) and external validation (n =
Ying Xu, Zhuo Li, Weihua Zhi, Yi Yang, Jingzhong Ouyang, Yanzhao Zhou, Zeliang Ma, Sicong Wang, Lizhi Xie, Jianming Ying, Jinxue Zhou, Xinming Zhao, Feng Ye   +12 more
doaj   +1 more source

C‐Reactive Protein to Lymphocyte Ratio (CLR) and Lactate Dehydrogenase to Albumin Ratio (LAR) as Prognostic Biomarkers in Acral Melanoma: Association With Tertiary Lymphoid Structures and Immune Cell Infiltration

Cancer Medicine
Objective To investigate the correlation between peripheral blood CRP‐to‐lymphocyte ratio (CLR) and lactate dehydrogenase‐to‐albumin ratio (LAR) levels, prognosis, and the tumor microenvironment (TME) in patients with acral melanoma (AM), with a focus on
Donglin Kang, Xinyu Su, Jiayu Wang, Lianjun Zhao, Rong Huang, Zhengyun Zou   +5 more
doaj   +1 more source

Subtractive isolation of phage-displayed single-chain antibodies to thymic stromal cells by using intact thymic fragments [PDF]

, 1997
In the murine thymus, the stroma forms microenvironments that control different steps in T cell development. To study the architecture of such microenvironments and more particularly the nature of communicative signals in lympho–stromal interaction ...
Berendes, P.B. (Paul), Ewijk, W. (Willem) van, Germeraad, W.T.V. (Wilfred), Kruif, J. (John) de, Logtenberg, T. (Ton), Platenburg, P.P. (Peter Paul), Röpke, C. (Carsten)   +6 more
core   +3 more sources

Mature tertiary lymphoid structures linked to HPV status and anti-PD-1 based chemoimmunotherapy response in head and neck squamous cell carcinoma

OncoImmunology
Mature tertiary lymphoid structures (TLSs) are immune aggregates associated with immune checkpoint blockade (ICB) responses in various cancers, yet their role in chemoimmunotherapy response in head and neck squamous cell carcinoma (HNSCC) remains unclear.
Lizao Zhang, Siqi Ren, Tianjun Lan, Ventin Marco, Niu Liu, Bin Wei, Yunsheng Chen, Jiaying Wu, Qunxing Li, Fan Wu, Peichia Lu, Jiahao Miao, Hsinyu Lin, Xinhui Wang, Jianglong Zhong, Jinsong Li, Song Fan   +16 more
doaj   +1 more source

Proinflammatory bacterial peptidoglycan as a cofactor for the development of central nervous system autoimmune disease [PDF]

, 2005
Upon stimulation by microbial products through TLR, dendritic cells (DC) acquire the capacity to prime naive T cells and to initiate a proinflammatory immune response.
Boven, L.A. (Leonie), Heer, H.J. de, Laman, J.D. (Jon), Lambrecht, B.N.M. (Bart), Melief, M.J. (Marie-José), Meurs, M. (Marjan) van, Nieuwenhuis, E.E.S. (Edward), Riel, D.A.J. (Debby) van, Strijp, J. van, Visser, L. (Lizette), Zahringer, U.   +10 more
core   +2 more sources