Results 61 to 70 of about 11,902 (192)

Lymphoid aggregates in desmoplastic melanoma have features of tertiary lymphoid structures [PDF]

Melanoma Research, 2018
Desmoplastic melanomas (DM) have unique and challenging clinical presentations and histomorphology. A characteristic feature is the presence of scattered lymphoid aggregates. However, the nature of these aggregates is not defined. We hypothesized that they may be tertiary lymphoid structures (TLS), and may be associated with programmed death ligand 1 ...
Anne M, Stowman, Alexandra W, Hickman, Ileana S, Mauldin, Adela, Mahmutovic, Alejandro A, Gru, Craig L, Slingluff   +5 more
openaire   +2 more sources

Intratumoral tertiary lymphoid structure (TLS) maturation is influenced by draining lymph nodes of lung cancer

, 2023
Background Tertiary lymphoid structure (TLS) is an organized infiltration of immune cells, showing features of germinal center (GC) commonly seen in secondary lymphoid organs. However, its relationship with tumor-draining lymph nodes (TDLNs) has not been
Caichen Li, Zisheng Chen, Qihua He, Miao He, Wenhua Liang, Jianxing He, Jun Liu, Jianfu Li, Hongshen Deng, Haoxin Peng, Feng Li, Yi Lu, Ran Zhong, Shen Lao, Xiuyu Cai, Xiangrong Wu   +15 more
core   +1 more source

T cell exhaustion initiates tertiary lymphoid structures and turbocharges cancer-immunity cycle

EBioMedicine
Summary: Immune therapies represented by immune checkpoint blockade (ICB) have significantly transformed cancer treatment. However, the effectiveness of these treatments depends on the status of T cells.
Wen-Ping Lin, Hao Li, Zhi-Jun Sun
doaj   +1 more source

Tertiary lymphoid structures in ovarian cancer

Frontiers in Immunology
Ovarian cancer (OC) is a significant cause of cancer-related mortality in women worldwide. Despite advances in treatment modalities, including surgery and chemotherapy, the overall prognosis for OC patients remains poor, particularly for patients with advanced or recurrent disease.
Guojuan Sun, Yi Liu
openaire   +3 more sources

DataSheet_1_Combination of Tertiary Lymphoid Structure and Neutrophil-to-Lymphocyte Ratio Predicts Survival in Patients With Hepatocellular Carcinoma.docx

, 2022
BackgroundHepatocellular carcinoma (HCC) is the most common pathological type of primary liver cancer. The lack of prognosis indicators is one of the challenges in HCC.
Yuzhong Chen (1556500), Xiaoyue Du (1624822), Yun Chen (279569), Bo Shen (419737), Qingbo Wang (8561751), Chupeng Hu (6710015), Jingwei Xia (10801584), Xin Wang (91924), Wei Zhu (23646), Miaolin Zhu (11940524), Shaodi Wen (10801581)   +10 more
core   +1 more source

CD169+ Macrophages in Primary Breast Tumors Associate with Tertiary Lymphoid Structures, Tregs and a Worse Prognosis for Patients with Advanced Breast Cancer [Elektronisk resurs]

, 2023
The presence of CD169+ macrophages in the draining lymph nodes of cancer patients is, for unknown reasons, associated with a beneficial prognosis. We here investigated the prognostic impact of tumor-infiltrating CD169+ macrophages in primary tumors (PTs)
Leandersson, Karin,, Källberg, Eva,, Kimbung, Siker,, Stenström, Jenny,, Hedenfalk, Ingrid,, Veerla, Srinivas,, Hatschek, Thomas,, Briem, Oscar,, Lund University., Hagerling, Catharina,   +9 more
core   +2 more sources

Advances on tumor-associated tertiary lymphoid structures in immunotherapy

生物医学转化
Tertiary lymphoid structures (TLS) are ectopic lymphoid structures found in non-lymphoid tissues under chronic inflammatory conditions in recent years.
Hu Chupeng, Chen Yun
doaj   +1 more source

Distinct Tertiary Lymphoid Structure Associations and Their Prognostic Relevance in HER2 Positive and Negative Breast Cancers

, 2017
Background The presence of tumor infiltrating lymphocytes (TIL) is associated with favorable prognosis. Recent evidence suggested that not only their density, but also the spatial organization as tertiary lymphoid structures (TLS), play
Thazin Hlaing, Yun-Bi Ni, Sai Yin Cheung, Jintao Hu, Siu Ki Chan, Julia Y.S. Tsang, Gary M. Tse, Xia Liu   +7 more
core   +1 more source

Dynamics of tertiary lymphoid structures and immune cross talk in early versus advanced colorectal cancer: potential implications for immunotherapy

Cancer Immunology, Immunotherapy
Background Irrespective of microsatellite status, immune checkpoint inhibitor therapy shows superior efficacy in early-stage colorectal cancer (CRC) compared to advanced cases.
Zixu Chen, Bang Hu, Keyu Cai, Han Gao, Zhenyu Xian, Shuang Zhang, Zhen Fang, Qian Zhou, Donglin Ren, Qi Zou   +9 more
doaj   +1 more source

Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice.

, 2021
BACKGROUND AND AIMS: The presence of tertiary lymphoid structures (TLSs) may confer survival benefit to patients with pancreatic ductal adenocarcinoma (PDAC), in an otherwise immunologically inert malignancy.
Hemant M. Kocher, Marina Roy-Luzarraga, Fincham, REA, Spear, S, Balkwill, FR, John G. Gribben, Rachel E.A. Fincham, Sarah Spear, Roy-Luzarraga, M, Kairbaan Hodivala-Dilke, Hodivala-Dilke, K, Michele Bombardieri, Kocher, HM, Capasso, M, Clear, A, Melania Capasso, Delvecchio, FR, Francesca R. Delvecchio, Andrew Clear, Frances R. Balkwill, Bombardieri, M, Gribben, JG   +21 more
core   +1 more source