Results 11 to 20 of about 11,725 (256)
Tertiary lymphoid structures in colorectal cancer
Annals of MedicineBackground Tertiary lymphoid structures (TLS) are ectopic clusters of immune cells found in non-lymphoid tissues, particularly within the tumor microenvironment (TME).
Jianyu Lv +5 more
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Heterogeneity of tertiary lymphoid structures in cancer
Frontiers in Immunology, 2023 The success of immunotherapy approaches, such as immune checkpoint blockade and cellular immunotherapy with genetically modified lymphocytes, has firmly embedded the immune system in the roadmap for combating cancer. Unfortunately, the majority of cancer patients do not yet benefit from these therapeutic approaches, even when the prognostic relevance ...
Xin You +5 more
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Chinese Journal of Lung Cancer, 2023 Lung cancer is the leading cause of cancer death, and non-small cell lung cancer (NSCLC) accounts for 85%. Immunotherapy has significantly improved the clinical prognosis of patients with NSCLC. However, because of the complexity and heterogeneousness of
Ying LIU +6 more
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The Impact of Programmed Cell Death on the Formation of Tertiary Lymphoid Structures
Frontiers in Immunology, 2021 Tertiary lymphoid structures are clusters of lymphoid tissue that develop post-natally at sites of chronic inflammation. They have been described in association with infection, autoimmune disorders, cancer, and allograft rejection. In their mature stage,
Mélanie Dieudé +8 more
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Frontiers in Immunology, 2021 Tertiary lymphoid structures (TLS) are ectopically formed aggregates of organized lymphocytes and antigen-presenting cells that occur in solid tissues as part of a chronic inflammation response.
Shota Aoyama +4 more
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Tertiary Lymphoid Structures and Cancer Prognosis (Brief Review)
Креативная хирургия и онкология, 2020 This brief review is devoted to the role of tertiary lymphoid structures in oncological processes. A number of research studies carried out over the past ten years have shed light on the functions of such structures in various diseases, as well as their ...
R. A. Rustamkhanov +2 more
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Tertiary lymphoid structures in pancreatic cancer: a new target for immunotherapy
Frontiers in Immunology, 2023 Pancreatic cancer (PC) is extremely malignant and shows limited response to available immunotherapies due to the hypoxic and immunosuppressive nature of its tumor microenvironment (TME). The aggregation of immune cells (B cells, T cells, dendritic cells,
Xinlei Zou +5 more
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Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer
Frontiers in Immunology, 2023 Tertiary lymphoid structures (TLS) are lymph node-like aggregates that can form in association with chronic inflammation or cancer. Mature TLS are organized into B and T cell zones, and are not encapsulated but include all cell types necessary for eliciting an adaptive immune response.
Vaccaro, Alessandra +4 more
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Tertiary lymphoid structures and gastric cancer prognosis
APMIS, 2022 Tertiary lymphoid structures (TLSs) are part of immune response against cancer. Their high density and high diameter have been shown to be associated with prognosis in different cancer types. The aim of this study was to examine the prognostic significance of TLS density and diameter in gastric cancer and reproducibility of their assessments.
Kemi, N. (Niko) +7 more
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Current Clinical and Pre-Clinical Imaging Approaches to Study the Cancer-Associated Immune System
Frontiers in Immunology, 2021 In the light of the success and the expected growth of its arsenal, immuno-therapy may become the standard neoadjuvant procedure for many cancers in the near future.
Christopher G. Mueller +3 more
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