Results 11 to 20 of about 7,278,692 (246)

Tertiary Lymphoid Structures and Cancer Prognosis (Brief Review) [PDF]

Креативная хирургия и онкология, 2020
This brief review is devoted to the role of tertiary lymphoid structures in oncological processes. A number of research studies carried out over the past ten years have shed light on the functions of such structures in various diseases, as well as their ...
R. A. Rustamkhanov, K. Sh. Gantsev, D. S. Tursumetov   +2 more
doaj   +2 more sources

Molecular and spatial analysis of tertiary lymphoid structures in Sjogren’s syndrome [PDF]

Nature Communications
Tertiary lymphoid structures play important roles in autoimmune and non-autoimmune conditions. While many of the molecular mechanisms involved in tertiary lymphoid structure formation have been identified, the cellular sources and temporal and spatial ...
Saba Nayar, Jason D. Turner, Saba Asam, Eanna Fennell, Matthew Pugh, Serena Colafrancesco, Onorina Berardicurti, Charlotte G. Smith, Joe Flint, Ana Teodosio, Valentina Iannizzotto, David H. Gardner, Joel van Roon, Ilya Korsunsky, Dawn Howdle, Roche Fibroblast Network Consortium, Andreas P. Frei, Kara G. Lassen, Simon J. Bowman, Wan-Fai Ng, Adam P. Croft, Andrew Filer, Benjamin A. Fisher, Christopher D. Buckley, Francesca Barone   +24 more
doaj   +9 more sources

Single-cell and spatial landscape reveals impaired tertiary lymphoid structure maturation in <i>Helicobacter pylori</i>-associated gastric cancer. [PDF]

Front Immunol
BackgroundTertiary lymphoid structures (TLSs) are key immune niches involved in antitumor immunity. However, their functional impact depends on spatial localization, maturation status, and cellular composition within the tumor immune microenvironment ...
Zhang N, Jiang Q, Ma Q, Huang H, Ma L, Zhou S.   +5 more
europepmc   +2 more sources

Exploring effects of gut microbiota on tertiary lymphoid structure formation for tumor immunotherapy. [PDF]

Front Immunol
Anti-tumor immunity, including innate and adaptive immunity is critical in inhibiting tumorigenesis and development of tumor. The adaptive immunity needs specific lymph organs such as tertiary lymphoid structures (TLSs), which are highly correlated with ...
Liu Y, Li F, Wang J, Yang R.
europepmc   +2 more sources

Tertiary lymphoid structures in pulmonary granulomas of cattle experimentally infected with aerosolized Mycobacterium bovis

BMC Veterinary Research
Mycobacterium bovis is the primary cause of tuberculosis in animals, most notably cattle. In cattle and other susceptible hosts, the hallmark lesion of tuberculosis is the granuloma.
Mitchell V. Palmer, Douglas E. Jones, Nicholas J. Bockenstedt, Paola M. Boggiatto   +3 more
doaj   +2 more sources

The pivotal role of tertiary lymphoid structures in the tumor immune microenvironment

Frontiers in Oncology
Tertiary lymphoid structures (TLS) are ectopic lymphoid structures that form in non-lymphoid tissues in response to chronic inflammatory stimulation. Structurally and functionally resembling lymph nodes, TLS are primarily composed of B cells, T cells ...
Chengsen Liu, Jiandong Cao
doaj   +3 more sources

The gene signature of tertiary lymphoid structures within ovarian cancer predicts the prognosis and immunotherapy benefit

Frontiers in Genetics, 2023
Ovarian cancer (OC) has the lowest survival rate among gynecologic malignancies. Ectopic lymphocyte aggregates, namely tertiary lymphoid structures (TLSs), have been reported as positive biomarkers for tumor prognosis. However, the related gene signature
Yue Hou, Yue Hou, Yue Hou, Yue Hou, Sijing Qiao, Sijing Qiao, Sijing Qiao, Sijing Qiao, Miao Li, Miao Li, Miao Li, Miao Li, Xue Han, Xue Han, Xue Han, Xue Han, Xuan Wei, Xuan Wei, Xuan Wei, Xuan Wei, Yingxin Pang, Yingxin Pang, Yingxin Pang, Yingxin Pang, Hongluan Mao, Hongluan Mao, Hongluan Mao, Hongluan Mao   +27 more
doaj   +1 more source

Expression of lymphoid structure-associated cytokine/chemokine gene transcripts in tumor and protein in serum are prognostic of melanoma patient outcomes

Frontiers in Immunology, 2023
BackgroundProinflammatory chemokines/cytokines support development and maturation of tertiary lymphoid structures (TLS) within the tumor microenvironment (TME).
Lilit Karapetyan, Hassan M. AbuShukair, Aofei Li, Andrew Knight, Ayah Nedal Al Bzour, Ian P. MacFawn, Zachary J. Thompson, Ann Chen, Xi Yang, Rebekah Dadey, Arivarasan Karunamurthy, Danielle Vargas De Stefano, Cindy Sander, Sheryl R. Kunning, Yana G. Najjar, Diwakar Davar, Jason J. Luke, William Gooding, Tullia C. Bruno, Tullia C. Bruno, John M. Kirkwood, John M. Kirkwood, Walter J. Storkus, Walter J. Storkus   +23 more
doaj   +1 more source

Tumor-Associated Tertiary Lymphoid Structures: From Basic and Clinical Knowledge to Therapeutic Manipulation

Frontiers in Immunology, 2021
The tumor microenvironment is a complex ecosystem almost unique to each patient. Most of available therapies target tumor cells according to their molecular characteristics, angiogenesis or immune cells involved in tumor immune-surveillance ...
Charlotte Domblides, Charlotte Domblides, Charlotte Domblides, Juliette Rochefort, Juliette Rochefort, Juliette Rochefort, Juliette Rochefort, Juliette Rochefort, Clémence Riffard, Clémence Riffard, Clémence Riffard, Marylou Panouillot, Marylou Panouillot, Marylou Panouillot, Géraldine Lescaille, Géraldine Lescaille, Géraldine Lescaille, Géraldine Lescaille, Géraldine Lescaille, Jean-Luc Teillaud, Jean-Luc Teillaud, Jean-Luc Teillaud, Véronique Mateo, Véronique Mateo, Véronique Mateo, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean   +27 more
doaj   +1 more source

Recent Progress of Tertiary Lymphoid Structure in Prognosis and Immunotherapy of Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2023
Lung cancer is the leading cause of cancer death, and non-small cell lung cancer (NSCLC) accounts for 85%. Immunotherapy has significantly improved the clinical prognosis of patients with NSCLC. However, because of the complexity and heterogeneousness of
Ying LIU, Lei XIONG, Ruoxue CAI, Yue CHEN, Jinjun YE, Bo SHEN, Guoren ZHOU   +6 more
doaj   +1 more source