Results 11 to 20 of about 11,902 (192)
STINGing the Tumor Microenvironment to Promote Therapeutic Tertiary Lymphoid Structure Development
Frontiers in Immunology, 2021 Tertiary lymphoid structures (TLS), also known as ectopic lymphoid structures (ELS) or tertiary lymphoid organs (TLO), represent a unique subset of lymphoid tissues noted for their architectural similarity to lymph nodes, but which conditionally form in ...
Jessica N. Filderman +7 more
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Mechanisms of tertiary lymphoid structure formation: cooperation between inflammation and antigenicity [PDF]
Frontiers in Immunology, 2023 To mount an effective anti-tumor immune response capable of controlling or eliminating disease, sufficient numbers of lymphocytes must be recruited to malignant tissue and allowed to sustain their effector functions.
Shrijan Khanal +2 more
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Cellular and Vascular Components of Tertiary Lymphoid Structures
, 2018 Inflammatory immune cells recruited at the site of chronic inflammation form structures that resemble secondary lymphoid organs (SLO). These are characterized by segregated areas of prevalent T- or B-cell aggregation, differentiation of high endothelial venules, and local activation of resident stromal cells, including lymphatic endothelial cells.
Christopher George, Mueller +3 more
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Frontiers in Genetics, 2023 Ovarian cancer (OC) has the lowest survival rate among gynecologic malignancies. Ectopic lymphocyte aggregates, namely tertiary lymphoid structures (TLSs), have been reported as positive biomarkers for tumor prognosis. However, the related gene signature
Yue Hou +27 more
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Frontiers in Immunology, 2023 BackgroundProinflammatory chemokines/cytokines support development and maturation of tertiary lymphoid structures (TLS) within the tumor microenvironment (TME).
Lilit Karapetyan +23 more
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Heterogeneity of tertiary lymphoid structures in cancer
Frontiers in Immunology, 2023 The success of immunotherapy approaches, such as immune checkpoint blockade and cellular immunotherapy with genetically modified lymphocytes, has firmly embedded the immune system in the roadmap for combating cancer. Unfortunately, the majority of cancer patients do not yet benefit from these therapeutic approaches, even when the prognostic relevance ...
Xin You +5 more
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Chinese Journal of Lung Cancer, 2023 Lung cancer is the leading cause of cancer death, and non-small cell lung cancer (NSCLC) accounts for 85%. Immunotherapy has significantly improved the clinical prognosis of patients with NSCLC. However, because of the complexity and heterogeneousness of
Ying LIU +6 more
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Frontiers in Immunology, 2021 The tumor microenvironment is a complex ecosystem almost unique to each patient. Most of available therapies target tumor cells according to their molecular characteristics, angiogenesis or immune cells involved in tumor immune-surveillance ...
Charlotte Domblides +27 more
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The Impact of Programmed Cell Death on the Formation of Tertiary Lymphoid Structures
Frontiers in Immunology, 2021 Tertiary lymphoid structures are clusters of lymphoid tissue that develop post-natally at sites of chronic inflammation. They have been described in association with infection, autoimmune disorders, cancer, and allograft rejection. In their mature stage,
Mélanie Dieudé +8 more
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Frontiers in Immunology, 2021 Tertiary lymphoid structures (TLS) are ectopically formed aggregates of organized lymphocytes and antigen-presenting cells that occur in solid tissues as part of a chronic inflammation response.
Shota Aoyama +4 more
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