Results 71 to 80 of about 4,240 (183)

Tertiary Lymphoid Structures as Predictors of Recurrence in Colorectal Cancer: Development and Validation of a Machine Learning‐Based Scoring Model

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Background Tertiary lymphoid structures (TLS) are prognostic immune aggregates in the tumor microenvironment, but the value of location‐specific TLS features for predicting colorectal cancer (CRC) recurrence remains unclear. This study developed and internally validated a machine‐learning (ML) model integrating TLS features for recurrence ...
Xian‐Hua Lei, Rong Li, Dong‐Mei Wang, Li Liu, Zhi‐Qiang Wang, Hui‐Juan Li   +5 more
wiley   +1 more source

TP53 Mutation and Tumor‐Infiltrating Lymphocytes as Predictors of PD‐1/PD‐L1 Inhibitor Efficacy in PD‐L1‐High Advanced NSCLC

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Programmed death‐ligand 1 (PD‐L1) expression is widely used to guide immune checkpoint inhibitor (ICI) therapy in advanced nonsmall cell lung cancer (NSCLC); however, substantial heterogeneity in clinical outcomes persists among patients with high PD‐L1 expression.
Hui Yan, Qian Xu, Yushuang Zheng, Meng Shen, Dapeng Li   +4 more
wiley   +1 more source

Tertiary lymphoid structure-associated B cells are key players in anti-tumor immunity

Frontiers in Immunology, 2015
It is now admitted that the immune system plays a major role in tumor control. Besides the existence of tumor-specific T cells and B cells, many studies have demonstrated that high numbers of tumor-infiltrating lymphocytes are associated with good ...
Claire eGermain, Sacha eGnjatic, Marie-Caroline eDieu-Nosjean   +2 more
doaj   +1 more source

The Dual Role of the Gut Microbiota in Cancer Chemoresistance

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Comparison between Microbiota and Cancer therapy. ABSTRACT Chemoresistance is one of the primary reasons that cancer chemotherapy fails to deliver successful treatment outcomes and contributes to poor overall survival rates for patients with cancer. New research has begun to shed light on the effects of the gut microbiome (GM).
Hamed Tahmasebi, Aisa Bahar, Meisam Khazaei, Mohammad Reza Arabestani   +3 more
wiley   +1 more source

Turning Cold Tumors Into Hot Tumors: Implications for Cancer Therapy

MedComm, Volume 7, Issue 8, August 2026.
Barrier‐defined strategies for cold‐to‐hot tumor conversion. Cold tumors include immune‐desert and immune‐excluded states marked by poor antigen visibility, limited T‐cell priming, stromal or vascular exclusion, metabolic stress and suppressive immune programs.
Xiao Ge, Dong Han, Jing Wang, Xinyu Dai, Chen Ma, Feihong Chen   +5 more
wiley   +1 more source

Multiple mechanisms and applications of tertiary lymphoid structures and immune checkpoint blockade

Journal of Experimental & Clinical Cancer Research
Background Immune checkpoint blockade (ICB) inhibits tumor immune escape and has significantly advanced tumor therapy. However, ICB benefits only a minority of patients treated and may lead to many immune-related adverse events.
Zelin Li, Shuhan Liu, Deyu Liu, Kangping Yang, Jing Xiong, Ziling Fang   +5 more
doaj   +1 more source

TLS as Predictors and Targets in Neoadjuvant Chemoimmunotherapy for NSCLC

Thoracic Cancer, Volume 17, Issue 16, August 2026.
TLS in lung cancer adjuvant therapy: (A) cellular composition (T/B cells, DCs); (B) mechanistic pathways (antigen presentation, GC‐like B responses, TRM maintenance); (C) clinical evaluation (IHC, digital pathology, spatial transcriptomics); (D) future directions (dynamic monitoring, intercellular interactions, multicenter trials, clinical translation).
Zhiqi Li, Lina Zhang, Yujie Dong, Ling Yi, Weiying Li, Jinghui Wang, Yuanming Pan   +6 more
wiley   +1 more source

Age‐Associated B Cells: Origins, Regulation, and Tissue‐Specific Pathogenic Contributions in Autoimmune, Metabolic, and Neurological Diseases

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Age‐associated B cells (ABCs) are a distinct B cell population characterized by coexpression of T‐bet and CD11c. First described in aged female mice and autoimmune‐prone strains, ABCs are now recognized to be associated with multiple human autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis,
Kira Rubtsova
wiley   +1 more source

From mechanisms to therapy: the role of tertiary lymphoid structures in bladder cancer

World Journal of Surgical Oncology
Tertiary lymphoid structures (TLS) are ectopic lymphoid tissues that form within the tumor microenvironment (TME) and play a crucial role in anti-tumor immunity.
Jinshan Yang, Xinxin Li, Hao Xie, Jiahao Guo, Jiahui Wang, Chunhua Lin   +5 more
doaj   +1 more source

Tertiary lymphoid structures: exploring opportunities to improve immunotherapy in ovarian cancer

Frontiers in Immunology
Tertiary lymphoid structures (TLS) are organized ectopic lymphoid clusters of immune cells that develop in non-lymphoid tissue to promote antigen presentation, drive cytotoxic immune responses, and enhance humoral immunity via B cell clonal expansion ...
Aaron Varghese, Aaron Varghese, Suzanne M. Hess, Shanmuga Chilakapati, Shanmuga Chilakapati, Jose R. Conejo-Garcia, A.J. Robert McGray, A.J. Robert McGray, Emese Zsiros   +8 more
doaj   +1 more source