Results 51 to 60 of about 5,610 (204)

Myc Cooperates with Ras by Programming Inflammation and Immune Suppression. [PDF]

, 2017
The two oncogenes KRas and Myc cooperate to drive tumorigenesis, but the mechanism underlying this remains unclear. In a mouse lung model of KRasG12D-driven adenomas, we find that co-activation of Myc drives the immediate transition to highly ...
Brown Swigart, Lamorna, Burkhart, Deborah L, Evan, Gerard I, Kortlever, Roderik M, Littlewood, Trevor D, Pellegrinet, Luca, Sodir, Nicole M, Wilson, Catherine H   +7 more
core   +1 more source

Stem-like CD4+T Cells in Perivascular Tertiary Lymphoid Structures Sustain Autoimmune Vasculitis [PDF]

, 2023
Autoimmune vasculitis of the medium and large elastic arteries can cause blindness, stroke, aortic arch syndrome, and aortic aneurysm. The disease is often refractory to immunosuppressive therapy and progresses over decades as smoldering aortitis.
Berry, Gerald J, Bois, Melanie C, Goronzy, Jörg J, Jain, Abhinav, Le, Kevin-Phu C, Ohtsuki, Shozo, Okuyama, Hirohisa, Sato, Yuki, Sturmlechner, Ines, Takashima, Yoshinori, Warrington, Kenneth J, Weyand, Cornelia M   +11 more
core   +2 more sources

Additional file 1 of Prognostic value of tertiary lymphoid structures (TLS) in digestive system cancers: a systematic review and meta-analysis

, 2023
Additional file 1: Supplementary Materials. Table S1. Quality assessment details for included studies. Table S2. Summary of controlled covariates in multivariate analyses. Figure S1. Sensitivity analysis for TLS with OS in digestive system cancers patients. Figure S2.
Sun, Hao, Shi, Yuanyu, Ran, Hailiang, Peng, Junwei, Li, Qiongxian, Zheng, Guiqing, He, Yandie, Liu, Shuqing, Chang, Wei, Xiao, Yuanyuan   +9 more
openaire   +1 more source

Tumor-Infiltrating Lymphocytes (TIL), Tertiary Lymphoid Structures (TLS), and Expression of PD-1, TIM-3, LAG-3 on TIL in Invasive and In Situ Ductal Breast Carcinomas and Their Relationship with Prognostic Factors

Clinical Breast Cancer, 2022
Immunotherapy has been determined as an important choice in breast carcinomas, especially in tumors with markedly inflammatory response. About this promising subject, tumor-infiltrating lymphocytes (TIL) and the expression of immune control point receptors on TIL have gained importance.In this study, stromal TIL and tertiary lymphoid structures (TLS ...
Elif Acar, Güldal Esendağlı, Ozan Yazıcı, Ayşe Dursun   +3 more
openaire   +4 more sources

Advances on tumor-associated tertiary lymphoid structures in immunotherapy

生物医学转化
Tertiary lymphoid structures (TLS) are ectopic lymphoid structures found in non-lymphoid tissues under chronic inflammatory conditions in recent years.
Hu Chupeng, Chen Yun
doaj   +1 more source

Deciphering the maturation of tertiary lymphoid structures in cancer and inflammatory diseases of the digestive tract using imaging mass cytometry

Frontiers in Immunology, 2023
Persistent inflammation can promote the development of tertiary lymphoid structures (TLS) within tissues resembling secondary lymphoid organs (SLO) such as lymph nodes (LN).
Marion Le Rochais, Patrice Hémon, Danivanh Ben-guigui, Soizic Garaud, Christelle Le Dantec, Jacques-Olivier Pers, Jacques-Olivier Pers, Divi Cornec, Divi Cornec, Arnaud Uguen, Arnaud Uguen   +10 more
doaj   +1 more source

Prognostic Significance of Gene Signature of Tertiary Lymphoid Structures in Patients With Lung Adenocarcinoma

Frontiers in Oncology, 2021
BackgroundLung adenocarcinoma (LUAD) is a highly mortal cancer. Tertiary lymphoid structures (TLS) are ectopic lymphoid organs with similar morphological and molecular characters to secondary lymphoid organ.
Hong Feng, Hong Feng, Fujun Yang, Lihong Qiao, Kai Zhou, Kai Zhou, Junfei Wang, Jiao Zhang, Tian Tian, Ying Du, Hong Shangguan   +10 more
doaj   +1 more source

Automated classification of tertiary lymphoid structures in colorectal cancer using TLS-PAT artificial intelligence tool

Scientific Reports
Abstract Colorectal cancer (CRC) ranks as the third most common and second deadliest cancer worldwide. The immune system, particularly tertiary lymphoid structures (TLS), significantly influences CRC progression and prognosis. TLS maturation, especially in the presence of germinal centers, correlates with improved patient outcomes; however ...
Le Rochais, Marion, Brahim, Ikram, Zeghlache, Rachid, Redoulez, Geoffroy, Guillard, Matthieu, Le Noac’h, Pierre, Castillon, Marine, Bourhis, Amélie, Uguen, Arnaud   +8 more
openaire   +4 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Prognostic value of immune cell infiltration, tertiary lymphoid structures and PD-L1 expression in Merkel cell carcinomas [PDF]

, 2014
Merkel cell carcinoma (MCC) is an aggressive, virus-associated, neuroendocrine tumor of the skin mainly affecting immunocompromised patients. Higher intratumoral infiltration with CD3 and CD8 positive T-cells is associated with a better prognosis ...
Behr, Daniel S., Dollt, Claudia, Goebeler, Matthias, Goerdt, Sergij, Hametner, Christian, Houben, Roland, Lasitschka, Felix, Marx, Alexander, Michel, Julia, Peitsch, Wiebke K., Schmieder, Astrid, Schönhaar, Kathrin   +11 more
core