Results 121 to 130 of about 3,823 (146)

Abstract PO4-25-04: MHC Class I and II Expression, Functional Tertiary Lymphoid Structure (TLS), and Outcomes in Early-Stage HER2-Positive (HER2+) Breast Cancer in NCCTG N9831 (Alliance)

Cancer Research
Abstract Background: Tertiary lymphoid structure (TLS) is an organized form of ectopic lymphoid aggregates (LA) with secondary lymphoid organ structure. Several studies showed that the presence of TLS associates with improved outcomes in multiple cancers when treated with immune checkpoint inhibitors.
Saranya Chumsri, Tracy Shachner, Zhuo Li, Nadine Norton, Alvaro Moreno-Aspitia, Gerardo Colon-Otero, Edith Perez, Aziza Nassar, E. Thompson, Keith Knutson   +9 more
openaire   +1 more source

Abstract 2919: A little STING spices up tertiary lymphoid structures: Therapeutic induction of mature TLS by STING and lymphotoxin-β receptor activation confers immune protection against cancer metastasis

Cancer Research
Abstract Significant clinical evidence demonstrates an association of tertiary lymphoid structure (TLS) formation with cancer survival. Clinically translatable pharmacologic/biologic agents that induce TLS-rich tumor immune environment could provide a breakthrough strategy to treat therapy-resistant cancers.
Yasuhiro Kikuchi, Maxwell Duah, Fumiaki Kanamori, Masanobu Komatsu   +3 more
openaire   +1 more source

Abstract 3358: Tertiary lymphoid structures (TLS) estimated by AI tools from digital H&E slides significantly enhance survival prediction in high-risk AJCC stages III/IV melanoma

Cancer Research
Abstract Tertiary lymphoid structures (TLS) in tumors have emerged as novel disease prognostic and predictive biomarkers with immunotherapy. Recent advances in whole-slide image (WSI) digitization of pathology slides and AI tools are making in situ prediction of TLS more feasible. Methods:
Ahmad A. Tarhini, Tingyi Li, Ranran Tao, Sandra J. Lee, Islam Eljilany, F. Stephen Hodi, Howard Streicher, Arivarasan Karunamurthy, John M. Kirkwood, Xuefeng Wang   +9 more
openaire   +1 more source

702 Tertiary lymphoid structures (TLS) observed in non-small cell lung cancer (NSCLC) tumors treated with pulsed electric fields

Regular and Young Investigator Award Abstracts, 2022
Jeff Iding, Paul VanderLaan, Marcelo Jimenez, José Fernández García-Hierro, Javier Flandes Aldeyturriaga, Erik HFM van der Heijden, Calvin SH Ng, Rainbow WH Lau, Maria Ludeña, Rafael Carías, Oderay Cedeño, Alicia Moreno-Gonzalez, Beryl Hatton, William Krimsky   +13 more
openaire   +1 more source

Abstract 3205: Artificial intelligence (AI) -powered H&E whole-slide image (WSI) analysis of tertiary lymphoid structure(TLS) to predict response to immunotherapy in non-small cell lung cancer (NSCLC)

Cancer Research
Background: The efficacy of ICIs in treating NSCLC is limited to a subset of patients, necessitating reliable predictive biomarkers. TLSs within the tumor microenvironment have emerged as potential indicators. This study aims to investigate the association between an AI-powered TLS analysis and treatment response of
Young Kwang Chae, Leeseul Kim, Sangwon Shin, Sooick Cho, Sanghoon Song, Borislav Alexiev, Behtash Nezami   +6 more
openaire   +1 more source

Tertiary lymphoid structures and B lymphocytes: a promising therapeutic strategy to fight cancer

Frontiers in Immunology, 2023
Arantzazu Alfranca, Esparcia-Pinedo Laura, Alfranca Arantzazu   +2 more
exaly  

5P Tertiary lymphoid structures (TLS) presence and stromal blood vessels heterogeneity differentially influence recurrence, lymphovascular, and perineural invasion in breast cancer molecular subtypes

Annals of Oncology, 2023
A.A. Cosma, A.C. Barb, S.M. Negru, M.M. Pasca Fenesan, A.M. Cimpean   +4 more
openaire   +1 more source

The impact of tertiary lymphoid structures on clinicopathological, genetic and gene expression characteristics in lung adenocarcinoma

Lung Cancer, 2022
Saori Miyazaki
exaly  

Tertiary lymphoid structures in cancer

Science, 2022
Ton N Schumacher, Daniela S Thommen
exaly  

The enrichment of the gut microbiota Lachnoclostridium is associated with the presence of intratumoral tertiary lymphoid structures in hepatocellular carcinoma

Frontiers in Immunology, 2023
Jungang Zhao, Qiwen Chen, Fang Wu
exaly