Molecular, Immunological, and Clinical Features Associated With Lymphoid Neogenesis in Muscle Invasive Bladder Cancer [PDF]
Frontiers in Immunology, 2022 Lymphoid neogenesis gives rise to tertiary lymphoid structures (TLS) in the periphery of multiple cancer types including muscle invasive bladder cancer (MIBC) where it has positive prognostic and predictive associations.
Fabio Pagliarulo +7 more
doaj +4 more sources
Chronic Inflammation: A Common Promoter in Tertiary Lymphoid Organ Neogenesis [PDF]
Frontiers in Immunology, 2019 Tertiary lymphoid organs (TLOs) frequently develop locally in adults in response to non-resolving inflammation. Chronic inflammation leads to the differentiation of stromal fibroblast cells toward lymphoid tissue organizer-like cells, which interact with
Shanshan Luo +7 more
doaj +5 more sources
The pathological features of ectopic lymphoid neogenesis in idiopathic dacryoadenitis [PDF]
BMC Ophthalmology, 2016 Lymphoid neogenesis has been reported in various diseases but not in idiopathic dacryoadenitis. The aim of this paper is to discuss the pathological features of lymphoid neogenesis in idiopathic dacryoadenitis.20 cases of idiopathic dacryoadenitis were collected retrospectively.
Jiang Qian
exaly +5 more sources
Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency [PDF]
Journal of Allergy and Clinical Immunology, 2014 Despite reducing pneumonia and other infections, antibody replacement does not appear to treat pulmonary lymphoid hyperplasia (PLH) in patients with common variable immunodeficiency (CVID). The pathogenesis and optimal treatments remain to be clarified.We aimed to better understand the pathology of CVID-associated lung disease.
Paul J Maglione +2 more
exaly +5 more sources
Cigarette Smoke-Induced Lymphoid Neogenesis in COPD Involves IL-17/RANKL Pathway [PDF]
Frontiers in Immunology, 2021 IL-17 is critical in lung lymphoid neogenesis in COPD, but the cellular and molecular mechanisms remain to be elucidated. Receptor activator of nuclear factor-κB ligand (RANKL) functions in lymphoid follicle formation in other organs, whether it is ...
Jing Xiong +8 more
doaj +2 more sources
The Role of Lymphoid Neogenesis in Allografts. [PDF]
Am J Transplant, 2016 De novo induction of organized lymphoid aggregates at nonlymphoid sites has been observed in many chronic inflammatory conditions where foreign antigens such as infectious agents, autoantigens or alloantigens, persist. The prevailing opinion in the field of transplantation is that lymphoid neogenesis within allografts is detrimental to the ...
Hsiao HM +4 more
europepmc +4 more sources
Lymphoid Neogenesis and Tertiary Lymphoid Organs in Transplanted Organs. [PDF]
Front Immunol, 2016 The progressive organization of immune effectors into functional ectopic lymphoid structures, named tertiary lymphoid organs (TLO), has been observed in many conditions in which target antigens fail to be eliminated by the immune system. Not surprisingly, TLO have been recurrently identified in chronically rejected allografts.
Koenig A, Thaunat O.
europepmc +4 more sources
Lymphoid neogenesis in melanoma: What does it tell us? [PDF]
Oncoimmunology, 2013 Metastatic melanoma lesions sometimes host ectopic lymphoid structures exhibiting ongoing adaptive immune responses. Here, we discuss how this finding fits in our current view of antitumor immunity.
van Baren N, Baurain JF, Coulie PG.
europepmc +4 more sources
Rapid Induction of Pulmonary Inflammation, Autoimmune Gene Expression, and Ectopic Lymphoid Neogenesis Following Acute Silica Exposure in Lupus-Prone Mice [PDF]
Frontiers in Immunology, 2021 Occupational exposure to crystalline silica (cSiO2) is etiologically associated with systemic lupus erythematosus (lupus) and other autoimmune diseases.
Preeti S. Chauhan +17 more
doaj +2 more sources
Lymphoid Neogenesis in Murine Cardiac Allografts Undergoing Chronic Rejection [PDF]
American Journal of Transplantation, 2005 Lymphoid neogenesis is the process by which ectopic lymphoid accumulations that resemble lymph nodes arise in nonlymphoid tissues. Such lymphoid accumulations, known as tertiary lymphoid organs (TLO), are observed in chronic autoimmunity and they propagate immune pathology by setting up local antigen presenting sites. Whether lymphoid neogenesis occurs
Fadi G Lakkis +2 more
exaly +3 more sources