Results 21 to 30 of about 78,214 (186)

Lymphoid neogenesis and immune infiltration in aged liver. [PDF]

Hepatology, 2008
Immune dysregulation and inflammation play a major role in the pathology of age-related disorders. In an earlier study, the microarray data from our laboratory indicated an increase in inflammation-related gene expression in the liver with age. We further investigated immune-related changes in
Singh P, Coskun ZZ, Goode C, Dean A, Thompson-Snipes L, Darlington G.   +5 more
europepmc   +4 more sources

CCL21 Expression Pattern of Human Secondary Lymphoid Organ Stroma Is Conserved in Inflammatory Lesions with Lymphoid Neogenesis [PDF]

The American Journal of Pathology, 2007
CCL21 is a homeostatic lymphoid chemokine instrumental in the recruitment and organization of T cells and dendritic cells into lymphoid T areas. In human secondary lymphoid organs (SLOs), CCL21 is produced by cells distributed throughout the T zone, whereas high endothelial venules (HEVs) lack CCL21 mRNA.
MANZO, ANTONIO, BUGATTI, SERENA, CAPORALI, ROBERTO, Prevo R., Jackson D.G., Uguccioni M., Buckley C.D., MONTECUCCO, CARLOMAURIZIO, Pitzalis C.   +8 more
openaire   +5 more sources

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research
Tertiary lymphoid structures (TLSs) are inducible, ectopic aggregates that mirror the architecture and immunological functions of secondary lymphoid organs, arising in nonlymphoid tissues during chronic inflammation, infection, autoimmunity, and cancer ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
doaj   +2 more sources

Cancer-associated fibroblasts and tertiary lymphoid structure orchestrate the spatial architecture of tumor immunity [PDF]

Journal of Hematology & Oncology
Tumor immunity is shaped not only by the cellular composition of the tumor microenvironment (TME), but also by how stromal and immune elements are spatially organized within it.
Haijia Tang, Youyang Shi, Qintao Ge, Rui Wang, Jianfeng Yang, Yao Zhu, Sheng Liu, Wenhao Xu   +7 more
doaj   +2 more sources

Tertiary lymphoid structures in thyroid cancer [PDF]

Archives of Endocrinology and Metabolism
Objective: This study aimed to investigate the presence of tertiary lymphoid structures (TLSs) and tumor-infiltrating B cells within the germinal centers of TLSs in the tumor microenvironment of thyroid cancer, utilizing a morphological approach ...
Katia Sakimi Nakadaira, Kelly Cristina Saito, Cesar Seigi Fuziwara, Patricia Künzle Ribeiro Magalhães, Leandra Naira Zambelli Ramalho, Julio C. Ricarte-Filho, Lea Maria Zanini Maciel, Edna Teruko Kimura   +7 more
doaj   +2 more sources

Inflammatory micro-environmental cues of human atherothrombotic arteries confer to vascular smooth muscle cells the capacity to trigger lymphoid neogenesis. [PDF]

PLoS ONE, 2014
BACKGROUND: Experimental atherosclerosis is characterized by the formation of tertiary lymphoid structures (TLOs) within the adventitial layer, which involves the chemokine-expressing aortic smooth muscle cells (SMCs).
Kevin Guedj, Jamila Khallou-Laschet, Marc Clement, Marion Morvan, Sandrine Delbosc, Anh-Thu Gaston, Francesco Andreata, Yves Castier, Catherine Deschildre, Jean-Baptiste Michel, Giuseppina Caligiuri, Antonino Nicoletti   +11 more
doaj   +2 more sources

Lung transplant acceptance is facilitated by early events in the graft and is associated with lymphoid neogenesis. [PDF]

Mucosal Immunol, 2012
Early immune responses are important in shaping long-term outcomes of human lung transplants. To examine the role of early immune responses in lung rejection and acceptance, we developed a method to retransplant mouse lungs. Retransplantation into T-cell-deficient hosts showed that for lungs and hearts alloimmune responses occurring within 72 h of ...
Li W, Bribriesco AC, Nava RG, Brescia AA, Ibricevic A, Spahn JH, Brody SL, Ritter JH, Gelman AE, Krupnick AS, Miller MJ, Kreisel D.   +11 more
europepmc   +4 more sources

Synovial cytokine expression in psoriatic arthritis and associations with lymphoid neogenesis and clinical features. [PDF]

Arthritis Res Ther, 2012
Abstract Introduction Psoriatic arthritis (PsA) is an autoantibody-negative immune-mediated disease in which synovial lymphoid neogenesis (LN) occurs. We determined whether LN is associated with specific patterns of inflammatory cytokine expression in paired synovial tissue (ST) and fluid (SF) samples and
Celis R, Planell N, Fernández-Sueiro JL, Sanmartí R, Ramírez J, González-Álvaro I, Pablos JL, Cañete JD.   +7 more
europepmc   +4 more sources

Supramolecular hydrogel viscoelasticity regulates in situ tertiary lymphoid neogenesis

Abstract Tertiary lymphoid structures (TLSs) are organized three-dimensional immune niches associated with improved antitumor immunity, which has galvanized efforts to induce them artificially using biomaterials. However, these strategies have largely focused on soluble cue delivery, leaving the role of scaffold physical
Ryan Ramsey Hosn, Oriana Marrone Mantovani, Artemis Margaronis, James S. Wang, Ethan Kriss, Claire Wu, Michael Kissner, José L. McFaline-Figueroa, Santiago Correa   +8 more
openaire   +2 more sources

Role of Tertiary Lymphoid Structures in Autoimmune Diseases and Cancer. [PDF]

MedComm (2020)
Schematic overview of tertiary lymphoid structures (TLSs): The development process, detection, and the immune function that depends on the environment in different disease contexts of TLS. TLSs originate from loose lymphoid aggregates that acquire ordered follicular architecture to become primary follicular‐like TLS, before maturing into ...
Yan Z, Wen B, Hu Y, Wang X, Duan X, Li H, Dong S, Fan Y, Wang C, Yang S, Shang H, Jing Y.   +11 more
europepmc   +2 more sources