Results 31 to 40 of about 78,214 (186)

TLS as Predictors and Targets in Neoadjuvant Chemoimmunotherapy for NSCLC. [PDF]

Thorac Cancer
TLS in lung cancer adjuvant therapy: (A) cellular composition (T/B cells, DCs); (B) mechanistic pathways (antigen presentation, GC‐like B responses, TRM maintenance); (C) clinical evaluation (IHC, digital pathology, spatial transcriptomics); (D) future directions (dynamic monitoring, intercellular interactions, multicenter trials, clinical translation).
Li Z, Zhang L, Dong Y, Yi L, Li W, Wang J, Pan Y.   +6 more
europepmc   +2 more sources

Tertiary lymphoid structures in gynecological cancers: prognostic role, methods for evaluating, antitumor immunity, and induction for therapy

Frontiers in Oncology, 2023
Tertiary lymphoid structures (TLSs), referred to as tertiary lymphoid organs and lymphoid tissue neogenesis, are aggregates of immune cells that occur in nonlymphoid tissues.
Ke Zhang, Xiao Xie, Shuang-Lin Zheng, Yuan-Run Deng, Yuan-Run Deng, Dan Liao, Dan Liao, Hai-Chen Yan, Xi Kang, Hui-Ping Jiang, Hui-Ping Jiang, Sui-Qun Guo, Sui-Qun Guo   +12 more
doaj   +1 more source

Role of the CXCL13/CXCR5 Axis in Autoimmune Diseases

Frontiers in Immunology, 2022
CXCL13 is a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer cells, follicular dendritic cells, and human T follicular helper cells.
Zijian Pan, Zijian Pan, Tong Zhu, Tong Zhu, Yanjun Liu, Nannan Zhang   +5 more
doaj   +1 more source

Lymphoid Neogenesis in Rheumatoid Synovitis [PDF]

The Journal of Immunology, 2001
Abstract In rheumatoid arthritis (RA), tissue-infiltrating lymphocytes can be arranged in sophisticated organizations that resemble microstructures usually formed in secondary lymphoid organs. Molecular pathways and host risk factors involved in this process of lymphoid neogenesis remain to be defined.
S, Takemura, A, Braun, C, Crowson, P J, Kurtin, R H, Cofield, W M, O'Fallon, J J, Goronzy, C M, Weyand   +7 more
openaire   +2 more sources

NLRC5-Deficient Macrophages Promote a Tumor-Permissive Phenotype via AXL- and MERTK-Mediated Efferocytosis. [PDF]

FASEB J
Defective NLRC5 signaling in macrophages drives TAM phenotype and anti‐inflammatory responses via STAT3/ERK, leading to tumor‐permissive conditions and gastric lymphoid neogenesis during Helicobacter infection. ABSTRACT The innate immune protein NLRC5 plays a key role in cancer immune surveillance.
Haile SA, Gatta A, Colon N, Philpott DJ, Kufer TA, Ying L, Tong D, Ferrero RL.   +7 more
europepmc   +2 more sources

Tumor-Associated Tertiary Lymphoid Structures: From Basic and Clinical Knowledge to Therapeutic Manipulation

Frontiers in Immunology, 2021
The tumor microenvironment is a complex ecosystem almost unique to each patient. Most of available therapies target tumor cells according to their molecular characteristics, angiogenesis or immune cells involved in tumor immune-surveillance ...
Charlotte Domblides, Charlotte Domblides, Charlotte Domblides, Juliette Rochefort, Juliette Rochefort, Juliette Rochefort, Juliette Rochefort, Juliette Rochefort, Clémence Riffard, Clémence Riffard, Clémence Riffard, Marylou Panouillot, Marylou Panouillot, Marylou Panouillot, Géraldine Lescaille, Géraldine Lescaille, Géraldine Lescaille, Géraldine Lescaille, Géraldine Lescaille, Jean-Luc Teillaud, Jean-Luc Teillaud, Jean-Luc Teillaud, Véronique Mateo, Véronique Mateo, Véronique Mateo, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean   +27 more
doaj   +1 more source

Interplay between inflammation, autoimmunity and regeneration in the NOD mouse model of type 1 diabetes and Sjogren’s Syndrome. [PDF]

, 2011
PhDA continuous process of tissue remodelling and regeneration is a fundamental feature of the homeostatic response of the target organ of several autoimmune diseases.
Astorri, Elisa
core   +4 more sources

Tertiary Lymphoid Structures in Cancer: The Double-Edged Sword Role in Antitumor Immunity and Potential Therapeutic Induction Strategies

Frontiers in Immunology, 2021
The complex tumor microenvironment (TME) plays a vital role in cancer development and dramatically determines the efficacy of immunotherapy. Tertiary lymphoid structures (TLSs) within the TME are well recognized and consist of T cell-rich areas ...
Wendi Kang, Zhichao Feng, Zhichao Feng, Jianwei Luo, Zhenhu He, Jun Liu, Jianzhen Wu, Pengfei Rong, Pengfei Rong   +8 more
doaj   +1 more source

L19. Lymphoid neogenesis in vascular chronic inflammation [PDF]

La Presse Médicale, 2013
no ...
Nicoletti, Antonino, Khallou-Laschet, Jamila, Guedj, Kevin, Clement, Marc, Gaston, Anh-Thu, Morvan, Marion, Dutertre, Charles-Antoine, Michel, Jean-Baptiste, Thaunat, Olivier, Caligiuri, Giuseppina   +9 more
openaire   +3 more sources

Ectopic lymphoid neogenesis in rheumatic autoimmune diseases [PDF]

Nature Reviews Rheumatology, 2017
Ectopic lymphoid neogenesis often occurs in the target tissues of patients with chronic rheumatic autoimmune diseases such as rheumatoid arthritis, Sjögren syndrome and other connective tissue disorders, including systemic lupus erythematosus and myositis.
Bombardieri, M, Lewis, M, Pitzalis, C
openaire   +3 more sources