Results 51 to 60 of about 78,214 (186)

Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis

Frontiers in Molecular Biosciences, 2021
Tertiary lymphoid structures (TLSs) develop in non-lymphatic tissue in chronic inflammation and cancer. TLS can mature to lymph node (LN) like structures with germinal centers and associated vasculature.
Rami Mustapha, Rami Mustapha, Kenrick Ng, Kenrick Ng, James Monypenny, Tony Ng, Tony Ng, Tony Ng, Tony Ng   +8 more
doaj   +1 more source

Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?

Frontiers in Immunology, 2017
Secondary lymphoid organs are integral to initiation and execution of adaptive immune responses. These organs provide a setting for interactions between antigen-specific lymphocytes and antigen-presenting cells recruited from local infected or inflamed ...
Emily Jayne Colbeck, Ann Ager, Awen Gallimore, Gareth Wyn Jones   +3 more
doaj   +1 more source

Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer

Frontiers in Immunology, 2022
Immune checkpoint inhibitors (ICI) have provided significant improvement in clinical outcomes for some patients with solid tumors. However, for patients with head and neck cancer, the response rate to ICI monotherapy remains low, leading to the ...
James H. A. Clubb, James H. A. Clubb, James H. A. Clubb, Tatiana V. Kudling, Tatiana V. Kudling, Camilla Heiniö, Camilla Heiniö, Saru Basnet, Saru Basnet, Santeri Pakola, Santeri Pakola, Víctor Cervera Carrascón, Víctor Cervera Carrascón, Víctor Cervera Carrascón, João Manuel Santos, João Manuel Santos, João Manuel Santos, Dafne C. A. Quixabeira, Dafne C. A. Quixabeira, Riikka Havunen, Riikka Havunen, Riikka Havunen, Suvi Sorsa, Suvi Sorsa, Suvi Sorsa, Vincent Zheng, Vincent Zheng, Tuula Salo, Tuula Salo, Tuula Salo, Tuula Salo, Tuula Salo, Leif Bäck, Leif Bäck, Katri Aro, Katri Aro, Sanni Tulokas, Venla Loimu, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki   +41 more
doaj   +1 more source

Immunophenotypic Landscape of synovial tissue in rheumatoid arthritis: Insights from ACPA status

Heliyon
Objective: To examine the clinical features and synovial pathologies in rheumatoid arthritis (RA) patients across varying titers of circulating anti-citrullinated protein antibodies (ACPA).
JianBin Li, PengCheng Liu, YiPing Huang, Yan Wang, Jun Zhao, ZhenFang Xiong, MengXia Liu, Rui Wu   +7 more
doaj   +1 more source

Mapping of Dynamic Transcriptome Changes Associated With Silica-Triggered Autoimmune Pathogenesis in the Lupus-Prone NZBWF1 Mouse

Frontiers in Immunology, 2019
Crystalline silica (cSiO2) is a widely recognized environmental trigger of autoimmune disease. In the lupus-prone female NZBWF1 mouse, airway exposure to cSiO2 triggers pulmonary ectopic lymphoid neogenesis, systemic autoantibody elevation, and ...
Melissa A. Bates, Melissa A. Bates, Abby D. Benninghoff, Kristen N. Gilley, Andrij Holian, Jack R. Harkema, James J. Pestka, James J. Pestka, James J. Pestka   +8 more
doaj   +1 more source

Silica Triggers Inflammation and Ectopic Lymphoid Neogenesis in the Lungs in Parallel with Accelerated Onset of Systemic Autoimmunity and Glomerulonephritis in the Lupus-Prone NZBWF1 Mouse. [PDF]

PLoS ONE, 2015
Genetic predisposition and environmental factors influence the development of human autoimmune disease. Occupational exposure to crystalline silica (cSiO2) has been etiologically linked to increased incidence of autoimmunity, including systemic lupus ...
Melissa A Bates, Christina Brandenberger, Ingeborg Langohr, Kazuyoshi Kumagai, Jack R Harkema, Andrij Holian, James J Pestka   +6 more
doaj   +1 more source

Renal Interstitial Infiltration and Tertiary Lymphoid Organ Neogenesis in IgA Nephropathy [PDF]

Clinical Journal of the American Society of Nephrology, 2014
Previous studies have identified inflammatory features that enable the prediction of renal outcome of IgA nephropathy (IgAN); however, validation of these findings is still needed. This prospective study was performed to determine the characteristics of renal interstitial infiltration and tertiary lymphoid organ (TLO) neogenesis in a cohort of Chinese ...
Guangchang, Pei, Rui, Zeng, Min, Han, Panli, Liao, Xuan, Zhou, Yueqiang, Li, Ying, Zhang, Ping, Liu, Chunxiu, Zhang, XiaoCheng, Liu, Ying, Yao, Gang, Xu   +11 more
openaire   +2 more sources

T cell alterations and lymphoid neogenesis favoring autoimmunity in Wegener's granulomatosis [PDF]

Arthritis & Rheumatism, 2007
Wegener’s granulomatosis (WG) is a chronic inflammatory autoimmune disease of as-yet-unknown etiology characterized by necrotizing granulomatous lesions, glomerulonephritis, and an autoimmune vasculitis that predominantly affects small vessels (i.e., arterioles, capillaries, and venules).
Peter, Lamprecht, Wolfgang L, Gross, Dieter, Kabelitz   +2 more
openaire   +2 more sources

IL-17A is Elevated in End-stage COPD and Contributes to Cigarette Smoke-induced Lymphoid Neogenesis.

, 2015
End-stage chronic obstructive pulmonary disease (COPD) is associated with an accumulation of pulmonary lymphoid follicles. Interleukin (IL)-17A is implicated in COPD and pulmonary lymphoid neogenesis in response to microbial stimuli. We hypothesized that
Mori, Michiko, Sandén, Caroline, Stampfli, Martin R, Erjefält, Jonas, Roos, Abraham, Bjermer, Leif   +5 more
core   +1 more source

DataSheet_9_Molecular, Immunological, and Clinical Features Associated With Lymphoid Neogenesis in Muscle Invasive Bladder Cancer.pdf

, 2022
Lymphoid neogenesis gives rise to tertiary lymphoid structures (TLS) in the periphery of multiple cancer types including muscle invasive bladder cancer (MIBC) where it has positive prognostic and predictive associations.
Phil F. Cheng (11995322), Mitchell P. Levesque (11995331), Laurin Brugger (11995325), Karina Silina (5989283), Fabio Pagliarulo (11995319), Maries van den Broek (194983), Nick van Dijk (11857070), Michiel van den Heijden (11995328)   +7 more
core   +1 more source