Results 41 to 50 of about 78,214 (186)

Characterization of lymphoid tissue inducer cells and lymphoid tissue development in adult interleukin 7 transgenic mice [PDF]

, 2008
During embryogenesis, the development of secondary lymphoid organs (SLOs) such as lymph nodes (LNs) and Peyer’s patches (PPs) requires the cellular crosstalk between vascular cell adhesion molecule (VCAM)-1+ mesenchymal organizer cells and CD45+CD4 ...
Schmutz, Sandrine
core   +1 more source

Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium [PDF]

, 2009
BackgroundFollicular structures resembling germinal centres (GCs) that are characterized by follicular dendritic cell (FDC) networks have long been recognized in chronically inflamed tissues in autoimmune diseases, including the synovium of rheumatoid ...
Kelly, Stephen, Kelly, S, Blades, Mark C., Kirkham, Bruce, Spencer, Jo, Frances Humby, Bruce Kirkham, Pitzalis, Costantino, Michele Bombardieri, Kelly Stephen, Mark C Blades, Humby, F, Bombardieri M., Blades, MC, Manzo Antonio, Humby, Frances, Stephen Kelly, Bombardieri, M, Pitzalis C., Bombardieri, Michele, Spencer, J, Humby F., Blades M.C., Bombardieri Michele, Humby Frances, Blades Mark C, Kirkham, B, Kirkham Bruce, Manzo, A, Spencer Jo, Spencer J., MANZO, ANTONIO, Pitzalis Costantino, Antonio Manzo, Pitzalis, C, Kirkham B., Jo Spencer, Costantino Pitzalis, Kelly S.   +38 more
core   +1 more source

Mechanisms of tertiary lymphoid structure formation: cooperation between inflammation and antigenicity

Frontiers in Immunology, 2023
To mount an effective anti-tumor immune response capable of controlling or eliminating disease, sufficient numbers of lymphocytes must be recruited to malignant tissue and allowed to sustain their effector functions.
Shrijan Khanal, Andreas Wieland, Andrew J. Gunderson   +2 more
doaj   +1 more source

Tertiary Lymphoid Structures in cancers: prognostic value, regulation and manipulation for therapeutic intervention

Frontiers in Immunology, 2016
Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that reflect lymphoid neogenesis occurring in tissues at sites of inflammation. They are detected in tumors where they orchestrate local and systemic anti-tumor responses.
Catherine Sautes-Fridman, Catherine Sautes-Fridman, Catherine Sautes-Fridman, Myriam Lawand, Myriam Lawand, Myriam Lawand, Nicolas A. Giraldo, Nicolas A. Giraldo, Nicolas A. Giraldo, Helene Kaplon, Helene Kaplon, Helene Kaplon, Claire Germain, Claire Germain, Claire Germain, Wolf Hervé Fridman, Wolf Hervé Fridman, Wolf Hervé Fridman, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean   +20 more
doaj   +1 more source

Cutaneous Melanoma: Mutational Status and Potential Links to Tertiary Lymphoid Structure Formation

Frontiers in Immunology, 2021
Recent advances in immunotherapy have enabled rapid evolution of novel interventional approaches designed to reinvigorate and expand patient immune responses against cancer.
Deepak Salem, Manoj Chelvanambi, Walter J. Storkus, Walter J. Storkus, Walter J. Storkus, Walter J. Storkus, Ronald J. Fecek   +6 more
doaj   +1 more source

Leukocyte Trafficking via Lymphatic Vessels in Atherosclerosis

Cells, 2021
In recent years, lymphatic vessels have received increasing attention and our understanding of their development and functional roles in health and diseases has greatly improved. It has become clear that lymphatic vessels are critically involved in acute
Kim Pin Yeo, Hwee Ying Lim, Veronique Angeli   +2 more
doaj   +1 more source

Silica Induction of Diverse Inflammatory Proteome in Lungs of Lupus-Prone Mice Quelled by Dietary Docosahexaenoic Acid Supplementation

Frontiers in Immunology, 2022
Repeated short-term intranasal instillation of lupus-prone mice with crystalline silica (cSiO2) induces inflammatory gene expression and ectopic lymphoid neogenesis in the lung, leading to early onset of systemic autoimmunity and rapid progression to ...
Lichchavi D. Rajasinghe, Lichchavi D. Rajasinghe, Melissa A. Bates, Melissa A. Bates, Abby D. Benninghoff, Kathryn A. Wierenga, Jack R. Harkema, James J. Pestka, James J. Pestka, James J. Pestka   +9 more
doaj   +1 more source

Understanding Immune Cells in Tertiary Lymphoid Organ Development: It’s All Starting to Come Together

Frontiers in Immunology, 2016
Tertiary lymphoid organs (TLOs) are frequently observed in tissues affected by non-resolving inflammation as a result of infection, autoimmunity, cancer and allograft rejection.
Gareth Wyn Jones, David G Hill, Simon Arnett Jones   +2 more
doaj   +1 more source

Ectopic Tertiary Lymphoid Tissue in Inflammatory Bowel Disease: Protective or Provocateur?

Frontiers in Immunology, 2016
Organized lymphoid tissues like the thymus first appeared in jawed vertebrates around 500 million years ago and have evolved to equip the host with a network of specialized sites, strategically located to orchestrate strict immune-surveillance and ...
Eoin Neil McNamee, Jesus Rivera-Nieves
doaj   +1 more source

M1 macrophages, key contributors to lymphoid neogenesis in atherosclerotic aorta [PDF]

Cardiovascular Research, 2014
This editorial refers to ‘M1 macrophages act as LTβR-independent lymphoid tissue inducer cells during atherosclerosis-related lymphoid neogenesis’ by K. Guedj et al. , pp. 434–443, this issue. The immune system has evolved to optimize the chances of encounter between rare antigen-specific T and B cells of the adaptive immune system with antigen ...
Alexander, Bobik, Tin Soe, Kyaw, Peter, Tipping, Ban-Hock, Toh   +3 more
openaire   +2 more sources