Results 71 to 80 of about 78,214 (186)

DataSheet_15_Molecular, Immunological, and Clinical Features Associated With Lymphoid Neogenesis in Muscle Invasive Bladder Cancer.pdf

, 2022
Lymphoid neogenesis gives rise to tertiary lymphoid structures (TLS) in the periphery of multiple cancer types including muscle invasive bladder cancer (MIBC) where it has positive prognostic and predictive associations.
Phil F. Cheng (11995322), Mitchell P. Levesque (11995331), Laurin Brugger (11995325), Karina Silina (5989283), Fabio Pagliarulo (11995319), Maries van den Broek (194983), Nick van Dijk (11857070), Michiel van den Heijden (11995328)   +7 more
core   +1 more source

Differential Effects of the Absence of Nkx2-3 and MAdCAM-1 on the Distribution of Intestinal Type 3 Innate Lymphoid Cells and Postnatal SILT Formation in Mice

Frontiers in Immunology, 2019
Seeding of leukocytes to developing lymphoid tissues in embryonic and early postnatal age and to the mucosa throughout adulthood depends on the interaction between endothelial MAdCAM-1 addressin and its cognate ligand α4β7 integrin.
Dóra Vojkovics, Dóra Vojkovics, Zoltán Kellermayer, Zoltán Kellermayer, Fanni Gábris, Fanni Gábris, Angela Schippers, Norbert Wagner, Gergely Berta, Kornélia Farkas, Péter Balogh, Péter Balogh   +11 more
doaj   +1 more source

B Cell Orchestration of Anti-tumor Immune Responses: A Matter of Cell Localization and Communication

Frontiers in Cell and Developmental Biology, 2021
The immune system plays a crucial role in cancer development either by fostering tumor growth or destroying tumor cells, which has open new avenues for cancer immunotherapy.
Gabriela Sarti Kinker, Glauco Akelinghton Freire Vitiello, Glauco Akelinghton Freire Vitiello, Wallax Augusto Silva Ferreira, Wallax Augusto Silva Ferreira, Alexandre Silva Chaves, Vladmir Cláudio Cordeiro de Lima, Vladmir Cláudio Cordeiro de Lima, Tiago da Silva Medina, Tiago da Silva Medina   +9 more
doaj   +1 more source

Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy

MedComm, Volume 7, Issue 7, July 2026.
Tumor progression is driven by heterogeneity occurring across multiple biological scales. At the molecular level, tumor cells exhibit alterations across distinct omics layers, including genomic mutations, epigenomic reprogramming, transcriptional changes, and proteomic remodeling, collectively shaping tumor cell phenotypes and functional states.
Hanwen Hu, Zhixing Hao, Lili Li, Huiying Liu, Chenghui Yang, Zhen Wang   +5 more
wiley   +1 more source

Epigenetic targets to enhance antitumor immune response through the induction of tertiary lymphoid structures

Frontiers in Immunology
Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates found in sites of chronic inflammation such as tumors and autoimmune diseases. The discovery that TLS formation at tumor sites correlated with good patient prognosis has triggered ...
Quadri Ajibola Omotesho, Quadri Ajibola Omotesho, Alejandro Escamilla, Alejandro Escamilla, Elisabeth Pérez-Ruiz, Cecilia A. Frecha, Antonio Rueda-Domínguez, Isabel Barragán, Isabel Barragán   +8 more
doaj   +1 more source

DataSheet_6_Molecular, Immunological, and Clinical Features Associated With Lymphoid Neogenesis in Muscle Invasive Bladder Cancer.pdf

, 2022
Lymphoid neogenesis gives rise to tertiary lymphoid structures (TLS) in the periphery of multiple cancer types including muscle invasive bladder cancer (MIBC) where it has positive prognostic and predictive associations.
Phil F. Cheng (11995322), Mitchell P. Levesque (11995331), Laurin Brugger (11995325), Karina Silina (5989283), Fabio Pagliarulo (11995319), Maries van den Broek (194983), Nick van Dijk (11857070), Michiel van den Heijden (11995328)   +7 more
core   +1 more source

Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies

MedComm, Volume 7, Issue 6, June 2026.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by unleashing antitumor immunity. This review comprehensively examines the molecular mechanisms underlying key immune checkpoints—including PD‐1/PD‐L1, CTLA‐4, and TIM‐3—and their clinical applications.
Qintao Ge, Liu Yu, Jiahe Lu, Aihetaimujiang Anwaier, Xiyue Xiao, Yonghao Chen, Dingwei Ye, Hailiang Zhang, Wenhao Xu, Wenbin Dai   +9 more
wiley   +1 more source

DataSheet_5_Molecular, Immunological, and Clinical Features Associated With Lymphoid Neogenesis in Muscle Invasive Bladder Cancer.pdf

, 2022
Lymphoid neogenesis gives rise to tertiary lymphoid structures (TLS) in the periphery of multiple cancer types including muscle invasive bladder cancer (MIBC) where it has positive prognostic and predictive associations.
Phil F. Cheng (11995322), Mitchell P. Levesque (11995331), Laurin Brugger (11995325), Karina Silina (5989283), Fabio Pagliarulo (11995319), Maries van den Broek (194983), Nick van Dijk (11857070), Michiel van den Heijden (11995328)   +7 more
core   +1 more source

Neoadjuvant Immunochemotherapy Increases the Abundance of Tertiary Lymphoid Structures and Lymphocyte Subpopulations Is Associated With Prognosis of Esophageal Squamous Cell Carcinoma

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Neoadjuvant immunochemotherapy (NIC) has emerged as a promising strategy for esophageal squamous cell carcinoma (ESCC). However, its impact on tertiary lymphoid structures (TLSs) and the immune microenvironment remains to be fully elucidated. We retrospectively analyzed 50 ESCC patients treated with NIC (n = 25) or chemotherapy alone (n = 25 ...
Ning Li, Xiaoyan Zhang, Xupeng Tang, Juanning Shen, Qing Qi, Huili Wu, Yuze Zhao, Shuo Wang   +7 more
wiley   +1 more source

Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes

Cell Reports, 2019
Summary: There is a current imperative to unravel the hierarchy of molecular pathways that drive the transition of early to established disease in rheumatoid arthritis (RA).
Myles J. Lewis, Michael R. Barnes, Kevin Blighe, Katriona Goldmann, Sharmila Rana, Jason A. Hackney, Nandhini Ramamoorthi, Christopher R. John, David S. Watson, Sarah K. Kummerfeld, Rebecca Hands, Sudeh Riahi, Vidalba Rocher-Ros, Felice Rivellese, Frances Humby, Stephen Kelly, Michele Bombardieri, Nora Ng, Maria DiCicco, Désirée van der Heijde, Robert Landewé, Annette van der Helm-van Mil, Alberto Cauli, Iain B. McInnes, Christopher D. Buckley, Ernest Choy, Peter C. Taylor, Michael J. Townsend, Costantino Pitzalis   +28 more
doaj   +1 more source