Results 91 to 100 of about 78,214 (186)

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

MedComm, Volume 7, Issue 2, February 2026.
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu, Zhi‐Shan Ge, Qing‐Yue Cao, Zi‐Han Li, An Zhang, Hai‐Dong Zhu, Gao‐Jun Teng   +6 more
wiley   +1 more source

Adaptive immunity in the joint of rheumatoid arthritis

Immunological Medicine, 2022
Adaptive immunity plays central roles in the pathogenesis of rheumatoid arthritis (RA), as it is regarded as an autoimmune disease. Clinical investigations revealed infiltrations of B cells in the synovium, especially those with ectopic lymphoid ...
Hisakata Yamada
doaj   +1 more source

Artery Tertiary Lymphoid Organs Form Neuroimmune Cardiovascular Interfaces in Atherosclerosis

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Arterial walls of large‐ and intermediate‐sized arteries consist of three layers, that is, the intima, the media, and the adventitia. Under physiological conditions, the intima mainly comprises endothelial cells and a few monocyte/macrophages and dendritic cells; the media consists of smooth muscle cells and elastic fibers; and the adventitia ...
Sarajo K. Mohanta, Mingyang Hong, Xinyi Deng, Xinwen Dou, Xu Xu, Mohammad Monjezi, Yutao Li, Ting Sun, Zhihua Wang, Andreas J. R. Habenicht, Changjun Yin   +10 more
wiley   +1 more source

Absence of sympathetic innervation hampers the generation of tertiary lymphoid structures upon acute lung inflammation

Scientific Reports
Tertiary lymphoid structures (TLS) are lymphoid organs present in inflammatory non-lymphoid tissues. Studies have linked TLS to favorable outcomes for patients with cancers or infectious diseases, but the mechanisms underlying their formation are not ...
Clémence Riffard, Laïla Letaïef, Safa Azar, Armanda Casrouge, Isabelle Brunet, Jean-Luc Teillaud, Marie-Caroline Dieu-Nosjean   +6 more
doaj   +1 more source

Activation-induced cytidine deaminase in tertiary lymphoid structures: dual roles and implications in cancer prognosis

Frontiers in Oncology
Activation-induced cytidine deaminase (AID) serves as a critical molecular orchestrator in the germinal center (GC) reaction within secondary lymphoid organs (SLOs), driving the production of high-affinity antibodies through somatic hypermutation.
Zhuangwei Lv, Junna Jiao, Junna Jiao, Wuyang Xue, Xiaoyu Shi, Ruihan Wang, Jinhua Wu   +6 more
doaj   +1 more source

Lymphoid tissue reactions in rheumatoid arthritis

, 2007
Frequently, the immune cell infiltrate of chronically inflamed tissues develops functional germinal centres and acquires structural features of secondary lymphoid organs.
Pitzalis C., MANZO, ANTONIO
core   +1 more source

DataSheet_8_Molecular, Immunological, and Clinical Features Associated With Lymphoid Neogenesis in Muscle Invasive Bladder Cancer.pdf

, 2022
Lymphoid neogenesis gives rise to tertiary lymphoid structures (TLS) in the periphery of multiple cancer types including muscle invasive bladder cancer (MIBC) where it has positive prognostic and predictive associations.
Phil F. Cheng (11995322), Mitchell P. Levesque (11995331), Laurin Brugger (11995325), Karina Silina (5989283), Fabio Pagliarulo (11995319), Maries van den Broek (194983), Nick van Dijk (11857070), Michiel van den Heijden (11995328)   +7 more
core   +1 more source

A Tertiary Lymphoid Structure–Derived Prognostic Signature Integrates Immune Microenvironment and Mutational Landscapes in Clear Cell Renal Cell Carcinoma

Human Mutation, Volume 2026, Issue 1, 2026.
Tertiary lymphoid structures (TLSs) are increasingly recognized as important components of the tumor immune microenvironment, yet their prognostic and immunological implications in clear cell renal cell carcinoma (ccRCC) remain incompletely characterized.
Xuanyu Zhou, Zhongwei Zhao, Kai Huang, Guangxin Ma, Run Shi   +4 more
wiley   +1 more source

SYK Inhibition Induces Apoptosis in Germinal Center-Like B Cells by Modulating the Antiapoptotic Protein Myeloid Cell Leukemia-1, Affecting B-Cell Activation and Antibody Production

Frontiers in Immunology, 2018
B cells play a major role in the antibody-mediated rejection (AMR) of solid organ transplants, a major public health concern. The germinal center (GC) is involved in the generation of donor-specific antibody-producing plasma cells and memory B cells ...
Nathalie Roders, Nathalie Roders, Nathalie Roders, Florence Herr, Florence Herr, Florence Herr, Gorbatchev Ambroise, Gorbatchev Ambroise, Olivier Thaunat, Olivier Thaunat, Olivier Thaunat, Alain Portier, Alain Portier, Aimé Vazquez, Aimé Vazquez, Antoine Durrbach, Antoine Durrbach, Antoine Durrbach   +17 more
doaj   +1 more source

DataSheet_3_Molecular, Immunological, and Clinical Features Associated With Lymphoid Neogenesis in Muscle Invasive Bladder Cancer.pdf

, 2022
Lymphoid neogenesis gives rise to tertiary lymphoid structures (TLS) in the periphery of multiple cancer types including muscle invasive bladder cancer (MIBC) where it has positive prognostic and predictive associations.
Phil F. Cheng (11995322), Mitchell P. Levesque (11995331), Laurin Brugger (11995325), Karina Silina (5989283), Fabio Pagliarulo (11995319), Maries van den Broek (194983), Nick van Dijk (11857070), Michiel van den Heijden (11995328)   +7 more
core   +1 more source