Results 41 to 50 of about 3,969,489 (270)

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

, 2020
Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable tumour control and result in the long-term survival of patients with advanced cancers1.
Skaarup Larsen, Mathilde, Karolin Isaksson, Bastholt, Lars, Vallon-Christersson, Johan, Marco Donia, Lauss, Martin, Göran Jönsson, Sarah Warren, Mitra, Shamik, Wargo, Jennifer A., Martin Lauss, Kristian Pietras, Svane, Inge Marie, Rita Cabrita, Kristina Lövgren, Pietras, Kristian, Lövgren, Kristina, Sanna, Adriana, Henrik Schmidt, Johan Vallon-Christersson, Dirk Schadendorf, Lars Bastholt, van Schoiack, Alison, Cabrita, Rita, Iva Johansson, Ana Carneiro, Donia, Marco, Bengt Phung, Isaksson, Karolin, Carneiro, Ana, Jirström, Karin, Karin Jirström, Bastholt, Lars; id_orcid, Adriana Sanna, Håkan Olsson, Shamik Mitra, Jönsson, Göran, Mathilde Skaarup Larsen, Warren, Sarah, Schadendorf, Dirk, Ingvar, Christian, Inge Marie Svane, Jennifer A. Wargo, Johansson, Iva, Katja Harbst, Alison van Schoiack, Christian Ingvar, Phung, Bengt, Harbst, Katja, Schmidt, Henrik, Olsson, Håkan   +50 more
core   +1 more source

Cancer Immunotherapies: From Efficacy to Resistance Mechanisms – Not Only Checkpoint Matters

Frontiers in Immunology, 2021
The immunotherapeutic treatment of various cancers with an increasing number of immune checkpoint inhibitors (ICIs) has profoundly improved the clinical management of advanced diseases.
Shuyue Wang, Kun Xie, Tengfei Liu
doaj   +1 more source

Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy [PDF]

Cellular & Molecular Immunology, 2017
Tertiary lymphoid structures (TLS) often develop at sites of persistent inflammation, including cancers and autoimmune diseases. In most cases, the presence of TLS correlates with active immune responses. Because of their proximity to pathological loci, TLS are an intriguing target for the manipulation of immune responses.
Haidong, Tang, Mingzhao, Zhu, Jian, Qiao, Yang-Xin, Fu   +3 more
openaire   +2 more sources

Tertiary lymphoid structures in the era of cancer therapy. [PDF]

J Exp Clin Cancer Res
Abstract On September 9th, 2025, the 3rd Workshop on Tertiary lymphoid structures (TLS) took place in Utrecht as pre-meeting to CICON2025. Advances in TLS biology, diversity, and clinical significance are rapidly reshaping the field.
Hernández-Verdin I, Dimberg A, Thommen DS, Engblom C, Vanhersecke L, Silina K, Bruno TC, Fridman WH, Nisticò P, Sautès-Fridman C.   +9 more
europepmc   +4 more sources

DataSheet1_The gene signature of tertiary lymphoid structures within ovarian cancer predicts the prognosis and immunotherapy benefit.docx

, 2023
Ovarian cancer (OC) has the lowest survival rate among gynecologic malignancies. Ectopic lymphocyte aggregates, namely tertiary lymphoid structures (TLSs), have been reported as positive biomarkers for tumor prognosis. However, the related gene signature
Yue Hou (2562085), Miao Li (337830), Xue Han (25073), Yingxin Pang (4537759), Hongluan Mao (8192757), Sijing Qiao (14367501), Xuan Wei (613185)   +6 more
core   +1 more source

Tertiary lymphoid structures and their association to immune phenotypes and circulatory IL2 levels in pancreatic ductal adenocarcinoma

OncoImmunology, 2022
Pancreatic ductal adenocarcinoma (PDA) is usually unresponsive to immunotherapeutic approaches. However, tertiary lymphoid structures (TLS) are associated with favorable patient outcomes in PDA.
Azaz Ahmed, Sophia Köhler, Rosa Klotz, Nathalia Giese, Thilo Hackert, Christoph Springfeld, Inka Zörnig, Dirk Jäger, Niels Halama   +8 more
doaj   +1 more source

Association of tertiary lymphoid structures and benign lymphoepithelial lesions in NIH-category IV prostatitis: pathophysiological correlations

The Canadian Journal of Urology
Background: Chronic inflammation is closely associated with the most common and socially significant prostate conditions, including benign prostatic hyperplasia (BPH), prostate cancer (PCa), and prostatitis syndromes.
Dorian Dikov, Maria Koleva, Kiril Simitchiev, Anelia Bivolarska, Albena Fakirova, Victoria Sarafian   +5 more
doaj   +1 more source

A CT-based radiomics approach to predict intra-tumoral tertiary lymphoid structures and recurrence of intrahepatic cholangiocarcinoma

Insights into Imaging, 2023
Purpose To predict the tertiary lymphoid structures (TLSs) status and recurrence-free survival (RFS) of intrahepatic cholangiocarcinoma (ICC) patients using preoperative CT radiomics.
Ying Xu, Zhuo Li, Yi Yang, Lu Li, Yanzhao Zhou, Jingzhong Ouyang, Zhen Huang, Sicong Wang, Lizhi Xie, Feng Ye, Jinxue Zhou, Jianming Ying, Hong Zhao, Xinming Zhao   +13 more
doaj   +1 more source

Identifying Patterns of Hospitalizations Among Childhood Cancer Survivors: A Population‐Based Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Childhood cancer survivors (CCSs) experience more hospitalizations than the general population. We aimed to identify distinct hospitalization patterns among Queensland CCSs and the associated characteristics. Methods Cases (aged ≤14 years) diagnosed between 1995 and 2019 while residents of Queensland were identified through the ...
Hai Pham, Teyl Engstrom, Peter Baade, Natalie Bradford, Sarah Pont, Louise Marquart‐Wilson, Natasha Nassar, Jason D. Pole   +7 more
wiley   +1 more source

Orchestration of tertiary lymphoid structures: decoding developmental mechanisms for next-generation cancer immunotherapies

Medical Review
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates that form in non-lymphoid organs, frequently observed in conditions such as cancer, autoimmune diseases, transplant rejection, and chronic inflammation.
Hao Wenqin, Zhao Ying
doaj   +1 more source