Results 41 to 50 of about 27,427 (193)

Tertiary lymphoid structures and their association to immune phenotypes and circulatory IL2 levels in pancreatic ductal adenocarcinoma

OncoImmunology, 2022
Pancreatic ductal adenocarcinoma (PDA) is usually unresponsive to immunotherapeutic approaches. However, tertiary lymphoid structures (TLS) are associated with favorable patient outcomes in PDA.
Azaz Ahmed, Sophia Köhler, Rosa Klotz, Nathalia Giese, Thilo Hackert, Christoph Springfeld, Inka Zörnig, Dirk Jäger, Niels Halama   +8 more
doaj   +1 more source

Long-lasting cross-protection against influenza A by neuraminidase and M2e-based immunization strategies [PDF]

, 2016
There is mounting evidence that in the absence of neutralizing antibodies cross-reactive T cells provide protection against pandemic influenza viruses. Here, we compared protection and CD8+ T cell responses following challenge with H1N1 2009 pandemic and
Callewaert, Nico, Fiers, Walter, Saelens, Xavier, Schepens, Bert, Schotsaert, Michael, Smet, Anouk, Stegalkina, Svetlana, Vanderschaeghe, Dieter, Vogel, Thorsten U, Ysenbaert, Tine   +9 more
core   +2 more sources

Characteristics of tertiary lymphoid structures in primary cancers [PDF]

OncoImmunology, 2013
Tumors are sustained by complex networks of interactions between malignant cells, stromal cells and tumor-infiltrating immune cells. These networks differ from patient to patient in terms of nature, composition and organization as well as with regard to the precise localization of tumor-infiltrating cells.
Goc, Jérémy, Fridman, Wolf-Herman, Sautès-Fridman, Catherine, Dieu-Nosjean, Marie-Caroline   +3 more
openaire   +2 more sources

Anaplastic Thyroid Carcinoma Histologically Mimicking a Plasmacytoma. [PDF]

, 2020
Anaplastic (undifferentiated) thyroid carcinoma (ATC) is a rare malignancy which may arise from transformation of a pre-existing differentiated carcinoma. We report the unique case where a lesion of thyroid origin presented with the histological features
Mo, Joshua H, Tan, Donald, Tjoa, Tjoson, Wang, Beverly Y, Zhao, Xiaohui S   +4 more
core   +1 more source

A CT-based radiomics approach to predict intra-tumoral tertiary lymphoid structures and recurrence of intrahepatic cholangiocarcinoma

Insights into Imaging, 2023
Purpose To predict the tertiary lymphoid structures (TLSs) status and recurrence-free survival (RFS) of intrahepatic cholangiocarcinoma (ICC) patients using preoperative CT radiomics.
Ying Xu, Zhuo Li, Yi Yang, Lu Li, Yanzhao Zhou, Jingzhong Ouyang, Zhen Huang, Sicong Wang, Lizhi Xie, Feng Ye, Jinxue Zhou, Jianming Ying, Hong Zhao, Xinming Zhao   +13 more
doaj   +1 more source

Tertiary lymphoid structures in endometriosis

F&S Science
To determine whether tertiary lymphoid structures (TLSs), which reflect organized immune cell aggregates present in non-lymphoid tissues, are consistent features of endometriosis lesions.Detailed histopathological analysis of endometrial and lesion tissue from patients with endometriosis and controls was performed.
Katherine B. Zutautas, Priyanka Yolmo, Minqi Xu, Timothy Childs, Madhuri Koti, Chandrakant Tayade   +5 more
openaire   +2 more sources

Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy [PDF]

Cellular & Molecular Immunology, 2017
Tertiary lymphoid structures (TLS) often develop at sites of persistent inflammation, including cancers and autoimmune diseases. In most cases, the presence of TLS correlates with active immune responses. Because of their proximity to pathological loci, TLS are an intriguing target for the manipulation of immune responses.
Haidong, Tang, Mingzhao, Zhu, Jian, Qiao, Yang-Xin, Fu   +3 more
openaire   +2 more sources

Ectopic expression of CXCL13, BAFF, APRIL and LT-ß is associated with artery tertiary lymphoid organs in giant cell arteritis [PDF]

, 2016
Objectives To investigate whether artery tertiary lymphoid organs (ATLOs) are present in giant cell arteritis (GCA) and that their formation is associated with the ectopic expression of constitutive lymphoid tissue-homing chemokines.
ALESSANDRO, Riccardo, CANNIZZARO, Alessandra, Cavazza, A., CICCIA, Francesco, Croci, S., GUGGINO, Giuliana, Iacopino, D., Maugeri, R., RAIMONDO, Stefania, Rizzo, A., Salvarani, C., TRIOLO, Giovanni   +11 more
core   +1 more source

Synthesis of artificial lymphoid tissue with immunological function. [PDF]

, 2010
The ability to generate functional artificial lymphoid tissue to induce specific immunity at ectopic sites could offer a potential breakthrough for treatment of diseases such as cancer and severe infection using immunotherapy.
Kobayashi, Yuka, Watanabe, Takeshi
core   +1 more source

Tertiary lymphoid structures in cancer – considerations for patient prognosis [PDF]

Cellular & Molecular Immunology, 2020
Tertiary lymphoid structures (TLS) are ectopic lymphoid formations that form within nonlymphoid tissue. They share structural and functional characteristics with secondary lymphoid structures such as lymph nodes and can contain B-cell follicles and germinal centers surrounded by a T-cell region.
Luis, Munoz-Erazo, Janet L, Rhodes, Valentine C, Marion, Roslyn A, Kemp   +3 more
openaire   +2 more sources