Results 51 to 60 of about 3,969,489 (270)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Tertiary Lymphoid Structures: Diversity in Their Development, Composition, and Role

, 2021
Lymph node stromal cells coordinate the adaptive immune response in secondary lymphoid organs, providing both a structural matrix and soluble factors that regulate survival and migration of immune cells, ultimately promoting Ag encounter.
Gago da Graça, Catarina, van Baarsen, Lisa G. M., Mebius, Reina E, Mebius, Reina E., van Baarsen, Lisa G M   +4 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

B cells and tertiary lymphoid structures promote immunotherapy response [PDF]

, 2020
International audienceTreatment with immune checkpoint blockade (ICB) has revolutionized cancer therapy. Until now, predictive biomarkers1-10 and strategies to augment clinical response have largely focused on the T cell compartment.
Alexandre Reuben, Patel, Sapna, Reddy, S.M., Han, G.C., Patrick Hwu, Spencer, C.N., Tetzlaff, Michael,, Lee, Jeffrey, E, Padmanee Sharma, McBride, K.M., Linghua Wang, Yizhak, Keren, Rohit Thakur, Warren, S., Gaudreau, P.O., Hwu, P., Amaria, Rodabe, N, Wang, Linghua, Haydu, Lauren E, Catherine Sautès-Fridman, Reddy, Sangeetha,, Helmink, Beth,, Reuben, Alexandre, Hudgens, Courtney W, Burton, E.M., McBride, Kevin M, Hwu, Patrick, Allison, James, Reddy, Sangeetha, M, Vancheswaran Gopalakrishnan, Butterfield, Lisa H, Kalluri, Raghu, Lazar, Alexander J, Liu, Wenbin, Lucci, A., Jianjun Gao, Tawbi, Hussein,, Zhang, S.J., Kugeratski, Fernanda G, Gershenwald, J.E., Wang, L.H., Keung, Emily, Z, Allison, J., Jennifer A. Wargo, Sapna Patel, Davies, Michael,, Basar, R., Tetzlaff, Michael, T, Ong, S., Burton, Elizabeth M, Cogdill, Alex, Patel, S., Blank, C.U., Elizabeth M. Burton, Reddy, Sangeetha M, Hacohen, N., Davies, Michael A, Xi, Y.X., Fridman, Wolf Herman, LeBleu, Valerie S, Lee, Jeffrey E, Hao Zhao, Rozeman, Elisa,, Blank, Christian, U., Cogdill, A.P., Rezvani, K., Blando, J., Davies, Michael, E., Keung, E.Z., Amaria, R.N., Bailey, M., Rezvani, Katayoun, Hudgens, C.W., Gershenwald, Jeffrey E, Wargo, Jennifer A, Zhao, Hao, Schumacher, Ton, Haydu, Lauren, E, Kugeratski, Fernanda, Scott Woodman, Raghu Kalluri, Guangchun Han, Emily Z. Keung, Wenbin Liu, Blank, Christian U, Rao, Disha, Butterfield, L.H., Ledesma, D.A., Burton, Elizabeth, M, Petitprez, F., Gershenwald, Jeffrey, E, Deborah A. Ledesma, Woodman, Scott, Yuanxin Xi, Fridman, W.H., Nir Hacohen, Hussein A. Tawbi, James Allison, Haydu, Lauren,, Sharma, Padmanee, Zhang, Shaojun, Hacohen, Nir, Spencer, Christine,, Oscar Krijgsman, Liu, W.B., Lee, J.E., Hudgens, Courtney, Michael Bailey, Davies, M.A., Kevin M. McBride, Lucci, Anthony, Krijgsman, Oscar, Florent Petitprez, Rozeman, E.A., Elisa A. Rozeman, Tawbi, Hussein, A, Thakur, Rohit, Zapassodi, Roberta, Spencer, Christine N, Tetzlaff, M.T., Michael A. Davies, Daniel Peeper, Keung, Emily,, Sautes-Fridman, C., Sharma, P., Wargo, Jennifer, Krijgsman, O., Schumacher, T.N., Butterfield, Lisa, Lazar, Alexander, J, Moshe Sade-Feldman, Tawbi, H.A., Wargo, J.A., Sade-Feldman, Moshe, Ong, Sufey, Zhao, H., Alex P. Cogdill, Michael T. Tetzlaff, Helmink, Beth A, Keren Yizhak, Tetzlaff, Michael T, Wolf Herman Fridman, Jorge Blando, Reetakshi Arora, Xi, Yuanxin, Lauren E. Haydu, Yizhak, K., Pierre-Olivier Gaudreau, Lazar, Alexander,, Arora, Reetakshi, Fernanda G. Kugeratski, Anthony Lucci, Rodabe N. Amaria, LeBleu, V.S., Valerie S. LeBleu, Zelazowska, M.A., Amaria, Rodabe N, Gopalakrishnan, V., Gopalakrishnan, Vancheswaran, Sade-Feldman, M., Roberta Zapassodi, Woodman, S., Lazar, A.J., Amaria, Rodabe,, Ledesma, Deborah, A, Rafet Basar, Schumacher, Ton N, Kalluri, R., Sarah Warren, Arora, R., Lebleu, Valerie, Disha Rao, Zapassodi, R., Haydu, L.E., Monika A. Zelazowska, Burton, Elizabeth,, Ton N. Schumacher, Jeffrey E. Gershenwald, Courtney W. Hudgens, Keung, Emily Z, Thakur, R., Sautès-Fridman, Catherine, Basar, Rafet, Blank, Christian,, Kugeratski, F.G., Alexander J. Lazar, Gao, J.J., Rao, D., Lee, Jeffrey,, Peeper, D., Sangeetha M. Reddy, SuFey Ong, Helmink, B.A., Reuben, A., Han, Guangchun, Rozeman, Elisa, A, Peeper, Daniel, Gershenwald, Jeffrey,, Warren, Sarah, Beth A. Helmink, Katayoun Rezvani, Ledesma, Deborah A, Gaudreau, Pierre-Olivier, Petitprez, Florent, Gao, Jianjun, Jeffrey E. Lee, Mcbride, Kevin, Cogdill, Alex P, Christian U. Blank, Bailey, Michael, Helmink, Beth, A, Rozeman, Elisa A, Blando, Jorge, Ledesma, Deborah,, Christine N. Spencer, Tawbi, Hussein A, Spencer, Christine, N, Zelazowska, Monika A, Shaojun Zhang, Lisa H. Butterfield   +219 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Using immunovascular characteristics to predict very early recurrence and prognosis of resectable intrahepatic cholangiocarcinoma

BMC Cancer, 2023
Objective To predict the very early recurrence (VER) of patients with intrahepatic cholangiocarcinoma (ICC) based on TLSs and MVI status, and further perform prognosis stratifications. Methods A total of 160, 51 ICC patients from two institutions between
Ying Xu, Zhuo Li, Yanzhao Zhou, Yi Yang, Jingzhong Ouyang, Lu Li, Zhen Huang, Feng Ye, Jianming Ying, Hong Zhao, Jinxue Zhou, Xinming Zhao   +11 more
doaj   +1 more source

Research trends, hotspots and future directions of tertiary lymphoid structures in cancer: a comprehensive informatics analysis and visualization study

Discover Oncology
Many studies have reported the presence of tertiary lymphoid structures (TLSs) in cancer, but the research progress of TLSs in cancer has not been systematically analyzed.
Chengdong Yu, Jiawei Xu, Siyi Xu, Lei Tang, Qinyuan Han, Zhengkui Sun   +5 more
doaj   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source