Results 61 to 70 of about 27,427 (193)

Stromal cells in tertiary lymphoid structures: Architects of autoimmunity

Immunological Reviews, 2021
AbstractThe molecular mediators present within the inflammatory microenvironment are able, in certain conditions, to favor the initiation of tertiary lymphoid structure (TLS) development. TLS is organized lymphocyte clusters able to support antigen‐specific immune response in non‐immune organs.
Saba Asam, Saba Nayar, David Gardner, Francesca Barone   +3 more
openaire   +2 more sources

Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization [PDF]

, 2009
In this report we describe a transplantation system where embryonic spleens are grafted into adult hosts. This model can be used to analyze the cellular and molecular requirements for the development and organization of splenic microenvironments.Whole ...
Rennert, Fu, Mackay, Ngo, Luther, Link, Nolte, Bajenoff, Togni, Futterer, Bekiaris, Mebius, Yoshida, Kim, Cupedo, Cupedo, Cupedo, Honda, Meier, Veiga-Fernandes, Withers, Ngo, Yokota, Eberl, Sun, Kim, Kim, Kim, Kim, White, Rossi, Vondenhoff, Brendolan, Bekiaris, Scandella, Fu, Drayton, Aloisi, Kratz, Fan, Luther, Luther, Chen, Wang   +43 more
core   +2 more sources

The roles of tertiary lymphoid structures in chronic diseases

Nature Reviews Nephrology, 2023
Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such as lymph nodes, TLSs lack capsules and have their own unique characteristics and functions.
Sato, Yuki, Silina, Karina, van den Broek, Maries, Hirahara, Kiyoshi, Yanagita, Motoko   +4 more
openaire   +3 more sources

New insights into the pathogenesis of giant cell arteritis [PDF]

, 2016
Giant cell arteritis (GCA) is an inflammatory chronic disease occurring exclusively in elderly individuals. Until recently, the disease has been considered a unique disease resulting from the interaction in the walls of susceptible arteries, between an ...
Francesco Ciccia, Aroldo Rizzo, Angelo Ferrante, Giuliana Guggino, Stefania Croci, Alberto Cavazza, Carlo Salvarani, Giovanni Triolo, Salvarani, Calamia, Hunder, Salehi-Abari, Genereau, Cavazza, Hernández-Rodríguez, Lie, Weyand, Weyand, Gabriel, Esteban, Restuccia, Wing, Petursdottir, Wagner, Giardina, Nagel, Nagel, Jones, Pisapia, Rhee, Carmona, Gonzalez-Gay, Weyand, Mackie, Carmona, González-Gay, Rauzy, Mackie, Lester, Carmona, Coit, Mattey, Gonzalez-Gay, Boiardi, Amoli, Salvarani, Márquez, Palomino-Morales, Rodríguez-Rodríguez, Márquez, Amoli, Makki, Salvarani, Boiardi, Gonzalez-Gay, Rodriguez-Pla, Alvarez-Rodriguez, Morgan, Salvarani, Carmona, Serrano, Alvarez-Rodríguez, Hu, Pitzalis, Ciccia, Amft, Litsiou, Álvarez Rodríguez, Ma-Krupa, Wagner, VandenEijnden, Netea, Shao, Kim, Nold-Petry, Ciccia, Hunter, Wong, Palmer, Ciccia, Weyand, DuPage, Deng, Weyand, Ciccia, Weyand, Espígol-Frigolé, Zhang, Said, Miyabe, Leavy, Banks, Cid, Martinez-Taboada, Samson, Wen, Schmits, Smith, Brack, Weyand, van der Geest, Alba, Foell, Nadkarni, Sibilano, Mäyränpää, Dimitrijevic, Cid, Régent, Croci, Kriegel   +110 more
core   +3 more sources

Control of Dichotomic Innate and Adaptive Immune Responses by Artery Tertiary Lymphoid Organs in Atherosclerosis [PDF]

, 2012
Tertiary lymphoid organs (TLOs) emerge in tissues in response to non-resolving inflammation such as chronic infection, graft rejection, and autoimmune disease.
Andreas Johann Habenicht, Desheng eHu, Desheng eHu, Falk eWeih, Michael eBeer, Rolf eGräbner   +5 more
core   +2 more sources

Rare Variants of Putative Candidate Genes Associated With Sporadic Meniere's Disease in East Asian Population [PDF]

, 2020
Objectives: The cause of Meniere's disease (MD) is unclear but likely involves genetic and environmental factors. The aim of this study was to investigate the genetic basis underlying MD by screening putative candidate genes for MD.
Arweiler-Harbeck, Begovich, Brama, Cabrera, Campbell, de Lima, Doi, Dong, Eichler, Filipo, Flook, Foster, Frejo, Frejo, Frejo, Furuta, Gallego-Martinez, Gazquez, Gazquez, Girirajan, Greco, Hietikko, Huang, Kawaguchi, Khorsandi, Kim, Kimura, Klar, Koo, Lee, Lee, Lee, Lee, Lettre, Li, Li, Lien, Lien, Liew, Lopez-Escamez, Lopez-Escamez, Lopez-Escamez, Lopez-Escamez, Marcus, Martín-Sierra, Martín-Sierra, Melchiorri, Meng, Morrison, Mustelin, Nair, Nair, Nair, Nishio, Oliveira-Paula, Qin, Rasheed, Rauch, Recupero, Reich, Rentzsch, Requena, Requena, Requena, Requena, Roman-Naranjo, Saint Pierre, Schwanitz, Shu, Sun, Takumida, Teggi, Teggi, Teggi, Teranishi, Tilburg, Tomoda, Uchida, Vrabec, Yang, Yazdani, Yazdani   +81 more
core   +1 more source

Profiling tumour-infiltrating immune cells in a large paediatric medulloblastoma cohort: a retrospective analysisResearch in context

EBioMedicine
Summary: Background: Tumour-infiltrating immune cells exert both pro-tumour and anti-tumour effects on intracranial tumours. In this study, we investigated the prognostic value of various infiltrating immune cells in medulloblastoma (MB) within a large ...
Mingze Chen, Xiangjun Shi, Yi Wang, Jiao Zhang, Jirong Guo, Xiuchen Guan, Yu Sun, Wenhao Wu, Chunde Li, Yongji Tian, Yunwei Ou, Tian Li, Kai Jiang, Michael D. Taylor, Xuebin Liao, Liwei Zhang, Tao Sun   +16 more
doaj   +1 more source

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity. [PDF]

, 2018
Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in cancer patients.
Abnousian, Arbi, Bluestone, Jeffrey A, DuPage, Michel, Fong, Lawrence, Harwin, Tory, Mahuron, Kelly, Pagani, Massimiliano, Pai, Chien-Chun, Quiros, Jason, Ranzani, Valeria, Rosenblum, Michael D, Silveria, Stephanie, Van Gool, Frederic, Wang, David, Young, Arabella   +14 more
core   +2 more sources

Determining the status of tertiary lymphoid structures in invasive pulmonary adenocarcinoma based on chest CT radiomic features

Insights into Imaging
Objectives The aim of this study was to determine the status of tertiary lymphoid structures (TLSs) using radiomic features in patients with invasive pulmonary adenocarcinoma (IA).
Ye Yu, Tianshu Yang, Pengfei Ma, Yan Zeng, Yongming Dai, Yicheng Fu, Aie Liu, Ying Zhang, Guanglei Zhuang, Yan Zhou, Huawei Wu   +10 more
doaj   +1 more source

Histological, histochemical and ultrastructural studies on Harderian and lacrimal glands of the Capercaillie (Tetrao urogallus major L.) [PDF]

, 2016
This study describes the macroscopic anatomy and the microscopic and ultrastructural features of the Harderian gland and lacrimal gland of the Capercaillies. It was conducted both on adult male and female Capercaillies.
Goździewska-Harłajczuk, Karolina, Klećkowska-Nawrot, Joanna, Kowalczyk, Artur, Nowaczyk, Renata, Łukaszewicz, Ewa   +4 more
core   +1 more source