Results 61 to 70 of about 13,664 (142)

Involvement of lymphoid inducer cells in the development of secondary and tertiary lymphoid structure

BMB Reports, 2009
During development lymphoid tissue inducer (LTi) cells are the first hematopoietic cells to enter the secondary lymphoid anlagen and induce lymphoid tissue neogenesis. LTi cells induce lymphoid tissue neogensis by expressing a wide range of proteins that are associated with lymphoid organogenesis.
Isabel, Evans, Mi-Yeon, Kim
openaire   +3 more sources

The Impact of Tertiary Lymphoid Structures on Tumor Prognosis and the Immune Microenvironment in Colorectal Cancer

Biomedicines
Background: Colorectal cancer (CRC) ranks as the third most common cancer worldwide. Tertiary lymphoid structures (TLSs), organized immune cell aggregates in non-lymphoid tissues, are linked to chronic inflammation and tumorigenesis. However, the precise
Leyi Zhao, Lingze Xi, Yani Liu, Guoliang Wang, Mingtong Zong, Peng Xue, Shijie Zhu   +6 more
doaj   +1 more source

A Tertiary lymphoid structures-based pathological score predicts survival and recurrence in colorectal Cancer patients

Immunobiology
Background & Aim: Colorectal cancer (CRC) is a major global health burden. The immune response within the tumor microenvironment (TME), especially the presence of tertiary lymphoid structures (TLS), plays a critical role in prognosis.
Marion Le Rochais, Marie Morvan, Servane Bouzeloc, Jean-Baptiste Nousbaum, Matthieu Guillard, Pierre Le Noac'h, Soizic Garaud, Arnaud Uguen   +7 more
doaj   +1 more source

Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?

Frontiers in Immunology, 2017
Secondary lymphoid organs are integral to initiation and execution of adaptive immune responses. These organs provide a setting for interactions between antigen-specific lymphocytes and antigen-presenting cells recruited from local infected or inflamed ...
Emily Jayne Colbeck, Ann Ager, Awen Gallimore, Gareth Wyn Jones   +3 more
doaj   +1 more source

Ectopic Lymphoid Structures: powerhouse of autoimmunity

Frontiers in Immunology, 2016
Ectopic lymphoid structures (ELS) often develop at sites of inflammation in target tissues of autoimmune diseases such as rheumatoid arthritis, Sjögren’s syndrome, multiple sclerosis, myasthenia gravis and systemic lupus erythematosus.
Elisa Corsiero, Alessandra Nerviani, Michele Bombardieri, Costantino Pitzalis   +3 more
doaj   +1 more source

Association between tertiary lymphoid structures and clinical outcomes in cancer patients treated with immune checkpoint inhibitors: an updated meta-analysis

Frontiers in Immunology
BackgroundAlthough numerous studies have reported the association between tertiary lymphoid structures (TLSs) and clinical outcomes in cancer patients treated with immune checkpoint inhibitors (ICIs), there remains a lack of a newer and more ...
Lingli Li, Lingli Li, Yusheng Guo, Yusheng Guo, Bingxin Gong, Bingxin Gong, Sichen Wang, Maggie Meijia Wang, Peng Sun, Shanshan Jiang, Shanshan Jiang, Lian Yang, Lian Yang   +12 more
doaj   +1 more source

Unveiling immune resistance mechanisms in nasopharyngeal carcinoma and emerging targets for antitumor immune response: tertiary lymphoid structures

Journal of Translational Medicine
Nasopharyngeal carcinoma (NPC) is a prevalent malignancy in China, commonly associated with undifferentiated cell types and Epstein-Barr virus (EBV) infection.
Huilin Wang, Yuting Zhan, Jiadi Luo, Weiyuan Wang, Songqing Fan   +4 more
doaj   +1 more source

Tertiary Lymphoid Structures in Microorganism-Related Cancer

Cancers
Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues formed by the accumulation of lymphocytes and other components outside lymphoid organs. They have been shown to be widespread in cancers and have predictive effects on prognosis and immunotherapy efficacy; however, there is no standardized measurement guide.
Shuzhe Deng, Xinxin Yang, Lin He, Yunjing Hou, Hongxue Meng   +4 more
openaire   +2 more sources

Advances on tumor-associated tertiary lymphoid structures in immunotherapy

生物医学转化
Tertiary lymphoid structures (TLS) are ectopic lymphoid structures found in non-lymphoid tissues under chronic inflammatory conditions in recent years.
Hu Chupeng, Chen Yun
doaj   +1 more source

Impact of tertiary lymphoid structure-associated biomarkers on pancreatic cancer via a dual-disease analysis of psoriasis and pancreatic cancer

Discover Oncology
Pancreatic cancer (PC), often referred to as the “king of cancers”, has demonstrated limited success with immunotherapies, many of which are still under development.
Hao Yu, Quan Yuan, Liu-Xing Feng, Jia-Huan Xu, Shen-Yuan Zhan, Zhi-min Li, Shuang-Jia Wang   +6 more
doaj   +1 more source