Results 61 to 70 of about 3,969,489 (270)

The Sunrise of Tertiary Lymphoid Structures in Cancer

Immunological Reviews
ABSTRACTFirst considered as a negative epiphenomenon in autoimmune and inflammatory diseases, with possible deleterious consequences through the production of pathological autoantibodies and antiself T cells, tertiary lymphoid structures (TLS) have gained major scientific and clinical interest in cancer due to their association with better clinical ...
Juliette Rochefort, Gilles Marodon, Jean‐Luc Teillaud, Marie‐Caroline Dieu‐Nosjean   +3 more
openaire   +2 more sources

Tertiary lymphoid structures and B lymphocytes: a promising therapeutic strategy to fight cancer

Frontiers in Immunology, 2023
Tertiary lymphoid structures (TLSs) are clusters of lymphoid cells with an organization that resembles that of secondary lymphoid organs. Both structures share common developmental characteristics, although TLSs usually appear in chronically inflamed non-
Laura Esparcia-Pinedo, Laura Esparcia-Pinedo, Nuria Romero-Laorden, Nuria Romero-Laorden, Arantzazu Alfranca, Arantzazu Alfranca, Arantzazu Alfranca, Arantzazu Alfranca   +7 more
doaj   +1 more source

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

Tertiary lymphoid structures critical for prognosis in endometrial cancer patients [PDF]

, 2022
B-cells play a key role in cancer suppression, particularly when aggregated in tertiary lymphoid structures (TLS). Here, we investigate the role of B-cells and TLS in endometrial cancer (EC).
Church, D.N., Koelzer, VH, Jürgenliemk-Schulz, Ina M., Nijman, Hans W., Workel, Hagma H, de Boer, Stephanie M, Powell, M.E., Krog, R.T., Nijman, Hans W, Horeweg, N., de Bruyn, M, Boer, S.M. de, Powell, ME, Horeweg, Nanda, Leary, A, Bosse, Tjalling, Workel, HH, Workel, H.H., de Boer, SM, Koelzer, V.H., Nout, R.A., Leary, A., Nout, Remi A., Vermij, Lisa, Singh, N, Creutzberg, C.L., Koelzer, Viktor H, de Bruyn, Marco, Singh, N., Leon-Castillo, A., Workel, Hagma H., Mileshkin, Linda R, Church, David N, Loiero, D., de Boer, Stephanie M., Mileshkin, Linda R., Bruyn, M. de, Powell, Melanie E., Mileshkin, LR, Jürgenliemk-Schulz, IM, Nout, Remi A, Loiero, Dominik, Horeweg, N, Smit, VTHBM, Bosse, T, Church, David N., Nijman, HW, Vermij, L., Léon-Castillo, A, Bosse, T., Jürgenliemk-Schulz, Ina M, MacKay, H, Jurgenliemk-Schulz, I.M., Léon-Castillo, Alicia, MacKay, H., Krog, Ricki T., Vermij, L, Creutzberg, Carien L, Smit, Vincent T H B M, Loiero, D, Koelzer, Viktor H., de Bruyn, Marco; id_orcid, Krog, Ricki T, Creutzberg, Carien L., MacKay, Helen, Nijman, H.W., Nout, RA, Smit, Vincent T.H.B.M., Creutzberg, CL, Singh, Naveena, Church, DN, Smit, V.T.H.B.M., Powell, Melanie E, Mileshkin, L.R., Leary, Alexandra, Krog, RT   +75 more
core   +3 more sources

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Spatiotemporally Ultrasound‐Controlled Nanoparticles Reprogramming Immunostimulatory Antigen‐Presenting Cancer‐Associated Fibroblasts to Enhance Cancer Immunotherapy

Advanced Science, EarlyView.
We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai, Weikai Sun, Yuxuan Zhao, Daqian Sun, Ting Meng, Yafei Qi, Fengyang Jiang, Jintang Sun, Zhiliang Gao, Dexin Yu   +9 more
wiley   +1 more source

Lymphoid aggregates in desmoplastic melanoma have features of tertiary lymphoid structures [PDF]

Melanoma Research, 2018
Desmoplastic melanomas (DM) have unique and challenging clinical presentations and histomorphology. A characteristic feature is the presence of scattered lymphoid aggregates. However, the nature of these aggregates is not defined. We hypothesized that they may be tertiary lymphoid structures (TLS), and may be associated with programmed death ligand 1 ...
Anne M, Stowman, Alexandra W, Hickman, Ileana S, Mauldin, Adela, Mahmutovic, Alejandro A, Gru, Craig L, Slingluff   +5 more
openaire   +2 more sources

Seroprevalence of human T-lymphotropic virus antibodies among patients with lymphoid malignancies at a tertiary center in Lagos, Nigeria [PDF]

, 2014
Background: There is a significant association of human T-lymphotropic viruses (HTLV) with lymphoid malignancies. HTLV causes a lymphoproliferative malignancy of CD4-activated cells called adult T-cell leukemia/lymphoma (ATL) and a chronic myelopathy ...
Ebele Uche, Akinola Dada, Olaitan Okunoye, Adewumi Adediran, Olajumoke Oshinaike, Sarah John-Olabode, Adedoyin Dosunmu, Mojeed Odesanya, Akinsegun Akinbami, Idris Durojaiye   +9 more
core   +1 more source

The prognostic significance of tumor-infiltrating lymphocytes assessment with hematoxylin and eosin sections in resected primary lung adenocarcinoma.

PLoS ONE, 2019
The prognostic significance of tumor-infiltrating lymphocytes has been determined in cancers of the lung, colon and breast, though there is no standardized method for using this prognostic indicator for lung cancer.
Ahrong Kim, So Jeong Lee, Jihyun Ahn, Won Young Park, Dong Hoon Shin, Chang Hun Lee, Hoon Kwon, Yeon Joo Jeong, Hyo Yeong Ahn, Hoseok I, Yeong Dae Kim, Jeong Su Cho   +11 more
doaj   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source