Results 81 to 90 of about 27,427 (193)

The avian lung-associated immune system [PDF]

, 2006
The lung is a major target organ for numerous viral and bacterial diseases of poultry. To control this constant threat birds have developed a highly organized lung-associated immune system.
Dalamani, Grammatia, Kaspers, Bernd, Reese, Sven   +2 more
core   +3 more sources

Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]

, 2008
Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad, Daley, George, Gray, Nathanael, KURIYAN, John, Seeliger, Markus   +4 more
core   +1 more source

The Impact of Tertiary Lymphoid Structures on Tumor Prognosis and the Immune Microenvironment in Colorectal Cancer

Biomedicines
Background: Colorectal cancer (CRC) ranks as the third most common cancer worldwide. Tertiary lymphoid structures (TLSs), organized immune cell aggregates in non-lymphoid tissues, are linked to chronic inflammation and tumorigenesis. However, the precise
Leyi Zhao, Lingze Xi, Yani Liu, Guoliang Wang, Mingtong Zong, Peng Xue, Shijie Zhu   +6 more
doaj   +1 more source

The Molecular Pathology of Prion Diseases [PDF]

, 2004
Prion diseases, or transmissible spongiform encephalopathies (TSEs), are a group of invariably fatal neurodegenerative disorders. Uniquely, they may present as sporadic, inherited, or infectious forms, all of which involve conversion of the normal ...
Herms, Jochen, Kretzschmar, Hans A., Vassallo, Neville   +2 more
core  

A Tertiary lymphoid structures-based pathological score predicts survival and recurrence in colorectal Cancer patients

Immunobiology
Background & Aim: Colorectal cancer (CRC) is a major global health burden. The immune response within the tumor microenvironment (TME), especially the presence of tertiary lymphoid structures (TLS), plays a critical role in prognosis.
Marion Le Rochais, Marie Morvan, Servane Bouzeloc, Jean-Baptiste Nousbaum, Matthieu Guillard, Pierre Le Noac'h, Soizic Garaud, Arnaud Uguen   +7 more
doaj   +1 more source

Ectopic Lymphoid Structures: powerhouse of autoimmunity

Frontiers in Immunology, 2016
Ectopic lymphoid structures (ELS) often develop at sites of inflammation in target tissues of autoimmune diseases such as rheumatoid arthritis, Sjögren’s syndrome, multiple sclerosis, myasthenia gravis and systemic lupus erythematosus.
Elisa Corsiero, Alessandra Nerviani, Michele Bombardieri, Costantino Pitzalis   +3 more
doaj   +1 more source

Is minor salivary gland biopsy more than a diagnostic tool in primary Sjorgren's syndrome? Association between clinical, histopathological, and molecular features: A retrospective study [PDF]

, 2014
Objectives: Several histological scoring systems, including the focus score, performed in minor salivary glands (MSGs) by hematoxylin-eosin (H&E) staining, have been employed in clinical practice to assess the inflammatory infiltrate and provide the ...
Alunno, A., Bartoloni, E., Berardicurti, O., Bistoni, O., Carubbi, F., Caterbi, S., CICCIA, Francesco, Cipriani, P., Di Benedetto, P., Gerli, R., Giacomelli, R., Ruscitti, P., TRIOLO, Giovanni   +12 more
core   +2 more sources

Interactions between Type 1 Interferons and the Th17 Response in Tuberculosis: Lessons Learned from Autoimmune Diseases [PDF]

, 2017
textabstractThe classical paradigm of tuberculosis (TB) immunity, with a central protective role for Th1 responses and IFN-γ-stimulated cellular responses, has been challenged by unsatisfactory results of vaccine strategies aimed at enhancing Th1 ...
Abhimanyu, Achkar, Afshar, Amarilyo, Ambrosi, Andersson, Antonelli, Arnason, Asano, Ashenafi, Askenase, Avci, Axtell, Axtell, Babudieri, Baccala, Bach, Baechler, Bafica, Bandaru, Barber, Barnes, Basile, Basile, Behar, Belkahla, Bennett, Benson, Berclaz, Berry, Bjornsdottir, Blanco, Blanco, Blomgran, Boer, Boniface, Boum, Braian, Brkic, Brkic, Brkic, Bulat-Kardum, Caccamo, Campbell, Canavan, Carmona-Rivera, Chen, Chen, Choi, Cliff, Cohen, Colditz, Collins, Conrady, Cooper, Coquery, Correa, Coscolla, Cowan, Craft, Crouse, Crow, Crow, Croxford, Cruz, Cunningham, Dalod, de Bruin, de Jong, de Paus, Decker, Demers, Deng, Desvignes, Dey, Di Paolo, Divangahi, Dolff, Dorhoi, Doz, Dragon, Du, Edwards, El-Behi, Elkayam, Elkington, Eruslanov, Eshleman, Eum, Fairweather, Farah, Farkas, Fejer, Feng, Fischer, Fleetwood, Francis, Francois, Freches, Fremond, Gagliani, Ganguly, Garcia-Romo, Gautier, Giosue, Giosue, Godfrey, Gonzalez-Juarrero, Gopal, Gopal, Gopal, Goriely, Goriely, Grainger, Griffin, Grogan, Grosset, Guarda, Guardigni, Guenova, Hedlund, Heidarnezhad, Higgins, Higgs, Hochrein, Hoeksema, Hoeve, Houben, Huebener, Hwang, Ifergan, Ireland, Ivashkiv, Jacob, Jayaraman, Jiao, Jin, Jones, Jones, Joosten, Joosten, Jurado, Kalinski, Kaminskaia, Kara, Kearney, Keller, Khader, Khader, Kim, Kim, Kirou, Kisich, Klose, Knaul, Kolb-Maurer, Korn, Kumar, Lande, Langrish, Langrish, Lazar-Molnar, Lazarus, Li, Liang, Lichtner, Lienard, Lindau, Linterman, Litinskiy, Liu, Lockhart, Longhi, Lood, Lopez, Lozza, Lu, Luan, Lubberts, Lyadova, Lyadova, Lyakh, MacKenzie, Maertzdorf, Maione, Manca, Manca, Manni, Manry, Mansoori, Manzanillo, Mao, Marin, Marin, Mariotti, Martin, Matsuoka, Mayer-Barber, Mayer-Barber, McNab, McNab, McNab, Merrill, Metcalfe, Midgley, Milano, Mishra, Mobley, Moguche, Monin, Mourik, Mueller, Munari, Mvubu, Nakayamada, Nandi, Napolitani, Navarra, Ndiaye, Ng, Niewold, Noster, Novikov, Nunnari, Okada, Okamoto Yoshida, Olobo, Ordway, Ottenhoff, O’Garra, Pai, Palmero, Pandey, Parkes, Parsa, Paulson, Peng, Perreau, Pers, Persson, Puthia, Rahman, Ramos-Kichik, Rangel Moreno, Rangel-Moreno, Raphael, Rasouli, Reboldi, Redford, Remoli, Repasy, Roberts, Ronnblom, Ronnblom, Roses, Rothchild, Rottenberg, Rovin, Russell, Sabbatani, Sage, Saiga, Sakai, Saraav, Sargentini, Scaffidi, Scapini, Schett, Schiffer, Schlitzer, Schreiber, Schreiber, Scordo, Scriba, Serezani, Shah, Shaler, Shapira, Shen, Shi, Shiomi, Shishikura, Shu, Sierra-Filardi, Silverpil, Simpson, Singh, Sjostrand, Slight, Sorgi, Spits, Stanley, Stephen-Victor, Stifter, Stohl, Strachan, Sutton, Swiecki, Szczucinski, Szeliga, Tada, Tall, Tameris, Teles, Telesca, Terawaki, Thien, Tian, Tian, Toossi, Torrado, Toubi, Trentini, Trinchieri, Tsai, Tsiganov, Tully, Ueno, Ulrichs, Umemura, Une, van Meijgaarden, van Nieuwenhuijze, Verreck, Verreck, Vincent, Vogt, von Scheidt, Wahren-Herlenius, Wang, Wassermann, Watson, Wilson, Wolf, Wong, Xu, Yamazaki, Yeremeev, Yoshimura, Zak, Zarogoulidis, Zhang, Zhang, Zhou, Zhou, Zitvogel, Zizzo, Zollars   +347 more
core   +4 more sources

Tertiary lymphoid structures in the central nervous system

Trends in Molecular Medicine
Tertiary lymphoid structures (TLSs) frequently occur at sites of chronic inflammation. A more advanced stage of multiple sclerosis (MS) has been associated with certain TLSs. However, tumor-associated TLSs have been shown to correlate with a greater treatment response rate and a better prognosis in glioma mouse models.
Chao Yang, Yu-Xiang Cai, Ze-Fen Wang, Su-Fang Tian, Zhi-Qiang Li   +4 more
openaire   +2 more sources

Editorial: “Cancer Immunotherapy: Lights and Shadows” [PDF]

, 2015
Cancer immunotherapy has recently emerged as the fourth treatment modality, in addition to surgery, chemotherapy, and radiotherapy. These advances are the result of important discoveries in the field of regulation of the immune response, especially on ...
Estrella Mariel Levy, José Mordoh, María Marcela Barrio   +2 more
core   +1 more source