Results 101 to 110 of about 375,831 (354)

Advances and Strategies in Enhancing mRNA Cancer Vaccines

open access: yesAdvanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang   +4 more
wiley   +1 more source

Cellular composition and microanatomy of lymphoid formations of the vestibule of the vagina in postnatal ontogenesis

open access: yesСеченовский вестник, 2019
Aim - presents data on the number of cells of the lymphoid series and the cellular composition of the lymphoid tissue in the mucosa of the vaginal vestibule at different age periods of ontogenesis. Materials and methods.
S. V. Shadlinskaya
doaj   +1 more source

Transcript Identification Using Arrayed Hydrogels With TrapFISH

open access: yesAdvanced Materials Technologies, EarlyView.
TrapFISH is a novel method for high‐throughput single‐cell transcriptomics. It embeds cells in hyaluronic acid hydrogel beads and uses probe hybridization to quantify custom gene panels. By arraying hydrogels in microfluidic devices, cell barcoding is removed, enhancing scalability for studying cellular heterogeneity and rare cell states by targeting ...
David B. Morse   +5 more
wiley   +1 more source

Mechanical Interactions Impact the Functions of Immune Cells and Their Application in Immunoengineering

open access: yesAdvanced Therapeutics, EarlyView.
This review covers the mechanical forces experienced by immune cells through cell–cell and cell–extracellular matrix interactions and how these forces influence their receptors and functions. These relationships between forces and cellular functions can be exploited using engineering techniques to modify the physical properties of materials for novel ...
Yu‐Chang Chen   +2 more
wiley   +1 more source

The Lymphoid Tissue and Antibody Formation

open access: yesExperimental Biology and Medicine, 1947
SummaryAdrenalectomized rabbits with hypertrophy of the lymphoid tissues produce antibodies in amounts far in excess of that produced by intact animals. this is evident not only by definite reactions in higher dilution but by the more masive precipitate in low dilutions.
James B. Murphy, Ernest Sturm
openaire   +3 more sources

Type 2 innate lymphoid cell and kidney disease

open access: yesLinchuang shenzangbing zazhi, 2021
Innate lymphoid cells(ILCs)are a newly-discovered family of immune cells in innate immunity with acquired immune function.Usually located at mucosal barriers, they mediate early immunosurveillance and regulate immune responses through secreting cytokines.
Yao Deng-hu   +2 more
doaj  

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

open access: yesAdvanced Therapeutics, EarlyView.
Emerging microphysiological systems reproduce the spatial, biochemical, and cellular complexity of the tumor microenvironment, surpassing 2D cultures and murine models. By integrating patient‐derived tumors, perfusable vasculature, and immune trafficking, these organ‐on‐chip platforms reveal mechanisms of immune evasion, predict therapeutic responses ...
Fabiana Moresi   +5 more
wiley   +1 more source

Uterine natural killer cell heterogeneity: Lessons from mouse models [PDF]

open access: yes, 2020
Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes.
Sojka, Dorothy K
core   +1 more source

Cytokine Engineering Approaches for Regenerative Medicine

open access: yesAdvanced Therapeutics, EarlyView.
Engineered cytokines represent a powerful strategy to promote tissue repair and regeneration by precisely modulating immune responses. This review highlights recent advances in cytokine engineering, including strategies to enhance half‐life, improve tissue and cell targeting, and control receptor signaling.
Shiyi Li, Wenhao You, Mikaël M. Martino
wiley   +1 more source

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